Age-related thymic involution is mediated by Fas on thymic epithelial cells

International Immunology

Volumn 16, Issue 7, 2004, Pages 1027-1035

  Yajima, Nobuyuki ^a   Sakamaki, Kazuhiro ^a   Yonehara, Shin ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Aging; Apoptosis; FasL; Thymocyte

Indexed keywords

CD3 ANTIGEN; CYTOKINE RECEPTOR; FAS LIGAND; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL AGING; CELL MATURATION; CONTROLLED STUDY; EPITHELIUM CELL; IMMUNE SYSTEM; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS; WILD TYPE;

AGING; ANIMALS; ANTIGENS, CD95; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; EPITHELIAL CELLS; GAMMA RAYS; MICE; MICE, KNOCKOUT; RECEPTORS, TUMOR NECROSIS FACTOR; THYMUS GLAND;

EID: 3242675314     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh104     Document Type: Article

References (45)

1. van Ewijk, W. 1991. T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol. 9:591.
2. Gill, J., Malin, M., Sutherland, J., Gray, D., Hollander, G. and Boyd, R. 2003. Thymic generation and regeneration. Immunol. Rev. 195:28.
3. von Boehmer, H. and Fehling, H. J. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15:433.
4. Alam, S. M., Travers, P. J., Wung, J. L., Nasholds, W., Redpath, S., Jameson, S. C. and Gascoigne, N. R. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
5. Jameson, S. C., Hogquist, K. A. and Bevan, M. J. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93.
6. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
7. Bodey, B., Bodey, B. Jr, Siegel, S. E. and Kaiser, H. E. 1997. Involution of the mammalian thymus, one of the leading regulators of aging. In Vivo 11:421.
8. Mackall, C. L. and Gress, R. E. 1997. Thymic aging and T-cell regeneration. Immunol. Rev. 160:91.
9. Aspinall, R. 1997. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158:3037.
10. Tyan, M. L. 1977. Age-related decrease in mouse T cell progenitors. J. Immunol. 118:846.
11. Mackall, C. L., Punt, J. A., Morgan, P., Farr, A. G. and Gress, R. E. 1998. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28:1886.
12. Farr, A. G. and Sidman, C. L. 1984. Reduced expression of la antigens by thymic epithelial cells of aged mice. J. Immunol. 133:98.
13. Andrew, D. and Aspinall, R. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37:455.
14. Nagata, S. and Golstein, P. 1995. The Fas death factor. Science 267:1449.
15. Locksley, R. M., Killeen, N. and Lenardo, M. J. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487.
16. Suda, T., Takahashi, T., Golstein, P. and Nagata, S. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
17. Yonehara, S., Nishimura, Y., Kishil, S., Yonehara, M., Takazawa, K., Tamatani, T. and Ishii, A. 1994. Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes. Int. Immunol. 6:1849.
18. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. and Nagata, S. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
19. Nishimura, Y., Ishii, A., Kobayashi, Y., Yamasaki, Y. and Yonehara, S. 1995. Expression and function of mouse Fas antigen on immature and mature T cells. J. Immunol. 154:4395.
20. Senju, S., Negishi, I., Motoyama, N., Wang, F., Nakayama, K., Lucas, P. J., Hatakeyama, S., Zhang, Q., Yonehara, S. and Loh, D. Y. 1996. Functional significance of the Fas molecule in naive lymphocytes. Int. Immunol. 8:423.
21. Ikawa, M., Yamada, S., Nakanishi, T. and Okabe, M. 1998. 'Green mice' and their potential usage in biological research. FEBS Lett. 430:83.
22. Rideout, W. M. 3rd, Hochedlinger, K., Kyba, M., Daley, G. Q. and Jaenisch, R. 2002. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109:17.
23. Sakata, S., Sakamaki, K., Watanabe, K., Nakamura, N., Toyokuni, S., Nishimune, Y., Mori, C. and Yonehara, S. 2003. Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient W(v)/W(v) mutant mice. Cell Death Differ. 10:676.
24. Namen, A. E., Lupton, S., Hjerrild, K., Wignall, J., Mochizuki, D. Y., Schmierer, A., Mosley, B., March, C. J., Urdal, D. and Gillis, S. 1988. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571.
25. Lu, X. A. and Werner, D. 1989. The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1 alpha) mRNA. Nucleic Acids Res. 17:442.
26. Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N. and Nagata, S. 1996. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl Acad. Sci. USA 93:2131.
27. Candeias, S., Muegge, K. and Durum, S. K. 1997. L-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity 6:501.
28. Oosterwegel, M. A., Haks, M. C., Jeffry, U., Murray, R. and Kruisbeek, A. M. 1997. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Immunity 6:351.
29. Bhatia, S. K., Tygrett, L. T., Grabstein, K. H. and Waldschmidt, T. J. 1995. The effect of in vivo IL-7 deprivation on T cell maturation. J. Exp. Med. 181:1399.
30. Drappa, J., Brot, N. and Elkon, K. B. 1993. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr. Proc. Natl Acad. Sci. USA 90:10340.
31. Nishimura, Y., Hirabayashi, Y., Matsuzaki, Y., Musette, P., Ishii, A., Nakauchi, H., Inoue, T. and Yonehara, S. 1997. In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver. Int. Immunol. 9:307.
32. Dhein, J., Walczak, H., Baumler, C., Debatin, K. M. and Krammer, P. H. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438.
33. Ju, S. T., Panka, D. J., Cui, H., Ettinger, R., el-Khatib, M., Sherr, D. H., Stanger, B. Z. and Marshak-Rothstein, A. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
34. Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F. et al. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441.
35. Chu, J. L., Ramos, P., Rosendorff, A., Nikolic-Zugic, J., Lacy, E., Matsuzawa, A. and Elkon, K. B. 1995. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J. Exp. Med. 181:393.
36. Andrews, B. S., Eisenberg, R. A., Theofilopoulos, A. N., Izui, S., Wilson, C. B., McConahey, P. J., Murphy, E. D., Roths, J. B. and Dixon, F. J. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
37. Izui, S., Kelley, V. E., Masuda, K., Yoshida, H., Roths, J. B. and Murphy, E. D. 1984. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133:227.
38. Kamogawa, J., Terada, M., Mizuki, S., Nishihara, M., Yamamoto, H., Mori, S., Abe, Y., Morimoto, K., Nakatsuru, S., Nakamura, Y. and Nose, M. 2002. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum. 46:1067.
39. Moore, N. C., Anderson, G., Smith, C. A., Owen, J. J. and Jenkinson, E. J. 1993. Analysis of cytolkine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur. J. Immunol. 23:922.
40. Anderson, G., Jenkinson, E. J., Moore, N. C. and Owen, J. J. 1993. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362:70.
41. Moulian, N., Renvoize, C., Desodt, C., Serraf, A. and Berrih-Aknin, S. 1999. Functional Fas expression in human thymic epithelial cells. Blood 93:2660.
42. Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K. and Nagata, S. 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:3806.
43. Allen, R. D., Marshall, J. D., Roths, J. B. and Sidman, C. L. 1990. Bone marrow transplantation from mutant lpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft-vs.-host-like syndrome. Eur. J. Immunol. 20:2057.
44. Nakagawa, T., Nagata, N., Hosaka, N., Inaba, M., Yasumizu, R., Ogawa, R. and Ikehara, S. 1991. Analyses of acute graft-versus-host-like reaction in [MRL/lpr-MRL/+] chimeric mice using MRL/lpr-Thy-1. 1 congenic mice. Cell. Immunol. 137:189.
45. Zhu, B., Beaudette, B. C., Rifkin, I. R. and Marshak-Rothstein, A. 2000. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur. J. Immunol. 30:1778.