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Volumn 12, Issue 6, 1999, Pages 326-335

The pretreatment effect of chemical skin penetration enhancers in transdermal drug delivery using iontophoresis

Author keywords

Chemical enhancer; Electron microscope; Insulin; Iontophoresis; Skin barrier impairment; Transdermal drug delivery

Indexed keywords

ALCOHOL; GLUCOSE; INSULIN; LINOLEIC ACID; LIPID; OLEIC ACID; PROPYLENE GLYCOL; SKIN LIPID;

EID: 0032720359     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000029894     Document Type: Article
Times cited : (69)

References (35)
  • 1
    • 0001529489 scopus 로고
    • Synergistic effects in percutaneous enhancement
    • Walters KA, Hadgraft J (eds): New York, Dekker
    • Mollgaard B: Synergistic effects in percutaneous enhancement; in Walters KA, Hadgraft J (eds): Pharmaceutical Skin Penetration Enhancement. New York, Dekker, 1993, pp 229-242.
    • (1993) Pharmaceutical Skin Penetration Enhancement , pp. 229-242
    • Mollgaard, B.1
  • 3
    • 0020608231 scopus 로고
    • Epidermal lipids, barrier function, and desquamation
    • Elias PM: Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 1983;80(suppl):44S-49S.
    • (1983) J Invest Dermatol , vol.80 , Issue.SUPPL.
    • Elias, P.M.1
  • 4
    • 0030765030 scopus 로고    scopus 로고
    • Effect of penetration enhancers and iontophoresis on the ultrastructure and cholecystokinin-8 permeability through porcine skin
    • Bhatia KS, Gao S, Freeman TP, Singh J: Effect of penetration enhancers and iontophoresis on the ultrastructure and cholecystokinin-8 permeability through porcine skin. J Pharm Sci 1997;86:1011-1015.
    • (1997) J Pharm Sci , vol.86 , pp. 1011-1015
    • Bhatia, K.S.1    Gao, S.2    Freeman, T.P.3    Singh, J.4
  • 5
    • 0025346716 scopus 로고
    • Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin
    • Srinivasan V, Su MH, Higuchi WI, Behl CR: Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin. J Pharm Sci 1990; 79:588-591.
    • (1990) J Pharm Sci , vol.79 , pp. 588-591
    • Srinivasan, V.1    Su, M.H.2    Higuchi, W.I.3    Behl, C.R.4
  • 6
    • 0025253212 scopus 로고
    • Enhancement of the in vivo skin permeability of azidothymidine (AZT) via iontophoresis and chemical enhancer
    • Wearly L, Chien YW: Enhancement of the in vivo skin permeability of azidothymidine (AZT) via iontophoresis and chemical enhancer. Pharm Res 1990;7:34-40.
    • (1990) Pharm Res , vol.7 , pp. 34-40
    • Wearly, L.1    Chien, Y.W.2
  • 7
    • 0024841175 scopus 로고
    • Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery
    • Srinivasan V, Higuchi WI, Sims SM, Ghanem AH, Behl CR: Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery. J Pharm Sci 1989;78:370-375.
    • (1989) J Pharm Sci , vol.78 , pp. 370-375
    • Srinivasan, V.1    Higuchi, W.I.2    Sims, S.M.3    Ghanem, A.H.4    Behl, C.R.5
  • 8
    • 0015617741 scopus 로고
    • Mechanisms of percutaneous absorption. IV. Penetration of nonelectrolytes (alcohols) from aqueous solutions and from pure liquids
    • Scheuplein RJ, Blank IH: Mechanisms of percutaneous absorption. IV. Penetration of nonelectrolytes (alcohols) from aqueous solutions and from pure liquids. J Invest Dermatol 1973;60:286-296.
    • (1973) J Invest Dermatol , vol.60 , pp. 286-296
    • Scheuplein, R.J.1    Blank, I.H.2
  • 9
    • 0016053262 scopus 로고
    • Mass transport phenomena and models: Theoretical concepts
    • Flynn GL,Yalkowsky SH, Roseman TJ: Mass transport phenomena and models: Theoretical concepts. J Pharm Sci 1974;63:479-509.
    • (1974) J Pharm Sci , vol.63 , pp. 479-509
    • Flynn, G.L.1    Yalkowsky, S.H.2    Roseman, T.J.3
  • 10
    • 0024639484 scopus 로고
    • Structure-effect studies of fatty acid isomers as skin penetration enhancers and skin irritations
    • Aungst BJ: Structure-effect studies of fatty acid isomers as skin penetration enhancers and skin irritations. Pharm Res 1989;6:244-247.
    • (1989) Pharm Res , vol.6 , pp. 244-247
    • Aungst, B.J.1
  • 11
    • 0013477799 scopus 로고
    • The effect of hydration on the permeability of the skin
    • Bronaugh RL, Maibach HI (ed): New York, Dekker
    • Blank IH: The effect of hydration on the permeability of the skin; in Bronaugh RL, Maibach HI (ed): Percutaneous Absorption. New York, Dekker, 1985, pp 97-105.
    • (1985) Percutaneous Absorption , pp. 97-105
    • Blank, I.H.1
  • 12
    • 0021182767 scopus 로고
    • Increased skin permeability for liphophilic molecules
    • Cooper ER: Increased skin permeability for liphophilic molecules. J Pharm Sci 1984;73:1153-1156.
    • (1984) J Pharm Sci , vol.73 , pp. 1153-1156
    • Cooper, E.R.1
  • 13
    • 84986706431 scopus 로고
    • Action of skin permeation enhancers azone, oleic acid and decylmethyl sulphoxide: Permeation and DSC studies
    • Goodman M, Barry BW: Action of skin permeation enhancers azone, oleic acid and decylmethyl sulphoxide: Permeation and DSC studies. J Pharm Pharmacol 1986;38(suppl): 71.
    • (1986) J Pharm Pharmacol , vol.38 , Issue.SUPPL. , pp. 71
    • Goodman, M.1    Barry, B.W.2
  • 14
    • 0023107312 scopus 로고
    • Role of stratum corneum lipid fluidity in transdermal drug flux
    • Golden GM, Mckie JE, Potts RU: Role of stratum corneum lipid fluidity in transdermal drug flux. J Pharm Sci 1987;76:25-28.
    • (1987) J Pharm Sci , vol.76 , pp. 25-28
    • Golden, G.M.1    McKie, J.E.2    Potts, R.U.3
  • 15
    • 0023950151 scopus 로고
    • Vehicle effect on topical drug delivery. IV. Effect of N-methylpyrrolidone and polar lipids on percutaneous drug transport
    • Hoelgaard A, Mollgaard B, Baker E: Vehicle effect on topical drug delivery. IV. Effect of N-methylpyrrolidone and polar lipids on percutaneous drug transport. Int J Pharm 1988;43:233-240.
    • (1988) Int J Pharm , vol.43 , pp. 233-240
    • Hoelgaard, A.1    Mollgaard, B.2    Baker, E.3
  • 16
    • 0025030097 scopus 로고
    • Oleic acid: Its effects on stratum corneum in relation to (trans)dermal drug delivery
    • Francoeur ML, Golden GM, Potts RO: Oleic acid: Its effects on stratum corneum in relation to (trans)dermal drug delivery. Pharm Res 1990;7:621-627.
    • (1990) Pharm Res , vol.7 , pp. 621-627
    • Francoeur, M.L.1    Golden, G.M.2    Potts, R.O.3
  • 17
    • 0025346850 scopus 로고
    • Oleic acid concentration and effect in human stratum corneum: Non-invasive determination by attenuated total reflectance infrared spectroscopy in vivo
    • Mak VHW, Potts RO, Guy RH: Oleic acid concentration and effect in human stratum corneum: Non-invasive determination by attenuated total reflectance infrared spectroscopy in vivo. J Controlled Release 1990;12:67-75.
    • (1990) J Controlled Release , vol.12 , pp. 67-75
    • Mak, V.H.W.1    Potts, R.O.2    Guy, R.H.3
  • 18
    • 0025905320 scopus 로고
    • Evidence that oleic acid exits in a separate phase within stratum corneum lipids
    • Ongpipattanakul B, Burnette RR, Potts RO, Francoeur ML: Evidence that oleic acid exits in a separate phase within stratum corneum lipids. Pharm Res 1991;8:350-354.
    • (1991) Pharm Res , vol.8 , pp. 350-354
    • Ongpipattanakul, B.1    Burnette, R.R.2    Potts, R.O.3    Francoeur, M.L.4
  • 19
    • 0027504419 scopus 로고
    • Effects of oleic acid/propylene glycol on rat abdominal stratum corneum: Lipid extraction and appearance of propylene glycol in the dermis measured by Fourier transform infrared/attenuated total reflectance (FT-IR/ATR) spectroscopy
    • Takeuchi Y, Yasukawa H, Yamaoka Y, Takahashi N, Tamura C, Morimoto Y, Fukushima S, Vasavada RC: Effects of oleic acid/propylene glycol on rat abdominal stratum corneum: Lipid extraction and appearance of propylene glycol in the dermis measured by Fourier transform infrared/attenuated total reflectance (FT-IR/ATR) spectroscopy. Chem Pharm Bull (Tokyo) 1993;41:1434-1437.
    • (1993) Chem Pharm Bull (Tokyo) , vol.41 , pp. 1434-1437
    • Takeuchi, Y.1    Yasukawa, H.2    Yamaoka, Y.3    Takahashi, N.4    Tamura, C.5    Morimoto, Y.6    Fukushima, S.7    Vasavada, R.C.8
  • 20
    • 0028928328 scopus 로고
    • Behavior of propylene glycol (PG) in dermis after treatment of rat intact skin surface with fatty acids, fatty amines or azone dissolved in PG
    • Takeuchi Y, Yasukawa H, Yamaoka Y, Taguchi K, Fukushima S, Shimonaka Y, Nishinaga H, Morimoto Y: Behavior of propylene glycol (PG) in dermis after treatment of rat intact skin surface with fatty acids, fatty amines or azone dissolved in PG. Biol Pharm Bull 1995;18:304-309.
    • (1995) Biol Pharm Bull , vol.18 , pp. 304-309
    • Takeuchi, Y.1    Yasukawa, H.2    Yamaoka, Y.3    Taguchi, K.4    Fukushima, S.5    Shimonaka, Y.6    Nishinaga, H.7    Morimoto, Y.8
  • 21
    • 0029585859 scopus 로고
    • Mechanism of oleic acid-induced skin penetration enhancement in vivo in human
    • Naik A, Pechtold LARM, Potts RO, Guy RH: Mechanism of oleic acid-induced skin penetration enhancement in vivo in human. J Controlled Release 1995;37:299-306.
    • (1995) J Controlled Release , vol.37 , pp. 299-306
    • Naik, A.1    Larm, P.2    Potts, R.O.3    Guy, R.H.4
  • 22
    • 0031750460 scopus 로고    scopus 로고
    • Relevance of hairless mouse as an experimental model of percutaneous penetration in man
    • Simon GA, Maibach HI: Relevance of hairless mouse as an experimental model of percutaneous penetration in man. Skin Pharmacol Appl Skin Physiol 1998;11:80-86.
    • (1998) Skin Pharmacol Appl Skin Physiol , vol.11 , pp. 80-86
    • Simon, G.A.1    Maibach, H.I.2
  • 23
    • 0023274940 scopus 로고
    • Presence of intact intercellular lamellae in the upper layers of the stratum corneum
    • Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular lamellae in the upper layers of the stratum corneum. J Invest Dermatol 1987;88: 714-718.
    • (1987) J Invest Dermatol , vol.88 , pp. 714-718
    • Madison, K.C.1    Swartzendruber, D.C.2    Wertz, P.W.3    Downing, D.T.4
  • 24
    • 0030899370 scopus 로고    scopus 로고
    • The changes of stratum corneum interstices and calcium distribution of follicular epithelium of experimentally induced comedones (EIC) by oleic acid
    • Choi EH, Ahn SK, Lee SH: The changes of stratum corneum interstices and calcium distribution of follicular epithelium of experimentally induced comedones (EIC) by oleic acid. Exp Dermatol 1997;6: 29-35.
    • (1997) Exp Dermatol , vol.6 , pp. 29-35
    • Choi, E.H.1    Ahn, S.K.2    Lee, S.H.3
  • 25
    • 7144226580 scopus 로고    scopus 로고
    • Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment
    • Lee SH, Choi EH, Feingold KR, Jiang S, Ahn SK: Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol 1998;111: 39-43.
    • (1998) J Invest Dermatol , vol.111 , pp. 39-43
    • Lee, S.H.1    Choi, E.H.2    Feingold, K.R.3    Jiang, S.4    Ahn, S.K.5
  • 26
    • 0012571517 scopus 로고    scopus 로고
    • The effect of repeated iontophoresis on the epidermal barrier of hairless mouse
    • Choi EH, Ahn SK, Jiang S, Lee SH: The effect of repeated iontophoresis on the epidermal barrier of hairless mouse (abstract). J Invest Dermatol 1998;110:675.
    • (1998) J Invest Dermatol , vol.110 , pp. 675
    • Choi, E.H.1    Ahn, S.K.2    Jiang, S.3    Lee, S.H.4
  • 27
    • 26844546765 scopus 로고    scopus 로고
    • The effect of saline iontophoresis on skin integrity in human volunteers. I. Methodology and reproducibility
    • Camel E, O'Connell M, Sage B, Gross M, Maibach H: The effect of saline iontophoresis on skin integrity in human volunteers. I. Methodology and reproducibility. Fundam Appl Toxicol 1996;32:168-178.
    • (1996) Fundam Appl Toxicol , vol.32 , pp. 168-178
    • Camel, E.1    O'Connell, M.2    Sage, B.3    Gross, M.4    Maibach, H.5
  • 28
    • 0029904252 scopus 로고    scopus 로고
    • The effect of iontophoresis on skin barrier integrity: Non-invasive evaluation by impedance spectroscopy and transepidermal water loss
    • Kalia YN, Nonato LB, Guy RH: The effect of iontophoresis on skin barrier integrity: Non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res 1996;13:957-960.
    • (1996) Pharm Res , vol.13 , pp. 957-960
    • Kalia, Y.N.1    Nonato, L.B.2    Guy, R.H.3
  • 29
    • 0021236368 scopus 로고
    • Pathways of ionic flow through human skin in vivo
    • Grimnes S: Pathways of ionic flow through human skin in vivo. Acta Dermatol Venereol (Stockh) 1984; 64:93-98.
    • (1984) Acta Dermatol Venereol (Stockh) , vol.64 , pp. 93-98
    • Grimnes, S.1
  • 30
    • 0023854208 scopus 로고
    • Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis
    • Burnette RR, Ongpipattanakul B: Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis. J Pharm Sci 1988;77:132-137.
    • (1988) J Pharm Sci , vol.77 , pp. 132-137
    • Burnette, R.R.1    Ongpipattanakul, B.2
  • 31
    • 0025865078 scopus 로고
    • Sites of iontophoretic current flow into the skin: Identification and characterization with the vibrating probe electrode
    • Cullander C, Guy RH: Sites of iontophoretic current flow into the skin: Identification and characterization with the vibrating probe electrode. J Invest Dermatol 1991; 97:55-64.
    • (1991) J Invest Dermatol , vol.97 , pp. 55-64
    • Cullander, C.1    Guy, R.H.2
  • 32
    • 0029807734 scopus 로고    scopus 로고
    • Visualization of iontophoretic transport paths in cultured and animal skin models
    • Lee RD, White HS, Scott ER: Visualization of iontophoretic transport paths in cultured and animal skin models. J Pharm Sci 1996;85: 1186-1190.
    • (1996) J Pharm Sci , vol.85 , pp. 1186-1190
    • Lee, R.D.1    White, H.S.2    Scott, E.R.3
  • 33
    • 0031033446 scopus 로고    scopus 로고
    • Interaction between penetration enhancers and iontophoresis: Effect on human skin impedance in vivo
    • Kalia YN, Guy RH: Interaction between penetration enhancers and iontophoresis: Effect on human skin impedance in vivo. J Controlled Release 1997;44:33-42.
    • (1997) J Controlled Release , vol.44 , pp. 33-42
    • Kalia, Y.N.1    Guy, R.H.2
  • 34
    • 26844546765 scopus 로고    scopus 로고
    • The effect of saline iontophoresis on skin integrity in human volunteers. I. Methodology and reproducibility
    • Camel E, O'Connell M, Sage B, Gross M, Maibach H: The effect of saline iontophoresis on skin integrity in human volunteers. I. Methodology and reproducibility. Fundam Appl Toxicol 1996;32:168-178.
    • (1996) Fundam Appl Toxicol , vol.32 , pp. 168-178
    • Camel, E.1    O'Connell, M.2    Sage, B.3    Gross, M.4    Maibach, H.5
  • 35
    • 0022575154 scopus 로고
    • Control of blood glucose levels in alloxandiabetic rabbits by iontophoresis of insulin
    • Karl B: Control of blood glucose levels in alloxandiabetic rabbits by iontophoresis of insulin. Diabetes 1986; 35:217-221.
    • (1986) Diabetes , vol.35 , pp. 217-221
    • Karl, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.