QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2976-2983

  Daunes, S ^a   D'Silva, C ^a   Kendrick, H ^b   Yardley, V ^b   Croft, S L ^b  

^a MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE DERIVATIVE; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE 1 BUTYL GLUTAMATE; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE 1 BUTYL GLYCINATE; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE 2 BUTYL GLYCINATE; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE DI 2 CHLOROETHYL ESTER; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE DI 2 PROPYL ESTER; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE DI 3 METHYL 2 BUTYL ESTER; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE DICYCLOPENTYL ESTER; N BENZYLOXYCARBONYL S (2,4 DINITROPHENYL)GLUTATHIONE DIPENTYL ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LEISHMANIA DONOVANI; MEMBRANE PERMEABILITY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CELL LINE; ESTERS; GLUTATHIONE; HUMANS; LEISHMANIA DONOVANI; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0035974742     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000502n     Document Type: Article

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