Intracrinology and the local enzymatic control of hormone distribution and metabolism: Dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens

European Journal of Clinical Investigation, Supplement

Volumn 30, Issue 3, 2000, Pages 34-38

  Kuhn Velten W N ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

DHEA; Intracrinology; Review

Indexed keywords

ANDROGEN; ESTROGEN; HORMONE PRECURSOR; PRASTERONE; STEROID HORMONE;

CONFERENCE PAPER; ENZYME REGULATION; HORMONE ACTION; HORMONE RELEASE; HUMAN; PRIORITY JOURNAL; STEROID METABOLISM; STEROIDOGENESIS;

EID: 3042735882     PISSN: 0960135X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2000.0300s3034.x     Document Type: Conference Paper

References (40)

1. Editorial: Did eucaryotic steroid receptors evolve from intracrine gene regulators?
2. Intracrinology
3. Fusion of enzyme kinetics with quantitative cell biology constitutes a novel, synergistic approach to calculate local enzyme activities in situ from subcellular-site concentrations of enzymes and their substrates: An endocrinologist's contribution to the 'metabolite channelling' debate
4. Cortisol, hypertension and obesity: The role of 11β-hydroxysteroid dehydrogenase
5. Modelling of intracellular steroid hormone interaction with membrane-bound enzymes by analyses in highly volume-occupied solutions
6. Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization
7. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting
8. Thyroid hormone deiodinases - A selenoenzyme family acting as gate keepers to thyroid hormone action
9. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes. Evidence for distinct physiological functions
10. A working hypothesis for the regulation of steroidogenesis and germ cell development in the gonads by glucocorticoids and 11β-hydroxysteroid dehydrogenase (11βHSD)
11. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation
12. Loss of estrogen inactivation in colonic cancer
13. The actions of exogenous dehydroepiandrosterone in experimental animals and humans
14. The importance of being dehydroepiandrosterone sulfate (in the blood of primates)
15. Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline
16. Cytochrome P450c17: Regulation of gene expression and enzyme function at the bifurcation in steroid hormone synthesis
17. Serine phosphorylation of human P450c17 increases 17,20-lyase activity: Implications for adrenarche and the polycystic ovary syndrome
18. Protein phosphorylation changes ligand-binding efficiency of cytochrome P450c17 (CYP17) and accelerates its proteolytic degradation: Putative relevance for hormonal regulation of CYP17 activity
19. Enzymology of human cytosolic sulfotransferases
20. Metabolism of dehydroepiandrosterone
21. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans
22. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging
23. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator
24. Multiple steroid-binding orientations: Alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209
25. Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7α-hydroxydehydroepiandrosterone by human adipose stromal cells
26. Biotransformation of oral dehydroepiandrosterone in elderly men: Significant increase in circulating estrogens
27. Endocrine interactions: Adrenal steroids and precursors
28. Dehydroepiandrosterone stimulates the estrogen response element
29. Studies of dehydroepiandrosterone (DHEA) with the human estrogen receptor in yeast
30. Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydropiandrosterone in activated human T lymphocytes
31. Transport of dehydroepiandrosterone and dehydroepiandrosterone sulphate into rat hepatocytes
32. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging
33. Regulation of cytochromes P450 by DHEA and its carcinogenic action
34. Peroxisome proliferator-activated receptor α required for gene induction by dehydroepiandrosterone-3β-sulfate
35. Inverse relationship between peroxisomal and mitochondrial β-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid
36. Correlation of serum L-carnitine and dehydroepiandrosterone sulphate levels with age and sex in healthy adults
37. Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line
38. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: Relationship to thermogenesis
39. Estrone potentiates myeloid cell differentiation: A role for 17β-hydroxysteroid dehydrogenase in modulating hemopoiesis
40. Identification of target cells by immunohistochemical detection of covalently rearranged estradiol in rehydrated paraffin sections