Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia

Biological Psychiatry

Volumn 45, Issue 1, 1999, Pages 41-48

  Wassink, Thomas H ^a   Andreasen, Nancy C ^a   Nopoulos, Peg ^a   Flaum, Michael ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cerebellum; Psychosocial outcome; Schizophrenia; Symptom dimensions

Indexed keywords

ADULT; ARTICLE; CEREBELLUM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOMES RESEARCH; PREDICTION; PRIORITY JOURNAL; SCHIZOPHRENIA; SOCIAL PSYCHOLOGY; SYMPTOMATOLOGY;

ADULT; CEREBELLUM; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INPATIENTS; MAGNETIC RESONANCE IMAGING; MALE; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SOCIAL BEHAVIOR; TREATMENT OUTCOME;

EID: 0032967989     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00175-9     Document Type: Article

References (75)

1. Akshoomoff N.A., Courchesne E. A new role for the cerebellum in cognitive operations. Behav Neurosci. 5:1992;731-738.
2. Akshoomoff N.A., Courchesne E., Press G.A., Iragui V. Contribution of the cerebellum to neuropsychological functioning Evidence from a case of cerebellar degenerative disorder . Neuropsychologica. 30:1992;315-328.
3. Andreasen N.C. The Scale for the Assessment of Negative Symptoms. 1983;The University of Iowa, Iowa City, IA.
4. Andreasen N.C. The Scale for the Assessment of Positive Symptoms. 1984;The University of Iowa, Iowa City, IA.
5. Andreasen N.C. Psychiatric Symptoms You Currently Have - Baseline. 1987;The University of Iowa, Iowa City, IA.
6. Andreasen N.C. Psychiatric Symptoms You Currently Have - Follow-up. 1987;The University of Iowa, Iowa City, IA.
7. Andreasen N.C.A., Grove W.M. Evaluation of positive and negative symptoms in schizophrenia. Psychiatr Psychobiol. 2:1986;108-121.
8. Andreasen N.C., Olsen S. Negative vs positive schizophrenia Definition and validation . Arch Gen Psychiatry. 39:1982;789-794.
9. Andreasen N.C., Nasrallah H.A., Dunn V.D., Olson S.C., Grove W.M., Ehrhardt J.C., et al. Structural abnormalities in the frontal system in schizophrenia A magnetic resonance imaging study . Arch Gen Psychiatry. 43:1986;136-144.
10. Andreasen N.C., Flaum M., Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry. 49:1992;615-623.
11. Andreasen N.C., Cohen G., Harris G., Cizadlo T., Parkkinen J., Rezai K., et al. Image processing for the study of brain structure and function Problems and programs . J Neuropsychiatry Clin Neurosci. 4:1992;125-133.
12. Andreasen N.C., Flaum M., Swayze V., O'Leary D.S., Alliger R., Cohen G., et al. Intelligence and brain structure in normal individuals. Am J Psychiatry. 150:1993;130-134.
13. Andreasen N.C., Arndt S., Alliger R., Miller D., Flaum M. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch Gen Psychiatry. 52:1995;341-351.
14. Andreasen N.C., O'Leary D.S., Arndt S., Cizadlo T., Hurtig R., Rezai K., et al. Short-term and long-term verbal memory A positron emission tomography study . Proc Natl Acad Sci USA. 92:1995;5111-5115.
15. Andreasen N.C., O'Leary D.S., Arndt S., Cizadlo T., Rezai K., Watkins G.L., et al. PET studies of memory I. Novel and practiced free recall of complex narratives . Neuroimage. 2:1995;284-295.
16. Andreasen N.C., O'Leary D.S., Cizadlo T., Arndt S., Rezai K., Watkins G.L., et al. PET studies of memory II. Novel versus practiced free recall of word lists . Neuroimage. 2:1995;296-305.
17. Andreasen N.C., O'Leary D.S., Arndt S., Cizadlo T., Hurtig R., Rezai K., et al. Neural substrates of facial recognition. J Neuropsychiatry Clin Neurosci. 8:1996;139-146.
18. Andreasen N.C., O'Leary D.S., Cizadlo T., Arndt S., Rezai K., Ponto L.L., et al. Schizophrenia and cognitive dysmetria A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry . Proc Natl Acad Sci USA. 93:1996;9985-9990.
19. Andreasen NC, Paradiso S, O'Leary DS (in press): "Cognitive dysmetria" as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr Bull.
20. Appolonio I.M., Grafman J., Schwartz V., Massaquoi S., Hallet M. Memory in patients with cerebellar degeneration. Neurology. 43:1993;1536-1544.
21. Arndt S., Cohen G., Alliger R.J., Swayze V.W., Andreasen N.C. Problems with ratio and proportion measures of imaged cerebral structures. Psychiatry Res. 40:1991;79-89.
22. Arndt S., Andreasen N.C., Flaum M., Miller D., Nopoulos P. A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change. Arch Gen Psychiatry. 52:1995;352-360.
23. Barta P.E., Pearlson G.D., Powers R.E., Richards S.S., Tune L.E. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry. 147:1990;1457-1462.
24. Bilder R.M., Mukherjee S., Rieder R.O., Pandurangi A.K. Symptomatic and neuropsychological components of defect states. Schizophr Bull. 11:1985;409-419.
25. Bilder R.M., Degreef G., Pandurangi A.K., Rieder R.O., Sackeim H.A., Mukherjee S. Neuropsychological deterioration and CT scan findings in chronic schizophrenia. Schizophr Res. 1:1988;37-45.
26. Carpenter W.T. Psychopathology and common sense. Biol Psychiatry. 29:1991;735-737.
27. Carpenter W.T., Heinrichs D.W., Wagman A.M.I. Deficit and non-deficit forms of schizophrenia The concept . Psychiatry Res. 22:1987;319-330.
28. Coffman J.A., Mefferd J., Golden C.J., Bloch S., Graber B. Cerebellar atrophy in chronic schizophrenia. Lancet. i:1981;666.
29. Deister A., Marneros A. Long-term stability of subtypes in schizophrenic disorders A comparison of four diagnostic systems . Eur Arch Psychiatry Clin Neurosci. 242:1993;184-190.
30. DeLisi L.E., Stritzke P., Riordan H., Holan V., Boccio A., Kushner M., et al. The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry. 31:1992;241-254.
31. DeLisi L.E., Tew W., Xie S., Hoff A.L., Sakuma M., Kushner M., et al. A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients Preliminary findings . Biol Psychiatry. 38:1995;349-360.
32. DeLisi L.E., Sakuma M., Tew W., Kushner M., Hoff A.L., Grimson R. Schizophrenia as a chronic active brain process A study of progressive brain structural change subsequent to the onset of schizophrenia . Psychiatry Res. 74:1997;129-140.
33. Flaum M.A., Andreasen N.C., Arndt S. The Iowa Prospective Longitudinal Study of Recent-Onset Psychoses. Schizophr Bull. 18:1992;481-490.
34. Flaum M., O'Leary D.S., Swayze V.W., Miller D.D., Arndt S., Andreasen N.C. Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. J Psychiatr Res. 29:1995;261-276.
35. Flaum M., Swayze V.W., O'Leary D.S., Yuh W.T., Ehrhardt J.C., Arndt S.V., et al. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am J Psychiatry. 152:1995;704-714.
36. Grafman J., Litvan I., Massaquoi S., Stewart M., Sirigu A., Hallet M. Cognitive planning in patients with cerebellar atrophy. Neurology. 42:1992;1493-1496.
37. Grasby P.M., Frith C.D., Friston K.J., Bench C., Frackowiak R.S.J., Dolan R.J. Functional mapping of brain areas implicated in auditory-verbal memory function. Brain. 116:1993;1-20.
38. Gur R.E., Pearlson G.D. Neuroimaging in schizophrenia research. Schizophr Bull. 19:1993;337-353.
39. Jueptner M., Rijntjes M., Weiller C., Faiss J.H., Timmann D., Mueller S.P., et al. Localization of a cerebellar timing process using PET. Neurology. 45:1995;1540-1545.
40. Kendler K.S., Gruenberg A.M., Tsuang M.T. Subtype stability in schizophrenia. Am J Psychiatry. 142:1985;827-832.
41. Kim S.G., Ugurbil K., Strick P.L. Activation of a cerebellar output nucleus during cognitive processing. Science. 265:1994;949-951.
42. Klimke A., Knecht S. Abnormalities of the left temporal lobe in schizophrenia. N Engl J Med. 327:1992;1689.
43. Leiner H.C., Leiner A.L., Dow R.S. Reappraising the cerebellum what does the hindbrain contribute to the forebrain? Behav Neurosci. 103:1989;998-1008.
44. Liddle P.F. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry. 151:1987;145-151.
45. Lieberman J.A., Koreen A.R., Chakos M., Sheitman B., Woerner M., Alvir J.M., et al. Factors influencing treatment response and outcome of first-episode schizophrenia Implications for understanding the pathophysiology of schizophrenia . J Clin Psychiatry. 9:1996;5-9.
46. Lippmann S., Manshadi M., Baldwin H., Drasin G., Rice J., Alrajeh S. Cerebellar vermis dimensions on computerized tomographic scans of schizophrenic and bipolar patients. Am J Psychiatry. 139:1982;667-668.
47. Marks RC, Luchins DJ (1990): Relationship between brain imaging findings in schizophrenia and psychopathology: A review of the literature relating to positive and negative symptoms. Mod Probl Pharmacopsychiatry 24:89-123.
48. Mayberg H.S., Solomon D.H. Depression in Parkinson's disease A biochemical and organic viewpoint . Adv Neurol. 65:1995;49-60.
49. Middleton F.A., Strick P.L. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science. 266:1994;458-461.
50. Mozley P.D., Gur R.E., Resnick S.M., Shtasel D.L., Richards J., Kohn M., et al. Magnetic resonance imaging in schizophrenia Relationship with clinical measures . Schizophr Res. 12:1994;195-203.
51. Nasrallah H.A., Jacoby C.G., McCalley-Whitters M. Cerebellar atrophy in schizophrenia and mania. Lancet. i:1981;1102.
52. Nasrallah H.A., Kuperman S., Jacoby C., McCalley-Whitters M., Hamra B. Clinical correlates of sulcal widening in chronic schizophrenia. Psychiatry Res. 10:1983;237-242.
53. Nasrallah H.A., Schwarzkopf S.B., Olson S.C., Coffman J.A. Perinatal brain injury and cerebellar vermal lobules I-X in schizophrenia. Biol Psychiatry. 29:1991;567-574.
54. Nyberg L., Tulving E., Habib R., Nilsson L.G., Kapur S., Houle S., et al. Functional brain maps of retrieval mode and recovery of episodic information. Neuroreport. 7:1995;249-252.
55. Owens D.G.C., Johnstone E.C., Crow T.J., Frith C.D., Ragoe J.R., Kreel L. Lateral ventricular size in schizophrenia Relationship to the disease process and its clinical manifestations . Psychol Med. 15:1985;27-41.
56. Pandurangi A.K., Bilder R.M., Rieder R.O., Mukherjee S., Hamer R.M. Schizophrenic symptoms and deterioration. Relation to computed tomographic findings. J Nerv Ment Dis. 176:1988;200-206.
57. Paradiso S., Andreasen N.C., O'Leary D.S., Arndt S., Robinson R.G. Cerebellar size and cognition Correlations with IQ, verbal memory and motor dexterity . Neuropsychiatry Neuropsychol Behav Neurol. 10:1997;1-8.
58. Paradiso S., Robinson R.G., Andreasen N.C., Downhill J.E., Davidson R.J., Kirchner P.T., et al. Emotional activation of limbic circuitry in elderly normal subjects in a PET study. Am J Psychiatry. 154:1997;384-389.
59. Pascual-Leone A., Grafman J., Clark K., Stewart M., Massaquoi S., Lou J.S., et al. Procedural learning in Parkinson's disease and cerebellar degeneration. Ann Neurol. 34:1993;594-602.
60. Raichle M.E. Images of the mind Studies with modern imaging techniques . Annu Rev Psychol. 45:1994;333-356.
61. Raichle M.E., Fiez J.A., Videen T.O., MacLeod A.M., Pardo J.V., Fox P.T., et al. Practice-related changes in human brain functional anatomy during nonmotor learning. Cereb Cortex. 4:1994;8-26.
62. Reyes M.G., Gordon A. Cerebellar vermis in schizophrenia. Lancet. ii:1981;700-701.
63. Rossi A., Stratta P., Mancini F., de Cataldo C.S., Casacchia M. Cerebellar vermal size in schizophrenia A male effect . Biol Psychiatry. 33:1993;354-357.
64. Sandyk R., Kay S.R., Merriam A.E. Atrophy of the cerebellar vermis Relevance to the symptoms of schizophrenia . Int J Neurosci. 57:1991;205-212.
65. Schmahmann J.D., Pandya D.N. Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. J Neurosci. 17:1997;438-458.
66. Schroder J., Buchsbaum M.S., Siegel B.V., Geider F.J., Niethammer R. Structural and functional correlates of subsyndromes in chronic schizophrenia. Psychopathology. 28:1995;38-45.
67. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med. 327:1992;604-612.
68. Silveri M.C., Leggio M.G., Molinare M. The cerebellum contributes to linguistic production A case of agrammatic speech following a right cerebellar lesion . Neurology. 44:1994;2047-2050.
69. Stevens J.R. The neuropathology of schizophrenia. Arch Gen Psychiatry. 39:1982;1131-1139.
70. Turetsky B., Cowell P.E., Gur R.C., Grossman R.I., Shtasel D.L., Gur R.E. Frontal and temporal lobe brain volumes in schizophrenia. Relationship to symptoms and clinical subtype. Arch Gen Psychiatry. 52:1995;1061-1070.
71. Van Dongen H.R., Catsman-Berrevoets C.E., Van Mourik M. The syndrome of "cerebellar" mutism and subsequent dysarthria. Neurology. 44:1994;2040-2046.
72. Vita A., Dieci M., Biobbio F.M., Azzone P., Garbarini M., Sacchetti E., et al. CT scan abnormalities and outcome of chronic schizophrenia. Am J Psychiatry. 148:1991;1577-1579.
73. Volkow N.D., Levy A., Brodie J.D., Wolf A.P., Cancro R., Van G.P., et al. Low cerebellar metabolism in medicated patients with chronic schizophrenia. Am J Psychiatry. 149:1992;686-688.
74. Weinberger D.R., Torrey E.F., Wyatt R.J. Cerebellar atrophy in chronic schizophrenia. Lancet. i:1979;718-719.
75. Weinberger D.R., Kleinman J.E., Luchins D.J., Bigelow L.B., Wyatt R.J. Cerebellar pathology in schizophrenia A controlled postmortem study . Am J Psychiatry. 137:1980;359-361.