Derivation of [11C]WAY-100635 binding parameters with reference tissue models: Effect of violations of model assumptions

Nuclear Medicine and Biology

Volumn 27, Issue 5, 2000, Pages 487-492

  Slifstein, Mark ^a   Parsey, Ramin V ^a   Laruelle, Marc ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

5 HT(1A) receptors; 11C WAY 100635; Positron emission tomography; Reference tissue model

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RADIOLIGAND; SEROTONIN 1A RECEPTOR; CARBON; DIAGNOSTIC AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RACLOPRIDE; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ARTICLE; BINDING AFFINITY; BRAIN BLOOD FLOW; CHEMICAL ANALYSIS; COMPARTMENT MODEL; HUMAN; KINETICS; POSITRON EMISSION TOMOGRAPHY; RECEPTOR DENSITY; STRUCTURE ACTIVITY RELATION; BIOLOGICAL MODEL;

CARBON RADIOISOTOPES; HUMANS; MODELS, BIOLOGICAL; PIPERAZINES; PYRIDINES; RACLOPRIDE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS;

EID: 0033624541     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00117-7     Document Type: Article

References (16)

1. 123I]iomazenil Kinetic and equilibrium paradigms . J. Nucl. Med. 35:1994;228-238.
2. 18F]cyclofoxy and positron emission tomography . J. Cereb. Blood Flow Metab. 13:1993;24-42.
3. Drevets W., Frank E., Price J., Kupfer D., Holt D., Greer P.J., Huang Y., Gautier C., Mathis C. Pet imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry. 46:1999;1375-1387.
4. 2 dopamine receptor binding in the living human brain by PET. Science. 231:1986;258-261.
5. 11C]WAY-100635 for Pet. NeuroImage 8, 426-440.
6. Hume S. P., Myers R., Bloomfield P. M., Opacka-Juffry J., Cremer J. E., Ahier R. G. Luthra S. K., Brooks D. J. and. Lammertsma A. A (1992) Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography. Synapse 12, 47-54.
7. 2-receptor binding with iodine-123-IBF SPECT in healthy subjects. J. Nucl. Med. 38, 31-37.
8. 11C]WAY-100635 Pet with anatomic standardization technique . J. Nucl. Med. 40:1999;102-109.
9. 11C][raclopride studies. J. Cereb. Blood Flow Metab. 16:1999;42-52.
10. Lammertsma A.A., Hume S.P. Simplified reference tissue model for Pet receptor studies. NeuroImage. 4:1999;153-158.
11. Laruelle M. Modelling when and why? Eur. J. Nucl. Med. 26:1999;571-572.
12. Laruelle M. Imaging synaptic neurotransmission with in vivo competition techniques A critical review . J. Cereb. Blood Flow Metab. 20:2000;423-451.
13. Laruelle M., Abi-Dargaham A., van Dyck C. H., Rosenblatt W., Zea Ponce Y., Zoghbi S. S., Baldwin R. M., Charney D. S., Hoffer P. B., Kungh F. and Innis R. B. (1995) SPECT imaging of striatal dopamine release after amphetamine challenge. J. Nucl. Med. 36, 1182-1190.
14. Logan J., Fowler J.S., Volkow N.D., Wang G.J., Ding Y.S., Alexoff D.L. Distribution volume ratios without blood sampling from graphical analysis of Pet data. J. Cereb. Blood Flow Metab. 16:1996;834-840.
15. Mintun M.A., Raichle M.E., Kilbourn M.R., Wooten G.F., Welch M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 15:1984;217-227.
16. 11C]WAY-100635 in humans: Comparison of arterial and reference tissue input functions. J. Cereb. Blood Flow Metab. In press.