-
1
-
-
24344437295
-
Prospects and challenges of developing new agents for tough Gram-negatives
-
Meyer AL. Prospects and challenges of developing new agents for tough Gram-negatives. Curr. Opin. Pharmacol 5(5), 490-494 (2005).
-
(2005)
Curr. Opin. Pharmacol
, vol.5
, Issue.5
, pp. 490-494
-
-
Meyer, A.L.1
-
2
-
-
23844534048
-
Drug discovery and beyond: The role of public-private partnerships in improving access to new malaria medicines
-
Nwaka S. Drug discovery and beyond: the role of public-private partnerships in improving access to new malaria medicines. Trans. R Soc. Trop. Med. Hyg. 99(Suppl. 1), S20-S29 (2005).
-
(2005)
Trans. R Soc. Trop. Med. Hyg.
, vol.99
, Issue.SUPPL. 1
-
-
Nwaka, S.1
-
3
-
-
23044504046
-
How many genomics targets can a portfolio afford?
-
Betz UA. How many genomics targets can a portfolio afford? Drug Discov. Today 10(15), 1057-1063 (2005).
-
(2005)
Drug Discov. Today
, vol.10
, Issue.15
, pp. 1057-1063
-
-
Betz, U.A.1
-
5
-
-
21444453119
-
High-throughput screening-driven lead discovery: Meeting the challenges of finding new therapeutics
-
Posner BA. High-throughput screening-driven lead discovery: meeting the challenges of finding new therapeutics. Curr. Opin. Drug Discov. Devel. 8(4), 487-494 (2005).
-
(2005)
Curr. Opin. Drug Discov. Devel.
, vol.8
, Issue.4
, pp. 487-494
-
-
Posner, B.A.1
-
6
-
-
20944433525
-
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
-
Ganter B, Tugendreich S, Pearson CI et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 119(3), 219-244 (2005).
-
(2005)
J Biotechnol
, vol.119
, Issue.3
, pp. 219-244
-
-
Ganter, B.1
Tugendreich, S.2
Pearson, C.I.3
-
7
-
-
24044461406
-
RNAi versus small molecules: Different mechanisms and specificities can lead to different outcomes
-
Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr. Opin. Drug Discov. Devel. 8, 557-566 (2005). Timely review indicating the complementarity of the two approaches in abrogating protein function.
-
(2005)
Curr. Opin. Drug Discov. Devel.
, vol.8
, pp. 557-566
-
-
Fitzgerald, K.1
-
8
-
-
28544446014
-
How will RNAi facilitate drug development?
-
Bartz S, Jackson AL. How will RNAi facilitate drug development? Sci STKE 2005(295), pe39 (2005).
-
(2005)
Sci STKE
, vol.2005
, Issue.295
-
-
Bartz, S.1
Jackson, A.L.2
-
9
-
-
0028505040
-
Towards a pharmacological genetics
-
Mitchison TJ. Towards a pharmacological genetics. Chem. Biol. 1(1), 3-6 (1994). One of the first discussions on the concerted use of small molecules to probe protein function.
-
(1994)
Chem. Biol.
, vol.1
, Issue.1
, pp. 3-6
-
-
Mitchison, T.J.1
-
11
-
-
0038522853
-
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
-
Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10(5), 383-396 (2003).
-
(2003)
Chem. Biol.
, vol.10
, Issue.5
, pp. 383-396
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Butcher, R.A.4
Schreiber, S.L.5
-
12
-
-
0037562075
-
Chemical genetic modifier screens: Small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation
-
Koeller KM, Haggarty SJ, Perkins BD et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem. Biol. 10(5), 397-410 (2003).
-
(2003)
Chem. Biol.
, vol.10
, Issue.5
, pp. 397-410
-
-
Koeller, K.M.1
Haggarty, S.J.2
Perkins, B.D.3
-
13
-
-
26844477542
-
High-throughput kinase assays with protein substrates using fluorescent polymer superquenching
-
Rininsland F, Stankewicz C, Weatherford W, McBranch D. High-throughput kinase assays with protein substrates using fluorescent polymer superquenching. BMC Biotechnol 5(1), 16 (2005).
-
(2005)
BMC Biotechnol
, vol.5
, Issue.1
, pp. 16
-
-
Rininsland, F.1
Stankewicz, C.2
Weatherford, W.3
McBranch, D.4
-
14
-
-
20944442425
-
Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening
-
Toledo-Sherman L, Deretey E, Slon-Usakiewicz JJ et al. Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J. Med. Chem. 48(9), 3221-3230 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, Issue.9
, pp. 3221-3230
-
-
Toledo-Sherman, L.1
Deretey, E.2
Slon-Usakiewicz, J.J.3
-
15
-
-
17144373673
-
Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases
-
Hirai H, Kawanishi N, Iwasawa Y. Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases. Curr. Top. Med. Chem. 5(2), 167-179 (2005).
-
(2005)
Curr. Top. Med. Chem.
, vol.5
, Issue.2
, pp. 167-179
-
-
Hirai, H.1
Kawanishi, N.2
Iwasawa, Y.3
-
16
-
-
19944432425
-
Selective benzopyranone and pyrimido [2, 1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: Synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro
-
Griffin RJ, Fontana G, Golding BT et al. Selective benzopyranone and pyrimido [2, 1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. J. Med. Chem. 48(2), 569-585 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, Issue.2
, pp. 569-585
-
-
Griffin, R.J.1
Fontana, G.2
Golding, B.T.3
-
17
-
-
12144249613
-
Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening
-
Chuaqui C, Deng Z, Singh J. Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening. J. Med. Chem. 48(1), 121-133 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, Issue.1
, pp. 121-133
-
-
Chuaqui, C.1
Deng, Z.2
Singh, J.3
-
19
-
-
0029783934
-
Neighborhood behavior: A useful concept for validation of 'molecular diversity' descriptors
-
Patterson DE, Cramer RD, Ferguson AM, Clark RD, Weinberger LE. Neighborhood behavior: a useful concept for validation of 'molecular diversity' descriptors. J. Med. Chem. 39(16), 3049-3059 (1996).
-
(1996)
J. Med. Chem.
, vol.39
, Issue.16
, pp. 3049-3059
-
-
Patterson, D.E.1
Cramer, R.D.2
Ferguson, A.M.3
Clark, R.D.4
Weinberger, L.E.5
-
20
-
-
11144311139
-
Lessons from natural molecules
-
Clardy J, Walsh C. Lessons from natural molecules. Nature 432(7019), 829-837 (2004).
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 829-837
-
-
Clardy, J.1
Walsh, C.2
-
21
-
-
0029739680
-
Natural products as a resource for new drugs
-
Clark AM. Natural products as a resource for new drugs. Pharm. Res. 13(8), 1133-1144 (1996).
-
(1996)
Pharm. Res.
, vol.13
, Issue.8
, pp. 1133-1144
-
-
Clark, A.M.1
-
22
-
-
2942565810
-
Natural products and combinatorial chemistry: Back to the future
-
Ortholand JY, Ganesan A. Natural products and combinatorial chemistry: back to the future. Curr. Opin. Chem. Biol. 8(3), 271-280 (2004).
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, Issue.3
, pp. 271-280
-
-
Ortholand, J.Y.1
Ganesan, A.2
-
23
-
-
0034697139
-
Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries
-
Ye XS, Wong CH. Anomeric reactivity-based one-pot oligosaccharide synthesis: a rapid route to oligosaccharide libraries. J Org. Chem. 65(8), 2410-2431 (2000).
-
(2000)
J Org. Chem.
, vol.65
, Issue.8
, pp. 2410-2431
-
-
Ye, X.S.1
Wong, C.H.2
-
24
-
-
0000803894
-
-
Wolff ME (Ed.), John Wiley & Sons, NY, USA
-
Sweetnam PM, Price CH, Ferkany JW. Burger's Medicinal Chemistry and Drug Discovery. Principles and Practice. VoL 1. Wolff ME (Ed.), John Wiley & Sons, NY, USA 349-397 (1995).
-
(1995)
Burger's Medicinal Chemistry and Drug Discovery. Principles and Practice. VoL 1
, vol.1
, pp. 349-397
-
-
Sweetnam, P.M.1
Price, C.H.2
Ferkany, J.W.3
-
25
-
-
0002790087
-
Trends in development of high-throughput screening technologies for rapid discovery of novel drugs
-
Hill DC. Trends in development of high-throughput screening technologies for rapid discovery of novel drugs. Curr. Opin. Drug Discov. Devel. 1(1), 92-97 (1998).
-
(1998)
Curr. Opin. Drug Discov. Devel.
, vol.1
, Issue.1
, pp. 92-97
-
-
Hill, D.C.1
-
26
-
-
0032895673
-
Affinity chromatography: A review of clinical applications
-
Hage DS. Affinity chromatography: a review of clinical applications. Clin. Chem. 45(5), 593-615 (1999).
-
(1999)
Clin. Chem.
, vol.45
, Issue.5
, pp. 593-615
-
-
Hage, D.S.1
-
27
-
-
3242689995
-
Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery
-
Lewis LM, Engle LJ, Pierceall WE, Hughes DE, Shaw K. Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery. Methods Mol. Biol. 261, 187-198 (2004).
-
(2004)
Methods Mol. Biol.
, vol.261
, pp. 187-198
-
-
Lewis, L.M.1
Engle, L.J.2
Pierceall, W.E.3
Hughes, D.E.4
Shaw, K.5
-
29
-
-
0029831026
-
Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection
-
Kelly MA, Liang H, Sytwu II et al. Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection. Biochemistry 35(36), 11747-11755 (1996).
-
(1996)
Biochemistry
, vol.35
, Issue.36
, pp. 11747-11755
-
-
Kelly, M.A.1
Liang, H.2
Sytwu, I.I.3
-
30
-
-
0034710882
-
Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
-
Cancilla MT, Leavell MD, Chow J, Leary JA. Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries. Proc. Natl Acad. Sci. USA 97(22), 12008-12013 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, Issue.22
, pp. 12008-12013
-
-
Cancilla, M.T.1
Leavell, M.D.2
Chow, J.3
Leary, J.A.4
-
31
-
-
18344396306
-
Biochemical applications of mass spectrometry in pharmaceutical drug discovery
-
Geoghegan KF, Kelly MA. Biochemical applications of mass spectrometry in pharmaceutical drug discovery. Mass Spectrom. Rev. 24(3), 347-366 (2005).
-
(2005)
Mass Spectrom. Rev.
, vol.24
, Issue.3
, pp. 347-366
-
-
Geoghegan, K.F.1
Kelly, M.A.2
-
32
-
-
0001903886
-
Early discovery drug screening using mass spectrometry
-
Siegel MM. Early discovery drug screening using mass spectrometry. Curr. Top. Med. Chem. 2(1), 13-33 (2002).
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, Issue.1
, pp. 13-33
-
-
Siegel, M.M.1
-
33
-
-
0038771153
-
Surface plasmon resonance mass spectrometry: Recent progress and outlooks
-
Nedelkov D, Nelson RW. Surface plasmon resonance mass spectrometry: recent progress and outlooks. Trends Biotechnol. 21(7), 301-305 (2003).
-
(2003)
Trends Biotechnol.
, vol.21
, Issue.7
, pp. 301-305
-
-
Nedelkov, D.1
Nelson, R.W.2
-
34
-
-
0035605455
-
Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry
-
Sünksen CP, Markgren P-O, Danielson UH, Hämäläinen MD, Jansson O, Roepstorff E. Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry. Eur. J. Mass Spectrom. 7, 385-391 (2001).
-
(2001)
Eur. J. Mass Spectrom.
, vol.7
, pp. 385-391
-
-
Sünksen, C.P.1
Markgren, P.-O.2
Danielson, U.H.3
Hämäläinen, M.D.4
Jansson, O.5
Roepstorff, E.6
-
35
-
-
0035298739
-
Chromatographic immunoassays
-
Hage DS, Nelson MA. Chromatographic immunoassays. Anal. Chem. 73(7), 199A-205A (2001).
-
(2001)
Anal. Chem.
, vol.73
, Issue.7
-
-
Hage, D.S.1
Nelson, M.A.2
-
36
-
-
0037106506
-
Displacement and nonlinear Chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized α3β4 nicotinic acetylcholine receptor liquid Chromatographic stationary phase
-
Jozwiak K, Haginaka J, Moaddel R, Wainer IW. Displacement and nonlinear Chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized α3β4 nicotinic acetylcholine receptor liquid Chromatographic stationary phase. Anal. Chem. 74(18), 4618-4624 (2002).
-
(2002)
Anal. Chem.
, vol.74
, Issue.18
, pp. 4618-4624
-
-
Jozwiak, K.1
Haginaka, J.2
Moaddel, R.3
Wainer, I.W.4
-
37
-
-
0035170479
-
Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid Chromatographic stationary phase
-
Lu L, Leonessa F, Clarke R, Wainer IW. Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid Chromatographic stationary phase. Mol. Pharmacol. 59(1), 62-68 (2001).
-
(2001)
Mol. Pharmacol.
, vol.59
, Issue.1
, pp. 62-68
-
-
Lu, L.1
Leonessa, F.2
Clarke, R.3
Wainer, I.W.4
-
38
-
-
0037437704
-
Immobilized nicotinic receptor stationary phases: Going with the flow in high-throughput screening and pharmacological studies
-
Moaddel R, Wainer IW. Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies. J. Pharm. Biomed. Anal. 30(6), 1715-1724 (2003).
-
(2003)
J. Pharm. Biomed. Anal.
, vol.30
, Issue.6
, pp. 1715-1724
-
-
Moaddel, R.1
Wainer, I.W.2
-
39
-
-
13244289976
-
Conformational mobility of immobilized α3β2, α3β4, α4β2, and α4β4 nicotinic acetylcholine receptors
-
Moaddel R, Jozwiak K, Whittington K, Wainer IW. Conformational mobility of immobilized α3β2, α3β4, α4β2, and α4β4 nicotinic acetylcholine receptors. Anal. Chem. 77(3), 895-901 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.3
, pp. 895-901
-
-
Moaddel, R.1
Jozwiak, K.2
Whittington, K.3
Wainer, I.W.4
-
40
-
-
0036147555
-
Multiple receptor liquid Chromatographic stationary phases: The co-immobilization of nicotinic receptors, γ-amino-butyric acid receptors, and N-methyl D-aspartate receptors
-
Moaddel R, Cloix JF, Ertem G, Wainer IW. Multiple receptor liquid Chromatographic stationary phases: the co-immobilization of nicotinic receptors, γ-amino-butyric acid receptors, and N-methyl D-aspartate receptors. Pharma. Res. 19(1), 104-107 (2002). Seminal paper demonstrating that multiple proteins present in membrane preparation can be introduced and interrogated in a Chromatographic assay.
-
(2002)
Pharma. Res.
, vol.19
, Issue.1
, pp. 104-107
-
-
Moaddel, R.1
Cloix, J.F.2
Ertem, G.3
Wainer, I.W.4
-
41
-
-
53249119425
-
Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries
-
Kaur S, McGuire L, Tang D, Dollinger G, Huebner V. Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries. J. Protein Chem. 16(5), 505-511 (1997).
-
(1997)
J. Protein Chem.
, vol.16
, Issue.5
, pp. 505-511
-
-
Kaur, S.1
McGuire, L.2
Tang, D.3
Dollinger, G.4
Huebner, V.5
-
42
-
-
0032503030
-
Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases
-
Huyer G, Kelly J, Moffat J et al. Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases. Anal. Biochem. 258(1), 19-30 (1998).
-
(1998)
Anal. Biochem.
, vol.258
, Issue.1
, pp. 19-30
-
-
Huyer, G.1
Kelly, J.2
Moffat, J.3
-
43
-
-
9644302954
-
A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures
-
Annis DA, Nazef N, Chuang CC, Scott MP, Nash HM. A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures. J. Am. Chem. Soc. 126(47), 15495-15503 (2004). Thorough treatment of size-exclusion chromatography for characterizing protein-small-molecule interactions.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, Issue.47
, pp. 15495-15503
-
-
Annis, D.A.1
Nazef, N.2
Chuang, C.C.3
Scott, M.P.4
Nash, H.M.5
-
44
-
-
8444221197
-
An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries. Discovery of a novel antagonist of E. coli dihydrofolate reductase
-
Annis DA, Athanasopoulos J, Curran PJ et al. An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries. Discovery of a novel antagonist of E. coli dihydrofolate reductase. Int. J. Mass Spectrom. 238, 77-83 (2004).
-
(2004)
Int. J. Mass Spectrom.
, vol.238
, pp. 77-83
-
-
Annis, D.A.1
Athanasopoulos, J.2
Curran, P.J.3
-
45
-
-
0022467156
-
Frontal affinity chromatography: Theory for its application to studies on specific interaction of biomolecules
-
Kasai K, Oda YJ. Frontal affinity chromatography: theory for its application to studies on specific interaction of biomolecules. J Chromatogr. 376, 33-47 (1986).
-
(1986)
J Chromatogr.
, vol.376
, pp. 33-47
-
-
Kasai, K.1
Oda, Y.J.2
-
46
-
-
0033521531
-
Micro-scale frontal affinity chromatography with mass spectrometric detection: A new method for the screening of compound libraries
-
Schriemer DC, Yalcin T, Li L. Micro-scale frontal affinity chromatography with mass spectrometric detection: a new method for the screening of compound libraries. Angew Chem. Int. Ed. 37(24), 3387-3388 (1998).
-
(1998)
Angew Chem. Int. Ed.
, vol.37
, Issue.24
, pp. 3387-3388
-
-
Schriemer, D.C.1
Yalcin, T.2
Li, L.3
-
47
-
-
10044275162
-
Biosensor alternative: Frontal affinity chromatography
-
Schriemer DC. Biosensor alternative: frontal affinity chromatography. Anal, Chem. 76(23), 440A-448A (2004).
-
(2004)
Anal, Chem.
, vol.76
, Issue.23
-
-
Schriemer, D.C.1
-
48
-
-
0038353368
-
Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: Applications of a Chromatographic biosensor
-
Chan NW, Lewis DF, Rosner PJ, Kelly MA, Schriemer DC. Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a Chromatographic biosensor. Anal. Biochem. 319(1), 1-12(2003). Presentation of frontal affinity chromatography (FAC) methods for characterizing molecular interactions and screening activities.
-
(2003)
Anal. Biochem.
, vol.319
, Issue.1
, pp. 1-12
-
-
Chan, N.W.1
Lewis, D.F.2
Rosner, P.J.3
Kelly, M.A.4
Schriemer, D.C.5
-
49
-
-
0036346862
-
Frontal affinity chromatography for the screening of mixtures
-
Chan NW, Lewis DF, Hewko S, Hindsgaul O, Schriemer DC. Frontal affinity chromatography for the screening of mixtures. Comb. Chem. High Throughput Screen. 5(5), 395-406 (2002).
-
(2002)
Comb. Chem. High Throughput Screen.
, vol.5
, Issue.5
, pp. 395-406
-
-
Chan, N.W.1
Lewis, D.F.2
Hewko, S.3
Hindsgaul, O.4
Schriemer, D.C.5
-
50
-
-
14744272646
-
Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery
-
Slon-Usakiewicz JJ, Dai JR, Ng W et al Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery. Anal. Chem. 77(5), 1268-1274 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.5
, pp. 1268-1274
-
-
Slon-Usakiewicz, J.J.1
Dai, J.R.2
Ng, W.3
-
51
-
-
0036256850
-
The role of intraparticle convection in protein adsorption by liquid chromatography using POROS 20 HQ/M particles
-
Leitao A, Li M, Rodrigues A. The role of intraparticle convection in protein adsorption by liquid chromatography using POROS 20 HQ/M particles. Biochem. Eng. J. 11, 33-48 (2002).
-
(2002)
Biochem. Eng. J.
, vol.11
, pp. 33-48
-
-
Leitao, A.1
Li, M.2
Rodrigues, A.3
-
53
-
-
0036164684
-
Estimation of drug-protein binding parameters on assuming the validity of thermodynamic equilibrium
-
Soltes L, Mach M. Estimation of drug-protein binding parameters on assuming the validity of thermodynamic equilibrium. J. Chromatogr. 5768, 113-119(2002).
-
(2002)
J. Chromatogr.
, vol.5768
, pp. 113-119
-
-
Soltes, L.1
Mach, M.2
-
54
-
-
8344226902
-
Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography
-
Chen J, Hage DS. Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography. Nature Biotechnol. 22(11), 1445-1448 (2004).
-
(2004)
Nature Biotechnol.
, vol.22
, Issue.11
, pp. 1445-1448
-
-
Chen, J.1
Hage, D.S.2
-
55
-
-
0031297758
-
Effects of ligand heterogeneity in the characterization of affinity columns by frontal analysis
-
Tweed SA, Loun B, Hage DS. Effects of ligand heterogeneity in the characterization of affinity columns by frontal analysis. Anal. Chem. 69(23), 4790-4798 (1997).
-
(1997)
Anal. Chem.
, vol.69
, Issue.23
, pp. 4790-4798
-
-
Tweed, S.A.1
Loun, B.2
Hage, D.S.3
-
56
-
-
15944412467
-
Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery
-
Slon-Usakiewicz JJ, Ng W, Dai JR, Pasternak A, Redden PR. Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery. Drug Discov. Today 10(6), 409-416 (2005).
-
(2005)
Drug Discov. Today
, vol.10
, Issue.6
, pp. 409-416
-
-
Slon-Usakiewicz, J.J.1
Ng, W.2
Dai, J.R.3
Pasternak, A.4
Redden, P.R.5
-
57
-
-
0033952576
-
Chromatography on cells: Analyses of solute interactions with the glucose transporter Glut1 in human red cells adsorbed on lectin-gel beads
-
Gottschalk I, Li YM, Lundahl P. Chromatography on cells: analyses of solute interactions with the glucose transporter Glut1 in human red cells adsorbed on lectin-gel beads. J. Chromatogr. B Biomed. Sci. Appl. 739(1), 55-62 (2000).
-
(2000)
J. Chromatogr. B Biomed. Sci. Appl.
, vol.739
, Issue.1
, pp. 55-62
-
-
Gottschalk, I.1
Li, Y.M.2
Lundahl, P.3
-
58
-
-
2442701784
-
Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: Applications to frontal affinity chromatography
-
Hodgson RJ, Chen Y, Zhang Z et al. Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography. Anal. Chem. 76(10), 2780-2790 (2004). First application of protein entrapment to the preparation of small-scale FAC assays. Enables homogeneous assays.
-
(2004)
Anal. Chem.
, vol.76
, Issue.10
, pp. 2780-2790
-
-
Hodgson, R.J.1
Chen, Y.2
Zhang, Z.3
-
59
-
-
18844365068
-
Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns
-
Kovarik P, Hodgson RJ, Covey T, Brook MA, Brennan JD. Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns. Anal. Chem. 77(10), 3340-3350 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.10
, pp. 3340-3350
-
-
Kovarik, P.1
Hodgson, R.J.2
Covey, T.3
Brook, M.A.4
Brennan, J.D.5
-
60
-
-
26444610191
-
High throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry
-
Ng ES, Yang F, Kameyama A, Palcic MM, Hindsgaul O, Schriemer DC. High throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry. Anal. Chem. 77(19), 6125-6133 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.19
, pp. 6125-6133
-
-
Ng, E.S.1
Yang, F.2
Kameyama, A.3
Palcic, M.M.4
Hindsgaul, O.5
Schriemer, D.C.6
-
61
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nature Rev. Drug Discov. 4(3), 206-220 (2005).
-
(2005)
Nature Rev. Drug Discov.
, vol.4
, Issue.3
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
62
-
-
22044441118
-
Fragment-based lead discovery: Leads by design
-
Carr RA, Congreve M, Murray CW, Rees DC. Fragment-based lead discovery: leads by design. Drug Discov. Today 10(14), 987-992 (2005).
-
(2005)
Drug Discov. Today
, vol.10
, Issue.14
, pp. 987-992
-
-
Carr, R.A.1
Congreve, M.2
Murray, C.W.3
Rees, D.C.4
|