Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement

International Journal of Obesity

Volumn 26, Issue 9, 2002, Pages 1165-1172

  Mingrone, G ^a   Rosa, G ^a   Di Rocco, P ^a   Manco, M ^a   Capristo, E ^a   Castagneto, M ^a   Vettor, R ^b   Gasbarrini, G ^a   Greco, A V ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Euglycaemic hyperinsulinaemic clamp; GLUT4 mRNA; mRNA; Muscle triglycerides; TNF

Indexed keywords

GLUCOSE TRANSPORTER 4; MESSENGER RNA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; FEMALE; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MORBID OBESITY; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SKELETAL MUSCLE; WEIGHT REDUCTION;

ADULT; BILIOPANCREATIC DIVERSION; BIOPSY, NEEDLE; BLOOD GLUCOSE; BODY COMPOSITION; DIET, REDUCING; ELECTROPHORESIS, AGAR GEL; FEMALE; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; OBESITY, MORBID; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 0036734285     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802053     Document Type: Article

References (37)

1. Tumor necrosis factor alpha: A key component of the obesity-diabetes link
2. The expression of TNF alpha by human muscle: Relationship to insulin resistance
3. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
4. The effect of insulin on the disposal of intravenous glucose: Results from indirect colorimetry and hepatic and femoral venous catheterization
5. Skeletal muscle triglyceride levels are inversely related to insulin action
6. Tissue oxidative capacity, fuel stores and skeletal muscle fatty acid composition in obesity-prone and obesity-resistant rats
7. Reversibility of insulin resistance in obese diabetic patients: Role of plasma lipids
8. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides
9. An 18-year-old woman with familial chylomicronaemia who would not stick to a diet
10. Triglyceride-induced diabetes associated with familiar lipoprotein lipase deficiency
11. Biliopancreatic bypass for obesity: II. Initial experience in man
12. Total body water and the exchangeable hydrogen I. Theoretical calculation of nonaqueous exchangeable hydrogen in men
13. Body composition of humans: Comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure
14. Total body fat content and fat topography are associated differently with in vivo glucose metabolism in non obese and obese non diabetic women
15. Glucose clamp technique: A model for quantifying insulin secretion and resistance
16. An application of high performance liquid chromatography to analysis of lipids in archaeological samples
17. A rapid enzymatic assay for glycerol
18. Insulin resistance and hypersecretion in obesity
19. Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acids availability in rats
20. Insulin resistance in morbid obesity. Reversal with intramyocellular fat depletion
21. The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
22. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
23. Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-γ-2 (PPARγ-2), leptin, uncoupling proteins 2 and 3, and Tumor Necrosis Factor-α gene expression in human subcutaneous fat by lipid infusion
24. Tumor necrosis factor not detectable in patients with clinical cancer cachexia
25. Seminars in medicine of the Beth Israel Hospital, Boston: Metabolic disturbances and wasting in the acquired immunodeficiency syndrome
26. Insulin resistance in cancer patients is associated with enhanced tumor necrosis factor α expression in skeletal muscle
27. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
28. Obesity sheds its secrets
29. Lessons from transgenic and knockout animals about non-insulin-dependent diabetes mellitus
30. Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: Implication of the p80 tumor necrosis factor receptor
31. Thiazolidionediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
32. An in vivo model for elucidation of the mechanism of tumor necrosis factor-α (TNF-α)-induced insulin resistance: Evidence for differential regulation of insulin signaling by TNF-α
33. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
34. Obesity: Common symptom of diverse gene based metabolic dysregulations. Potential role of TNF and lipoprotein lipase as candidate genes for obesity
35. Medium- and long-chain fatty acids differentially modulate Interleukin-8 secretion in human fetal intestinal epithelial cells