PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone

Journal of Cell Biology

Volumn 157, Issue 7, 2002, Pages 1175-1186

  Mollinari, Cristiana ^a   Kleman, Jean Philippe ^a   Jiang, Wei ^b   Schoehn, Guy ^c   Hunter, Tony ^d   Margolis, Robert L ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b NEW YORK UNIVERSITY   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Cdk; Cytokinesis; Cytoskeleton; Microtubule associated protein; Mitosis

Indexed keywords

CYCLIN DEPENDENT KINASE; MICROTUBULE ASSOCIATED PROTEIN;

ARTICLE; CYTOKINESIS; CYTOSKELETON; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; CELL CYCLE PROTEINS; CELL NUCLEUS; CENTROSOME; CYCLIN-DEPENDENT KINASES; HELA CELLS; HISTONES; HUMANS; INTERPHASE; MICROTUBULES; MITOTIC SPINDLE APPARATUS; MUTATION; PACLITAXEL; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0037166936     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111052     Document Type: Article

References (52)

1. Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
2. Telophase disc: A new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis
3. Stable expression of heterologous microtubule-associated proteins (MAPs) in Chinese hamster ovary cells: Evidence for differing roles of MAPs in microtubule organization
4. Mechanism of the formation of contractile ring in dividing cultured animal cells. I. Recruitment of preexisting actin filaments into the cleavage furrow
5. Signals from the spindle midzone are required for the stimulation of cytokinesis in cultured epithelial cells
6. Drosophila polo kinase is required for cytokinesis
7. The 65-kDa carrot microtubule-associated protein forms regularly arranged filamentous cross-bridges between microtubules
8. A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos
9. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
10. Phase dynamics at microtubule ends: The coexistence of microtubule length changes and tread-milling
11. The mechanism and control of cytokinesis
12. Cyclin is degraded by the ubiquitin pathway
13. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis
14. CYK-4: A Rho family GTPase activating protein (GAP) required for central spindle formation and cytokinesis
15. PRC 1: A human mitotic spindle-associated CDK substrate protein required for cyrokinesis
16. APC-mediated proteolysis of Asel and the morphogenesis of the mitotic spindle
17. Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)
18. Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position
19. CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis
20. Suppression of tubulin ryrosine ligase during tumor growth
21. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
22. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
23. Role of citron kinase as a target of the small GTPase Rho in cytokinesis
24. Structure, microtubule interactions, and phosphorylation of tau protein
25. Colocalization of TD-60 and INCENP throughout G2 and mitosis: Evidence for their possible interaction in signaling cytokinesis
26. Interpolar spindle microtubules in PTK cells
27. Central spindle assembly and cytokinesis requires a kinesin-like protein/RhoGAP complex with microtubule bundle activity
28. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
29. The small GTP-binding protein rho regulates cortical activities in cultured cells during division
30. Mutation of a gene for a Drosophila kinesin-like protein, Klp38B, leads to failure of cytokinesis
31. Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae
32. T7 vectors with a modified T71ac promoter for expression of proteins in Escherichia coli
33. The KEN box: An APC recognition signal distinct from the D box targeted by Cdhl
34. A putative exchange factor for Rhol GTPase is required for initiation of cytokinesis in Drosophila
35. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4
36. Towards a molecular understanding of cytokinesis
37. Distribution of a matrix component of the midbody during the cell cycle in Chinese hamster ovary cells
38. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
39. Human survivin is a kinetochore-associated passenger protein
40. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1
41. The involvement of the rho gene product, a small molecular weight GTP-binding protein in polyploidization of a human megakaryocytic cell line, CMK
42. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
43. AIM-1: A mammalian midbody-associated protein required for cytokinesis
44. Novel features of the light chain of microtubule-associated protein MAP1B: Microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain
45. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
46. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)
47. Reorganisation of the microtubular cytoskeleton by embryonic microtubule-associated protein 2 (MAP2c)
48. Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells
49. The Drosophila kinesin-like protein KLP3A is a midbody component required for central spindle assembly and initiation of cytokinesis
50. Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments
51. CENP-E is a putative kinetochore motor that accumulates just before mitosis
52. Animal cytokinesis: Breaking up is hard to do