2′-O-methyl-modified phoshorothioate antisense oligonucleotides have reduced non-specific effects in vitro

Nucleic Acids Research

Volumn 32, Issue 6, 2004, Pages 2008-2016

  Yoo, Byong Hoon ^c   Bochkareva, Elena ^a   Bochakarev, Alexey ^a   Mou, Tung Chung ^b   Gray, Donald M ^c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY RNA; DNA; DNA BINDING PROTEIN; MESSENGER RNA; METHYL GROUP; NUCLEASE; OBLIMERSEN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGOMER; PROTEIN BCL 2; REPLICATION PROTEIN A; RIBONUCLEASE H; ANTISENSE OLIGONUCLEOTIDE; NUCLEOTIDE; RNA; RPA1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STABILITY; ENZYME DEGRADATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MELTING POINT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; BIOSYNTHESIS; CELL DIVISION; CHEMISTRY; COMPARATIVE STUDY; DOWN REGULATION; GENETICS; METABOLISM; METHYLATION; TEMPERATURE; TUMOR CELL LINE;

APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DNA-BINDING PROTEINS; DOWN-REGULATION; HUMANS; METHYLATION; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-BCL-2; REPLICATION PROTEIN A; RIBONUCLEASE H, CALF THYMUS; RNA; RNA, MESSENGER; TEMPERATURE; THIONUCLEOTIDES;

EID: 3042836355     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh516     Document Type: Article

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