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Volumn 270, Issue 16, 2003, Pages 3291-3299

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling: Delivered on 24 October 2002 at the 28th FEBS Meeting in Istanbul

Author keywords

Cell signalling; Growth control; MAP kinases; MAPK phosphatases; Nucleus; Scaffolding proteins

Indexed keywords

GROWTH FACTOR; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN P42; PROTEIN P44; RAF PROTEIN;

EID: 0041926731     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03707.x     Document Type: Conference Paper
Times cited : (157)

References (65)
  • 1
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann, C., Gibson, S., Jarpe, M.B. & Johnson, G.L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143-180.
    • (1999) Physiol. Rev. , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 2
    • 0034989234 scopus 로고    scopus 로고
    • The Ras-Raf relationship: An unfinished puzzle
    • Kerkhoff, E. & Rapp, U.R. (2001) The Ras-Raf relationship: an unfinished puzzle. Adv. Enzyme Regul. 41, 261-267.
    • (2001) Adv. Enzyme Regul. , vol.41 , pp. 261-267
    • Kerkhoff, E.1    Rapp, U.R.2
  • 3
    • 0027935756 scopus 로고
    • Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation
    • Hallberg, B., Rayter, S.I. & Downward, J. (1994) Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol Chem. 269, 3913-3916.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3913-3916
    • Hallberg, B.1    Rayter, S.I.2    Downward, J.3
  • 5
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie, J.N., L'Allemain, G., Brunet, A., Muller, R. & Pouyssegur, J. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol Chem. 271, 20608-20616.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1    L'Allemain, G.2    Brunet, A.3    Muller, R.4    Pouyssegur, J.5
  • 6
    • 0030310201 scopus 로고    scopus 로고
    • A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry
    • Lavoie, J.N., Rivard, N., L'Allemain, G. & Pouyssegur, J. (1996) A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry. Prog. Cell Cycle Res. 2, 49-58.
    • (1996) Prog. Cell Cycle Res. , vol.2 , pp. 49-58
    • Lavoie, J.N.1    Rivard, N.2    L'Allemain, G.3    Pouyssegur, J.4
  • 7
    • 0034688287 scopus 로고    scopus 로고
    • A central control for cell growth
    • Whitmarsh, A.J. & Davis, R.J. (2000) A central control for cell growth. Nature. 403, 255-256.
    • (2000) Nature , vol.403 , pp. 255-256
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 8
    • 0028483678 scopus 로고
    • EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
    • Traverse, S., Seedorf, K., Paterson, H., Marshall, C., Cohen, P. & Ullrich, A. (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4, 694-701.
    • (1994) Curr. Biol. , vol.4 , pp. 694-701
    • Traverse, S.1    Seedorf, K.2    Paterson, H.3    Marshall, C.4    Cohen, P.5    Ullrich, A.6
  • 9
    • 0026772506 scopus 로고
    • Coordinate, biphasic activation of p44 mitogen activated protein kinase and S6 kinase by growth factors in hamster fibroblasts
    • Kahan, C., Seuwen, K., Méloche, S. & Pouysségur, J. (1992) Coordinate, biphasic activation of p44 mitogen activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. J. Biol. Chem. 267, 13369-13375.
    • (1992) J. Biol. Chem. , vol.267 , pp. 13369-13375
    • Kahan, C.1    Seuwen, K.2    Méloche, S.3    Pouysségur, J.4
  • 12
    • 0032422785 scopus 로고    scopus 로고
    • Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
    • Whitmarsh, A.J. & Davis, R.J. (1998) Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23, 481-485.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 481-485
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 13
    • 0029012079 scopus 로고
    • STE5: A meeting place for MAP kinases and their associates
    • Elion, E.A. (1995) STE5: a meeting place for MAP kinases and their associates. Trends Cell Biology 5, 322-327.
    • (1995) Trends Cell Biology , vol.5 , pp. 322-327
    • Elion, E.A.1
  • 14
    • 0035490201 scopus 로고    scopus 로고
    • MAP kinases bite back
    • Pryciak, P.M. (2001) MAP kinases bite back. Dev. Cell. 1, 449-451.
    • (2001) Dev. Cell , vol.1 , pp. 449-451
    • Pryciak, P.M.1
  • 15
    • 0035203511 scopus 로고    scopus 로고
    • MAP kinase dynamics in response to pheromones in budding yeast
    • van Drogen, F., Stucke, V.M., Jorritsma, G. & Peter, M. (2001) MAP kinase dynamics in response to pheromones in budding yeast. Nat. Cell Biol. 3, 1051-1059.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 1051-1059
    • Van Drogen, F.1    Stucke, V.M.2    Jorritsma, G.3    Peter, M.4
  • 16
    • 0033588242 scopus 로고    scopus 로고
    • Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
    • Mahanty, S.K., Wang, Y., Farley, F.W. & Elion, E.A. (1999) Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade. Cell 98, 501-512.
    • (1999) Cell , vol.98 , pp. 501-512
    • Mahanty, S.K.1    Wang, Y.2    Farley, F.W.3    Elion, E.A.4
  • 17
    • 0032508538 scopus 로고    scopus 로고
    • MPl: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
    • Schaeffer, H.J., Catling, A.D., Eblen, S.T., Collier, L.S., Krauss, A. & Weber, M.J. (1998) MPl: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science. 281, 1668-1671.
    • (1998) Science , vol.281 , pp. 1668-1671
    • Schaeffer, H.J.1    Catling, A.D.2    Eblen, S.T.3    Collier, L.S.4    Krauss, A.5    Weber, M.J.6
  • 18
    • 0035911147 scopus 로고    scopus 로고
    • A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mpl on a late endosomal/lysosomal compartment
    • Wunderlich, W., Fialka, I., Teis, D., Alpi, A., Pfeifer, A., Parton, R.G., Lottspeich, F. & Huber, L.A. (2001) A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mpl on a late endosomal/lysosomal compartment. J. Cell Biol. 152, 765-776.
    • (2001) J. Cell Biol. , vol.152 , pp. 765-776
    • Wunderlich, W.1    Fialka, I.2    Teis, D.3    Alpi, A.4    Pfeifer, A.5    Parton, R.G.6    Lottspeich, F.7    Huber, L.A.8
  • 19
    • 0036899420 scopus 로고    scopus 로고
    • Localization of the MPl-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    • Teis, D., Wunderlich, W. & Huber, L.A. (2002) Localization of the MPl-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell. 3, 803-814.
    • (2002) Dev. Cell , vol.3 , pp. 803-814
    • Teis, D.1    Wunderlich, W.2    Huber, L.A.3
  • 21
    • 0035018017 scopus 로고    scopus 로고
    • KSR: A MAPK scaffold of the Ras pathway?
    • Morrison, D.K. (2001) KSR: a MAPK scaffold of the Ras pathway? J. Cell Sci. 114, 1609-1612.
    • (2001) J. Cell Sci. , vol.114 , pp. 1609-1612
    • Morrison, D.K.1
  • 22
    • 0035930343 scopus 로고    scopus 로고
    • C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
    • Muller, J., Ory, S., Copeland, T., Piwnica-Worms, H. & Morrison, D.K. (2001) C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol. Cell. 8, 983-993.
    • (2001) Mol. Cell , vol.8 , pp. 983-993
    • Muller, J.1    Ory, S.2    Copeland, T.3    Piwnica-Worms, H.4    Morrison, D.K.5
  • 24
  • 25
    • 0038701654 scopus 로고    scopus 로고
    • The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK
    • Willoughby, E.A., Perkins, G.R., Collins, M.K. & Whitmarsh, A.J. (2003) The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. J. Biol. Chem. 278, 10731-10736.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10731-10736
    • Willoughby, E.A.1    Perkins, G.R.2    Collins, M.K.3    Whitmarsh, A.J.4
  • 26
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis, T.S., Shapiro, P.S. & Ahn, N.G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139.
    • (1998) Adv. Cancer Res. , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 27
    • 0033788484 scopus 로고    scopus 로고
    • A conserved docking motif in MAP kinases common to substrates, activators and regulators
    • Tanoue, T., Adachi, M., Moriguchi, T. & Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, 110-116.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 110-116
    • Tanoue, T.1    Adachi, M.2    Moriguchi, T.3    Nishida, E.4
  • 28
    • 0030272039 scopus 로고    scopus 로고
    • A conserved motif at the amino termini of MEKs might mediate high affinity interaction with the cognate MAPKs
    • Bardwell, L. & Thorner, J. (1996) A conserved motif at the amino termini of MEKs might mediate high affinity interaction with the cognate MAPKs. Trends in Biochem. Sci. 21, 373-374.
    • (1996) Trends in Biochem. Sci. , vol.21 , pp. 373-374
    • Bardwell, L.1    Thorner, J.2
  • 29
    • 0035254671 scopus 로고    scopus 로고
    • Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
    • Tanoue, T., Maeda, R., Adachi, M. & Nishida, E. (2001) Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 20, 466-479.
    • (2001) EMBO J. , vol.20 , pp. 466-479
    • Tanoue, T.1    Maeda, R.2    Adachi, M.3    Nishida, E.4
  • 30
    • 0037169487 scopus 로고    scopus 로고
    • Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP
    • Tarrega, C., Blanco-Aparicio, C., Munoz, J.J. & Pulido, R. (2002) Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP. J. Biol. Chem. 277, 2629-2636.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2629-2636
    • Tarrega, C.1    Blanco-Aparicio, C.2    Munoz, J.J.3    Pulido, R.4
  • 31
    • 0034284131 scopus 로고    scopus 로고
    • Docking domains and substrate-specificity determination for MAP kinases
    • Sharrocks, A.D., Yang, S.H. & Galanis, A. (2000) Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem. Sci. 25, 448-453.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 448-453
    • Sharrocks, A.D.1    Yang, S.H.2    Galanis, A.3
  • 32
    • 0031882123 scopus 로고    scopus 로고
    • The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif
    • Yang, S.H., Yates, P.R., Whitmarsh, A.J., Davis, R.J. & Sharrocks, A.D. (1998) The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell. Biol. 18, 710-720.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 710-720
    • Yang, S.H.1    Yates, P.R.2    Whitmarsh, A.J.3    Davis, R.J.4    Sharrocks, A.D.5
  • 33
    • 0030972494 scopus 로고    scopus 로고
    • Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
    • Fukuda, M., Gotoh, Y. & Nishida, E. (1997) Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 1901-08.
    • (1997) EMBO J. , pp. 1901-1908
    • Fukuda, M.1    Gotoh, Y.2    Nishida, E.3
  • 34
    • 0035920179 scopus 로고    scopus 로고
    • Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues
    • Fantz, D.A., Jacobs, D., Glossip, D. & Kornfeld, K. (2001) Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues. J. Biol. Chem. 276, 27256-27265.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27256-27265
    • Fantz, D.A.1    Jacobs, D.2    Glossip, D.3    Kornfeld, K.4
  • 35
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S. & Pouyssegur, J. (1999) Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 18, 664-674.
    • (1999) EMBO J. , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouyssegur, J.6
  • 36
    • 0029786994 scopus 로고    scopus 로고
    • Cytoplasmic localization of MAP kinase kinase directed by its N-terminal, leucin-rich amino acid sequence, which acts as a nuclear export signal
    • Fukuda, M., Gotoh, I., Gotoh, Y. & Nishida, E. (1996) Cytoplasmic localization of MAP kinase kinase directed by its N-terminal, leucin-rich amino acid sequence, which acts as a nuclear export signal. J. Biol. Chem. 271, 20024-20028.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20024-20028
    • Fukuda, M.1    Gotoh, I.2    Gotoh, Y.3    Nishida, E.4
  • 37
    • 0034757776 scopus 로고    scopus 로고
    • The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases
    • Volmat, V., Camps, M., Arkinstall, S., Pouysségur, J. & Lenormand, P. (2001) The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases. J. Cell. Sci. 114, 3433-3443.
    • (2001) J. Cell Sci. , vol.114 , pp. 3433-3443
    • Volmat, V.1    Camps, M.2    Arkinstall, S.3    Pouysségur, J.4    Lenormand, P.5
  • 38
    • 0036787934 scopus 로고    scopus 로고
    • Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis
    • Roberts, E.C., Shapiro, P.S., Nahreini, T.S., Pages, G., Pouyssegut, J. & Ahn, N.G. (2002) Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol. Cell Biol. 22, 7226-7241.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7226-7241
    • Roberts, E.C.1    Shapiro, P.S.2    Nahreini, T.S.3    Pages, G.4    Pouyssegut, J.5    Ahn, N.G.6
  • 39
    • 0026541205 scopus 로고
    • Requirements for phosphorylation of MAP kinase during meiosis in xenopus oocytes
    • Posada, J. & Cooper, J.A. (1992) Requirements for phosphorylation of MAP kinase during meiosis in xenopus oocytes. Science. 255, 212-215.
    • (1992) Science , vol.255 , pp. 212-215
    • Posada, J.1    Cooper, J.A.2
  • 40
    • 0029257329 scopus 로고
    • Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
    • Alessi, D., Gomez, N., Moorhead, G., Lewis, T., Keyse, S.M. & Cohen, P. (1995) Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Curr. Biol. 5, 283-295.
    • (1995) Curr. Biol. , vol.5 , pp. 283-295
    • Alessi, D.1    Gomez, N.2    Moorhead, G.3    Lewis, T.4    Keyse, S.M.5    Cohen, P.6
  • 41
    • 0032695312 scopus 로고    scopus 로고
    • Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: Implications for p42 MAPK regulation in vivo
    • Sohaskey, M.L. & Ferrell, J.E Jr (1999) Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation in vivo. Mol. Biol. Cell. 10, 3729-3743.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3729-3743
    • Sohaskey, M.L.1    Ferrell J.E., Jr.2
  • 42
    • 0033178615 scopus 로고    scopus 로고
    • Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase
    • Oh-hora, M., Ogata, M., Mori, Y., Adachi, M., Imai, K., Kosugi, A. & Hamaoka, T. (1999) Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase. J. Immunol. 163, 1282-1288.
    • (1999) J. Immunol. , vol.163 , pp. 1282-1288
    • Oh-hora, M.1    Ogata, M.2    Mori, Y.3    Adachi, M.4    Imai, K.5    Kosugi, A.6    Hamaoka, T.7
  • 43
    • 0034677544 scopus 로고    scopus 로고
    • The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP
    • Pettiford, S.M. & Herbst, R. (2000) The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP. Oncogene. 19, 858-869.
    • (2000) Oncogene , vol.19 , pp. 858-869
    • Pettiford, S.M.1    Herbst, R.2
  • 44
    • 0033153370 scopus 로고    scopus 로고
    • PTP-ER, a novel tyrosine phosphatase, functions downstream of Rasl to downregulate MAP kinase during Drosophila eye development
    • Karim, F.D. & Rubin, G.M. (1999) PTP-ER, a novel tyrosine phosphatase, functions downstream of Rasl to downregulate MAP kinase during Drosophila eye development. Mol. Cell. 3, 741-750.
    • (1999) Mol. Cell , vol.3 , pp. 741-750
    • Karim, F.D.1    Rubin, G.M.2
  • 45
    • 0031033716 scopus 로고    scopus 로고
    • The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade
    • Brondello, J.M., Brunet, A., Pouyssegur, J. & McKenzie, F.R. (1997) The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J. Biol. Chem. 272, 1368-1376.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1368-1376
    • Brondello, J.M.1    Brunet, A.2    Pouyssegur, J.3    McKenzie, F.R.4
  • 46
    • 0033970533 scopus 로고    scopus 로고
    • Dual specificity phosphatases: A gene family for control of MAP kinase function
    • Camps, M., Nichols, A. & Arkinstall, S. (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. Faseb J. 14, 6-16.
    • (2000) Faseb J. , vol.14 , pp. 6-16
    • Camps, M.1    Nichols, A.2    Arkinstall, S.3
  • 47
    • 0034096201 scopus 로고    scopus 로고
    • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
    • Keyse, S.M. (2000) Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12, 186-192.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 186-192
    • Keyse, S.M.1
  • 48
    • 0038832564 scopus 로고    scopus 로고
    • Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
    • Brondello, J.M., Pouyssegur, J. & McKenzie, F.R. (1999) Reduced MAP kinase phosphatase-1 degradation after p42/ p44MAPK-dependent phosphorylation. Science. 286, 2514-2517.
    • (1999) Science , vol.286 , pp. 2514-2517
    • Brondello, J.M.1    Pouyssegur, J.2    McKenzie, F.R.3
  • 50
    • 0035844140 scopus 로고    scopus 로고
    • Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    • Slack, D.N., Seternes, O.M., Gabrielsen, M. & Keyse, S.M. (2001) Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J. Biol Chem. 276, 16491-16500.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16491-16500
    • Slack, D.N.1    Seternes, O.M.2    Gabrielsen, M.3    Keyse, S.M.4
  • 51
    • 0029757347 scopus 로고    scopus 로고
    • Disruption of the erp/mkp-1 gene does not affect mouse development: Normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts
    • Dorfman, K., Carrasco, D., Gruda, M., Ryan, C., Lira, S.A. & Bravo, R. (1996) Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene. 13, 925-931.
    • (1996) Oncogene , vol.13 , pp. 925-931
    • Dorfman, K.1    Carrasco, D.2    Gruda, M.3    Ryan, C.4    Lira, S.A.5    Bravo, R.6
  • 52
    • 0034765383 scopus 로고    scopus 로고
    • Spatiotemporal regulation of the p42/p44 MAPK pathway
    • Volmat, V. & Pouyssegur, J. (2001) Spatiotemporal regulation of the p42/p44 MAPK pathway. Biol. Cell. 93, 71-79.
    • (2001) Biol. Cell , vol.93 , pp. 71-79
    • Volmat, V.1    Pouyssegur, J.2
  • 53
    • 0027283659 scopus 로고
    • Growth Factors Induce Nuclear Translocation of MAP Kinases (p42maPk and p44mapk) but not of Their Activator MAP Kinase Kinase (p45mapkk) in Fibroblasts
    • Lenormand, P., Sardet, C., Pagès, G., L'Allemain, G., Brunet, A. & Pouysségur, J. (1993) Growth Factors Induce Nuclear Translocation of MAP Kinases (p42maPk and p44mapk) but not of Their Activator MAP Kinase Kinase (p45mapkk) in Fibroblasts. J. Cell. Biol. 122, 1079-1089.
    • (1993) J. Cell Biol. , vol.122 , pp. 1079-1089
    • Lenormand, P.1    Sardet, C.2    Pagès, G.3    L'Allemain, G.4    Brunet, A.5    Pouysségur, J.6
  • 54
    • 0032558692 scopus 로고    scopus 로고
    • A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
    • Robinson, M.J., Stippec, S.A., Goldsmith, E., White, M.A. & Cobb, M.H. (1998) A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr. Biol. 8, 1141-1150.
    • (1998) Curr. Biol. , vol.8 , pp. 1141-1150
    • Robinson, M.J.1    Stippec, S.A.2    Goldsmith, E.3    White, M.A.4    Cobb, M.H.5
  • 56
    • 0037088585 scopus 로고    scopus 로고
    • Beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK mediated transcription following angiotensin ATla receptor stimulation
    • Tohgo, A., Pierce, K.L., Choy, E.W., Lefkowitz, R.J. & Luttrell, L.M. (2002) beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK mediated transcription following angiotensin ATla receptor stimulation. J. Biol. Chem. 277, 9429-9436.
    • (2002) J. Biol. Chem. , vol.277 , pp. 9429-9436
    • Tohgo, A.1    Pierce, K.L.2    Choy, E.W.3    Lefkowitz, R.J.4    Luttrell, L.M.5
  • 57
    • 0031852068 scopus 로고    scopus 로고
    • Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
    • Lenormand, P., Brondello, J.M., Brunet, A. & Pouyssegur, J. (1998) Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins. J. Cell Biol. 142, 625-633.
    • (1998) J. Cell Biol. , vol.142 , pp. 625-633
    • Lenormand, P.1    Brondello, J.M.2    Brunet, A.3    Pouyssegur, J.4
  • 58
    • 0033215340 scopus 로고    scopus 로고
    • Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
    • Adachi, M., Fukuda, M. & Nishida, E. (1999) Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 18, 5347-5358.
    • (1999) EMBO J. , vol.18 , pp. 5347-5358
    • Adachi, M.1    Fukuda, M.2    Nishida, E.3
  • 60
    • 0035834689 scopus 로고    scopus 로고
    • Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells
    • Matsubayashi, Y., Fukuda, M. & Nishida, E. (2001) Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J. Biol. Chem. 276, 41755-41760.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41755-41760
    • Matsubayashi, Y.1    Fukuda, M.2    Nishida, E.3
  • 61
    • 0035036212 scopus 로고    scopus 로고
    • Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
    • Lorenzen, J.A., Baker, S.E., Denhez, F., Melnick, M.B., Brower, D.L. & Perkins, L.A. (2001) Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin. Development. 128, 1403-1414.
    • (2001) Development , vol.128 , pp. 1403-1414
    • Lorenzen, J.A.1    Baker, S.E.2    Denhez, F.3    Melnick, M.B.4    Brower, D.L.5    Perkins, L.A.6
  • 62
    • 0034610996 scopus 로고    scopus 로고
    • Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism
    • Adachi, M., Fukuda, M. & Nishida, E. (2000) Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J. Cell Biol. 148, 849-856.
    • (2000) J. Cell Biol. , vol.148 , pp. 849-856
    • Adachi, M.1    Fukuda, M.2    Nishida, E.3
  • 64
    • 0013202857 scopus 로고    scopus 로고
    • Pharmacological inhibitors of the ERK signaling pathway: Application as anticancer drugs
    • Kohno, M. & Pouyssegur, J. (2003) Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs. Prog. Cell Cycle Res. 5, 219-224.
    • (2003) Prog. Cell Cycle Res. , vol.5 , pp. 219-224
    • Kohno, M.1    Pouyssegur, J.2


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