Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors

American Journal of Pathology

Volumn 167, Issue 2, 2005, Pages 355-363

  Feng, Zheng ^a,c   Plati, Anna Rita ^a   Cheng, Qing Li ^a   Berho, Mariana ^a   Banerjee, Anita ^a   Potier, Mylene ^a   Jy, Wen Che ^a   Koff, Andrew ^b   Striker, Liliane J ^a   Striker, Gary E ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; CDKN1A PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; TUMOR SUPPRESSOR PROTEIN;

AGE DISTRIBUTION; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; GLOMERULOSCLEROSIS; GLOMERULUS; HYPERTROPHY; MALE; MENOPAUSE; MOUSE; NONHUMAN; PHENOTYPE; POSTMENOPAUSE; PRIORITY JOURNAL; STEM CELL; ANIMAL; C57BL MOUSE; CYTOLOGY; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; MESANGIUM; METABOLISM; PHYSIOLOGY; SCLEROSIS; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; FLOW CYTOMETRY; GLOMERULAR MESANGIUM; HYPERTROPHY; IMMUNOENZYME TECHNIQUES; KIDNEY GLOMERULUS; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; PHENOTYPE; SCLEROSIS; STEM CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 25144453517     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62981-1     Document Type: Article

References (28)

1. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS: Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003, 41:1-12
2. US Renal Data System: USRDS 1999 Annual Report. Washington, DC, The National Institutes of Health, NIDDK, 1999
3. Zheng F, Plati AR, Potier M, Schulman Y, Berho M, Banerjee A, Leclercq B, Zisman A, Striker LJ, Striker GE: Resistance to glomerulosclerosis in B6 mice disappears after menopause. Am J Pathol 2003, 162:1339-1348
4. Cornacchia F, Fornoni A, Plati AR, Thomas A, Wang Y, Inverardi L, Striker LJ, Striker GE: Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors. J Clin Invest 2001, 108:1649-1656
5. Zheng F, Cornaccia F, Schulman I, Banerjee A, Cheng QL, Potier M, Plati AR, Berho M, Elliot SJ, Li J, Fornoni A, Zang YJ, Zisman A, Striker LJ, Striker GE: Development of albuminuria and glomerular lesions in normoglycemic B6 recipients of db/db mice bone marrow: the role of mesangial cell progenitors. Diabetes 2004, 53:2420-2427
6. Doi T, Striker LJ, Quaife C, Conti FG, Palmiter R, Behringer R, Brinster R, Striker GE: Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulin-like growth factor-1. Am J Pathol 1988, 131:398-403
7. Doi T, Hattori M, Agodoa LY, Sato T, Yoshida H, Striker LJ, Striker GE: Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia. Lab Invest 1990, 63:204-212
8. He C, Esposito C, Phillips C, Zalups RK, Henderson DA, Striker GE, Striker LJ: Dissociation of glomerular hypertrophy, cell proliferation, and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J Clin Invest 1996, 97:1242-1249
9. Jacot TA, Striker GE, Stetler-Stevenson M, Striker LJ: Mesangial cells from transgenic mice with progressive glomerulosclerosis exhibit stable, phenotypic changes including undetectable MMP-9 and increased type IV collagen. Lab Invest 1996, 75:791-799
10. Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Mayday AC, Frohman LA, Koff A: Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 1996, 85:721-732
11. Awazu M, Omori S, Ishikura K, Hida M, Fujita H: The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. J Am Soc Nephrol 2003, 14:699-708
12. Wolf G, Schroeder R, Zahner G, Stahl RA, Shankland SJ: High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases. Am J Pathol 2001, 158:1091-1100
13. Kuan CJ, al Douahji M, Shankland SJ: The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy: potential role in glomerular hypertrophy. J Am Soc Nephrol 1998, 9:986-993
14. Peten EP, Garcia-Perez A, Terada Y, Woodrow D, Martin BM, Striker GE, Striker LJ: Age-related changes in alpha 1- and alpha 2-chain type IV collagen mRNAs in adult mouse glomeruli: competitive PCR. Am J Physiol 1992, 263:F951-F957
15. Zheng F, Fornoni A, Elliot SJ, Guan Y, Breyer MD, Striker LJ, Striker GE: Upregulation of type 1 collagen by TGF-beta in mesangial cells is blocked by PPARgamma activation. Am J Physiol 2002, 282:F639-F648
16. Imasawa T: Roles of bone marrow cells in glomerular diseases. Clin Exp Nephrol 2003, 7:179-185
17. Ito T, Suzuki A, Imai E, Okabe M, Hori M: Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol 2001, 12:2625-2635
18. Masuya M, Drake CJ, Fleming PA, Reilly CM, Zeng H, Hill WD, Martin-Studdard A, Hess DC, Ogawa M: Hematopoietic origin of glomerular mesangial cells. Blood 2003, 101:2215-2218
19. Ruiz-Torres P, Lucio J, Gonzalez-Rubio M, Rodriguez-Puyol M, Rodriguez-Puyol D: Oxidant/antioxidant balance in isolated glomeruli and cultured mesangial cells. Free Radic Biol Med 1997, 22:49-56
20. Mauney JR, Kaplan DL, Volloch V: Matrix-mediated retention of osteogenic differentiation potential by human adult bone marrow stromal cells during ex vivo expansion. Biomaterials 2004, 25:3233-3243
21. He CJ, Striker LJ, Tsokos M, Yang CW, Peten EP, Striker GE: Relationships between mesangial cell proliferation and types I and IV collagen mRNA levels in vitro. Am J Physiol 1995, 269:C554-C562
22. Santos OF, Nigam SK: HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev Biol 1993, 160:293-302
23. Sakai T, Larsen M, Yamada KM: Fibronectin requirement in branching morphogenesis. Nature 2003, 423:876-881
24. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA: Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005, 433:760-764
25. Nikolic-Paterson DJ, Atkins RC: The role of macrophages in glomerulonephritis. Nephrol Dial Transplant 2001, 16(Suppl 5):3-7
26. Li AC, Glass CK: The macrophage foam cell as a target for therapeutic intervention. Nat Med 2002, 8:1235-1242
27. Zheng F, Cheng QL, Plati AR, Ye SQ, Berho M, Banerjee A, Potier M, Jaimes EA, Guan Y, Hao C, Yu H, Striker LJ, Striker GE: The glomerulosclerosis of aging in females: contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration. Am J Pathol 2004, 165:1789-1798
28. Yang H, Rossini M, Pozzi A, Ma LJ, Fogo AB: Aging bone marrow augments mesangial collagen IV deposition in young mice. J Am Soc Nephrol Renal Week 2004, SU-PO790