The role of the extracellular signal-regulated kinase pathway in cerebellar abnormalities in schizophrenia

Cerebellum

Volumn 3, Issue 2, 2004, Pages 94-99

  Kyosseva, Svetlana V ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cerebellum; MAP kinases; Schizophrenia; Signal transduction; Synaptic plasticity

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHENCYCLIDINE;

ATTENTION; AUTOPSY; CELL SURVIVAL; CEREBELLUM; COGNITION; EMOTION; HUMAN; LEARNING; MEMORY; NERVE CELL PLASTICITY; NEUROIMAGING; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW;

ANIMALS; CEREBELLUM; DISEASE MODELS, ANIMAL; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHENCYCLIDINE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 2942699875     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220410029164     Document Type: Review

References (61)

1. Lewis DA, Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 2002; 25: 409-432.
2. Ashe P, Berry MD, Boulton AA. Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents. Prog Neuro-Psychopharmacol Biol Psychiat 2001; 25: 691-707.
3. Pearlson GD. Neurobiology of schizophrenia. Ann Neurol 2000; 48: 556-566.
4. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998; 74: 49-139.
5. Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three kinase module from yeast to human. Physiol Rev 1999; 79: 143-180.
6. Mazzucchelli C, Brambilla R. Ras-related and MAPK signaling in neuronal plasticity and memory formation. Cell Mol Life Sci 2000; 57: 604-611.
7. Sweatt JD. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 2001; 76: 1-10.
8. Adams J, Sweatt JD. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 2002; 42: 135-163.
9. Middleton FA, Strick PL. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 1994; 266: 458-461.
10. Allen G, Buxton RB, Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science 1997; 275: 1940-1943.
11. Katsetos CD, Hyde TM, Herman MM. Neuropathology of the cerebellum in schizophrenia-an update: 1996 and future directions. Biol Psychiat 1997; 42: 213-224.
12. Davis RJ. Transcriptional regulation of MAP kinases. Mol Reprod Dev 1995; 42: 459-467.
13. Whitmarsh AJ, Davis RJ. A central control for cell growth. Nature 2000; 403: 255-256.
14. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, De Pinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein- serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991; 165: 663-675.
15. Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/ ERK2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J Neurosci 2001; 21: 434-443.
16. Huang E, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001; 24: 677-736.
17. Fiore RS, Murphy TH, Sanghera JS, Pelech SL, Baraban JM. Activation of p42 mitogen- activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. J Neurochem 1993; 61: 1626-1633.
18. Kurino M, Fukunaga K, Ushio Y, Miyamoto E. Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors. J Neurochem 1995; 65: 1282-1289.
19. Xia Z, Dudek H, Miranti CK, Greenberg ME. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci 1996; 16: 5425-5436.
20. Rosenblum K, Futter M, Jones M, Hulme EC, Bliss TV. ERKI/II regulation by the muscarinic acetylcholine receptors in neurons. J Neurosci 2000; 20: 977-985.
21. Takagi N, Miyake-Takagi K, Takagi K, Tamura H, Takeo S. Altered extracellular signal- regulated kinase signal transduction by the muscarinic acetylcholine and metabotrophic glutamate receptors after cerebral ischemia. J Biol Chem 2002; 277: 6382-6390.
22. Errico M, Crozier RA, Plummer MR, Cowen DS. 5-HT-7 receptors activate the mitogen activated protein kinase extracellular signal regulated kinase in cultured rat hippocampal neurons. Neuroscience 2001; 102: 361-367.
23. Gerfen CR, Miyachi S, Paletzki R, Brown P. DI dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2 MAP kinase. J Neurosci 2002; 22: 5042-5054.
24. Yamagishi S, Yamada M, Ishikawa Y, Matsumoto T, Ikeuchi T, Hatanaka H. p38 Mitogen- activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. J Biol Chem 2001; 276: 5129-5133.
25. Dunn SL, Young EA, Hall MD, McNulty S. Activation of astrocyte intracellular signaling pathways by interleukin-1 in rat primary striatal cultures. GLIA 2002; 37: 31-42.
26. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326-1331.
27. Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, Gotoh Y, Nishida E. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem 1997; 272: 18518-18521.
28. Chen RW, Qin ZH, Ren M, Kanai H, Chalecka-Franaszek E, Leeds P, Chuang DW. Regulation of c-Jun N-terminal kinase, p38 kinase and AP1-1 DNA binding in cultured brain neurons; roles in glutamate excitoxicity and lithium neuroprotection. J Neurochem 2003; 84: 566-575.
29. Jiang Q, Gu Z, Zhang G, Jing G. Diphosphorylation and involvement of extracellular signal- regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons. Brain Res 2000; 857: 71-77.
30. Vaudry D, Falluel-Morel A, Leuillet S, Vaudry H, Gonzalez BJ. Regulators of cerebellar granule cell development act through specific signaling pathways. Science 2003; 300: 1532-1534.
31. Grewal SS, York RD, Stork PJS. Extracellular-signal-regulated kinase signaling in neurons. Curr Opin Neurobiol 1999; 9: 544-553.
32. Fukunaga K, Miyamoto E. Role of MAP kinase in neurons. Mol Neurobiol 1998; 16: 79-95.
33. Bading H, Greenberg ME. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science 1991; 253: 912-914.
34. English JD, Sweatt JD. Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem 1996; 271: 24329-24332.
35. Selcher JC, Nekrasova T, Paylor R, Landreth GE, Sweatt JD. Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Memory 2001; 8: 11-19.
36. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD. The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1998; 1: 602-609.
37. Blum S, Moore AN, Adams F, Dash PK. A mitogen-activated protein kinase cascade in the CA/1CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosi 1999; 19: 3535-3544.
38. Selcher JC, Atkins CM, Trzaskos JM, Paylor R, Sweatt JD. A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem 1999; 6: 478-490.
39. Kawasaki H, Fujii H, Gotoh Y, Morooka T, Shimohama S, Nishida E, Hirano T. Requirement for mitogen activated protein kinase in cerebellar long term depression. J Biol Chem 1999; 274: 13498-13502.
40. Kelly A, Laroche S, Davis S. Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory. J Neurosci 2003; 23: 5354-5360.
41. Kyosseva SV, Elbein AD, Griffin WST, Mrak RE, Lyon M, Karson CN. Mitogen-activated protein kinases in schizophrenia. Biol Psychiat 1999; 46: 689-696.
42. Pouyssegur J, Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signaling. Eur J Biochem 2003; 270: 3291-3299.
43. Porton B, Ferreira A, DeLisi LE, Kao HT. A rare polymorphism affects a mitogen-activated site in synapsin III: Possible relationship to schizophrenia. Biol Psychiat 2004; 55: 118-125.
44. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiat 1991; 148: 1301-1308.
45. Kyosseva SV, Owens SM, Elbein AD, Karson CN. Differential and region-specific activation of mitogen-activated protein kinases following chronic administration of phencyclidine. Neuropsychopharmacol 2001; 24: 267-277.
46. Ito M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 2001; 81: 1143-1195.
47. Martin P, Albers M. Cerebellum and schizophrenia: a selective review. Schizophr Bull 1995; 21: 214-250.
48. Jacobsen LK, Giedd JN, Berquin PC, Krain AL, Hamburger SD, Kumra S, Rapoport JL. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am J Psychiat 1997; 154: 1663-1669.
49. Wassink TH, Andreasen NC, Nopoulos P, Flaum M. Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia. Biol Psychiat 1999; 45: 41-48.
50. Nopoulos P, Ceilley J, Gailis E, Andreasen N. An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry. Biol Psychiat 2001; 49: 13-19.
51. Levitt JJ, McCarley RW, Nestor PG, Petrescu C, Donnino R, Hirayasu Y, Kikinis R, Jolesz FA, Shenton ME. Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates. Am J Psychiat 1999; 156: 1105-1107.
52. Ichimiya T, Okubo Y, Suhara T, Sudo Y. Reduced volume of the cerebellar vermis in neuroleptic-naïve schizophrenia. Biol Psychiatr 2001; 49: 20-27.
53. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Ponto LL, Watkins GL, Hichwa RD. Schizophrenia and cognitive dysmetria: a PET study of dysfunctional and prefrontal- thalamic-cerebellar circuitry. Proc Natl Acad Sci 1996; 93: 9985-9990.
54. Szeszko PR, Gunning-Dixon F, Goldman RS, Bates J, Ashtari M, Snyder P, Liebetman JA, Bilder RM. Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia. Am J Psychiat 2003; 160: 11884-1887.
55. Andreasen NC, O'Leary DS, Flaum M, Noupolos P, Watkins GL, Ponto LL, Hichwa RD. Hypofrontality in schizophrenia: disturbed dysfunctional circuits in neuroleptic naïve patients. Lancet 1997; 349: 1730-1734.
56. Andreasen NC, Paradiso S, O'leary DS. 'Cognitive dysmetria' as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical- cerebellar circuitry? Schizophr Bull 1998; 24: 203-218.
57. Karson CN, Griffin WST, Mrak RE, Huasain M, Dawson TM, Snyder SH, Moore NC, Sturner WQ. Nitric oxide synthase (NOS) in schizophrenia. Increased in cerebellar vermis. Mol Chem Neuropathol 1996; 27: 275-284.
58. Bernstein HG, Krell D, Barunwell KH, Baumann B, Gundelfinger ED, Diekmann S, Danos P, Bogerts B. Increased number of nitric oxide synthase immunoreactive Purkinje cells and dentate nucleus neurons in schizophrenia. J Neurocytol 2001; 30: 661-670.
59. 2A receptors in the human cerebellum and alterations in schizophrenia. Synapse 2001; 42: 104-114.
60. Eastwood SL, Cotter D, Harrison PJ. Cerebellar synaptic protein expression in schizophrenia. Neuroscience 2001; 105: 219-229.
61. Eastwood SL, Law AJ, Everall IP, Harrison PJ. The axonal chemorepellant semaphoring 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology. Mol Psychiatry 2003; 8: 148-155.