-
1
-
-
0033580822
-
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils
-
Akasaki, T., H. Koga, and H. Sumimoto. 1999. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J. Biol. Chem. 274:18055-18059.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18055-18059
-
-
Akasaki, T.1
Koga, H.2
Sumimoto, H.3
-
2
-
-
0037632986
-
Ras and Rac as activators of reactive oxygen species (ROS)
-
Archer, H., and D. Bar-Sagi. 2002. Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol. Biol. 189:67-73.
-
(2002)
Methods Mol. Biol.
, vol.189
, pp. 67-73
-
-
Archer, H.1
Bar-Sagi, D.2
-
3
-
-
0035836791
-
Rho signals to cell growth and apoptosis
-
Aznar, S., and J. C. Lacal. 2001. Rho signals to cell growth and apoptosis. Cancer Lett. 165:1-10.
-
(2001)
Cancer Lett.
, vol.165
, pp. 1-10
-
-
Aznar, S.1
Lacal, J.C.2
-
4
-
-
0034644537
-
Ras and Rho GTPases: A family reunion
-
Bar-Sagi, D., and A. Hall. 2000. Ras and Rho GTPases: a family reunion. Cell 103:227-238.
-
(2000)
Cell
, vol.103
, pp. 227-238
-
-
Bar-Sagi, D.1
Hall, A.2
-
5
-
-
0036849099
-
Survival signaling goes BAD
-
Bergmann, A. 2002. Survival signaling goes BAD. Dev. Cell. 3:607-608.
-
(2002)
Dev. Cell
, vol.3
, pp. 607-608
-
-
Bergmann, A.1
-
6
-
-
0033838716
-
Regulation of cell function by Rho family GTPases
-
Bokoch, G. M. 2000. Regulation of cell function by Rho family GTPases. Immunol. Res. 21:139-148.
-
(2000)
Immunol. Res.
, vol.21
, pp. 139-148
-
-
Bokoch, G.M.1
-
7
-
-
0036098594
-
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
-
Coleman, M. L., and M. F. Olson. 2002. Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death. Differ. 9:493-504.
-
(2002)
Cell Death. Differ.
, vol.9
, pp. 493-504
-
-
Coleman, M.L.1
Olson, M.F.2
-
8
-
-
0041631073
-
p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
-
Cotteret, S., Z. M. Jaffer, A. Beeser, and J. Chernoff. 2003. p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol. Cell. Biol. 23:5526-5539.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5526-5539
-
-
Cotteret, S.1
Jaffer, Z.M.2
Beeser, A.3
Chernoff, J.4
-
9
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2927.
-
(1999)
Genes Dev.
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
10
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
11
-
-
0036849192
-
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
-
Datta, S. R., A. M. Ranger, M. Z. Lin, J. F. Sturgill, Y. C. Ma, C. W. Cowan, P. Dikkes, S. J. Korsmeyer, and M. E. Greenberg. 2002. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell. 3:631-643.
-
(2002)
Dev. Cell
, vol.3
, pp. 631-643
-
-
Datta, S.R.1
Ranger, A.M.2
Lin, M.Z.3
Sturgill, J.F.4
Ma, Y.C.5
Cowan, C.W.6
Dikkes, P.7
Korsmeyer, S.J.8
Greenberg, M.E.9
-
12
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
13
-
-
0033813282
-
Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
-
Deshpande, S. S., P. Angkeow, J. Huang, M. Ozaki, and K. Irani. 2000. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J. 14:1705-1714.
-
(2000)
FASEB J.
, vol.14
, pp. 1705-1714
-
-
Deshpande, S.S.1
Angkeow, P.2
Huang, J.3
Ozaki, M.4
Irani, K.5
-
14
-
-
0033143385
-
How BAD phosphorylation is good for survival
-
Downward, J. 1999. How BAD phosphorylation is good for survival. Nat. Cell Biol. 1:E33-E35.
-
(1999)
Nat. Cell Biol.
, vol.1
-
-
Downward, J.1
-
15
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward, J. 2003. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer. 3:11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
16
-
-
0346995278
-
Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein Bad
-
Eisenmann, K. M., M. W. VanBrocklin, N. A. Staffend, S. M. Kitchen, and H. M. Koo. 2003. Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein Bad. Cancer Res. 63:8330-8337.
-
(2003)
Cancer Res.
, vol.63
, pp. 8330-8337
-
-
Eisenmann, K.M.1
VanBrocklin, M.W.2
Staffend, N.A.3
Kitchen, S.M.4
Koo, H.M.5
-
17
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420:629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
18
-
-
0033581927
-
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
-
Fang, X., S. Yu, A. Eder, M. Mao, R. C. Bast, Jr., D. Boyd, and G. B. Mills. 1999. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 18:6635-6640.
-
(1999)
Oncogene
, vol.18
, pp. 6635-6640
-
-
Fang, X.1
Yu, S.2
Eder, A.3
Mao, M.4
Bast Jr., R.C.5
Boyd, D.6
Mills, G.B.7
-
19
-
-
0035957986
-
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta, N., J. Qu, and A. Minden. 2001. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 276:14414-14419.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
Qu, J.2
Minden, A.3
-
20
-
-
0033120591
-
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
-
Harada, H., B. Becknell, M. Wilm, M. Mann, L. J. Huang, S. S. Taylor, J. D. Scott, and S. J. Korsmeyer. 1999. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell. 3:413-422.
-
(1999)
Mol. Cell
, vol.3
, pp. 413-422
-
-
Harada, H.1
Becknell, B.2
Wilm, M.3
Mann, M.4
Huang, L.J.5
Taylor, S.S.6
Scott, J.D.7
Korsmeyer, S.J.8
-
21
-
-
0141924878
-
Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes
-
Holzberg, D., C. G. Knight, O. Dittrich-Breiholz, H. Schneider, A. Dorrie, E. Hoffmann, K. Resch, and M. Kracht. 2003. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. J. Biol. Chem. 278:40213-40223.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40213-40223
-
-
Holzberg, D.1
Knight, C.G.2
Dittrich-Breiholz, O.3
Schneider, H.4
Dorrie, A.5
Hoffmann, E.6
Resch, K.7
Kracht, M.8
-
22
-
-
0035907371
-
p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts
-
Jakobi, R., E. Moertl, and M. A. Koeppel. 2001. p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts. J. Biol. Chem. 276:16624-16634.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16624-16634
-
-
Jakobi, R.1
Moertl, E.2
Koeppel, M.A.3
-
23
-
-
0037217977
-
Regulation of Akt-dependent cell survival by Syk and Rac
-
Jiang, K., B. Zhong, C. Ritchey, D. L. Gilvary, E. Hong-Geller, S. Wei, and J. Y. Djeu. 2003. Regulation of Akt-dependent cell survival by Syk and Rac. Blood 101:236-244.
-
(2003)
Blood
, vol.101
, pp. 236-244
-
-
Jiang, K.1
Zhong, B.2
Ritchey, C.3
Gilvary, D.L.4
Hong-Geller, E.5
Wei, S.6
Djeu, J.Y.7
-
24
-
-
0032803236
-
Suppression of Ras-induced apoptosis by the Rac GTPase
-
Joneson, T, and D. Bar-Sagi. 1999. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19:5892-5901.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5892-5901
-
-
Joneson, T.1
Bar-Sagi, D.2
-
25
-
-
0036449793
-
Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy
-
Kim, R., K. Tanabe, Y. Uchida, M. Emi, H. Inoue, and T. Toge. 2002. Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother. Pharmacol. 50:343-352.
-
(2002)
Cancer Chemother. Pharmacol.
, vol.50
, pp. 343-352
-
-
Kim, R.1
Tanabe, K.2
Uchida, Y.3
Emi, M.4
Inoue, H.5
Toge, T.6
-
26
-
-
0030912615
-
Bcl-2 does not protect Burkitt's lymphoma cells from oxidant-induced cell death
-
Lee, Y., and E. Shacter. 1997. Bcl-2 does not protect Burkitt's lymphoma cells from oxidant-induced cell death. Blood 89:4480-4492.
-
(1997)
Blood
, vol.89
, pp. 4480-4492
-
-
Lee, Y.1
Shacter, E.2
-
27
-
-
0034661857
-
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155
-
Lizcano, J. M., N. Morrice, and P. Cohen. 2000. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 349:547-557.
-
(2000)
Biochem. J.
, vol.349
, pp. 547-557
-
-
Lizcano, J.M.1
Morrice, N.2
Cohen, P.3
-
28
-
-
0034602690
-
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
-
Mira, J. P., V. Benard, J. Groffen, L. C. Sanders, and U. G. Knaus. 2000. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc. Natl. Acad. Sci. USA 97:185-189.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 185-189
-
-
Mira, J.P.1
Benard, V.2
Groffen, J.3
Sanders, L.C.4
Knaus, U.G.5
-
29
-
-
0032514903
-
Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation
-
Missy, K., P. Van, V., P. Raynal, C. Viala, G. Mauco, M. Plantavid, H. Chap, and B. Payrastre. 1998. Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J. Biol. Chem. 273: 30279-30286.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30279-30286
-
-
Missy, K.1
Van, P.V.2
Raynal, P.3
Viala, C.4
Mauco, G.5
Plantavid, M.6
Chap, H.7
Payrastre, B.8
-
31
-
-
0037050260
-
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB
-
Murga, C., M. Zohar, H. Teramoto, and J. S. Gutkind. 2002. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB. Oncogene 21:207-216.
-
(2002)
Oncogene
, vol.21
, pp. 207-216
-
-
Murga, C.1
Zohar, M.2
Teramoto, H.3
Gutkind, J.S.4
-
32
-
-
0028837170
-
Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors
-
Nobes, C. D., P. Hawkins, L. Stephens, and A. Hall. 1995. Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors. J. Cell Sci. 108:225-233.
-
(1995)
J. Cell Sci.
, vol.108
, pp. 225-233
-
-
Nobes, C.D.1
Hawkins, P.2
Stephens, L.3
Hall, A.4
-
33
-
-
0032191896
-
Linking extracellular survival signals and the apoptotic machinery
-
Nunez, G., and L. del Peso. 1998. Linking extracellular survival signals and the apoptotic machinery. Curr. Opin. Neurobiol. 8:613-618.
-
(1998)
Curr. Opin. Neurobiol.
, vol.8
, pp. 613-618
-
-
Nunez, G.1
Del Peso, L.2
-
34
-
-
0035959749
-
Activation of the RacGTPase inhibits apoptosis in human tumor cells
-
Pervaiz, S., J. Cao, O. S. Chao, Y. Y. Chin, and M. V. Clement. 2001. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20:6263-6268.
-
(2001)
Oncogene
, vol.20
, pp. 6263-6268
-
-
Pervaiz, S.1
Cao, J.2
Chao, O.S.3
Chin, Y.Y.4
Clement, M.V.5
-
35
-
-
0035431599
-
Cyclin' round the cell with Rac
-
Ridley, A. J. 2001. Cyclin' round the cell with Rac. Dev. Cell. 1:160-161.
-
(2001)
Dev. Cell
, vol.1
, pp. 160-161
-
-
Ridley, A.J.1
-
36
-
-
0035346409
-
The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts
-
Ruggieri, R., Y. Y. Chuang, and M. Symons. 2001. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Mol. Med. 7:293-300.
-
(2001)
Mol. Med.
, vol.7
, pp. 293-300
-
-
Ruggieri, R.1
Chuang, Y.Y.2
Symons, M.3
-
38
-
-
0034659739
-
Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform
-
Schnelzer, A., D. Prechtel, U. Knaus, K. Dehne, M. Gerhard, H. Graeff, N. Harbeck, M. Schmitt, and E. Lengyel. 2000. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19:3013-3020.
-
(2000)
Rac1b. Oncogene
, vol.19
, pp. 3013-3020
-
-
Schnelzer, A.1
Prechtel, D.2
Knaus, U.3
Dehne, K.4
Gerhard, M.5
Graeff, H.6
Harbeck, N.7
Schmitt, M.8
Lengyel, E.9
-
39
-
-
0040056864
-
p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis
-
Schurmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch. 2000. p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20:453-461.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 453-461
-
-
Schurmann, A.1
Mooney, A.F.2
Sanders, L.C.3
Sells, M.A.4
Wang, H.G.5
Reed, J.C.6
Bokoch, G.M.7
-
40
-
-
0038732434
-
Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP
-
Taghiyev, A. F., N. V. Guseva, H. Harada, C. M. Knudson, O. W. Rokhlin, and M. B. Cohen. 2003. Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP. Mol. Cancer Res. 1:500-507.
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 500-507
-
-
Taghiyev, A.F.1
Guseva, N.V.2
Harada, H.3
Knudson, C.M.4
Rokhlin, O.W.5
Cohen, M.B.6
-
41
-
-
0037401562
-
Cell death regulation by the Bcl-2 protein family in the mitochondria
-
Tsujimoto, Y. 2003. Cell death regulation by the Bcl-2 protein family in the mitochondria. J. Cell Physiol. 195:158-167.
-
(2003)
J. Cell Physiol.
, vol.195
, pp. 158-167
-
-
Tsujimoto, Y.1
-
42
-
-
0028809209
-
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
-
Yang, E., J. Zha, J. Jockel, L. H. Boise, C. B. Thompson, and S. J. Korsmeyer. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291.
-
(1995)
Cell
, vol.80
, pp. 285-291
-
-
Yang, E.1
Zha, J.2
Jockel, J.3
Boise, L.H.4
Thompson, C.B.5
Korsmeyer, S.J.6
-
43
-
-
0033678937
-
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
-
Yang, F. C., R. Kapur, A. J. King, W. Tao, C. Kim, J. Borneo, R. Breese, M. Marshall, M. C. Dinauer, and D. A. Williams. 2000. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 12:557-568.
-
(2000)
Immunity
, vol.12
, pp. 557-568
-
-
Yang, F.C.1
Kapur, R.2
King, A.J.3
Tao, W.4
Kim, C.5
Borneo, J.6
Breese, R.7
Marshall, M.8
Dinauer, M.C.9
Williams, D.A.10
-
44
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
Zha, J., H. Harada, E. Yang, J. Jockel, and S. J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628.
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
45
-
-
0035937768
-
Oligomerization of Rac1 GTPase mediated by the carboxyl-terminal polybasic domain
-
Zhang, B., Y. Gao, S. Y. Moon, Y. Zhang, and Y. Zheng. 2001. Oligomerization of Rac1 GTPase mediated by the carboxyl-terminal polybasic domain. J. Biol. Chem. 276:8958-8967.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8958-8967
-
-
Zhang, B.1
Gao, Y.2
Moon, S.Y.3
Zhang, Y.4
Zheng, Y.5
-
46
-
-
0041631013
-
Caspase 3-mediated inactivation of Rac GTPases promotes drug-induced apoptosis in human lymphoma cells
-
Zhang, B., Y. Zhang, and E. Shacter. 2003. Caspase 3-mediated inactivation of Rac GTPases promotes drug-induced apoptosis in human lymphoma cells. Mol. Cell. Biol. 23:5716-5725.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5716-5725
-
-
Zhang, B.1
Zhang, Y.2
Shacter, E.3
|