Crystal structure of the catalytic domain of human bile salt activated lipase

Protein Science

Volumn 9, Issue 9, 2000, Pages 1783-1790

  Terzyan, Simon ^a   Wang, Chi Sun ^a   Downs, Deborah ^a   Hunter, Bret ^a   Zhang, Xuejun C ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Bile salt activated lipase; Crystal structure; Esterase; Substrate specificity

Indexed keywords

BILE SALT; TRIACYLGLYCEROL LIPASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

EID: 0033809712     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.9.1783     Document Type: Article

References (42)

1. Structure of human milk bile salt activated lipase
2. ALSCRIPT a tool to format multiple sequence alignments
3. Bile salt-stimulated lipase in human milk. Evidence that bile salt induces lipid binding and activation via binding to different sites
4. Partic ipation of GRP94-related protein in secretion of pancreatic bile salt-dependent lipase and in its internalization by the intestinal epithelium
5. The free R value: A novel statistical quantity for assessing the accuracy of crystal structures
6. Crystallography and NMR system: A new software suite for macromolecular structure determination
7. Structure of bovine pancreatic cholesterol esterase at 1.6 Å: Novel structural features involved in lipase activation
8. Convergent solutions to binding at a protein-protein interface
9. Exon 11 of the rat cholesterol esterase gene encodes domains important for intracellular processing and bile salt-modulated activity of the protein
10. Proline-rich domain and glycosylation are not essential for the enzymatic activity of bile salt-activated lipase. Kinetic studies of T-BAL, a truncated form of the enzyme, expressed in Escherichia coli
11. Simultaneous introduction of multiple mutations using overlap extension PCR
12. Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase
13. Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase
14. Two conformational states of Candida rugosa lipase
15. Human milk lipases.III. Physiological implications of the bile salt-stimulated lipase
16. Carboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice
17. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice
18. Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase
19. MOLMOL: A program for display and analysis of macromolecular structures
20. PROCHECK: A program to check the stereochemical quality of protein structures
21. An intracellular role for pancreatic bile salt-dependent lipase: Evidence for modification of lipid turnover in transfected CHO cells
22. Structural organization of human bile-salt-activated lipase probed by limited proteolysis and expression of a recombinant truncated variant
23. Bite salt activation of human cholesterol esterase does not require protein dimerisation
24. Bile salt activation of human cholesterol esterase does not require protein dimerisation
25. Solvent contents of protein crystals
26. AMoRe: An automated package for molecular replacement
27. Human milk lipases and their possible role in fat digestion
28. The alpha/beta hydrolase fold
29. Processing of X-ray diffraction data collected in oscillation mode
30. Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase
31. Protein engineering as a tool for crystallography
32. TURBO-FRODO
33. Molecular cloning of the bile salt-dependent lipase of ferret lactating mammary gland: An overview of functional residues
34. Biochemistry
35. Function of specific bile acids in cholesterol esterase activity in vitro
36. Bile salt-activated lipase
37. Bile salt-activated lipase. A multiple function lipolytic enzyme
38. Kinetics of acylglycerol sequential hydrolysis by human milk bile salt activated lipase and effect of taurocholate as fatty acid acceptor
39. Kinetic properties of human milk bile salt-activated lipase: Studies using long chain triacylglycerol as substrate
40. Bile-salt-activated lipase: Effect on kitten growth rate
41. The crystal structure of bovine bile salt activated lipase: Insights into the bile salt activation mechanism
42. EDPDB: A multifunctional tool for protein structure analysis