Characterization of Trypanosoma brucei γ-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine)

Journal of Biological Chemistry

Volumn 271, Issue 29, 1996, Pages 17485-17490

  Lueder, Deirdre V ^a   Phillips, Margaret A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; BUTHIONINE SULFOXIMINE; CYSTAMINE; CYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTAMINE; GLUTATHIONE; TRYPANOTHIONE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE EXPRESSION; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPOMASTIGOTE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARDIOPULMONARY RESUSCITATION; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENES, PROTOZOAN; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; KINETICS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; RATS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SPERMIDINE; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0030016346     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.29.17485     Document Type: Article

References (48)

1. Kirchhoff, L. V. (1995) in Principles and Practice of Infectious Diseases Mandell, G. L., Bennett, J. E., and Dolin, R., eds) pp. 2442-2455, Churchill Livingstone, New York
2. Meister, A. (1989) Glutathione: Chemical, Biochemical, and Medical Aspects (Dolphin, D., Avramovic, O., and Poulson, R., eds) pp. 368-457, John Wiley & Sons, Inc., New York
3. Meister, A. (1981) Trends Biochem. Sci. 6, 231-234
4. Fairlamb, A. H., Blackburn, P., Ulrich, P., Chait, B. T., and Cerami, A. (1985) Science 227, 1485-1487
5. Smith, K., Nadeau, K., Bradley, M., Walsh, C., and Fairlamb, A. H. (1992) Protein Sci. 1, 874-883
6. Arrick, B. A., Griffith, O. W., and Cerami, A. (1981) J. Exp. Med. 153, 720-725
7. Fulton, J. D., and Spooner, D. F. (1956) Biochem. J. 63, 475-481
8. Meshnick, S. R., Chang, K. P., and Cerami, A. (1977) Biochem. Pharmacol. 26, 1923-1928
9. Smith, A. B., Esko, J. D., and Hajduk, S. L. (1995) Science 268, 284-286
10. Sekura, R., and Meister, A. (1977) J. Biol. Chem. 252, 2599-2605
11. Seelig, G. F., Simondsen, R. P., and Meister, A. (1984) J. Biol. Chem. 259, 9345-9347
12. Huang, C. S., Chang, L. S., Anderson, M. E., and Meister, A. (1993) J. Biol. Chem. 268, 19675-19680
13. Gipp, J. J., Chang, C., and Mulcahy, R. T. (1992) Biochem. Biophys. Res. Commun. 185, 29-35
14. Ohtake, Y., and Yabuuchi, S. (1991) Yeast 7, 953-961
15. Mutoh, N., Nakagawa, C. W., and Hayashi, Y. (1995) J. Biochem. (Tokyo) 117, 283-288
16. Wilson, R., et al. (1994) Nature 368, 32-38
17. Watanabe, K., Yamano, Y., Murata, K., and Kimura, A. (1986) Nucleic Acids Res. 14, 4393-4400
18. May, M. J., and Leaver, C. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 10059-10063
19. Gipp, J. J., Bailey, H. H., and Mulcahy, R. T. (1995) Biochem. Biophys. Res. Commun. 206, 584-589
20. Huang, C. S., Anderson, M. E., and Meister, A. (1993) J. Biol. Chem. 268, 20578-20583
21. Hussein, A. S., and Walter, R. D. (1995) Mol. Biochem. Parasitol. 72, 57-64
22. Blin, N., and Stafford, D. W. (1976) Nucleic Acids Res. 3, 2303-2308
23. Ullrich, A., Shine, J., Chirgwin, J., Pictet, R., Tischer, E., Rutter, W. J., and Goodman, H. M. (1977) Science 196, 1313-1319
24. Brun, R., and Schonenberger, M. (1979) Acta Trop. 36, 289-292
25. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 83, 8073-8076
26. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
27. Phillips, M. A., Coffino, P., and Wang, C. C. (1987) J. Biol. Chem. 262, 8721-8727
28. Studier, F. W., Rosenberg, A. H., Dunn, J. J., and Dubendorff, J. W. (1991) Methods Enzymol. 185, 60-69
29. Osterman, A., Grishin, N. V., Kinch, L. N., and Phillips, M. A. (1994) Biochemistry 33, 13662-13667
30. Parks, P. D., Leuther, K. K., Howard, E. D., Johnston, S. A., and Dougherty, W. G. (1994) Anal. Biochem. 216, 413-417
31. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
32. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
33. Matsudaira, P. (1987) J. Biol. Chem. 262, 10035-10038
34. Yan, N., and Meister, A. (1990) J. Biol. Chem. 265, 1588-1593
35. Perelman, D., and Boothroyd, J. C. (1990) Mol. Cell. Biol. 10, 3284-3288
36. Fernandes, A. P., Nelson, K., and Beverley, S. M. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11608-11612
37. Huang, C. S., Moore, W. R., and Meister, A. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 2464-2468
38. Henderson, G. B., Fairlamb, A. H., and Cerami, A. (1987) Mol. Biochem. Parasitol. 24, 39-45
39. Muhich, M. L., and Boothroyd, J. C. (1988) Mol. Cell. Biol. 8, 3837-3846
40. Sinning, I., Kleywegt, G. J., Cowan, S. W., Reinemer, P., Dirr, H. W., Huber, R., Gilliland, G. L., Armstrong, R. N., Ji, X., Board, P. G., Olin, B., Mannervik, B., and Jones, T. A. (1993) J. Mol. Biol. 232, 192-212
41. Karplus, P. A., and Schulz, G. E. (1989) J. Mol. Biol. 210, 163-180
42. Griffith, O. W., Larsson, A., and Meister, A. (1977) Biochem. Biophys. Res. Commun. 79, 919-925
43. Beamer, R. L., Griffith, O. W., Gass, J. D., Anderson, M. E., and Meister, A. (1980) J. Biol. Chem. 255, 11732-11736
44. Seelig, G. F., and Meister, A. (1982) J. Biol. Chem. 257, 5092-5096
45. Seelig, G. F., and Meister, A. (1984) J. Biol. Chem. 259, 3534-3538
46. Orlowski, M., and Meister, A. (1971) J. Biol. Chem. 246, 7095-7105
47. Saraste, M., Sibbald, P. R., and Wittinghofer, A. (1990) Trends Biochem. Sci. 15, 430-434
48. Yamaguchi, H., Kato, H., Hata, Y., Nishioka, T., Kimura, A., Oda, J., and Katsube, Y. (1993) J. Mol. Biol. 229, 1083-1100