Mitogen-activated protein kinases in schizophrenia

Biological Psychiatry

Volumn 46, Issue 5, 1999, Pages 689-696

  Kyosseva, Svetlana V ^a   Elbein, Alan D ^a   Griffin, W Sue T ^a,b   Mrak, Robert E ^a,c   Lyon, Melvin ^a   Karson, Craig N ^a,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Geriatric Res Educ Clinical Center   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Cerebellum; ERK1 and ERK2; MAP kinase phosphatase; MAP kinases; Postmortem; Schizophrenia

Indexed keywords

CARBAMAZEPINE; DIPHENHYDRAMINE; HALOPERIDOL; LOXAPINE; MESORIDAZINE; MITOGEN ACTIVATED PROTEIN KINASE; TRIFLUOPERAZINE;

ADULT; AGED; ARTICLE; BRAIN REGION; BRAIN TISSUE; CEREBELLUM VERMIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROPATHOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; TEGMENTUM;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CELL COMMUNICATION; CEREBELLUM; CULTURE TECHNIQUES; ELECTROPHORESIS, AGAR GEL; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 0032778651     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00104-3     Document Type: Article

References (39)

1. Alessi D.R., Smythe C., Keyse S.M. The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene. 8:1993;2015-2020.
2. Anderson S.A., Volk D.W., Lewis D.A. Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects. Schizophr Res. 19:1996;111-119.
3. Andreasen N.C., O'Leary D.S., Cizadlo T., et al. Schizophrenia and cognitive dysmetria A positron emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry . Proc Natl Acad Sci U S A. 93:1996;9985-9990.
4. Arnold S.E., Lee V.M.Y., Gur R.E., Trojanowski J.Q. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci U S A. 88:1991;10850-10854.
5. Bading H., Greenberg M.E. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science. 253:1991;912-914.
6. Boulton T.G., Cobb M.H. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul. 2:1991;357-371.
7. Boulton T.G., Nye S.H., Robbins D.J., et al. ERKs A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in responses to insulin and NGF . Cell. 65:1991;663-675.
8. Cobb M.H., Boulton T.G., Robbins D.J. Extracellular signal-regulated kinases ERKs in progress . Cell Regul. 2:1991;965-978.
9. Cotter D., Kerwin R., Doshi B., Martin C.S., Everall I.P. Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia. Brain Res. 765:1997;238-246.
10. Duff J.L., Monia B.P., Berk B.C. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides. J Biol Chem. 270:1995;7161-7166.
11. Fiore R.S., Bayer V.E., Pelech S.L., Posada J., Cooper J.A., Baraban J.M. p42 mitogen-activated protein kinase in brain Prominent localization in neuronal cell bodies and dendrites . Neuroscience. 55:1993;463-472.
12. Fiore R.S., Murphy T.H., Sanghera J.S., Pelech S.L., Baraban J.M. Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. J Neurochem. 61:1993;1626-1633.
13. Garcia-Rill E., Biedermann J.A., Chambers T., Skinner R.D., Mrak R.E., Husain M., Karson C.N. Mesopontine neurons in schizophrenia. Neuroscience. 66:1995;312-335.
14. Guan K.L. The mitogen activated protein kinase signal transduction pathway From the cell surface to the nucleus . Cell Signal. 6:1994;581-589.
15. Jacobsen L.K., Giedd J.N., Berquin P.C., et al. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am J Psychiatry. 154:1997;1663-1669.
16. Karson C.N., Casanova M.F., Kleinman J.E., Griffin W.S.T. Choline acetyltransferase in schizophrenia. Am J Psychiatry. 150:1993;454-459.
17. Karson C.N., Garcia-Rill E., Biedermann J.A., Mrak R.E., Husain M.M., Skinner R.D. The brain stem reticular formation in schizophrenia. Psychiatr Res Neuroimaging. 40:1991;31-48.
18. Karson C.N., Griffin W.S.T., Mrak R.E., et al. Nitric oxide synthase (NOS) in schizophrenia. Increases in cerebellar vermis. Mol Chem Neuropathol. 27:1996;275-284.
19. Katsetos C.D., Hyde T.M., Herman M.M. Neuropathology of the cerebellum in schizophrenia - An update 1996 and future directions . Biol Psychiatry. 42:1997;213-224.
20. Kerwin R.W. Glutamate receptors, microtubule associated proteins and developmental anomaly in schizophrenia An hypothesis . Psychol Medicine. 23:1993;547-551.
21. Kurino M., Fukunaga K., Ushio Y., Miyamoto E. Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors. J Neurochem. 65:1995;1282-1289.
22. Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Adv Cancer Res. 74:1998;49-139.
23. mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. J Neurosci Res. 35:1993;439-444.
24. Mandelkow E.M., Drewes G., Biernat J., et al. Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett. 314:1992;315-321.
25. Mirra S.S., Heyman A., McKeel D., et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
26. Miyasaka T., Chao M.V., Sherline P., Saltiel A.R. Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J Biol Chem. 265:1990;4730-4735.
27. Morishima-Kawashima M., Kosik K. The pool of MAP kinase associated with microtubules is small but constitutively active. Mol Biol Cell. 7:1996;893-905.
28. Nunez J. Differential expression of microtubule components during brain development. Dev Neurosci. 8:1986;125-141.
29. Ortiz J., Harris H.W., Guitart X., Terwilliger R.Z., Haycock J.W., Nestler E.J. Extracellular signal-regulated kinases (ERKs) and ERK kinase (MEK) in brain Regional distribution and regulation by chronic morphine . J Neurosci. 15:1995;1285-1297.
30. Pelech S.L., Sanghera J.S. MAP kinases, versatile transducers for cellular signalling. Trends Biochem Sci. 17:1992;233-238.
31. Reszka A.A., Bulinski J.C., Krebs E.G., Fischer E.H. Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions. Mol Biol Cell. 8:1997;1219-1232.
32. Rezska A.A., Seger R., Diltz C.D., Krebs E.G., Fischer E.H. Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci U S A. 92:1995;8881-8885.
33. Salzman S., Endicott J., Clayton P. Diagnostic Evaluation After Death (DEAD). 1983;National Institute of Mental Health (NIMH) Neuroscience Research Branch, Rockville, MD.
34. Sturgill T.W., Wu J. Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein Sb. Biochim Biophys Acta. 1092:1991;350-357.
35. Sun H., Charles C.H., Lau L.F., Tonks N.F. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vitro. Cell. 75:1993;487-493.
36. Thomas G. MAP kinase by any other name smells just as sweet. Cell. 68:1992;3-6.
37. Tran K.D., Smutzer G.S., Doty R.L., Arnord S.E. Reduced Purkinje cell size in the cerebellar vermis of elderly patients with schizophrenia. Am J Psychiatry. 155:1998;1288-1290.
38. Weinberger D.R. The biological basis of schizophrenia. J Clin Psychiatry Monograph. 15:1997;4-6.
39. Zheng C.F., Guan K.L. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J Biol Chem. 268:1993;16116-16119.