Regulation of Akt-dependent cell survival by Syk and Rac

Blood

Volumn 101, Issue 1, 2003, Pages 236-244

  Jiang, Kun ^a,b   Zhong, Bin ^a,b   Ritchey, Connie ^a,b   Gilvary, Danielle L ^a,b   Hong Geller, Elizabeth ^a,b   Wei, Sheng ^a,b   Djeu, Julie Y ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PICEATANNOL; PROTEIN; PROTEIN KINASE B; PROTEIN KINASE SYK; RAC PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

EID: 0037217977     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-04-1251     Document Type: Article

References (65)

1. Leonard WJ, O'Shea JJ. Jaks and STATS: Biological implications. Annu Rev Immunol. 1998;16:293-322.
2. Hatakeyama M, Kono T, Kobayashi N, et al. Interaction of the IL-2 receptor with the src-family kinase p56lck: Identification of novel intermolecular association. Science. 1991;252:1523-1528.
3. Horak ID, Gress RE, Lucas PJ, Horak EM, Waldmann TA, Bolen JB. T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proc Natl Acad Sci U S A. 1991;88:1996-2000.
4. Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science. 1995;268:251-255.
5. Johnston JA, Kawamura M, Kirken RA, et al. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature. 1994;370:151-153.
6. Witthuhn BA, Silvennoinen O, Miura O, et al. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994;370:153-157.
7. Ravichandran KS, Burakoff SJ. The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. J Biol Chem. 1994;269:1599-1602.
8. Karnitz LM, Abraham RT. Interleukin-2 receptor signaling mechanisms. Adv Immunol. 1996;61:147-199.
9. Monfar M, Lemon KP, Grammer TC, et al. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol Cell Biol. 1995;15:326-337.
10. Reif K, Burgering BM, Cantrell DA. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase. J Biol Chem. 1997;272:14426-14433.
11. Schlessinger J. How receptor tyrosine kinases activate Ras. Trends Biochem Sci. 1993;18:273-275.
12. Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A. 1996;93:5275-5280.
13. Gonzalez-Garcia A, Merida I, Martinez AC, Carrera AC. Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem. 1997;272:10220-10226.
14. Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci U S A. 1997;94:3627-3632.
15. Remillard B, Petrillo R, Maslinski W, et al. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J Biol Chem. 1991;266:14167-14170.
16. Minami Y, Nakagawa Y, Kawahara A, et al. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: Possible link with the c-myc induction pathway. Immunity. 1995;2:89-100.
17. Qin S, Inazu T, Yang C, Sada K, Taniguchi T, Yamamura H. Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes. FEBS Lett. 1994;345:233-236.
18. Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL. Tyrosine kinase SYK: Essential functions for immunoreceptor signalling. Immunol Today. 2000;21:148-154.
19. Law CL, Chandran KA, Sidorenko SP, Clark EA. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol. 1996;16:1305-1315.
20. Jabril-Cuenod B, Zhang C, Scharenberg AM, et al. Syk-dependent phosphorylation of Shc: A potential link between FcεRI and the Ras/mitogenactivated protein kinase signaling pathway through SOS and Grb2. J Biol Chem. 1996;271:16268-16272.
21. Ding J, Takano T, Gao S, et al. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress. J Biol Chem. 2000;275:30873-30877.
22. Pogue SL, Kurosaki T, Bolen J, Herbst R. B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J Immunol. 2000;165:1300-1306.
23. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vavl. Curr Biol. 1998;8:1289-1299.
24. Wei S, Gamero AM, Liu JH, et al. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2. J Exp Med. 1998;187:1753-1765.
25. Klippel A, Kavanaugh WM, Pot D, Williams LT. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol. 1997;17:338-344.
26. Scharenberg AM, Lin S, Cuenod B, Yamamura H, Kinet JP. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J. 1995;14:3385-3394.
27. Hong-Geller E, Cerione RA. Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells. J Cell Biol. 2000;148:481-494.
28. Jiang K, Zhong B, Gilvary DL, et al. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol. 2000;1:419-425.
29. Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature. 1985;315:239-242.
30. Oliver JM, Burg DL, Wilson BS, McLaughlin JL, Geahlen RL. Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem. 1994;269:29697-29703.
31. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241-5248.
32. Nelson BH, Willerford DM. Biology of the interleukin-2 receptor. Adv Immunol. 1998;70:1-81
33. Merida I, Diez E, Gaulton GN. IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. J Immunol. 1991;147:2202-2207.
34. Wymann MP, Bulgarelli-Leva G, Zvelebil M, et al. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol. 1996;16:1722-1733.
35. Nobes CD, Hawkins P, Stephens L, Hall A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci. 1995;108:225-233.
36. Arrieumerlou C, Donnadieu E, Brennan P, et al. Involvement of phosphoinositide 3-kinase and Rac in membrane ruffling induced by IL-2 in T cells. Eur J Immunol. 1998;28:1877-1885.
37. Cheng HL, Steinway ML, Russell JW, Feldman EL. GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-l-mediated Schwann cell motility. J Biol Chem. 2000;275:27197-27204.
38. Djouder N, Schmidt G, Frings M, Cavalie A, Thelen M, Aktories K. Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. J Immunol. 2001;166:1627-1634.
39. Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol. 1995;15:3049-3057.
40. Brennan P, Babbage JW, Thomas G, Cantrell D. p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol Cell Biol. 1999;19:4729-4738.
41. Colucci F, Turner M, Schweighoffer E, et al. Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation. J Immunol. 1999;163:1769-1774.
42. Colucci F, Schweighoffer E, Tomasello E, et al. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol. 2002;3:288-294.
43. Williams NS, Moore TA, Schatzle JD, et al. Generation of lytic natural killer 1.1+, Ly-49-cells from multipotential murine bone marrow progenitors in a stroma-free culture: Definition of cytokine requirements and developmental intermediates. J Exp Med. 1997;186:1609-1614.
44. Perussia B, Chan SH, D'Andrea A, et al. Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. J Immunol. 1992;149:3495-3502.
45. + hematopoietic progenitor cells. Blood. 1996;87:2632-2640.
46. Yu H, Fehniger TA, Fuchshuber P, et al. Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15. Blood. 1998;92:3647-3657.
47. Walk SF, March ME, Ravichandran KS. Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. Eur J Immunol. 1998;28:2265-2275.
48. Gu H, Maeda H, Moon JJ, et al. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol. 2000;20:7109-7120.
49. Gadina M, Sudarshan C, Visconti R, et al. The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. J Biol Chem. 2000;275:26959-26966.
50. Umehara H, Huang JY, Kono T, et al. Involvement of protein tyrosine kinase p72syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3.3. J Immunol. 1997;159:1200-1207.
51. Migone TS, Rodig S, RodigS, Cacalano NA, Berg M, Schreiber RD, Leonard WJ. Functional cooperation of the interleukin-2 receptor beta chain and Jakl in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol Cell Biol. 1998;18:6416-6422.
52. Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 2000;13:817-827.
53. von Willebrand M, Williams S, Tailor P, Mustelin T. Phosphorylation of the Grb2- and phosphatidylinositol 3-kinase p85-binding p36/38 by Syk in Lck-negative T cells. Cell Signal. 1998;10:407-413.
54. Alessi OR, Cohen P. Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev. 1998;8:55-62.
55. Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 1995;376:599-602.
56. Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81:727-736.
57. Li HL, Davis WW, Whiteman EL, Birnbaum MJ, Pure E. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. Proc Natl Acad Sci U S A. 1999;96:6890-6895.
58. Van Aelst L, D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 1997;11:2295-2322.
59. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J. 2000;348 Pt 2:241-255.
60. Genot EM, Arrieumerlou C, Ku G, Burgering BM, Weiss A, Kramer IM. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol. 2000;20:5469-5478.
61. Reif K, Nobes CD, Thomas G, Hall A, Cantrell DA. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol. 1996;6:1445-1455.
62. Liliental J, Moon SY, Lesche R, et al. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000;10:401-404.
63. Paramio JM, Navarro M, Segrelles C, GomezCasero E, Jorcano JL. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene. 1999;18:7462-7468.
64. Jiang K, Zhong B, Gilvary DL, et al. Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J Immunol. 2002;168:3155-3164.
65. Djeu JY, Jiang K, Wei S. A view to a kill: Signals triggering cytotoxicity. Clin Cancer Res. 2002;8:636-640.