CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner

Molecular and Cellular Biology

Volumn 24, Issue 13, 2004, Pages 5953-5966

  Sutrias Grau, Montserrat ^a   Arnosti, David N ^a,b  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN CTBP; PROTEIN KNIRPS; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; REPORTER GENE; REPRESSOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; MUTATION; NAD; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; TRANS-ACTIVATORS;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 2942750116     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.13.5953-5966.2004     Document Type: Article

References (46)

1. Abate, C., L. Patel, F. J. Rauscher III, and T. Curran. 1990. Redox regulation of fos and jun DNA-binding activity, in vitro. Science 249:1157-1161.
2. Arnosti, D. N., S. Gray, S. Barolo, J. Zhou, and M. Levine. 1996. The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo. EMBO J. 15:3659-3666.
3. Balasubramanian, P., L. J. Zhao, and G. Chinnadurai. 2003. Nicotinamide adenine dinuelcotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP. FEBS Lett. 537:157-160.
4. Barolo, S., and M. Levine. 1997. hairy mediates dominant repression in the Drosophila embryo. EMBO J. 16:2883-2891.
5. Chinnadurai, G. 2002. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 2:213-224.
6. Criqui-Filipe, P., C. Ducret, S. M. Maira, and B. Wasylyk. 1999. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 18:3392-3403.
7. Deckert, J., and K. Struhl. 2002. Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein. Mol. Cell. Biol. 22:6458-6470.
8. Fjeld, C. C., W. T. Birdsong, and R. H. Goodman. 2003. Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc. Natl. Acad. Sci. USA 100:9202-9207.
9. Gray, S., and M. Levine. 1996. Transcriptional repression in development. Curr. Opin. Cell Biol. 3:358-364.
10. Grooteclaes, M., Q. Deveraux, J. Hildebrand, Q. Zhang, R. H. Goodman, and S. M. Frisch. 2003. C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc. Natl. Acad. Sci. USA 100:4568-4573.
11. Hewitt, G. F., B. S. Strunk, C. Margulies, T. Priputin, X. D. Wang, R. Amey, B. A. Pabst, D. Kosman, J. Reinitz, and D. N. Arnosti. 1999. Transcriptional repression by the Drosophila Giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. Development 126:1201-1210.
12. Hildebrand, J. D., and P. Soriano. 2002. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 22:5296-5307.
13. Hoch, M., N. Gerwin, H. Taubert, and H. Jackle. 1992. Competition for overlapping sites in the regulatory region of the Drosophila gene Kruppel. Science 256:94-97.
14. Kagey, M. H., T. A. Melhuish, and D. Wotton. 2003. The polycomb protein Pc2 is a SUMO E3. Cell 113:127-137.
15. Keller, S. A., Y. Mao, P. Struffi, C. Margulies, C. E. Yurk, A. R. Anderson, R. L. Amey, S. Moore, J. M. Ebels, K. Foley, M. Corado, and D. N. Arnosti. 2000. dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein. Mol. Cell. Biol. 20:7247-7258.
16. Kumar, V., J. E. Carlson, K. A. Ohgi, T. A. Edwards, D. W. Rose, C. R. Escalante, M. G. Rosenfeld, and A. K. Aggarwal. 2002. Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol. Cell 10:857-869.
17. La Rosee-Borgreve, A., T. Hader, D. Wainwright, F. Sauer, and H. Jackle. 1999. hairy stripe 7 element mediates activation and repression in response to different domains and levels of Kruppel in the Drosophila embryo. Mech. Dev. 89:133-140.
18. Lin, X., B. Sun, M. Liang, Y. Y. Liang, A. Gast, J. Hildebrand, F. C. Brunicardi, F. Melchior, and X. H. Feng. 2003. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell 11:1389-1396.
19. Lunyak, V. V., R. Burgess, G. G. Prefontaine, C. Nelson, S. H. Sze, J. Chenoweth, P. Schwartz, P. A. Pevzner, C. Glass, G. Mandel, and M. G. Rosenfeld. 2002. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298:1747-1752.
20. Marmorstein, R. 2002. Dehydrogenases, NAD, and transcription-what's the connection? Structure (Cambridge) 10:1465-1466.
21. Nardini, M., S. Spanò, C. Cericola, A. Pesce, A. Massaro, E. Millo, A. Luini, D. Corda, and M. Bolognesi. 2003. CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J. 22:3122-3130.
22. Nibu, Y., K. Senger, and M. Levine. 2003. CtBP-independent repression in the Drosophila embryo. Mol. Cell. Biol. 23:3990-3999.
23. Nibu, Y., H. Zhang, E. Bajor, S. Barolo, S. Small, and M. Levine. 1998. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo. EMBO J. 23:7009-7020.
24. Nibu, Y., H. Zhang, and M. Levine. 1998. Interaction of short-range repressors with Drosophila CtBP in the embryo. Science 280:101-104.
25. Nissen, R. M., and K. R. Yamamoto. 2000. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 14:2314-2329.
26. Phippen, T. M., A. L. Sweigart, M. Moniwa, A. Krumm, J. R. Davie, and S. M. Parkhurst. 2000. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J. Biol. Chem. 275:37628-37637.
27. Poortinga, G., M. Watanabe, and S. M. Parkhurst. 1998. Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression. EMBO J. 17:2067-2078.
28. Postigo, A. A., and D. C. Dean. 1999. Independent repressor domains in ZEB regulate muscle and T-cell differentiation. Mol. Cell. Biol. 19:7961-7971.
29. Riefler, G. M., and B. L. Firestein. 2001. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J. Biol. Chem. 276:48262-48268.
30. Rutter, J., M. Reick, L. C. Wu, and S. L. McKnight. 2001. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293:510-514.
31. Ryu, J. R., and D. N. Arnosti. 2003. Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. Nucleic Acids Res. 31:4654-4662.
32. Schaeper, U., J. M. Boyd, S. Verma, E. Uhlmann, T. Subramanian, and G. Chinnadurai. 1995. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92:10467-10471.
33. Shi, Y., J. Sawada, G. Sui, E. B. Affar, J. R. Whetstine, F. Lan, H. Ogawa, M. P. Luke, Y. Nakatani, and Y. Shi. 2003. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422:735-738.
34. Small, S., D. N. Arnosti, and M. Levine. 1993. Spacing ensures autonomous expression of different stripe enhancers in the even-skipped promoter. Development 119:762-772.
35. Small, S., A. Blair, and M. Levine. 1992. Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J. 11:4047-4057.
36. Spano, S., M. G. Silletta, A. Colanzi, S. Alberti, G. Fiucci, C. Valente, A. Fusella, M. Salmona, A. Mironov, A. Luini, D. Corda, and S. Spanfo. 1999. Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. J. Biol. Chem. 274:17705-17710.
37. Struffi, P., M. Corado, M. Kulkarni, and D. N. Arnosti. 2004. Quantitative contributions of CtBP-dependent and -independent repression activities of Knirps. Development 131:2419-2429.
38. Strunk, B., P. Struffi, K. Wright, B. Pabst, J. Thomas, L. Qin, and D. N. Arnosti. 2001. Role of CtBP in transcriptional repression by the Drosophila giant protein. Dev. Biol. 239:229-240.
39. Subramanian, T., and G. Chinnadurai. 2003. Association of class I histone deacetylases with transcriptional corepressor CtBP. FEBS Lett. 540:255-258.
40. Sundqvist, A., K. Sollerbrant, and C. Svensson. 1998. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. FEBS Lett. 429:183-188.
41. Taguchi, H., and T. Ohta. 1993. Histidine 296 is essential for the catalysis in Lactobacillus plantarum D-lactate dehydrogenase. J. Biol. Chem. 268:18030-18034.
42. Turner, J., and M. Crossley. 1998. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:5129-5140.
43. Turner, J., and M. Crossley. 2001. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. BioEssays 23:683-690.
44. Weigert, R., M. G. Silletta, S. Spano, G. Turacchio, C. Cericola, A. Colanzi, S. Senatore, R. Mancini, E. V. Polishchuk, M. Salmona, F. Facchiano, K. N. Burger, A. Mironov, A. Luini, and D. Corda. 1999. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature 402:429-433.
45. Zhang, Q., D. W. Piston, and R. H. Goodman. 2002. Regulation of corepressor function by nuclear NADH. Science 295:1895-1897.
46. Zheng, L., R. G. Roeder, and Y. Luo. 2003. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114:255-266.