Ketorolac amide prodrugs for transdermal delivery: Stability and in vitro rat skin permeation studies

International Journal of Pharmaceutics

Volumn 293, Issue 1-2, 2005, Pages 193-202

  Kim, Bo Yeon ^a   Doh, Hea Jeong ^a   Le, Thanh Nguyen ^b   Cho, Won Jea ^b   Yong, Chul Soon ^c   Choi, Han Gon ^c   Kim, Jung Sun ^d   Lee, Chi Ho ^a   Kim, Dae Duk ^e  

^a Pusan National University   (South Korea)

^b Chonnam National University   (South Korea)

^c Yongnam University ^*  (South Korea)

^d Dongseo University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

Amide; Ketorolac; Prodrug; Skin permeation; Transdermal delivery

Indexed keywords

3 [(5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBONYL)AMINO]PROPIONIC ACID ETHYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID (3 METHOXYPROPYL)AMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID (4 METHOXYBENZYL)AMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID (4 METHOXYPHENYL)AMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID ALLYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID BENZYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID BUTYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID ISOPROPYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID PHENYLAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID PROPYLAMIDE; AMIDE; KETOROLAC; KETOROLAC DERIVATIVE; MACROGOL; OCTANOL; PRODRUG; UNCLASSIFIED DRUG; WATER; [(5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBONYL)AMINO]ACETIC ACID METHYL ESTER;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CHEMICAL MODIFICATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIPOPHILICITY; LIVER HOMOGENATE; MALE; NONHUMAN; PARTITION COEFFICIENT; PLASMA; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; TEMPERATURE; TISSUE HOMOGENATE; TRANSDERMAL DRUG ADMINISTRATION;

EID: 15044355680     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.01.002     Document Type: Article

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