-
1
-
-
0041453323
-
-
Central Brain Tumor Registry of the United States. Chicago, IL, USA
-
CBTRUS. Statistical Report: Primary Brain Tumors in the United States, 1995-1999. Central Brain Tumor Registry of the United States. Chicago, IL, USA (2002). Good report on the incidence of primary benign and malignant brain tumor.
-
(2002)
Statistical Report Primary Brain Tumors in the United States, 1995-1999
-
-
-
2
-
-
0033755187
-
Phase III randomized study of postradiotherapy chemotherapy with α-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N′- cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme
-
Levin VA, Uhm JH, Jaeckle KA et al. Phase III randomized study of postradiotherapy chemotherapy with α-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. Clin. Cancer Res. 6, 3878-3884 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3878-3884
-
-
Levin, V.A.1
Uhm, J.H.2
Jaeckle, K.A.3
-
3
-
-
0001911554
-
Neoplasms of the central nervous system
-
DeVita VTJ, Hellman S, Rosenberg SA (Eds). Lippincott-Raven, PA, USA
-
Levin VA, Leibel SA, Gutin PH. Neoplasms of the central nervous system. In: Cancer: Principles and Practice of Oncology. Sixth Edition. DeVita VTJ, Hellman S, Rosenberg SA (Eds). Lippincott-Raven, PA, USA, 2100-2160 (2001).
-
(2001)
Cancer: Principles and Practice of Oncology. Sixth Edition
, pp. 2100-2160
-
-
Levin, V.A.1
Leibel, S.A.2
Gutin, P.H.3
-
4
-
-
0031755577
-
Malignant glioma: Who benefits from adjuvant chemotherapy?
-
DeAngelis LM, Burger PC, Green SB et al. Malignant glioma: who benefits from adjuvant chemotherapy? Ann. Neurol. 44, 691-695 (1998).
-
(1998)
Ann. Neurol.
, vol.44
, pp. 691-695
-
-
DeAngelis, L.M.1
Burger, P.C.2
Green, S.B.3
-
8
-
-
0001872876
-
Infiltrating astrocytomas
-
Kleihues P, Cavenee WK (Eds). International Agency for Research on Cancer. International Agency for Research, Lyon, France
-
Cavenee WK, Furnari FB, Nagane M et al. Infiltrating astrocytomas. In: Pathology and Genetics of Tumours of the Nervous System. Second Edition. Kleihues P, Cavenee WK (Eds). International Agency for Research on Cancer. International Agency for Research, Lyon, France, 10-21 (2000).
-
(2000)
Pathology and Genetics of Tumours of the Nervous System. Second Edition
, pp. 10-21
-
-
Cavenee, W.K.1
Furnari, F.B.2
Nagane, M.3
-
9
-
-
0001989917
-
Oligodendroglioma
-
Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France
-
Reifenberger G, Kros JM, Burger PC et al. Oligodendroglioma. In: Pathology and Genetics of Tumors of the Nervous System. Second Edition. Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France, 56-61 (2000).
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. Second Edition
, pp. 56-61
-
-
Reifenberger, G.1
Kros, J.M.2
Burger, P.C.3
-
10
-
-
0002951385
-
Anaplastic oligodendroglioma
-
Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France
-
Reifenberger G, Kros JM, Burger PC et al. Anaplastic oligodendroglioma. In: Pathology and Genetics of Tumors of the Nervous System. Second Edition Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France, 62-64 (2000).
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. Second Edition
, pp. 62-64
-
-
Reifenberger, G.1
Kros, J.M.2
Burger, P.C.3
-
11
-
-
0002951385
-
Anaplastic oligodendroglioma
-
Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France
-
Reifenberger G, Kros JM, Burger PC et al. Anaplastic oligodendroglioma. In: Pathology and Genetics of Tumors of the Nervous System. Second Edition Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France, 65-67 (2000).
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. Second Edition
, pp. 65-67
-
-
Reifenberger, G.1
Kros, J.M.2
Burger, P.C.3
-
12
-
-
0002951385
-
Anaplastic oligodendroglioma
-
Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France
-
Reifenberger G, Kros JM, Burger PC et al. Anaplastic oligodendroglioma. In: Pathology and Genetics of Tumors of the Nervous System. Second Edition Kleihues P, Cavenee WK, (Eds). International Agency for Research on Cancer. IARC Press, Lyon, France, 68-69 (2000).
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. Second Edition
, pp. 68-69
-
-
Reifenberger, G.1
Kros, J.M.2
Burger, P.C.3
-
13
-
-
0030903111
-
Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas
-
Coons SW, Johnson PC, Scheithauer BW et al. Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer 79, 1381-1393 (1997). Demonstrates the high degree of interobserver variability in diagnostic neuropathology indicating a need for improved molecular methods for classification.
-
(1997)
Cancer
, vol.79
, pp. 1381-1393
-
-
Coons, S.W.1
Johnson, P.C.2
Scheithauer, B.W.3
-
14
-
-
0031705691
-
p53 and brain tumors: From gene mutations to gene therapy
-
Fulci G, Ishii N, Van Meir EG et al. p53 and brain tumors: from gene mutations to gene therapy, Brain Pathol. 8, 599-613 (1998).
-
(1998)
Brain Pathol.
, vol.8
, pp. 599-613
-
-
Fulci, G.1
Ishii, N.2
Van Meir, E.G.3
-
15
-
-
1842533782
-
Alterations in molecular pathways of diffusely infiltrating astrocytomas: Application to tumor classification and antitumor therapy
-
Hunter SB, Brat DJ, Olson JJ et al. Alterations in molecular pathways of diffusely infiltrating astrocytomas: application to tumor classification and antitumor therapy. Int. J. Oncol. 23, 857-869 (2003).
-
(2003)
Int. J. Oncol.
, vol.23
, pp. 857-869
-
-
Hunter, S.B.1
Brat, D.J.2
Olson, J.J.3
-
16
-
-
0027196974
-
Amplification and over expression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger G, Liu L, Ichimura K et al. Amplification and over expression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations, Cancer Res. 53, 2736-2739 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
-
17
-
-
0034601410
-
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
-
Fulci G, Labuhn M, Maier D et al. EG. p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene 19, 3816-3822 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3816-3822
-
-
Fulci, G.1
Labuhn, M.2
Maier, D.3
-
18
-
-
0034745338
-
p14ARF deletion and methylation in genetic pathways to glioblastomas
-
Nakamura M, Watanabe T, Klangby U et al. p14ARF deletion and methylation in genetic pathways to glioblastomas. Brain Pathol. 11, 159-168 (2001).
-
(2001)
Brain Pathol.
, vol.11
, pp. 159-168
-
-
Nakamura, M.1
Watanabe, T.2
Klangby, U.3
-
19
-
-
0036201832
-
Impact of genotype and morphology on the prognosis of glioblastoma
-
Schmidt MC, Antweiler S, Urban N et al. Impact of genotype and morphology on the prognosis of glioblastoma. J. Neuropathol. Exp. Neurol. 61, 321-328 (2002).
-
(2002)
J. Neuropathol. Exp. Neurol.
, vol.61
, pp. 321-328
-
-
Schmidt, M.C.1
Antweiler, S.2
Urban, N.3
-
20
-
-
0035880788
-
PTEN mutation, EGFR amplification and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
-
Smith JS, Tachibana I, Passe SM et al. PTEN mutation, EGFR amplification and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J. Natl Cancer Inst. 93, 1246-1256 (2001). Excellent multivariate analysis of genetic alterations in malignant astrocytomas as they relate to patient outcome.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1246-1256
-
-
Smith, J.S.1
Tachibana, I.2
Passe, S.M.3
-
21
-
-
0031920406
-
Genetic subtypes of human malignant astrocytoma correlate with survival
-
Leenstra S, Oskam NT, Bijleveld EH et al. Genetic subtypes of human malignant astrocytoma correlate with survival. Int. J. Cancer 79, 159-165 (1998).
-
(1998)
Int. J. Cancer
, vol.79
, pp. 159-165
-
-
Leenstra, S.1
Oskam, N.T.2
Bijleveld, E.H.3
-
22
-
-
0035111058
-
Analysis of complex relationships between age, p53, epidermal growth factor receptor and survival in glioblastoma patients
-
Simmons ML, Lamborn KR, Takahashi M et al. Analysis of complex relationships between age, p53, epidermal growth factor receptor and survival in glioblastoma patients. Cancer Res. 61, 1122-1128 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 1122-1128
-
-
Simmons, M.L.1
Lamborn, K.R.2
Takahashi, M.3
-
23
-
-
0031679407
-
Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes
-
Newcomb EW, Cohen H, Lee SR et al. Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. Brain Pathol. 8, 655-667 (1998).
-
(1998)
Brain Pathol.
, vol.8
, pp. 655-667
-
-
Newcomb, E.W.1
Cohen, H.2
Lee, S.R.3
-
24
-
-
0037099758
-
Influence of p53 mutations on prognosis of patients with glioblastoma
-
Shiraishi S, Tada K, Nakamura H et al. Influence of p53 mutations on prognosis of patients with glioblastoma. Cancer 95, 249-257 (2002).
-
(2002)
Cancer
, vol.95
, pp. 249-257
-
-
Shiraishi, S.1
Tada, K.2
Nakamura, H.3
-
25
-
-
0037093971
-
Molecular markers of prognosis in astrocytic tumors
-
Rasheed A, Herndon JE, Stenzel TT et al. Molecular markers of prognosis in astrocytic tumors. Cancer 94, 2688-2697 (2002).
-
(2002)
Cancer
, vol.94
, pp. 2688-2697
-
-
Rasheed, A.1
Herndon, J.E.2
Stenzel, T.T.3
-
26
-
-
0028652269
-
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
-
Schmidt EE, Ichimura K, Reifenberger G et al. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 54, 6321-6324 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 6321-6324
-
-
Schmidt, E.E.1
Ichimura, K.2
Reifenberger, G.3
-
27
-
-
0028986612
-
Loss of P16INK4 expression is frequent in high-grade gliomas
-
Nishikawa R, Furnari FB, Lin H et al. Loss of P16INK4 expression is frequent in high-grade gliomas. Cancer Res. 55, 1941-1945 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 1941-1945
-
-
Nishikawa, R.1
Furnari, F.B.2
Lin, H.3
-
28
-
-
0030982897
-
Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
-
Costello JF, Plass C, Arap W et al. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 57, 1250-1254 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 1250-1254
-
-
Costello, J.F.1
Plass, C.2
Arap, W.3
-
29
-
-
0030881477
-
Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
-
Biernat W, Tohma Y, Yonekawa Y et al. Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol. (Berl). 94, 303-309 (1997).
-
(1997)
Acta Neuropathol. (Berl)
, vol.94
, pp. 303-309
-
-
Biernat, W.1
Tohma, Y.2
Yonekawa, Y.3
-
30
-
-
0029789695
-
Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications
-
Maruno M, Yoshimine T, Muhammad AK et al. Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications. J. Neuro-oncol. 30, 19-24 (1996).
-
(1996)
J. Neuro-oncol.
, vol.30
, pp. 19-24
-
-
Maruno, M.1
Yoshimine, T.2
Muhammad, A.K.3
-
31
-
-
0033491737
-
Detection of p16, RB, CDK4 and p53 gene deletion and amplification by fluorescence in situ hybridization in 96 gliomas
-
Perry A, Anderl Y, Borell TJ et al. Detection of p16, RB, CDK4 and p53 gene deletion and amplification by fluorescence in situ hybridization in 96 gliomas. Am. J. Clin. Pathol. 112, 801-809 (1999).
-
(1999)
Am. J. Clin. Pathol.
, vol.112
, pp. 801-809
-
-
Perry, A.1
Anderl, Y.2
Borell, T.J.3
-
32
-
-
0036828260
-
Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma
-
Burton EC, Lamborn KR, Feuerstein BG et al. Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res. 62, 6205-6210 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6205-6210
-
-
Burton, E.C.1
Lamborn, K.R.2
Feuerstein, B.G.3
-
33
-
-
0033772866
-
Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme
-
Kraus JA, Glesmann N, Beck M et al. Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme. J. Neuro-oncol. 48, 89-94 (2000).
-
(2000)
J. Neuro-oncol.
, vol.48
, pp. 89-94
-
-
Kraus, J.A.1
Glesmann, N.2
Beck, M.3
-
34
-
-
1842536417
-
Analysis of 1p, 19q, 9p and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from RTOG trials
-
Brat DJ, Seiferheld W, Perry A et al. Analysis of 1p, 19q, 9p and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from RTOG trials. Neuro-oncology 6, 96-103 (2004).
-
(2004)
Neuro-oncology
, vol.6
, pp. 96-103
-
-
Brat, D.J.1
Seiferheld, W.2
Perry, A.3
-
35
-
-
0025790916
-
Genes for epidermal growth factor receptor, transforming growth factor alpha and epidermal growth factor and their expression in human gliomas in vivo
-
Ekstrand AJ, James CD, Cavenee WK et al. Genes for epidermal growth factor receptor, transforming growth factor alpha and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 51, 2164-7212 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 2164-7212
-
-
Ekstrand, A.J.1
James, C.D.2
Cavenee, W.K.3
-
36
-
-
0142188691
-
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
-
Shinojima N, Tada K, Shiraishi S et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res. 63, 6962-6970 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 6962-6970
-
-
Shinojima, N.1
Tada, K.2
Shiraishi, S.3
-
37
-
-
0033641896
-
Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: Results of a meta-analysis
-
Huncharek M, Kupelnick B. Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: results of a meta-analysis. Oncol. Res. 12, 107-112 (2000).
-
(2000)
Oncol. Res.
, vol.12
, pp. 107-112
-
-
Huncharek, M.1
Kupelnick, B.2
-
38
-
-
0032788101
-
Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter
-
Fujisawa H, Kurrer M, Reis RM et al. Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter. Am. J. Pathol. 155, 387-394 (1999).
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 387-394
-
-
Fujisawa, H.1
Kurrer, M.2
Reis, R.M.3
-
39
-
-
0032971251
-
Mutational analysis of the PTEN gene in gliomas: Molecular and pathological correlations
-
Zhou XP, Li YJ, Hoang-Xuan K et al. Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations. Int. J. Cancer. 84, 150-154 (1999).
-
(1999)
Int. J. Cancer
, vol.84
, pp. 150-154
-
-
Zhou, X.P.1
Li, Y.J.2
Hoang-Xuan, K.3
-
40
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer
-
Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science 275, 1943-1947 (1997).
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
41
-
-
0035887448
-
Genetic subgroups of anaplastic astrocytomas correlate with patient age and survival
-
Kunwar S, Mohapatra G, Bollen A et al. Genetic subgroups of anaplastic astrocytomas correlate with patient age and survival. Cancer Res. 61, 7683-7688 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 7683-7688
-
-
Kunwar, S.1
Mohapatra, G.2
Bollen, A.3
-
42
-
-
0034761379
-
Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: Correlation with patient age and survival
-
Tada K, Shiraishi S, Kamiryo T et al. Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival. J. Neurosurg. 95, 651-659 (2001).
-
(2001)
J. Neurosurg.
, vol.95
, pp. 651-659
-
-
Tada, K.1
Shiraishi, S.2
Kamiryo, T.3
-
43
-
-
0032731539
-
Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas
-
Balesaria S, Brock C, Bower M et al. Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas. Br. J. Cancer 81, 1371-1377 (1999).
-
(1999)
Br. J. Cancer
, vol.81
, pp. 1371-1377
-
-
Balesaria, S.1
Brock, C.2
Bower, M.3
-
44
-
-
0028095051
-
Prognostic factors in gliomas. A multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic and molecular markers
-
Ganju V, Jenkins RB, O'Fallon JR et al. Prognostic factors in gliomas. A multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic and molecular markers. Cancer 74, 920-927 (1994).
-
(1994)
Cancer
, vol.74
, pp. 920-927
-
-
Ganju, V.1
Jenkins, R.B.2
O'Fallon, J.R.3
-
45
-
-
0032494479
-
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
-
Cairncross JG, Ueki K, Zlatescu MC et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl Cancer Inst. 90, 1473-1479 (1998). Demonstrates that 1p/19q codeletion in oligodendroglioma is predictive of a therapeutic response. A conceptual break through in neuro-oncology.
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 1473-1479
-
-
Cairncross, J.G.1
Ueki, K.2
Zlatescu, M.C.3
-
46
-
-
0026597158
-
The treatment of oligodendrogliomas and mixed oligodendroglioma- astrocytomas with PCV chemotherapy
-
Glass J, Hochberg H, Gruber ML et al. The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. J. Neurosurg. 76, 741-745 (1992).
-
(1992)
J. Neurosurg.
, vol.76
, pp. 741-745
-
-
Glass, J.1
Hochberg, H.2
Gruber, M.L.3
-
47
-
-
0034791736
-
Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group
-
Jenkins RB, Curran W, Scott CB et al. Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group. Am. J. Clin. Oncol. 24, 506-508 (2001).
-
(2001)
Am. J. Clin. Oncol.
, vol.24
, pp. 506-508
-
-
Jenkins, R.B.1
Curran, W.2
Scott, C.B.3
-
48
-
-
0036796193
-
Advances in diagnosis and management of oligodendroglioma
-
Hussein MR, Baidas S et al. Advances in diagnosis and management of oligodendroglioma. Expert Rev. AntiCancer Ther. 2, 520-528 (2002).
-
(2002)
Expert Rev. AntiCancer Ther.
, vol.2
, pp. 520-528
-
-
Hussein, M.R.1
Baidas, S.2
-
49
-
-
0033951824
-
Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas and mixed oligoastrocytomas
-
Smith JS, Perry A, Borell TJ, Lee HK et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas and mixed oligoastrocytomas. J. Clin. Oncol. 18, 636-645 (2000). Addresses the important issue of whether 1/p 19 loss in astrocytic neoplasms was predictive of therapeutic response. No survival differences were noted.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 636-645
-
-
Smith, J.S.1
Perry, A.2
Borell, T.J.3
Lee, H.K.4
-
50
-
-
0038172954
-
Ancillary FISH analysis for 1p and 19q status: Preliminary observations in 287 gliomas and oligodendroglioma mimics
-
Perry A, Fuller CE, Banerjee R et al. Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci. 8, 1-9 (2003).
-
(2003)
Front Biosci.
, vol.8
, pp. 1-9
-
-
Perry, A.1
Fuller, C.E.2
Banerjee, R.3
-
51
-
-
0034036250
-
Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss
-
Ino Y, Zlatescu MC, Sasaki H et al. Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss. J. Neurosurg. 92, 983-990 (2002).
-
(2002)
J. Neurosurg.
, vol.92
, pp. 983-990
-
-
Ino, Y.1
Zlatescu, M.C.2
Sasaki, H.3
-
52
-
-
0037165140
-
Prediction of central nervous system embryonal tumour outcome based on gene expression
-
Pomeroy SL, Tamayo P, Gaasenbeek M et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415, 436-442 (2002). First article to show that gene expression profiles and computational algorithms can be used to successfully classify medulloblastomas and predict outcomes.
-
(2002)
Nature
, vol.415
, pp. 436-442
-
-
Pomeroy, S.L.1
Tamayo, P.2
Gaasenbeek, M.3
-
53
-
-
0037381008
-
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
-
Nutt CL, Mani DR, Betensky RA et al. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003). First article to show that gene expression profilesand computational algorithms can be used to successfully classify glial neoplasms and predict outcome.
-
(2003)
Cancer Res.
, vol.63
, pp. 1602-1607
-
-
Nutt, C.L.1
Mani, D.R.2
Betensky, R.A.3
-
54
-
-
0347659463
-
Advances in molecular therapies in patients with brain tumors
-
Tremont-Lukas I, Gilbert M. Advances in molecular therapies in patients with brain tumors. Cancer Control 10, 125-137 (2003). Reviews early results of clinical trials of targeted therapy agents.
-
(2003)
Cancer Control
, vol.10
, pp. 125-137
-
-
Tremont-Lukas, I.1
Gilbert, M.2
-
55
-
-
0031968285
-
The New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium: Organization, objectives and activities
-
Grossman SA, Fisher JD, Pdiantadosi S et al. The New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium: organization, objectives and activities. Cancer Control 5, 107-114 (1998). Reviews the organization structure of National Cancer Institute sponsored NABTT CNS Consortium in the USA.
-
(1998)
Cancer Control
, vol.5
, pp. 107-114
-
-
Grossman, S.A.1
Fisher, J.D.2
Pdiantadosi, S.3
-
56
-
-
0036016088
-
Antiepidermal growth factor receptor drugs in cancer therapy
-
Ciardiello F, Tortora G. Antiepidermal growth factor receptor drugs in cancer therapy. Expert Opin. Investig. Drugs 11, 755-768 (2002).
-
(2002)
Expert Opin. Investig. Drugs
, vol.11
, pp. 755-768
-
-
Ciardiello, F.1
Tortora, G.2
-
57
-
-
0036820993
-
Activity of antiepidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme
-
Eller JL, Longo SL, Hicklin DJ et al. Activity of antiepidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme, Neurosurgery 51, 1005-1014 (2002).
-
(2002)
Neurosurgery
, vol.51
, pp. 1005-1014
-
-
Eller, J.L.1
Longo, S.L.2
Hicklin, D.J.3
-
58
-
-
0035476803
-
The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
-
Moasser MM, Basso A, Averbuch SD et al. The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 61, 7184-7188 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 7184-7188
-
-
Moasser, M.M.1
Basso, A.2
Averbuch, S.D.3
-
59
-
-
0034758726
-
Tyrosine kinase inhibitors-ZD1839 (Iressa)
-
Arteaga, CL, Johnson DH. Tyrosine kinase inhibitors-ZD1839 (Iressa), Curr. Opin. Oncol. 13, 491-498 (2001).
-
(2001)
Curr. Opin. Oncol.
, vol.13
, pp. 491-498
-
-
Arteaga, C.L.1
Johnson, D.H.2
-
60
-
-
0036570203
-
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
-
Hirata A, Ogawa S, Kometani T et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase, Cancer Res. 62, 2554-2560 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 2554-2560
-
-
Hirata, A.1
Ogawa, S.2
Kometani, T.3
-
61
-
-
0242349431
-
Phase I-II study of ZD-1839 for recurrent malignant gliomas and meningiomas progressing after radiation therapy
-
Lieberman FS, Cloughesy T, Malkin M et al. Phase I-II study of ZD-1839 for recurrent malignant gliomas and meningiomas progressing after radiation therapy. Proc. Am. Soc. Clin. Oncol. 22, 105 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 105
-
-
Lieberman, F.S.1
Cloughesy, T.2
Malkin, M.3
-
62
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T et al. Phase II trial of gefitinib in recurrent glioblastoma. J. Clin. Oncol. 22(1), 133-142 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.1
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
-
63
-
-
0242286359
-
Phase I study of OSI-774 alone or with temozolomide in patient with malignant glioma
-
Prados M, Chang S, Burton E et al. Phase I study of OSI-774 alone or with temozolomide in patient with malignant glioma. Proc. Am. Soc. Clin. Oncol. 22, 99 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 99
-
-
Prados, M.1
Chang, S.2
Burton, E.3
-
64
-
-
0030797470
-
Association of EGFR gene amplification and CDKN2 (p12/MTS1) gene deletion in glioblastoma multiforme
-
Hayahi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A. Association of EGFR gene amplification and CDKN2 (p12/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol. 7, 871-875 (1997).
-
(1997)
Brain Pathol.
, vol.7
, pp. 871-875
-
-
Hayahi, Y.1
Ueki, K.2
Waha, A.3
Wiestler, O.D.4
Louis, D.N.5
Von Deimling, A.6
-
65
-
-
0014011131
-
Alanosine, a new antiviral and antitumour agent isolated from a Streptomyces
-
Murthy YK, Thiemann JE, Coronelli C et al. Alanosine, a new antiviral and antitumour agent isolated from a Streptomyces. Nature 211, 1098-1199 (1966).
-
(1966)
Nature
, vol.211
, pp. 1098-1199
-
-
Murthy, Y.K.1
Thiemann, J.E.2
Coronelli, C.3
-
67
-
-
0017274413
-
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine mmonophosphae
-
Graff JC, Plagermann PG. Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine mmonophosphae. Cancer Res. 36, 1428-1440 (1968).
-
(1968)
Cancer Res.
, vol.36
, pp. 1428-1440
-
-
Graff, J.C.1
Plagermann, P.G.2
-
69
-
-
0031752311
-
Expression of endothelin (A) receptors in human gliomas and ameningiomas, with high affinity for the selective antagonist PD 156707
-
Harland SP, Kuc RE, Pickard JD et al. Expression of endothelin (A) receptors in human gliomas and ameningiomas, with high affinity for the selective antagonist PD 156707. Neurosurgery 43 (4), 890-899 (1998).
-
(1998)
Neurosurgery
, vol.43
, Issue.4
, pp. 890-899
-
-
Harland, S.P.1
Kuc, R.E.2
Pickard, J.D.3
-
70
-
-
0028823940
-
Cellular localization of endothelin receptor mRNAa (ETA and ETB) in brain tumors and normal human brain
-
Pagotto U, Arzberger T, Hopfine U et al. Cellular localization of endothelin receptor mRNAa (ETA and ETB) in brain tumors and normal human brain. J. Cardiovasc. Pharmacol. 26(Suppl. 3), 104-106 (1995).
-
(1995)
J. Cardiovasc. Pharmacol.
, vol.26
, Issue.SUPPL. 3
, pp. 104-106
-
-
Pagotto, U.1
Arzberger, T.2
Hopfine, U.3
-
71
-
-
0027962395
-
Enhanced expression of an endothelin ETA receptor in capillaries from human glioblastoma: A quantative receptor autoradiographic analysis using a radioluminographic imaging plate system
-
Tsutsumi K, Niwa M, Kitagawa N et al. Enhanced expression of an endothelin ETA receptor in capillaries from human glioblastoma: a quantative receptor autoradiographic analysis using a radioluminographic imaging plate system. J. Neurochem. 63(6), 2240-2247 (1994).
-
(1994)
J. Neurochem.
, vol.63
, Issue.6
, pp. 2240-2247
-
-
Tsutsumi, K.1
Niwa, M.2
Kitagawa, N.3
-
72
-
-
0030717622
-
Correlation of endolthelin-1 and transforming growth factor-beta1 with malignancy and vascularity in human gliomas
-
Stiles JD, Ostrow PT, Balos LL et al. Correlation of endolthelin-1 and transforming growth factor-beta1 with malignancy and vascularity in human gliomas. J. Neuropath. Exp. Neurol. Exp. Neurol. 56 (4) 435-439 (1997).
-
(1997)
J. Neuropath. Exp. Neurol. Exp. Neurol.
, vol.56
, Issue.4
, pp. 435-439
-
-
Stiles, J.D.1
Ostrow, P.T.2
Balos, L.L.3
-
73
-
-
0037089676
-
Atrasentran, an endothelin-receptor antagonist for refractory adenocarcinomas; safety and pharmacokinetics
-
Carducci MA, Nelson JB, Bowling MK et al. Atrasentran, an endothelin-receptor antagonist for refractory adenocarcinomas; safety and pharmacokinetics. J. Clin. Oncol. 20, 2171-2180 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2171-2180
-
-
Carducci, M.A.1
Nelson, J.B.2
Bowling, M.K.3
-
75
-
-
0032704708
-
Ras protein farnesyltranferase: A strategic target for anticancer therapeutic development
-
Rowinsky E, Windle J, Hoff Von DD et al. Ras protein farnesyltranferase: a strategic target for anticancer therapeutic development. J. Clin. Oncol. 17, 3631-3652 (1999).
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3631-3652
-
-
Rowinsky, E.1
Windle, J.2
Hoff Von, D.D.3
-
76
-
-
0023835721
-
The ras oncognes increase the intrinsic resistance of NIH 3R3 cells to ionizing radiation
-
Sklar M. The ras oncognes increase the intrinsic resistance of NIH 3R3 cells to ionizing radiation. Science 239, 645-647 (1988).
-
(1988)
Science
, vol.239
, pp. 645-647
-
-
Sklar, M.1
-
77
-
-
0027362521
-
Oncogene-transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype
-
Pirollo KF, Tong YA, Villegas Z et al. Oncogene-transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype. Radiat. Res. 135(2), 234-243 (1993).
-
(1993)
Radiat. Res.
, vol.135
, Issue.2
, pp. 234-243
-
-
Pirollo, K.F.1
Tong, Y.A.2
Villegas, Z.3
-
78
-
-
0025191121
-
Synergistic effect of of the v-myc oncogene with H-ras on radioresistance
-
McKenna WG, Weiss MC, Endlich B et al. Synergistic effect of of the v-myc oncogene with H-ras on radioresistance. Cancer Res. 50(1) 97-102 (1990).
-
(1990)
Cancer Res.
, vol.50
, Issue.1
, pp. 97-102
-
-
McKenna, W.G.1
Weiss, M.C.2
Endlich, B.3
-
79
-
-
0026129706
-
Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and vmyc
-
McKenna WG, Iliakis G, Weiss MC et al. Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and vmyc. Radiat. Res. 125(3), 283-287 (1991).
-
(1991)
Radiat. Res.
, vol.125
, Issue.3
, pp. 283-287
-
-
McKenna, W.G.1
Iliakis, G.2
Weiss, M.C.3
-
80
-
-
0027473872
-
Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21 ras isoprenylatiob
-
Miller AC, Kariko K, Myers CE et al. Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21 ras isoprenylatiob. Int. J. Cancer 53(2), 302-307 (1993).
-
(1993)
Int. J. Cancer
, vol.53
, Issue.2
, pp. 302-307
-
-
Miller, A.C.1
Kariko, K.2
Myers, C.E.3
-
81
-
-
0025212684
-
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation
-
Jackson J, Cochrane CG, Bourne JR et al. Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proc. Natl Acad. Sci. USA 87, 3042-3046 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 3042-3046
-
-
Jackson, J.1
Cochrane, C.G.2
Bourne, J.R.3
-
82
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang F, Casey P. Protein prenylation: molecular mechanisms and functional consequences. Ann. Rev. Biochem. 65, 241-261 (1996).
-
(1996)
Ann. Rev. Biochem.
, vol.65
, pp. 241-261
-
-
Zhang, F.1
Casey, P.2
-
83
-
-
0021170342
-
The p21 ras C-terminus is required for transformation and membrane association
-
Willumsen BM, Christensen A, Hubbert NL et al. The p21 ras C-terminus is required for transformation and membrane association. Nature 310(5978), 583-586 (1984).
-
(1984)
Nature
, vol.310
, Issue.5978
, pp. 583-586
-
-
Willumsen, B.M.1
Christensen, A.2
Hubbert, N.L.3
-
84
-
-
0026747866
-
Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity
-
Kato K, Cox AD, Hisaka MM et al. Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA 89, 6403-6407 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
-
85
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohn N, Omer CA, Conner MW et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med. 1, 792-797 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 792-797
-
-
Kohn, N.1
Omer, C.A.2
Conner, M.W.3
-
86
-
-
0028063058
-
Benzodiazepine peptidomimetic BZA-5B interrupts the MAPK activation pathway in H-Ras-transformed Rat-1 cells but not in untransformed cells
-
James GL, Brown MS, Cobb MH, Goldstein JL. Benzodiazepine peptidomimetic BZA-5B interrupts the MAPK activation pathway in H-Ras-transformed Rat-1 cells but not in untransformed cells. J. Biol. Chem. 269(4), 9141-9251 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.4
, pp. 9141-9251
-
-
James, G.L.1
Brown, M.S.2
Cobb, M.H.3
Goldstein, J.L.4
-
87
-
-
0028603395
-
Protein farneyl transferase inhibitors block the growth of ras-dependent tumors in nude mice
-
Kohl N, Wilson FR, Mosser SD. Protein farneyl transferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl Acad. Sci. USA 91, 9141-9251 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9141-9251
-
-
Kohl, N.1
Wilson, F.R.2
Mosser, S.D.3
-
88
-
-
0028869067
-
Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
-
Nagusu T, Yoshimatsu K, Roswell C et al. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 55, 5310-5314 (1994).
-
(1994)
Cancer Res.
, vol.55
, pp. 5310-5314
-
-
Nagusu, T.1
Yoshimatsu, K.2
Roswell, C.3
-
89
-
-
0029023145
-
Ras CAAX peptiodomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with k-ras mutation and p53 deletion
-
Sun J, Qian AD, Hamilton AD, Sebti SM. Ras CAAX peptiodomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with k-ras mutation and p53 deletion. Cancer Res. 55, 4243-4247 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4243-4247
-
-
Sun, J.1
Qian, A.D.2
Hamilton, A.D.3
Sebti, S.M.4
-
90
-
-
0032546264
-
Both farnesyltranferase and geranlygeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
-
Sun J, Qian Y, Hamilton AD et al. Both farnesyltranferase and geranlygeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene 16(11), 1467-1473 (1998).
-
(1998)
Oncogene
, vol.16
, Issue.11
, pp. 1467-1473
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
-
91
-
-
0033214457
-
Antitumor efficacy of a novel class of nonthiol-containing peptidomimetic inhibitors of farnesyltransferase and geranlygeranyltranserase I: Combination of therapy with the cytotoxic agents cisplatin, taxol and gemcitabine
-
Sun J, Blaskovich MA, Knowles D et al. Antitumor efficacy of a novel class of nonthiol-containing peptidomimetic inhibitors of farnesyltransferase and geranlygeranyltranserase I: combination of therapy with the cytotoxic agents cisplatin, taxol and gemcitabine. Cancer Res. 59(19), 4919-4926 (1999).
-
(1999)
Cancer Res.
, vol.59
, Issue.19
, pp. 4919-4926
-
-
Sun, J.1
Blaskovich, M.A.2
Knowles, D.3
-
92
-
-
0031983131
-
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
-
Barrington RE, Subler MA, Rands E et al. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol. Cell Biol. 18(1), 85-92 (1998).
-
(1998)
Mol. Cell Biol.
, vol.18
, Issue.1
, pp. 85-92
-
-
Barrington, R.E.1
Subler, M.A.2
Rands, E.3
-
93
-
-
0028835253
-
A peptidomimetic inhibitorof farnesyl: Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L, Ma Z, Rands NE et al. A peptidomimetic inhibitorof farnesyl: protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55, 5302-5309 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, N.E.3
-
94
-
-
0003258673
-
Phase II trial of R115777 (Zarnestra) in patients with recurrent glioma not taking enzyme inducing antiepileptic drugs (EIAED): A North American Brain Tumor Consortium (NABTC) report
-
Cloughesy TF, Kuhn J, Wen P et al. Phase II trial of R115777 (Zarnestra) in patients with recurrent glioma not taking enzyme inducing antiepileptic drugs (EIAED): a North American Brain Tumor Consortium (NABTC) report. Proc. Am. Soc. Clin. Oncol. 21, 317 (2002).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
, pp. 317
-
-
Cloughesy, T.F.1
Kuhn, J.2
Wen, P.3
-
95
-
-
10244234032
-
Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo
-
Kock H, Harris MP, Anderson SC et al. Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo. Int. J. Cancer 67, 808-815 (1996).
-
(1996)
Int. J. Cancer
, vol.67
, pp. 808-815
-
-
Kock, H.1
Harris, M.P.2
Anderson, S.C.3
-
96
-
-
0032855038
-
Adenovirus-mediated wild type p53 expression induces apoptosis and suppresses tumori genesis of experimental intracranial human malignant glioma
-
Cirielli C, Inyaku K, Capogrossi MC et al. Adenovirus-mediated wild type p53 expression induces apoptosis and suppresses tumorigenesis of experimental intracranial human malignant glioma. J. Neurooncol. 43, 99-108 (1999).
-
(1999)
J. Neurooncol.
, vol.43
, pp. 99-108
-
-
Cirielli, C.1
Inyaku, K.2
Capogrossi, M.C.3
-
97
-
-
15644369261
-
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer
-
Cheney IW, Johnson DE, Vaillancourt MT et al. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res. 58, 2331-2334 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 2331-2334
-
-
Cheney, I.W.1
Johnson, D.E.2
Vaillancourt, M.T.3
-
98
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov VJ, Issaeva N, Shilov A et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Med. 8, 282-288 (2002).
-
(2002)
Nature Med.
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
Issaeva, N.2
Shilov, A.3
-
99
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
-
100
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria JN, Tibbetts RS, Busby EC et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 58, 4375-4382 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
-
101
-
-
0037221440
-
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor
-
Shingu T, Yamada K, Hara N et al. Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. J. Neurosurg. 98, 154-161 (2003).
-
(2003)
J. Neurosurg.
, vol.98
, pp. 154-161
-
-
Shingu, T.1
Yamada, K.2
Hara, N.3
-
102
-
-
0032946446
-
Intraoperative imaging techniques in the treatment of brain tumors
-
Zakhary R, Keles GE, Berger MS et al. Intraoperative imaging techniques in the treatment of brain tumors. Curr. Opin. Oncol. 11, 152-156 (1999).
-
(1999)
Curr. Opin. Oncol.
, vol.11
, pp. 152-156
-
-
Zakhary, R.1
Keles, G.E.2
Berger, M.S.3
-
103
-
-
0031049327
-
Mechanisms of glioma invasion: Role of matrix-metalloproteinases
-
Uhm JH, Dooley NP, Villemure JG et al. Mechanisms of glioma invasion: role of matrix-metalloproteinases. Can. J. Neurol. Sci. 24, 3-15 (1997).
-
(1997)
Can. J. Neurol. Sci.
, vol.24
, pp. 3-15
-
-
Uhm, J.H.1
Dooley, N.P.2
Villemure, J.G.3
-
104
-
-
0021179381
-
Total dose in fractionated radiotherapy: Implications of new radiobiologic data
-
Fowler JF. Total dose in fractionated radiotherapy: implications of new radiobiologic data. Int. J. Radiat. Biol. 46, 103-122 (1984).
-
(1984)
Int. J. Radiat. Biol.
, vol.46
, pp. 103-122
-
-
Fowler, J.F.1
-
105
-
-
0019142613
-
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
-
Walker MD, Breen SB, Byar DP et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery N. Engl. J. Med. 303, 1323-1329 (1980).
-
(1980)
N. Engl. J. Med.
, vol.303
, pp. 1323-1329
-
-
Walker, M.D.1
Breen, S.B.2
Byar, D.P.3
-
106
-
-
0027516695
-
Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults
-
Fine HA, Dear CB, Loeffler JS et al. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71, 2585-2597 (1993).
-
(1993)
Cancer
, vol.71
, pp. 2585-2597
-
-
Fine, H.A.1
Dear, C.B.2
Loeffler, J.S.3
-
107
-
-
0034176782
-
Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
-
Brown JM. Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol. Med. Today 6, 157-162 (2000).
-
(2000)
Mol. Med. Today
, vol.6
, pp. 157-162
-
-
Brown, J.M.1
-
108
-
-
0001885597
-
Primary central nervous system tumors of the supratentorial compartment
-
Levin VA (Ed.). Churchill Livingstone, NY, USA
-
Berger MS, Leibel SA, Bruner JM et al. Primary central nervous system tumors of the supratentorial compartment. In: Cancer in the Nervous System. Levin VA (Ed.). Churchill Livingstone, NY, USA 57-126, (1996).
-
(1996)
Cancer in the Nervous System
, pp. 57-126
-
-
Berger, M.S.1
Leibel, S.A.2
Bruner, J.M.3
-
109
-
-
0031959341
-
CNS drug design based on principles of blood-brain barrier transport
-
Pardridge WM. CNS drug design based on principles of blood-brain barrier transport. J. Neurochem. 70, 1781-1792 (1998).
-
(1998)
J. Neurochem.
, vol.70
, pp. 1781-1792
-
-
Pardridge, W.M.1
-
110
-
-
0031956722
-
Antisense oligodeoxynucleotide technology: Potential use for the treatment of malignant brain tumors
-
Engelhard HH. Antisense oligodeoxynucleotide technology: potential use for the treatment of malignant brain tumors. Cancer Control 5, 163-170 (1998).
-
(1998)
Cancer Control
, vol.5
, pp. 163-170
-
-
Engelhard, H.H.1
-
111
-
-
0033755180
-
The blood-brain and blood-tumor barriers: A review of strategies for increasing drug delivery
-
Groothuis DR. The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro-Oncology 2, 45-59 (2000).
-
(2000)
Neuro-Oncology
, vol.2
, pp. 45-59
-
-
Groothuis, D.R.1
-
112
-
-
0021739373
-
Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: Implications for chemotherapy
-
Blasberg R, Molnar P, Groothius D et al. Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: implications for chemotherapy. J. Pharmacol. Exp. Ther. 231, 724-735 (1984).
-
(1984)
J. Pharmacol. Exp. Ther.
, vol.231
, pp. 724-735
-
-
Blasberg, R.1
Molnar, P.2
Groothius, D.3
-
113
-
-
0029555077
-
Distribution of 1, 3-bis (2-chloroethyl)-1-nitrosourea and tracers in the rabbit brain after interstitial delivery by biodegradable polymer implants
-
Strasser JF, Fung LK, Eller S et al. Distribution of 1, 3-bis (2-chloroethyl)-1-nitrosourea and tracers in the rabbit brain after interstitial delivery by biodegradable polymer implants. J. Pharmacol. Exp. Ther. 275, 1647-1655 (1995).
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1647-1655
-
-
Strasser, J.F.1
Fung, L.K.2
Eller, S.3
-
114
-
-
0023117480
-
Direct delivery of medication into a brain tumor through multiple chronically implanted catheters
-
Bouvier G, Penn RD, Kroin JS et al. Direct delivery of medication into a brain tumor through multiple chronically implanted catheters. Neurosurgery 20, 286-291 (1987).
-
(1987)
Neurosurgery
, vol.20
, pp. 286-291
-
-
Bouvier, G.1
Penn, R.D.2
Kroin, J.S.3
-
116
-
-
23444437213
-
Convection-enhanced delivery of macromolecules in the brain
-
Bobo R, Laske D, Akbasak A et al. Convection-enhanced delivery of macromolecules in the brain. Proc. Natl Acad. Sci. USA 91, 2076-2080 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 2076-2080
-
-
Bobo, R.1
Laske, D.2
Akbasak, A.3
-
117
-
-
0032747338
-
Focal delivery during direct infusion to brain: Role of flow rate, catheter diameter and tissue mechanics
-
Morrison PF, Chen MY, Chadwick RS et al. Focal delivery during direct infusion to brain: role of flow rate, catheter diameter and tissue mechanics. Am. J. Physiol. 277(4 Pt 2), R1218-R1229 (1999).
-
(1999)
Am. J. Physiol.
, vol.277
, Issue.4 PART 2
-
-
Morrison, P.F.1
Chen, M.Y.2
Chadwick, R.S.3
-
118
-
-
0032949676
-
Variables affecting convection-enhanced delivery to the striatum: A systematic examination of rate of infusion, cannula size, infusate concentration and tissue-cannula sealing time
-
Chen MY, Lonser RR, Morrison PF et al. Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration and tissue-cannula sealing time. J. Neurosurg. 90(2), 315-320 (1999).
-
(1999)
J. Neurosurg.
, vol.90
, Issue.2
, pp. 315-320
-
-
Chen, M.Y.1
Lonser, R.R.2
Morrison, P.F.3
-
119
-
-
0029001712
-
Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion
-
Lieberman D, Laske K, Morrison P et al. Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J. Neurosurg. 82, 1021-1029 (1995).
-
(1995)
J. Neurosurg.
, vol.82
, pp. 1021-1029
-
-
Lieberman, D.1
Laske, K.2
Morrison, P.3
-
120
-
-
0030954720
-
Chronic interstitial infusion of protein to primate brain: Determination of drug distribution and clearance with single-photon emission computerized tomography imaging
-
Laske DW, Morrison PF, Lieberman DM et al. Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging. J. Neurosurg. 87, 586-594 (1997).
-
(1997)
J. Neurosurg.
, vol.87
, pp. 586-594
-
-
Laske, D.W.1
Morrison, P.F.2
Lieberman, D.M.3
-
121
-
-
0031451777
-
Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors
-
Laske D, Youle R, Oldfield E et al. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med 12, 1362-1368 (1997). First report in new technology of convection-enhanced delivery on brain tumor.
-
(1997)
Nature Med.
, vol.12
, pp. 1362-1368
-
-
Laske, D.1
Youle, R.2
Oldfield, E.3
-
122
-
-
0036053691
-
Local treatment of brain tumors with targeted chimera toxin proteins
-
Debinski W. Local treatment of brain tumors with targeted chimera toxin proteins. Cancer Invest. 20, 801-809 (2002).
-
(2002)
Cancer Invest.
, vol.20
, pp. 801-809
-
-
Debinski, W.1
-
123
-
-
0026598909
-
Immunotoxins and central nervous system neoplasia
-
Hall WA, Fostad O. Immunotoxins and central nervous system neoplasia. J. Neurosurg. 76, 1-12 (1992).
-
(1992)
J. Neurosurg.
, vol.76
, pp. 1-12
-
-
Hall, W.A.1
Fostad, O.2
-
124
-
-
0029041783
-
A novel chimeric protein composed of interleukin-13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin-13 and interleukin-4
-
Debnski W, Obiri H, Pastan I et al. A novel chimeric protein composed of interleukin-13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin-13 and interleukin-4. J. Biol. Chem. 270, 16775-16780 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 16775-16780
-
-
Debnski, W.1
Obiri, H.2
Pastan, I.3
-
125
-
-
0029839018
-
Receptor for interleukin-13 does not interact with IL4 but receptor for IL4 interacts with IL13 in human glioma cells
-
Debinski W, Miner R, Leland P et al. Receptor for interleukin-13 does not interact with IL4 but receptor for IL4 interacts with IL13 in human glioma cells. J. Biol. Chem. 271, 22428-22433 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22428-22433
-
-
Debinski, W.1
Miner, R.2
Leland, P.3
-
126
-
-
0027421951
-
Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells
-
Kunwar S, Pai L, Pastan I et al. Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. J. Neurosurg. 79, 569-576 (1993).
-
(1993)
J. Neurosurg.
, vol.79
, pp. 569-576
-
-
Kunwar, S.1
Pai, L.2
Pastan, I.3
-
127
-
-
0028859363
-
Human glioma cells overexpress receptors for interleukin-13 and are extremely sensitive to a novel chimeric protein composed of interleukin-13 and pseudomonas exotoxin
-
Debinski W, Obiri N, Powers S et al. Human glioma cells overexpress receptors for interleukin-13 and are extremely sensitive to a novel chimeric protein composed of interleukin-13 and pseudomonas exotoxin. Clin. Cancer Res. 1, 1253-1258 (1995).
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 1253-1258
-
-
Debinski, W.1
Obiri, N.2
Powers, S.3
-
128
-
-
10744219583
-
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-α and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors
-
Sampson JH, Akabani G, Archer GE et al. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-α and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J. Neuro-Oncology 65, 27-35, (2003).
-
(2003)
J. Neuro-Oncology
, vol.65
, pp. 27-35
-
-
Sampson, J.H.1
Akabani, G.2
Archer, G.E.3
-
129
-
-
0345183090
-
Phase I/II study: Intra-tumoral infusion of IL-13PE38QQR cytotoxin for recurrent supratentorial malignant glioma
-
Weingart J, Strauss L, Grossman S et al. Phase I/II study: intra-tumoral infusion of IL-13PE38QQR cytotoxin for recurrent supratentorial malignant glioma. Neurooncology 4(Suppl. 1), S79 (2002).
-
(2002)
Neurooncology
, vol.4
, Issue.SUPPL. 1
-
-
Weingart, J.1
Strauss, L.2
Grossman, S.3
-
130
-
-
0041849833
-
Convection-enhanced delivery (CED) by positive pressure infusion for intra-tumoral and peritumoral administration of IL13-PE38QQR, a recombinant tumor-targeted cytotoxin in recurrent malignant gliomas
-
Prados M, Lang F, Sherman J et al. Convection-enhanced delivery (CED) by positive pressure infusion for intra-tumoral and peritumoral administration of IL13-PE38QQR, a recombinant tumor-targeted cytotoxin in recurrent malignant gliomas. Neuro-oncology 4(Suppl. 1), S78, (2002).
-
(2002)
Neuro-oncology
, vol.4
, Issue.SUPPL. 1
-
-
Prados, M.1
Lang, F.2
Sherman, J.3
-
131
-
-
0023429079
-
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
-
Wong AJ, Bigner SH, Bigner DD et al. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl Acad. Sci. USA 84, 6899-6903 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, pp. 6899-6903
-
-
Wong, A.J.1
Bigner, S.H.2
Bigner, D.D.3
-
132
-
-
0021363560
-
Expression of epidermal growth factor receptors in human brain tumors
-
Libermann TA, Razon N, Bartal D et al. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 44, 753-760 (1984).
-
(1984)
Cancer Res.
, vol.44
, pp. 753-760
-
-
Libermann, T.A.1
Razon, N.2
Bartal, D.3
-
133
-
-
0026070577
-
Epidermal growth factor receptor expression in human gliomas
-
Torp SH, Halsted E, Dalen A et al. Epidermal growth factor receptor expression in human gliomas. Cancer Immunol. Immunother. 33, 61-64 (1991).
-
(1991)
Cancer Immunol. Immunother.
, vol.33
, pp. 61-64
-
-
Torp, S.H.1
Halsted, E.2
Dalen, A.3
-
134
-
-
0027532624
-
Heparin-binding transforming growth factor α-Pseudomonas exotoxin A. A heparin modulated recombinant toxin cytotoxic to cancer cells and proliferation smooth muscle cells
-
Mesri EA, Kreitman RJ, Fu YM et al. Heparin-binding transforming growth factor α-Pseudomonas exotoxin A. A heparin modulated recombinant toxin cytotoxic to cancer cells and proliferation smooth muscle cells. J. Biol. Chem. 268, 4853-4862 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4853-4862
-
-
Mesri, E.A.1
Kreitman, R.J.2
Fu, Y.M.3
-
135
-
-
0031706638
-
Direct convective delivery of macromolecules to the spinal cord
-
Lonser RR, Gogate N, Morrison P et al. Direct convective delivery of macromolecules to the spinal cord. Neurosurg. 89, 616-622 (1998).
-
(1998)
Neurosurg.
, vol.89
, pp. 616-622
-
-
Lonser, R.R.1
Gogate, N.2
Morrison, P.3
-
136
-
-
84949655795
-
Cerebral astrocytomas and their derivative
-
Scherer H. Cerebral astrocytomas and their derivative. Am. J. Cancer 40, 159-198 (1940).
-
(1940)
Am. J. Cancer
, vol.40
, pp. 159-198
-
-
Scherer, H.1
-
137
-
-
0036801706
-
Successful and safe perfusion of the primate brainstem: In vivo magnetic resonance imaging of macromolecular distribution during infusion
-
Lonser RR, Walbridge S, Garmestani K et al. Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion. J. Neurosurg. 9, 905-913 (2002).
-
(2002)
J. Neurosurg.
, vol.9
, pp. 905-913
-
-
Lonser, R.R.1
Walbridge, S.2
Garmestani, K.3
-
138
-
-
0034047780
-
Intratumoral administration of recombinant circularly permitted interleukin-4-pseudomaonas exotoxin in patients with high-grade glioma
-
Rand R, Kreitman R, Patronas N et al. Intratumoral administration of recombinant circularly permitted interleukin-4-pseudomaonas exotoxin in patients with high-grade glioma. Clin. Cancer Res. 6, 2157-2165 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2157-2165
-
-
Rand, R.1
Kreitman, R.2
Patronas, N.3
-
139
-
-
0028919606
-
Comparisons of rates of infection of two methods of emergency ventricular drainage
-
Kim D, Uttley D, Bell B et al. Comparisons of rates of infection of two methods of emergency ventricular drainage. J. Neurol. Neurosurg. Psychiatry 58, 444-446, (1995).
-
(1995)
J. Neurol. Neurosurg. Psychiatry
, vol.58
, pp. 444-446
-
-
Kim, D.1
Uttley, D.2
Bell, B.3
-
140
-
-
2542515446
-
Clinical outcome and distribution of a recombinant chimeric protein composed of transforming growth factor-α and a mutated Pseudomonas exotoxin (TP-38) via convection-enhanced microinfusion on a Phase I study for a malignant brain tumor
-
Samson JH, Akabani G, Archer G et al. Clinical outcome and distribution of a recombinant chimeric protein composed of transforming growth factor-α and a mutated Pseudomonas exotoxin (TP-38) via convection-enhanced microinfusion on a Phase I study for a malignant brain tumor. Proc. Am. Soc. Clin. Oncol. 22, 99 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 99
-
-
Samson, J.H.1
Akabani, G.2
Archer, G.3
-
141
-
-
0029057002
-
Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors
-
Lorimer IAJ, Wikstrand CJ, Batra SK et al. Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors. Clin. Cancer Res. 1, 859-864 (1995).
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 859-864
-
-
Lorimer, I.A.J.1
Wikstrand, C.J.2
Batra, S.K.3
-
142
-
-
1142287357
-
Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2
-
Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2. Expert Rev. AntiCancer Ther. 4(1) 105-128 (2004). Provides a good review of angiogenesis inhibitors; P13/Akr/phosphatidylinositol phosphate 3′-phosphatase, mTOR, SHH/PTCH and angiogenesis.
-
(2004)
Expert Rev. AntiCancer Ther.
, vol.4
, Issue.1
, pp. 105-128
-
-
Newton, H.B.1
-
143
-
-
2342611150
-
Emerging molecular therapies for brain tumors
-
Van Meir EG, Bellail A, Phuphanich S. Emerging molecular therapies for brain tumors. Semin. Oncol. 31(2 Suppl. 4), 38-46 (2004). Excellent review of cell cycle control, angiogenesis, prodrug/suicide gene therapy and immunotherapy.
-
(2004)
Semin. Oncol.
, vol.31
, Issue.2 SUPPL. 4
, pp. 38-46
-
-
Van Meir, E.G.1
Bellail, A.2
Phuphanich, S.3
|