Caspase 3-mediated inactivation of Rac GTPases promotes drug-induced apoptosis in human lymphoma cells

Molecular and Cellular Biology

Volumn 23, Issue 16, 2003, Pages 5716-5725

  Zhang, Baolin ^a   Zhang, Yaqin ^a   Shacter, Emily ^a  

^a Division of Viral Products   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GUANOSINE TRIPHOSPHATASE; RAC PROTEIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CATALYSIS; CELL PROTECTION; DRUG INDUCED DISEASE; EFFECTOR CELL; ENZYME INACTIVATION; ENZYME SPECIFICITY; GENETIC ORGANIZATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYTOSKELETON; DOWN-REGULATION; ETOPOSIDE; GENETIC VECTORS; HUMANS; LYMPHOMA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STAUROSPORINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0041631013     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.16.5716-5725.2003     Document Type: Article

References (47)

1. Archer, H., and D. Bar-Sagi. 2002. Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol. Biol. 189:67-73.
2. Aznar, S., and J. C. Lacal. 2001. Rho signals to cell growth and apoptosis. Cancer Lett. 165:1-10.
3. Benard, V., B. P. Bohl, and G. M. Bokoch. 1999. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils with a novel assay for active GTPases. J. Biol. Chem. 274:13198-13204.
4. Boehm, J. E., O. V. Chaika, and R. E. Lewis. 1999. Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain. J. Biol. Chem. 274:28632-28636.
5. Bokoch, G. M. 2000. Regulation of cell function by Rho family GTPases. Immunol. Res. 21:139-148.
6. Boulares, A. H., A. G. Yakovlev, V. Ivanova, B. A. Stoica, G. Wang, S. Iyer, and M. Smulson. 1999. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J. Biol. Chem. 274:22932-22940.
7. Cohen, G. M. 1997. Caspases: the executioners of apoptosis. Biochem. J. 326:1-16.
8. Coleman, M. L., and M. F. Olson. 2002. Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ. 9:493-504.
9. Deshpande, S. S., P. Angkeow, J. Huang, M. Ozaki, and K. Irani. 2000. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J. 14:1705-1714.
10. Droin, N., L. Dubrez, B. Eymin, C. Renvoize, J. Breard, M. T. Dimanche-Boitrel, and E. Solary. 1998. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Oncogene 16:2885-2894.
11. Embade, N., P. F. Valeron, S. Aznar, E. Lopez-Collazo, and J. C. Lacal. 2000. Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramide production. Mol. Biol. Cell 11:4347-4358.
12. Esteve, P., N. Embade, R. Perona, B. Jimenez, L. del Peso, J. Leon, M. Arends, T. Miki, and J. C. Lacal. 1998. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but BclII dependent pathway. Oncogene 17:1855-1869.
13. Fiorentini, C., P. Matarrese, E. Straface, L. Falzano, G. Donelli, P. Boquet, and W. Malorni. 1998. Rho-dependent cell spreading activated by E. coli cytotoxic necrotizing factor 1 hinders apoptosis in epithelial cells. Cell Death Differ. 5:921-929.
14. Flygare, J., D. Hellgren, and A. Wennborg. 2000. Caspase-3 mediated cleavage of HsRad51 at an unconventional site. Eur. J. Biochem. 267:5977-5982.
15. Gescher, A. 2000. Staurosporine analogues - pharmacological toys or useful antitumour agents? Crit. Rev. Oncol. Hematol. 34:127-135.
16. Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509-514.
17. Harrington, A. W., J. Y. Kim, and S. O. Yoon. 2002. Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. J. Neurosci. 22:156-166.
18. Hirshberg, M., R. W. Stockley, G. Dodson, and M. R. Webb. 1997. The crystal structure of human Rac1, a member of the Rho-family complexed with a GTP analogue. Nat. Struct. Biol. 4:147-152.
19. Jaffe, A. B., and A. Hall. 2002. Rho GTPases in transformation and metastasis. Adv. Cancer Res. 84:57-80.
20. Jeong, H. G., H. J. Cho, I. Y. Chang, S. P. Yoon, Y. J. Jeon, M. H. Chung, and H. J. You. 2002. Rac1 prevents cisplatin-induced apoptosis through downregulation of p38 activation in NIH 3T3 cells. FEBS Lett. 518:129-134.
21. Joneson, T., and D. Bar-Sagi. 1999. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19:5892-5901.
22. Kipp, M., B. L. Schwab, M. Przybylski, P. Nicotera, and F. O. Fackelmayer. 2000. Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase 3 occurs at a noncanonical cleavage site. J. Biol. Chem. 275:5031-5036.
23. Krieser, R. J., and A. Eastman. 1999. Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-guanine nucleotide dissociation inhibitors, during apoptosis. Cell Death Differ. 6:412-419.
24. Lee, Y., and E. Shacter. 1997. Bcl-2 does not protect Burkitt's lymphoma cells from oxidant-induced cell death. Blood 89:4480-4492.
25. Lores, P., L. Morin, R. Luna, and G. Gacon. 1997. Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase. Oncogene 15:601-605.
26. Meriane, M., S. Charrasse, F. Comunale, A. Mery, P. Fort, P. Roux, and C. Gauthier-Rouviere. 2002. Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation. Oncogene 21:2901-2907.
27. Mira, J. P., V. Benard, J. Groffen, L. C. Sanders, and U. G. Knaus. 2000. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc. Natl. Acad. Sci. USA 97:185-189.
28. Mow, B. M., A. L. Blajeski, J. Chandra, and S. H. Kaufmann. 2001. Apoptosis and the response to anticancer therapy. Curr. Opin. Oncol. 13:453-462.
29. Murga, C., M. Zohar, H. Teramoto, and J. S. Gutkind. 2002. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB. Oncogene 21:207-216.
30. Na, S., T. H. Chuang, A. Cunningham, T. G. Turi, J. H. Hanke, G. M. Bokoch, and D. E. Danley. 1996. D4-guanine nucleotide dissociation inhibitors, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271:11209-11213.
31. Nicholson, D. W., and N. A. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22:299-306.
32. Nishida, K., Y. Kaziro, and T. Satoh. 1999. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene 18:407-415.
33. Pervaiz, S., J. Cao, O. S. Chao, Y. Y. Chin, and M. V. Clement. 2001. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20:6263-6268.
34. Philips, A., P. Roux, V. Coulon, J. M. Bellanger, A. Vie, M. L. Vignais, and J. M. Blanchard. 2000. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts. J. Biol. Chem. 275:5911-5917.
35. Qi, H., P. Juo, J. Masuda-Robens, M. J. Caloca, H. Zhou, N. Stone, M. G. Kazanietz, and M. M. Chou. 2001. Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ. 12:603-611.
36. Rudel, T., and G. M. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276:1571-1574.
37. Ruggieri, R., Y. Y. Chuang, and M. Symons. 2001. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Mol. Med. 7:293-300.
38. Samejima, K., P. A. Svingen, G. S. Basi, T. Kottke, P. W. Mesner, Jr., L. Stewart, F. Durrieu, G. G. Poirier, E. S. Alnemri, J. J. Champoux, S. H. Kaufmann, and W. C. Earnshaw. 1999. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. J. Biol. Chem. 274:4335-4340.
39. Schnelzer, A., D. Prechtel, U. Knaus, K. Dehne, M. Gerhard, H. Graeff, N. Harbeck, M. Schmitt, and E. Lengyel. 2000. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19:3013-3020.
40. Schurmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch. 2000 p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20:453-461.
41. Senturker, S., R. Tschirret-Guth, J. Morrow, R. Levine, and E. Shacter. 2002. Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species. Arch. Biochem. Biophys. 397:262-272.
42. Subauste, M. C., M. Von Herrath, V. Benard, C. E. Chamberlain, T. H. Chuang, K. Chu, G. M. Bokoch, and K. M. Hahn. 2000. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol. Chem. 275:9725-9733.
43. Takahashi, M., H. Mukai, M. Toshimori, M. Miyamoto, and Y. Ono. 1998. Proteolytic activation of PKN by caspase 3 or related protease during apoptosis. Proc. Natl. Acad. Sci. USA 95:11566-11571.
44. Tu, S., and R. A. Cerione. 2001. Cdc42 is a substrate for caspases and influences Fas-induced apoptosis. J. Biol. Chem. 276:19656-19663.
45. Zhang, B., J. Chernoff, and Y. Zheng. 1998. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J. Biol. Chem. 273:8776-8782.
46. Zhang, B., Y. Gao, S. Y. Moon, Y. Zhang, and Y. Zheng. 2001. Oligomerization of Rac1 GTPase mediated by the carboxyl-terminal polybasic domain. J. Biol. Chem. 276:8958-8967.
47. Zhang, B., Z. X. Wang, and Y. Zheng. 1997. Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties Cdc42 binding to the Cdc42-interactive domains. J. Biol. Chem. 272:21999-22007.