Brain stem is a direct target for leptin's action in the central nervous system

Endocrinology

Volumn 143, Issue 9, 2002, Pages 3498-3504

  Hosoi, Toru ^a   Kawagishi, Toru ^a   Okuma, Yasunobu ^a   Tanaka, Jun ^a   Nomura, Yasuyuki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LEPTIN; LEPTIN RECEPTOR; STAT PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BODY WEIGHT; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MOUSE; NEGATIVE FEEDBACK; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SATIETY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN STEM; CARRIER PROTEINS; DNA-BINDING PROTEINS; FEEDBACK; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LEPTIN; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0036720939     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220077     Document Type: Article

References (48)

1. Positional cloning of the mouse obese gene and its human homologue
2. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
3. Effects of the obese gene product on body weight regulation in ob/ob mice
4. Leptin enters the brain by a saturable system independent of insulin
5. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
6. Identification and expression cloning of a leptin receptor, OB-R
7. Defective STAT signaling by the leptin receptor in diabetic mice
8. Abnormal splicing of the leptin receptor in diabetic mice
9. Divergent signaling capacities of the long and short isoforms of the leptin receptor
10. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
11. Leptin signaling in the hypothalamus of normal rats in vivo
12. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
13. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
14. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain
15. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
16. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain
17. Leptin activates neurons in ventrobasal hypothalamus and brainstem
18. Leptin activation in hypothalamus
19. Two types of leptin-responsive gastric vagal afferent terminals: An in vitro single-unit study in rats
20. Peripheral gastric leptin modulates brain stem neuronal activity in neonates
21. A new protein containing an SH2 domain that inhibits JAK kinases
22. Structure and function of a new STAT-induced STAT inhibitor
23. A family of cytokine-inducible inhibitors of signalling
24. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
25. Activation of downstream signals by the long form of the leptin receptor
26. Identification of SOCS-3 as a potential mediator of central leptin resistance
27. The role of SOCS-3 in leptin signaling and leptin resistance
28. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
29. Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby canine kidney cells
30. Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat
31. Distributions of leptin receptor mRNA isoforms in the rat brain
32. The stomach is a source of leptin
33. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice
34. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat
35. Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism
36. Electrical stimulation of afferent vagus nerve induces IL-1β expression in the brain and activates HPA axis
37. Cytokine-to-brain communication: A review, analysis of alternative mechanisms
38. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve
39. Central autonomic system
40. Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: Possible substrate for autonomic regulation of feeding
41. Pro-opiomelanocortin-derived peptides (ACTH/β3-endorphin/α-MSH) in brainstem baroreceptor areas of the rat
42. Melanin-concentrating hormone: A functional melanocortin antagonist in the hypothalamus
43. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
44. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
45. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
46. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats
47. Leptin injected into the fourth ventricle inhibits gastric emptying
48. Chemical characterization of leptin-activated neurons in the rat brain