Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 426-435

  Ravaschino, Esteban L ^a   Docampo, Roberta ^b   Rodriguez, Juan B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL [[(GAMMA GLUTAMYLLEUCYL)AMINO]METHYL]PHOSPHINATE; 1 PENTYL [[(GAMMA GLUTAMYLLEUCYL)AMINO]METHYL]PHOSPHINATE; PHOSPHINIC ACID DERIVATIVE; TRYPANOTHIONE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MYOBLAST; PHARMACOPHORE; TRYPANOSOMA CRUZI;

AMIDE SYNTHASES; ANIMALS; ANTIPROTOZOAL AGENTS; CELL PROLIFERATION; DRUG DESIGN; GLUTATHIONE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PEPTIDES; PHENYL ETHERS; PHOSPHINIC ACIDS; SPERMIDINE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCYANATES; TRYPANOSOMA CRUZI;

EID: 30444438035     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050922i     Document Type: Article

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