Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma

Genes Chromosomes and Cancer

Volumn 25, Issue 2, 1999, Pages 97-103

  Nakata, Tomoko ^a   Kitamura, Yutaka ^a   Shimizu, Kazuo ^a   Tanaka, Shigeo ^a   Fujimori, Minoru ^b   Yokoyama, Shiro ^b   Ito, Kouichi ^c   Emi, Mitsuru ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

^c ITO HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; CHROMOSOME TRANSLOCATION 10; CHROMOSOME TRANSLOCATION 12; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; GENE FUSION; GENE MAPPING; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LIGAND BINDING; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID PAPILLARY CARCINOMA;

AMINO ACID SEQUENCE; CARCINOMA, PAPILLARY; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 12; CLONING, MOLECULAR; DIMERIZATION; DNA, NEOPLASM; DROSOPHILA PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; THYROID NEOPLASMS; TRANSLOCATION, GENETIC;

EID: 0032942337     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L     Document Type: Article

References (29)

1. Boehnke M, Lange K, Cox DR. 1991. Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet 49:1174-1188.
2. Bongarzone I, Monzini N, Borrello MG, Carcano C, Ferraresi G, Arighi E, Mondellini P, Della Porta G, Pierotti MA. 1993. Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dcpendent protein kinase A. Mol Cell Biol 13:358-366.
3. Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA. 1994. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res 54:2979-2985.
4. Chen Z. 1996. Simple modifications to increase specificity of the 5′ RACE procedure, Trends Genet 12:87-88.
5. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
6. Enokido Y, Desauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM. 1998. GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr Biol 8:1019-1022.
7. Fabien N, Paulin C, Santoro M, Berger N, Grieco M, Galvain D, Barbier Y, Dubois PM, Fusco A. 1992. Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridization. Br J Cancer 66:1094-1098.
8. Fugazzola L, Pierotti MA, Vigano E, Pacini F, Vorontsova TV, Bongarzone I. 1996. Molecular and biochemical analysis of RET/ PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. Oncogene 13:1093-1097.
9. Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA. 1995. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol 15:6118-6127.
10. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G. 1990. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557-563.
11. Ishizaka Y, Kobayashi S, Ushijima T, Hirohashi S, Sugimura T, Nagao M. 1991. Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. Oncogene 6:1667-1672.
12. Jhiang SM, Mazzaferri EL. 1994. The ret/PTC oncogene in papillary thyroid carcinoma. J Lab Clin Med 123:331-337.
13. Jhiang SM, Smanik PA, Mazzaferri EL. 1994. Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma. Cancer Lett 78:69-76.
14. Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM. 1996. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85:1113-1124.
15. Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. 1991. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197.
16. Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q. Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A. 1997. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387:717-721.
17. Klugbauer S, Lengfelder E, Demidchik EP, Rabes HM. 1995. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene 11:2459-2467.
18. Klugbauer S, Lengfelder E, Demidchik EP, Rabes HM. 1996. A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident. Oncogene 13:1099-1102 .
19. Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM. 1998. Detection of a novel type of ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved ret-fused gene RFG5. Cancer Res 58:198-203.
20. Kozak M. 1984. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res 12:857-872.
21. Milbrandt J, Desauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, Sherman D, Nishimura M, Wang LC, Vandlen R, Moffat B, Klein RD, Poulsen K, Gray C, Garces A, Henderson CE, Phillips HS, Johnson EM Jr. 1998. Persephin, a novel neurotrophic factor related to GDNF and Neurturin. Neuron 20:245-253.
22. Namba H, Yamashita S, Pei HC, Ishikawa N, Villadolid MC, Tominaga T, Kimura H, Tsuruta M, Yokoyama N, Izumi M, Ishigaki J, Ito K, Nagataki S. 1991. Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors. Endocrinol Jpn 38:627-632.
23. Pearson WR, Lipman DJ. 1988. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85:2444-2448.
24. Rodrigues GA, Park M. 1993. Dimerization mediated through a leucine zipper activates the oncogenic potential of the ret receptor tyrosine kinase. Mol Cell Biol 13:6711-6722.
25. Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A. 1994. Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 9:509-516.
26. Tong Q, Li Y, Smanik PA, Fithian LJ, Xing S, Mazzaferri EL, Jhiang SM. 1995. Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. Oncogene 10:1781-1787.
27. Ullrich A, Schlessinger J. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
28. Wajjwalku W, Nakamura S, Hasegawa Y, Miyazaki K, Satoh Y, Funahashi H, Matsuyama M, Takahashi M. 1992. Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. Jpn J Cancer Res 83:671-675.
29. Wolf E, Kim PS, Berger B. 1997. MultiCoil: a program for predicting two-and three-stranded coiled coils. Protein Sci 6:1179-1189.