RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion

Medical Hypotheses

Volumn 66, Issue 3, 2006, Pages 570-576

  Tapia, Patrick C ^a,b  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b NIH funded UAB Summer Research Training Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FASUDIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IGF 1 GENE; INSULIN; JANUS KINASE 2; LEPTIN; PROTEIN TYROSINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

AGING; CALORIC RESTRICTION; CELL PROLIFERATION; COMMUNITY CARE; DIET RESTRICTION; ENZYME ACTIVITY; HUMAN; KIDNEY DISEASE; LONGEVITY; NUTRITION; OBESITY; PRIORITY JOURNAL; PROTEIN METABOLISM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TELOMERE;

MAMMALIA;

EID: 30344435268     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.09.008     Document Type: Article

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