Antisense ferritin oligonucleotides inhibit growth and induce apoptosis in human breast carcinoma cells

Anticancer Research

Volumn 22, Issue 3, 2002, Pages 1513-1524

  Yang, Ding Cheng ^a   Jiang, Xianpeng ^a   Elliott, Robert L ^a   Head, Jonathan F ^a  

^a The Mastology Research Institute   (United States)

Author keywords

Antisense oligonucleotides; Breast cancer; Ferritin; Human; RT PCR

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FERRITIN; FERRITIN HEAVY CHAIN A1; FERRITIN HEAVY CHAIN A2; FERRITIN LIGHT CHAIN A1; FERRITIN LIGHT CHAIN A2; IRON; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CELL VOLUME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG SYNTHESIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; DNA, NEOPLASM; FERRITINS; GROWTH INHIBITORS; HUMANS; IRON; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0036328448     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Iron in cancer
2. Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells
3. Minireview: Regulation of ferritin and transferrin receptor mRNAs
4. Review: Regulating the fate of mRNA: The control of cellular iron metabolism
5. Ferritin gene expression in health and malignancy
6. Manipulations of cellular iron metabolism for modulating and malignant cell proliferation: Achievements and prospects
7. The uptake of iron and transferrin by the human malignant melanoma cell
8. Regulation of ferritin synthesis in malignant and non-malignant lymphoid cells
9. Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro
10. Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones
11. Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene
12. Expression of transferrin receptor and ferritin H-chain mRNA are associated with clinical and histopathological prognostic indicators in breast cancer
13. Effect of hydroxyurea on cellular iron metabolism in human leukemic CCRF-CEM cells: Changes in iron uptake and the regulation of transferrin receptor and ferritin gene expression following inhibition of DNA synthesis
14. Doxorubicin-gallium-transferrin conjugate overcomes multidrug resistance: Evidence for drug accumulation in the nucleus of drug resistant MCF-7/ADR cells
15. Expression of mdr1, mrp, topoisomerase IIa/β, and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias
16. Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7
17. Modulation of Bcl-2 protein levels by an intracellular anti Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
18. Sodium phenylacetate induces growth inhibition and Bcl-2 down-regulation and apoptosis in MCF7ras cells in vitro and in nude mice
19. Comparison of transferrin receptors, iron content and isoferritin profile in normal and malignant human breast cell lines
20. Tissue ferritin concentration and prognosis in carcinoma of the breast
21. Breast carcinoma and the role of iron metabolism: A cytochemical, tissue culture, and ultrastructural study
22. Neuroblastomas contain iron-rich ferritin
23. Isotopic immunoglobulin: A new systemic therapy for advanced Hodgkin's disease
24. Iodine 131 antiferritin, a new treatment modality in hepatoma: A radiation therapy oncology group study
25. Yttrium antiferritin - A new therapeutic radiolabeled antibody
26. Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: Possible role in chemotherapy efficacy
27. Characterization of oligonucleotide transport into living cells
28. Specific regulation of gene expression by antisense, sense and antigene nucleic acids
29. The role of antisense RNA in gene regulation
30. Physicochemical properties of phosphorothioate oligonucleotides
31. Phase I trial of an antisense oligonucleotide OL(1) p 53 in hematologic malignancies
32. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma