Successful and safe perfusion of the primate brainstem: In vivo magnetic resonance imaging of macromolecular distribution during infusion

Journal of Neurosurgery

Volumn 97, Issue 4, 2002, Pages 905-913

  Lonser, Russell R ^a   Walbridge, Stuart ^a   Garmestani, Kayhan ^a   Butman, John A ^a   Walters, Hugh A ^a   Vortmeyer, Alexander O ^a   Morrison, Paul F ^a   Brechbiel, Martin W ^a   Oldfield, Edward H ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Brainstem; Convection enhanced delivery; Macaca mulatta; Magnetic resonance imaging; Rat

Indexed keywords

ALBUMIN; GADOLINIUM; PENTETIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN STEM; DRUG DISTRIBUTION; GLIOSIS; MACACA; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION; PRIORITY JOURNAL; RAT; SAFETY;

EID: 0036801706     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2002.97.4.0905     Document Type: Article

References (17)

1. Blasberg RG, Patlak C, Fenstermacher JD: Intrathecal chemotherapy: Brain tissue profiles after ventriculocistemal perfusion. J Pharmacol Exp Ther 195:73-83, 1975
2. Bobo RH, Laske DW, Akbasak A, et al: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91:2076-2080, 1994
3. 90Y radioimmunotherapy. Bioconjug Chem 2:187-194, 1991
4. Bruce JN, Falavigna A, Johnson JP, et al: Intracerebral clysis in a rat glioma model. Neurosurgery 46:683-691, 2000
5. Chen MY, Lonser RR, Morrison PF, et al: Variables affecting convection-enhanced delivery to the striatum: A systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time. J Neurosurg 90:315-320, 1999
6. Langer R: New methods of drug delivery. Science 249:1527-1533, 1990
7. Laske DW, Morrison PF, Lieberman DM, et al: Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging. J Neurosurg 87:586-594, 1997
8. Laske DW, Youle RJ, Oldfield EH: Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 3:1362-1368, 1997
9. Lieberman DM, Laske DW, Morrison PF, et al: Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82:1021-1029, 1995
10. Lonser RR, Gogate N, Morrison PF, et al: Direct convective delivery of macromolecules to the spinal cord. J Neurosurg 89:616-622, 1998
11. Mirzadeh S, Brechbiel MW, Atcher RW, et al: Radiometal labeling of immunoproteins: Covalent linkage of 2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid ligands to immunoglobulin. Bioconjug Chem 1:59-65, 1990
12. Morrison PF: Distribution models of drug kinetics, in Atkinson AJ Jr, Daniels CE, Dedrick RL, et al (eds): Principles of Clinical Pharmacology. New York: Academic Press, 2001, pp 93-112
13. Morrison PF, Chen MY, Chadwick RS, et al: Focal delivery during direct infusion to brain: Role of flow rate, catheter diameter, and tissue mechanics. Am J Physiol 277:R1218-R1229, 1999
14. Morrison PF, Laske DW, Bobo H, et al: High-flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 266:R292-R305, 1994
15. Pardridge WM: Drug delivery to the brain. J Cereb Blood Flow Metab 17:713-731, 1997
16. Pippin CG, Parker TA, McMurry TJ, et al: Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates. Bioconjug Chem 3:342-345, 1992
17. Sandberg DI, Edgar MA, Souweidane MM: Convection-enhanced delivery into the rat brainstem. J Neurosurg 96:885-891, 2002