메뉴 건너뛰기




Volumn 2, Issue 6, 2005, Pages 891-900

Emerging challenges in ligand discovery: New opportunities for Chromatographic assay

Author keywords

Affinity chromatography; Drug discovery; High throughput screening; Interaction analysis; Ligand discovery; Mass spectrometry

Indexed keywords

AFFINITY CHROMATOGRAPHY; EXTRACTION; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR PROBE; PROTEOMICS; REVIEW; STANDARDIZATION;

EID: 28544435359     PISSN: 14789450     EISSN: 17448387     Source Type: Journal    
DOI: 10.1586/14789450.2.6.891     Document Type: Review
Times cited : (7)

References (62)
  • 1
    • 24344437295 scopus 로고    scopus 로고
    • Prospects and challenges of developing new agents for tough Gram-negatives
    • Meyer AL. Prospects and challenges of developing new agents for tough Gram-negatives. Curr. Opin. Pharmacol 5(5), 490-494 (2005).
    • (2005) Curr. Opin. Pharmacol , vol.5 , Issue.5 , pp. 490-494
    • Meyer, A.L.1
  • 2
    • 23844534048 scopus 로고    scopus 로고
    • Drug discovery and beyond: The role of public-private partnerships in improving access to new malaria medicines
    • Nwaka S. Drug discovery and beyond: the role of public-private partnerships in improving access to new malaria medicines. Trans. R Soc. Trop. Med. Hyg. 99(Suppl. 1), S20-S29 (2005).
    • (2005) Trans. R Soc. Trop. Med. Hyg. , vol.99 , Issue.SUPPL. 1
    • Nwaka, S.1
  • 3
    • 23044504046 scopus 로고    scopus 로고
    • How many genomics targets can a portfolio afford?
    • Betz UA. How many genomics targets can a portfolio afford? Drug Discov. Today 10(15), 1057-1063 (2005).
    • (2005) Drug Discov. Today , vol.10 , Issue.15 , pp. 1057-1063
    • Betz, U.A.1
  • 5
    • 21444453119 scopus 로고    scopus 로고
    • High-throughput screening-driven lead discovery: Meeting the challenges of finding new therapeutics
    • Posner BA. High-throughput screening-driven lead discovery: meeting the challenges of finding new therapeutics. Curr. Opin. Drug Discov. Devel. 8(4), 487-494 (2005).
    • (2005) Curr. Opin. Drug Discov. Devel. , vol.8 , Issue.4 , pp. 487-494
    • Posner, B.A.1
  • 6
    • 20944433525 scopus 로고    scopus 로고
    • Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
    • Ganter B, Tugendreich S, Pearson CI et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 119(3), 219-244 (2005).
    • (2005) J Biotechnol , vol.119 , Issue.3 , pp. 219-244
    • Ganter, B.1    Tugendreich, S.2    Pearson, C.I.3
  • 7
    • 24044461406 scopus 로고    scopus 로고
    • RNAi versus small molecules: Different mechanisms and specificities can lead to different outcomes
    • Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr. Opin. Drug Discov. Devel. 8, 557-566 (2005). Timely review indicating the complementarity of the two approaches in abrogating protein function.
    • (2005) Curr. Opin. Drug Discov. Devel. , vol.8 , pp. 557-566
    • Fitzgerald, K.1
  • 8
    • 28544446014 scopus 로고    scopus 로고
    • How will RNAi facilitate drug development?
    • Bartz S, Jackson AL. How will RNAi facilitate drug development? Sci STKE 2005(295), pe39 (2005).
    • (2005) Sci STKE , vol.2005 , Issue.295
    • Bartz, S.1    Jackson, A.L.2
  • 9
    • 0028505040 scopus 로고
    • Towards a pharmacological genetics
    • Mitchison TJ. Towards a pharmacological genetics. Chem. Biol. 1(1), 3-6 (1994). One of the first discussions on the concerted use of small molecules to probe protein function.
    • (1994) Chem. Biol. , vol.1 , Issue.1 , pp. 3-6
    • Mitchison, T.J.1
  • 11
    • 0038522853 scopus 로고    scopus 로고
    • Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
    • Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10(5), 383-396 (2003).
    • (2003) Chem. Biol. , vol.10 , Issue.5 , pp. 383-396
    • Haggarty, S.J.1    Koeller, K.M.2    Wong, J.C.3    Butcher, R.A.4    Schreiber, S.L.5
  • 12
    • 0037562075 scopus 로고    scopus 로고
    • Chemical genetic modifier screens: Small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation
    • Koeller KM, Haggarty SJ, Perkins BD et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem. Biol. 10(5), 397-410 (2003).
    • (2003) Chem. Biol. , vol.10 , Issue.5 , pp. 397-410
    • Koeller, K.M.1    Haggarty, S.J.2    Perkins, B.D.3
  • 13
    • 26844477542 scopus 로고    scopus 로고
    • High-throughput kinase assays with protein substrates using fluorescent polymer superquenching
    • Rininsland F, Stankewicz C, Weatherford W, McBranch D. High-throughput kinase assays with protein substrates using fluorescent polymer superquenching. BMC Biotechnol 5(1), 16 (2005).
    • (2005) BMC Biotechnol , vol.5 , Issue.1 , pp. 16
    • Rininsland, F.1    Stankewicz, C.2    Weatherford, W.3    McBranch, D.4
  • 14
    • 20944442425 scopus 로고    scopus 로고
    • Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening
    • Toledo-Sherman L, Deretey E, Slon-Usakiewicz JJ et al. Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J. Med. Chem. 48(9), 3221-3230 (2005).
    • (2005) J. Med. Chem. , vol.48 , Issue.9 , pp. 3221-3230
    • Toledo-Sherman, L.1    Deretey, E.2    Slon-Usakiewicz, J.J.3
  • 15
    • 17144373673 scopus 로고    scopus 로고
    • Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases
    • Hirai H, Kawanishi N, Iwasawa Y. Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases. Curr. Top. Med. Chem. 5(2), 167-179 (2005).
    • (2005) Curr. Top. Med. Chem. , vol.5 , Issue.2 , pp. 167-179
    • Hirai, H.1    Kawanishi, N.2    Iwasawa, Y.3
  • 16
    • 19944432425 scopus 로고    scopus 로고
    • Selective benzopyranone and pyrimido [2, 1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: Synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro
    • Griffin RJ, Fontana G, Golding BT et al. Selective benzopyranone and pyrimido [2, 1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. J. Med. Chem. 48(2), 569-585 (2005).
    • (2005) J. Med. Chem. , vol.48 , Issue.2 , pp. 569-585
    • Griffin, R.J.1    Fontana, G.2    Golding, B.T.3
  • 17
    • 12144249613 scopus 로고    scopus 로고
    • Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening
    • Chuaqui C, Deng Z, Singh J. Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening. J. Med. Chem. 48(1), 121-133 (2005).
    • (2005) J. Med. Chem. , vol.48 , Issue.1 , pp. 121-133
    • Chuaqui, C.1    Deng, Z.2    Singh, J.3
  • 19
    • 0029783934 scopus 로고    scopus 로고
    • Neighborhood behavior: A useful concept for validation of 'molecular diversity' descriptors
    • Patterson DE, Cramer RD, Ferguson AM, Clark RD, Weinberger LE. Neighborhood behavior: a useful concept for validation of 'molecular diversity' descriptors. J. Med. Chem. 39(16), 3049-3059 (1996).
    • (1996) J. Med. Chem. , vol.39 , Issue.16 , pp. 3049-3059
    • Patterson, D.E.1    Cramer, R.D.2    Ferguson, A.M.3    Clark, R.D.4    Weinberger, L.E.5
  • 20
    • 11144311139 scopus 로고    scopus 로고
    • Lessons from natural molecules
    • Clardy J, Walsh C. Lessons from natural molecules. Nature 432(7019), 829-837 (2004).
    • (2004) Nature , vol.432 , Issue.7019 , pp. 829-837
    • Clardy, J.1    Walsh, C.2
  • 21
    • 0029739680 scopus 로고    scopus 로고
    • Natural products as a resource for new drugs
    • Clark AM. Natural products as a resource for new drugs. Pharm. Res. 13(8), 1133-1144 (1996).
    • (1996) Pharm. Res. , vol.13 , Issue.8 , pp. 1133-1144
    • Clark, A.M.1
  • 22
    • 2942565810 scopus 로고    scopus 로고
    • Natural products and combinatorial chemistry: Back to the future
    • Ortholand JY, Ganesan A. Natural products and combinatorial chemistry: back to the future. Curr. Opin. Chem. Biol. 8(3), 271-280 (2004).
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , Issue.3 , pp. 271-280
    • Ortholand, J.Y.1    Ganesan, A.2
  • 23
    • 0034697139 scopus 로고    scopus 로고
    • Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries
    • Ye XS, Wong CH. Anomeric reactivity-based one-pot oligosaccharide synthesis: a rapid route to oligosaccharide libraries. J Org. Chem. 65(8), 2410-2431 (2000).
    • (2000) J Org. Chem. , vol.65 , Issue.8 , pp. 2410-2431
    • Ye, X.S.1    Wong, C.H.2
  • 25
    • 0002790087 scopus 로고    scopus 로고
    • Trends in development of high-throughput screening technologies for rapid discovery of novel drugs
    • Hill DC. Trends in development of high-throughput screening technologies for rapid discovery of novel drugs. Curr. Opin. Drug Discov. Devel. 1(1), 92-97 (1998).
    • (1998) Curr. Opin. Drug Discov. Devel. , vol.1 , Issue.1 , pp. 92-97
    • Hill, D.C.1
  • 26
    • 0032895673 scopus 로고    scopus 로고
    • Affinity chromatography: A review of clinical applications
    • Hage DS. Affinity chromatography: a review of clinical applications. Clin. Chem. 45(5), 593-615 (1999).
    • (1999) Clin. Chem. , vol.45 , Issue.5 , pp. 593-615
    • Hage, D.S.1
  • 27
    • 3242689995 scopus 로고    scopus 로고
    • Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery
    • Lewis LM, Engle LJ, Pierceall WE, Hughes DE, Shaw K. Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery. Methods Mol. Biol. 261, 187-198 (2004).
    • (2004) Methods Mol. Biol. , vol.261 , pp. 187-198
    • Lewis, L.M.1    Engle, L.J.2    Pierceall, W.E.3    Hughes, D.E.4    Shaw, K.5
  • 29
    • 0029831026 scopus 로고    scopus 로고
    • Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection
    • Kelly MA, Liang H, Sytwu II et al. Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection. Biochemistry 35(36), 11747-11755 (1996).
    • (1996) Biochemistry , vol.35 , Issue.36 , pp. 11747-11755
    • Kelly, M.A.1    Liang, H.2    Sytwu, I.I.3
  • 30
    • 0034710882 scopus 로고    scopus 로고
    • Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
    • Cancilla MT, Leavell MD, Chow J, Leary JA. Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries. Proc. Natl Acad. Sci. USA 97(22), 12008-12013 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.22 , pp. 12008-12013
    • Cancilla, M.T.1    Leavell, M.D.2    Chow, J.3    Leary, J.A.4
  • 31
    • 18344396306 scopus 로고    scopus 로고
    • Biochemical applications of mass spectrometry in pharmaceutical drug discovery
    • Geoghegan KF, Kelly MA. Biochemical applications of mass spectrometry in pharmaceutical drug discovery. Mass Spectrom. Rev. 24(3), 347-366 (2005).
    • (2005) Mass Spectrom. Rev. , vol.24 , Issue.3 , pp. 347-366
    • Geoghegan, K.F.1    Kelly, M.A.2
  • 32
    • 0001903886 scopus 로고    scopus 로고
    • Early discovery drug screening using mass spectrometry
    • Siegel MM. Early discovery drug screening using mass spectrometry. Curr. Top. Med. Chem. 2(1), 13-33 (2002).
    • (2002) Curr. Top. Med. Chem. , vol.2 , Issue.1 , pp. 13-33
    • Siegel, M.M.1
  • 33
    • 0038771153 scopus 로고    scopus 로고
    • Surface plasmon resonance mass spectrometry: Recent progress and outlooks
    • Nedelkov D, Nelson RW. Surface plasmon resonance mass spectrometry: recent progress and outlooks. Trends Biotechnol. 21(7), 301-305 (2003).
    • (2003) Trends Biotechnol. , vol.21 , Issue.7 , pp. 301-305
    • Nedelkov, D.1    Nelson, R.W.2
  • 35
    • 0035298739 scopus 로고    scopus 로고
    • Chromatographic immunoassays
    • Hage DS, Nelson MA. Chromatographic immunoassays. Anal. Chem. 73(7), 199A-205A (2001).
    • (2001) Anal. Chem. , vol.73 , Issue.7
    • Hage, D.S.1    Nelson, M.A.2
  • 36
    • 0037106506 scopus 로고    scopus 로고
    • Displacement and nonlinear Chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized α3β4 nicotinic acetylcholine receptor liquid Chromatographic stationary phase
    • Jozwiak K, Haginaka J, Moaddel R, Wainer IW. Displacement and nonlinear Chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized α3β4 nicotinic acetylcholine receptor liquid Chromatographic stationary phase. Anal. Chem. 74(18), 4618-4624 (2002).
    • (2002) Anal. Chem. , vol.74 , Issue.18 , pp. 4618-4624
    • Jozwiak, K.1    Haginaka, J.2    Moaddel, R.3    Wainer, I.W.4
  • 37
    • 0035170479 scopus 로고    scopus 로고
    • Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid Chromatographic stationary phase
    • Lu L, Leonessa F, Clarke R, Wainer IW. Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid Chromatographic stationary phase. Mol. Pharmacol. 59(1), 62-68 (2001).
    • (2001) Mol. Pharmacol. , vol.59 , Issue.1 , pp. 62-68
    • Lu, L.1    Leonessa, F.2    Clarke, R.3    Wainer, I.W.4
  • 38
    • 0037437704 scopus 로고    scopus 로고
    • Immobilized nicotinic receptor stationary phases: Going with the flow in high-throughput screening and pharmacological studies
    • Moaddel R, Wainer IW. Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies. J. Pharm. Biomed. Anal. 30(6), 1715-1724 (2003).
    • (2003) J. Pharm. Biomed. Anal. , vol.30 , Issue.6 , pp. 1715-1724
    • Moaddel, R.1    Wainer, I.W.2
  • 39
    • 13244289976 scopus 로고    scopus 로고
    • Conformational mobility of immobilized α3β2, α3β4, α4β2, and α4β4 nicotinic acetylcholine receptors
    • Moaddel R, Jozwiak K, Whittington K, Wainer IW. Conformational mobility of immobilized α3β2, α3β4, α4β2, and α4β4 nicotinic acetylcholine receptors. Anal. Chem. 77(3), 895-901 (2005).
    • (2005) Anal. Chem. , vol.77 , Issue.3 , pp. 895-901
    • Moaddel, R.1    Jozwiak, K.2    Whittington, K.3    Wainer, I.W.4
  • 40
    • 0036147555 scopus 로고    scopus 로고
    • Multiple receptor liquid Chromatographic stationary phases: The co-immobilization of nicotinic receptors, γ-amino-butyric acid receptors, and N-methyl D-aspartate receptors
    • Moaddel R, Cloix JF, Ertem G, Wainer IW. Multiple receptor liquid Chromatographic stationary phases: the co-immobilization of nicotinic receptors, γ-amino-butyric acid receptors, and N-methyl D-aspartate receptors. Pharma. Res. 19(1), 104-107 (2002). Seminal paper demonstrating that multiple proteins present in membrane preparation can be introduced and interrogated in a Chromatographic assay.
    • (2002) Pharma. Res. , vol.19 , Issue.1 , pp. 104-107
    • Moaddel, R.1    Cloix, J.F.2    Ertem, G.3    Wainer, I.W.4
  • 41
    • 53249119425 scopus 로고    scopus 로고
    • Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries
    • Kaur S, McGuire L, Tang D, Dollinger G, Huebner V. Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries. J. Protein Chem. 16(5), 505-511 (1997).
    • (1997) J. Protein Chem. , vol.16 , Issue.5 , pp. 505-511
    • Kaur, S.1    McGuire, L.2    Tang, D.3    Dollinger, G.4    Huebner, V.5
  • 42
    • 0032503030 scopus 로고    scopus 로고
    • Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases
    • Huyer G, Kelly J, Moffat J et al. Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases. Anal. Biochem. 258(1), 19-30 (1998).
    • (1998) Anal. Biochem. , vol.258 , Issue.1 , pp. 19-30
    • Huyer, G.1    Kelly, J.2    Moffat, J.3
  • 43
    • 9644302954 scopus 로고    scopus 로고
    • A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures
    • Annis DA, Nazef N, Chuang CC, Scott MP, Nash HM. A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures. J. Am. Chem. Soc. 126(47), 15495-15503 (2004). Thorough treatment of size-exclusion chromatography for characterizing protein-small-molecule interactions.
    • (2004) J. Am. Chem. Soc. , vol.126 , Issue.47 , pp. 15495-15503
    • Annis, D.A.1    Nazef, N.2    Chuang, C.C.3    Scott, M.P.4    Nash, H.M.5
  • 44
    • 8444221197 scopus 로고    scopus 로고
    • An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries. Discovery of a novel antagonist of E. coli dihydrofolate reductase
    • Annis DA, Athanasopoulos J, Curran PJ et al. An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries. Discovery of a novel antagonist of E. coli dihydrofolate reductase. Int. J. Mass Spectrom. 238, 77-83 (2004).
    • (2004) Int. J. Mass Spectrom. , vol.238 , pp. 77-83
    • Annis, D.A.1    Athanasopoulos, J.2    Curran, P.J.3
  • 45
    • 0022467156 scopus 로고
    • Frontal affinity chromatography: Theory for its application to studies on specific interaction of biomolecules
    • Kasai K, Oda YJ. Frontal affinity chromatography: theory for its application to studies on specific interaction of biomolecules. J Chromatogr. 376, 33-47 (1986).
    • (1986) J Chromatogr. , vol.376 , pp. 33-47
    • Kasai, K.1    Oda, Y.J.2
  • 46
    • 0033521531 scopus 로고    scopus 로고
    • Micro-scale frontal affinity chromatography with mass spectrometric detection: A new method for the screening of compound libraries
    • Schriemer DC, Yalcin T, Li L. Micro-scale frontal affinity chromatography with mass spectrometric detection: a new method for the screening of compound libraries. Angew Chem. Int. Ed. 37(24), 3387-3388 (1998).
    • (1998) Angew Chem. Int. Ed. , vol.37 , Issue.24 , pp. 3387-3388
    • Schriemer, D.C.1    Yalcin, T.2    Li, L.3
  • 47
    • 10044275162 scopus 로고    scopus 로고
    • Biosensor alternative: Frontal affinity chromatography
    • Schriemer DC. Biosensor alternative: frontal affinity chromatography. Anal, Chem. 76(23), 440A-448A (2004).
    • (2004) Anal, Chem. , vol.76 , Issue.23
    • Schriemer, D.C.1
  • 48
    • 0038353368 scopus 로고    scopus 로고
    • Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: Applications of a Chromatographic biosensor
    • Chan NW, Lewis DF, Rosner PJ, Kelly MA, Schriemer DC. Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a Chromatographic biosensor. Anal. Biochem. 319(1), 1-12(2003). Presentation of frontal affinity chromatography (FAC) methods for characterizing molecular interactions and screening activities.
    • (2003) Anal. Biochem. , vol.319 , Issue.1 , pp. 1-12
    • Chan, N.W.1    Lewis, D.F.2    Rosner, P.J.3    Kelly, M.A.4    Schriemer, D.C.5
  • 50
    • 14744272646 scopus 로고    scopus 로고
    • Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery
    • Slon-Usakiewicz JJ, Dai JR, Ng W et al Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery. Anal. Chem. 77(5), 1268-1274 (2005).
    • (2005) Anal. Chem. , vol.77 , Issue.5 , pp. 1268-1274
    • Slon-Usakiewicz, J.J.1    Dai, J.R.2    Ng, W.3
  • 51
    • 0036256850 scopus 로고    scopus 로고
    • The role of intraparticle convection in protein adsorption by liquid chromatography using POROS 20 HQ/M particles
    • Leitao A, Li M, Rodrigues A. The role of intraparticle convection in protein adsorption by liquid chromatography using POROS 20 HQ/M particles. Biochem. Eng. J. 11, 33-48 (2002).
    • (2002) Biochem. Eng. J. , vol.11 , pp. 33-48
    • Leitao, A.1    Li, M.2    Rodrigues, A.3
  • 53
    • 0036164684 scopus 로고    scopus 로고
    • Estimation of drug-protein binding parameters on assuming the validity of thermodynamic equilibrium
    • Soltes L, Mach M. Estimation of drug-protein binding parameters on assuming the validity of thermodynamic equilibrium. J. Chromatogr. 5768, 113-119(2002).
    • (2002) J. Chromatogr. , vol.5768 , pp. 113-119
    • Soltes, L.1    Mach, M.2
  • 54
    • 8344226902 scopus 로고    scopus 로고
    • Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography
    • Chen J, Hage DS. Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography. Nature Biotechnol. 22(11), 1445-1448 (2004).
    • (2004) Nature Biotechnol. , vol.22 , Issue.11 , pp. 1445-1448
    • Chen, J.1    Hage, D.S.2
  • 55
    • 0031297758 scopus 로고    scopus 로고
    • Effects of ligand heterogeneity in the characterization of affinity columns by frontal analysis
    • Tweed SA, Loun B, Hage DS. Effects of ligand heterogeneity in the characterization of affinity columns by frontal analysis. Anal. Chem. 69(23), 4790-4798 (1997).
    • (1997) Anal. Chem. , vol.69 , Issue.23 , pp. 4790-4798
    • Tweed, S.A.1    Loun, B.2    Hage, D.S.3
  • 57
    • 0033952576 scopus 로고    scopus 로고
    • Chromatography on cells: Analyses of solute interactions with the glucose transporter Glut1 in human red cells adsorbed on lectin-gel beads
    • Gottschalk I, Li YM, Lundahl P. Chromatography on cells: analyses of solute interactions with the glucose transporter Glut1 in human red cells adsorbed on lectin-gel beads. J. Chromatogr. B Biomed. Sci. Appl. 739(1), 55-62 (2000).
    • (2000) J. Chromatogr. B Biomed. Sci. Appl. , vol.739 , Issue.1 , pp. 55-62
    • Gottschalk, I.1    Li, Y.M.2    Lundahl, P.3
  • 58
    • 2442701784 scopus 로고    scopus 로고
    • Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: Applications to frontal affinity chromatography
    • Hodgson RJ, Chen Y, Zhang Z et al. Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography. Anal. Chem. 76(10), 2780-2790 (2004). First application of protein entrapment to the preparation of small-scale FAC assays. Enables homogeneous assays.
    • (2004) Anal. Chem. , vol.76 , Issue.10 , pp. 2780-2790
    • Hodgson, R.J.1    Chen, Y.2    Zhang, Z.3
  • 59
    • 18844365068 scopus 로고    scopus 로고
    • Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns
    • Kovarik P, Hodgson RJ, Covey T, Brook MA, Brennan JD. Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns. Anal. Chem. 77(10), 3340-3350 (2005).
    • (2005) Anal. Chem. , vol.77 , Issue.10 , pp. 3340-3350
    • Kovarik, P.1    Hodgson, R.J.2    Covey, T.3    Brook, M.A.4    Brennan, J.D.5
  • 60
    • 26444610191 scopus 로고    scopus 로고
    • High throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry
    • Ng ES, Yang F, Kameyama A, Palcic MM, Hindsgaul O, Schriemer DC. High throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry. Anal. Chem. 77(19), 6125-6133 (2005).
    • (2005) Anal. Chem. , vol.77 , Issue.19 , pp. 6125-6133
    • Ng, E.S.1    Yang, F.2    Kameyama, A.3    Palcic, M.M.4    Hindsgaul, O.5    Schriemer, D.C.6
  • 61
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nature Rev. Drug Discov. 4(3), 206-220 (2005).
    • (2005) Nature Rev. Drug Discov. , vol.4 , Issue.3 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.