Estimation of drug-protein binding parameters on assuming the validity of thermodynamic equilibrium

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 768, Issue 1, 2002, Pages 113-119

  Šoltés, Ladislav ^a   Mach, Mojmír ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

Author keywords

1 Acid glycoprotein; Bjerrum plot; Drug protein binding; S Propafenone; Thermodynamic equilibrium

Indexed keywords

DRUG DOSAGE;

BINDING PARAMETERS;

PROTEINS;

PLASMA PROTEIN; PROPAFENONE;

BINDING AFFINITY; DATA ANALYSIS; DRUG PROTEIN BINDING; EVALUATION; HUMAN; MATHEMATICAL PARAMETERS; PRIORITY JOURNAL; REVIEW; THERMODYNAMICS;

PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEINS; THERMODYNAMICS;

EID: 0036164684     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(01)00498-4     Document Type: Review

References (14)

1. Methods of drug protein binding determinations
2. Separation procedures used to reveal and follow drug-protein binding
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4. Measurement of protein-binding phenomena by gel filtration
5. Equilibrium saturation chromatographic method for studying the binding of ligands to human serum albumin by high-performance liquid chromatography. Influence of fatty acids and sodium dodecylsulfate on warfarin-human serum albumin binding
6. Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions
7. The attractions of proteins for small molecules and ions
8. The curvilinear Scatchard plot. Experimental artifact or receptor heterogeneity?
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11. Binding constants for ligand-carrier complexes
12. Affinity spectra: A novel way for the evaluation of equilibrium binding experiments
13. In vitro protein binding of propafenone in normal and uraemic human sera
14. 1-acid glycoprotein: Assessing experimental design and data evaluation