-
1
-
-
0028223847
-
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
-
Takahashi T., Tanaka M., Brannan C.I., Jenkins N.A., Copeland N.G., Suda T., Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76:1994;969-976
-
(1994)
Cell
, vol.76
, pp. 969-976
-
-
Takahashi, T.1
Tanaka, M.2
Brannan, C.I.3
Jenkins, N.A.4
Copeland, N.G.5
Suda, T.6
Nagata, S.7
-
2
-
-
0026568919
-
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
-
Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 356:1992;314-317
-
(1992)
Nature
, vol.356
, pp. 314-317
-
-
Watanabe-Fukunaga, R.1
Brannan, C.I.2
Copeland, N.G.3
Jenkins, N.A.4
Nagata, S.5
-
3
-
-
0032538571
-
Definition and redesign of the extended substrate specificity of granzyme B
-
Harris J.L., Peterson E.P., Hudig D., Thornberry N.A., Craik C.S. Definition and redesign of the extended substrate specificity of granzyme B. J. Biol. Chem. 273:1998;27364-27373
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27364-27373
-
-
Harris, J.L.1
Peterson, E.P.2
Hudig, D.3
Thornberry, N.A.4
Craik, C.S.5
-
4
-
-
0028258577
-
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
-
Heusel J.W., Wesselschmidt R.L., Shresta S., Russell J.H., Ley T.J. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:1994;977-987
-
(1994)
Cell
, vol.76
, pp. 977-987
-
-
Heusel, J.W.1
Wesselschmidt, R.L.2
Shresta, S.3
Russell, J.H.4
Ley, T.J.5
-
5
-
-
0033598718
-
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
-
Mullbacher A., Waring P., Tha Hla R., Tran T., Chin S., Stehle T., Museteanu C., Simon M.M. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. USA. 96:1999;13950-13955
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13950-13955
-
-
Mullbacher, A.1
Waring, P.2
Tha Hla, R.3
Tran, T.4
Chin, S.5
Stehle, T.6
Museteanu, C.7
Simon, M.M.8
-
6
-
-
0037261142
-
Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway
-
Muller U., Sobek V., Balkow S., Holscher C., Mullbacher A., Museteanu C., Mossmann H., Simon M.M. Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway. Eur. J. Immunol. 33:2003;70-78
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 70-78
-
-
Muller, U.1
Sobek, V.2
Balkow, S.3
Holscher, C.4
Mullbacher, A.5
Museteanu, C.6
Mossmann, H.7
Simon, M.M.8
-
7
-
-
0029847228
-
Long-range disruption of gene expression by a selectable marker cassette
-
Pham C.T., MacIvor D.M., Hug B.A., Heusel J.W., Ley T.J. Long-range disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA. 93:1996;13090-13095
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13090-13095
-
-
Pham, C.T.1
MacIvor, D.M.2
Hug, B.A.3
Heusel, J.W.4
Ley, T.J.5
-
8
-
-
0029066661
-
Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I
-
Smyth M.J., McGuire M.J., Thia K.Y. Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I. J. Immunol. 154:1995;6299-6305
-
(1995)
J. Immunol.
, vol.154
, pp. 6299-6305
-
-
Smyth, M.J.1
McGuire, M.J.2
Thia, K.Y.3
-
9
-
-
0027452741
-
Granzymes a and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
-
Griffiths G.M., Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J. Cell Biol. 120:1993;885-896
-
(1993)
J. Cell Biol.
, vol.120
, pp. 885-896
-
-
Griffiths, G.M.1
Isaaz, S.2
-
10
-
-
0036195424
-
Cytotoxic cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
-
Metkar S.S., Wang B., Aguilar-Santelises M., Raja S.M., Uhlin-Hansen L., Podack E., Trapani J.A., Froelich C.J. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 16:2002;417-428
-
(2002)
Immunity
, vol.16
, pp. 417-428
-
-
Metkar, S.S.1
Wang, B.2
Aguilar-Santelises, M.3
Raja, S.M.4
Uhlin-Hansen, L.5
Podack, E.6
Trapani, J.A.7
Froelich, C.J.8
-
11
-
-
0028219791
-
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
-
Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K.J., Podack E.R., Zinkernagel R.M., Hengartner H. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:1994;31-37
-
(1994)
Nature
, vol.369
, pp. 31-37
-
-
Kagi, D.1
Ledermann, B.2
Burki, K.3
Seiler, P.4
Odermatt, B.5
Olsen, K.J.6
Podack, E.R.7
Zinkernagel, R.M.8
Hengartner, H.9
-
12
-
-
0033499729
-
Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
-
Browne K.A., Blink E., Sutton V.R., Froelich C.J., Jans D.A., Trapani J.A. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol. Cell Biol. 19:1999;8604-8615
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 8604-8615
-
-
Browne, K.A.1
Blink, E.2
Sutton, V.R.3
Froelich, C.J.4
Jans, D.A.5
Trapani, J.A.6
-
13
-
-
0034721646
-
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
-
Motyka B., Korbutt G., Pinkoski M.J., Heibein J.A., Caputo A., Hobman M., Barry M., Shostak I., Sawchuk T., Holmes C.F., Gauldie J., Bleackley R.C. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 103:2000;491-500
-
(2000)
Cell
, vol.103
, pp. 491-500
-
-
Motyka, B.1
Korbutt, G.2
Pinkoski, M.J.3
Heibein, J.A.4
Caputo, A.5
Hobman, M.6
Barry, M.7
Shostak, I.8
Sawchuk, T.9
Holmes, C.F.10
Gauldie, J.11
Bleackley, R.C.12
-
14
-
-
0037455545
-
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death
-
Trapani J.A., Sutton V.R., Thia K.Y., Li Y.Q., Froelich C.J., Jans D.A., Sandrin M.S., Browne K.A. A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell. Biol. 160:2003;223-233
-
(2003)
J. Cell. Biol.
, vol.160
, pp. 223-233
-
-
Trapani, J.A.1
Sutton, V.R.2
Thia, K.Y.3
Li, Y.Q.4
Froelich, C.J.5
Jans, D.A.6
Sandrin, M.S.7
Browne, K.A.8
-
15
-
-
9344261615
-
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
-
Martin S.J., Amarante-Mendes G.P., Shi L., Chuang T.H., Casiano C.A., O'Brien G.A., Fitzgerald P., Tan E.M., Bokoch G.M., Greenberg A.H., Green D.R. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J. 15:1996;2407-2416
-
(1996)
EMBO J.
, vol.15
, pp. 2407-2416
-
-
Martin, S.J.1
Amarante-Mendes, G.P.2
Shi, L.3
Chuang, T.H.4
Casiano, C.A.5
O'Brien, G.A.6
Fitzgerald, P.7
Tan, E.M.8
Bokoch, G.M.9
Greenberg, A.H.10
Green, D.R.11
-
16
-
-
0033521626
-
Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis
-
MacDonald G., Shi L., Van de Velde C., Lieberman J., Greenberg A.H. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis. J. Exp. Med. 189:1999;131-144
-
(1999)
J. Exp. Med.
, vol.189
, pp. 131-144
-
-
MacDonald, G.1
Shi, L.2
Van De Velde, C.3
Lieberman, J.4
Greenberg, A.H.5
-
17
-
-
0031570536
-
Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
-
Sutton V.R., Vaux D.L., Trapani J.A. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J. Immunol. 158:1997;5783-5790
-
(1997)
J. Immunol.
, vol.158
, pp. 5783-5790
-
-
Sutton, V.R.1
Vaux, D.L.2
Trapani, J.A.3
-
18
-
-
0033769857
-
Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1
-
Davis J.E., Sutton V.R., Smyth M.J., Trapani J.A. Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1. Cell Death. Differ. 7:2000;973-983
-
(2000)
Cell Death. Differ.
, vol.7
, pp. 973-983
-
-
Davis, J.E.1
Sutton, V.R.2
Smyth, M.J.3
Trapani, J.A.4
-
19
-
-
0034694091
-
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
-
Sutton V.R., Davis J.E., Cancilla M., Johnstone R.W., Ruefli A.A., Sedelies K., Browne K.A., Trapani J.A. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J. Exp. Med. 192:2000;1403-1414
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1403-1414
-
-
Sutton, V.R.1
Davis, J.E.2
Cancilla, M.3
Johnstone, R.W.4
Ruefli, A.A.5
Sedelies, K.6
Browne, K.A.7
Trapani, J.A.8
-
20
-
-
0035910057
-
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
-
Thomas D.A., Scorrano L., Putcha G.V., Korsmeyer S.J., Ley T.J. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc. Natl. Acad. Sci. USA. 98:2001;14985-14990
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14985-14990
-
-
Thomas, D.A.1
Scorrano, L.2
Putcha, G.V.3
Korsmeyer, S.J.4
Ley, T.J.5
-
21
-
-
0037341354
-
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
-
Sutton V.R., Wowk M.E., Cancilla M., Trapani J.A. Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity. 18:2003;319-329
-
(2003)
Immunity
, vol.18
, pp. 319-329
-
-
Sutton, V.R.1
Wowk, M.E.2
Cancilla, M.3
Trapani, J.A.4
-
22
-
-
0037343068
-
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition
-
Goping I.S., Barry M., Liston P., Sawchuk T., Constantinescu G., Michalak K.M., Shostak I., Roberts D.L., Hunter A.M., Korneluk R., Bleackley R.C. Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition. Immunity. 18:2003;355-365
-
(2003)
Immunity
, vol.18
, pp. 355-365
-
-
Goping, I.S.1
Barry, M.2
Liston, P.3
Sawchuk, T.4
Constantinescu, G.5
Michalak, K.M.6
Shostak, I.7
Roberts, D.L.8
Hunter, A.M.9
Korneluk, R.10
Bleackley, R.C.11
-
23
-
-
0029844220
-
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro
-
Jans D.A., Jans P., Briggs L.J., Sutton V., Trapani J.A. Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. J. Biol. Chem. 271:1996;30781-30789
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 30781-30789
-
-
Jans, D.A.1
Jans, P.2
Briggs, L.J.3
Sutton, V.4
Trapani, J.A.5
-
24
-
-
0032561352
-
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
-
Trapani J.A., Jans D.A., Jans P.J., Smyth M.J., Browne K.A., Sutton V.R. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J. Biol. Chem. 273:1998;27934-27938
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27934-27938
-
-
Trapani, J.A.1
Jans, D.A.2
Jans, P.J.3
Smyth, M.J.4
Browne, K.A.5
Sutton, V.R.6
-
25
-
-
0034954419
-
Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death
-
Andrade F., Bull H.G., Thornberry N.A., Ketner G.W., Casciola-Rosen L.A., Rosen A. Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death. Immunity. 14:2001;751-761
-
(2001)
Immunity
, vol.14
, pp. 751-761
-
-
Andrade, F.1
Bull, H.G.2
Thornberry, N.A.3
Ketner, G.W.4
Casciola-Rosen, L.A.5
Rosen, A.6
-
26
-
-
0242377107
-
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B
-
Cartier A., Broberg E., Komai T., Henriksson M., Masucci M.G. The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B. Cell Death Differ. 10:2003;1320-1328
-
(2003)
Cell Death Differ.
, vol.10
, pp. 1320-1328
-
-
Cartier, A.1
Broberg, E.2
Komai, T.3
Henriksson, M.4
Masucci, M.G.5
-
27
-
-
0029914132
-
A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier a is present in cytotoxic lymphocytes
-
Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., De Jong T.A., Trapani J.A., Bird P.I. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J. Biol. Chem. 271:1996;27802-27809
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27802-27809
-
-
Sun, J.1
Bird, C.H.2
Sutton, V.3
McDonald, L.4
Coughlin, P.B.5
De Jong, T.A.6
Trapani, J.A.7
Bird, P.I.8
-
28
-
-
0344406761
-
A triple-mutated allele of granzyme B incapable of inducing apoptosis
-
McIlroy D., Cartron P.F., Tuffery P., Dudoit Y., Samri A., Autran B., Vallette F.M., Debre P., Theodorou I. A triple-mutated allele of granzyme B incapable of inducing apoptosis. Proc. Natl. Acad. Sci. USA. 100:2003;2562-2567
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2562-2567
-
-
McIlroy, D.1
Cartron, P.F.2
Tuffery, P.3
Dudoit, Y.4
Samri, A.5
Autran, B.6
Vallette, F.M.7
Debre, P.8
Theodorou, I.9
-
29
-
-
2342442244
-
Granzyme B encoded by the commonly-occurring human RAH allele retains pro-apoptotic activity
-
Sun J., Bird C.H., Thia K.Y., Matthews A.Y., Trapani J.A., Bird P.I. Granzyme B encoded by the commonly-occurring human RAH allele retains pro-apoptotic activity. J. Biol. Chem. 279:2004;16907-16911
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16907-16911
-
-
Sun, J.1
Bird, C.H.2
Thia, K.Y.3
Matthews, A.Y.4
Trapani, J.A.5
Bird, P.I.6
-
30
-
-
0033137079
-
Granzyme a loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
-
Beresford P.J., Xia Z., Greenberg A.H., Lieberman J. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity. 10:1999;585-594
-
(1999)
Immunity
, vol.10
, pp. 585-594
-
-
Beresford, P.J.1
Xia, Z.2
Greenberg, A.H.3
Lieberman, J.4
-
32
-
-
2542448011
-
Granzyme M mediates a novel form of perforin-dependent cell death
-
Kelly J.M., Waterhouse N.J., Cretney E., Browne K.A., Ellis S., Trapani J.A., Smyth M.J. Granzyme M mediates a novel form of perforin-dependent cell death. J. Biol. Chem. 279:2004;22236-22252
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22236-22252
-
-
Kelly, J.M.1
Waterhouse, N.J.2
Cretney, E.3
Browne, K.A.4
Ellis, S.5
Trapani, J.A.6
Smyth, M.J.7
-
33
-
-
0037136311
-
Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
-
Balaji K.N., Schaschke N., Machleidt W., Catalfamo M., Henkart P.A. Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. J. Exp. Med. 196:2002;493-503
-
(2002)
J. Exp. Med.
, vol.196
, pp. 493-503
-
-
Balaji, K.N.1
Schaschke, N.2
MacHleidt, W.3
Catalfamo, M.4
Henkart, P.A.5
|