Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: Effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis

Metabolism: Clinical and Experimental

Volumn 54, Issue 12, 2005, Pages 1571-1581

  Colombo, Michele ^a   Gregersen, Soeren ^a   Kruhoeffer, Mogens ^a   Agger, Andreas ^a   Xiao, Jianzhong ^a   Jeppesen, Per Bendix ^a   Orntoft, Torben ^a   Ploug, Thorkil ^b   Galbo, Henrik ^b   Hermansen, Kjeld ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 1; INSULIN; LIPID; OLIGONUCLEOTIDE; PHOSPHORYLASE KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CALCIUM SIGNALING; CONTROLLED STUDY; DETOXIFICATION; DIABETES CONTROL; DNA MICROARRAY; DYNAMIC EXERCISE; EPIDIDYMIS FAT; EXPRESSED SEQUENCE TAG; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC CODE; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; LIPOGENESIS; LIVER CELL; MALE; METABOLIC REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PRIORITY JOURNAL; RAT; RAT STRAIN; SKELETAL MUSCLE; SOLEUS MUSCLE; TREADMILL EXERCISE;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION PROFILING; HYPERGLYCEMIA; ISLETS OF LANGERHANS; LIVER; MALE; MUSCLE, SKELETAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, ZUCKER; RNA, MESSENGER; SIGNAL TRANSDUCTION; VISCERA;

EID: 28444464812     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2005.06.003     Document Type: Article

References (56)

1. W.C. Knowler, E. Barrett-Connor, and S.E. Fowler Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin N Engl J Med 346 2002 393 403
2. J. Tuomilehto, J. Lindstrom, and J.G. Eriksson Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance N Engl J Med 344 2001 1343 1350
3. K.J. Stewart Exercise training and the cardiovascular consequences of type 2 diabetes and hypertension: plausible mechanisms for improving cardiovascular health JAMA 288 2002 1622 1631
4. K.J. Mikines, B. Sonne, and P.A. Farrell Effect of training on the dose-response relationship for insulin action in men J Appl Physiol 66 1989 695 703
5. F. Dela, J.J. Larsen, and K.J. Mikines Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training Diabetes 44 1995 1010 1020
6. M. Hargreaves, and D. Cameron-Smith Exercise, diet, and skeletal muscle gene expression Med Sci Sports Exerc 34 2002 1505 1508
7. D. Cameron-Smith Exercise and skeletal muscle gene expression Clin Exp Pharmacol Physiol 29 2002 209 213
8. R.J. Tunstall, K.A. Mehan, and G.D. Wadley Exercise training increases lipid metabolism gene expression in human skeletal muscle Am J Physiol Endocrinol Metab 283 2002 E66 E72
9. G.J. Etgen, and B.A. Oldham Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state Metabolism 49 2000 684 688
10. Y. Tokuyama, J. Sturis, and A.M. DePaoli Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat Diabetes 44 1995 1447 1457
11. P.E. Lacy, and M. Kostianovsky Method for the isolation of intact islets of Langerhans from the rat pancreas Diabetes 16 1967 35 39
12. J. Xiao, S. Gregersen, and M. Kruhoffer The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray Endocrinology 142 2001 4777 4784
13. I.P. Lopez, A. Marti, and F.I. Milagro DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats Obes Res 11 2003 188 194
14. G.M. Diffee, E.A. Seversen, and T.D. Stein Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles Am J Physiol Heart Circ Physiol 284 2003 H830 H837
15. N. Reyes, M. Iatropoulos, and A. Mittelman Microarray analysis of diet-induced alterations in gene expression in the ACI rat prostate Eur J Cancer Prev 11 Suppl 2 2002 S37 S42
16. M. Stegall, W. Park, and D. Kim Gene expression during acute allograft rejection: novel statistical analysis of microarray data Am J Transplant 2 2002 913 925
17. N. Yajima, M. Masuda, and M. Miyazaki Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray J Vasc Surg 36 2002 379 385
18. T. Stein, M. Schluter, and A. Galante Energy metabolism pathways in rat muscle under conditions of simulated microgravity J Nutr Biochem 13 2002 471
19. Y. Heled, Y. Shapiro, and Y. Shani Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus Am J Physiol Endocrinol Metab 282 2002 E370 E375
20. N.G. Boule, E. Haddad, and G.P. Kenny Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials JAMA 286 2001 1218 1227
21. A. Mourier, J.F. Gautier, and E. De Kerviler Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements Diabetes Care 20 1997 385 391
22. R.H. Unger Lipotoxic diseases Annu Rev Med 53 2002 319 336
23. V.K. Yechoor, M.E. Patti, and R. Saccone Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice Proc Natl Acad Sci U S A 99 2002 10587 10592
24. R. Weindruch, T. Kayo, and C.K. Lee Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice J Nutr 131 2001 918S 923S
25. T.F. Orntoft, T. Thykjaer, and F.M. Waldman Genome-wide study of gene copy numbers, transcripts, and protein levels in pairs of non-invasive and invasive human transitional cell carcinomas Mol Cell Proteomics 1 2002 37 45
26. T. Ploug, B.M. Stallknecht, and O. Pedersen Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle Am J Physiol 259 1990 E778 E786
27. J.D. McGarry Banting Lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes Diabetes 51 2002 7 18
28. T. Nishikawa, D. Edelstein, and X.L. Du Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage Nature 404 2000 787 790
29. F. Diraison, E. Dusserre, and H. Vidal Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity Am J Physiol Endocrinol Metab 282 2002 E46 E51
30. H. Lan, M.E. Rabaglia, and J.P. Stoehr Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility Diabetes 52 2003 688 700
31. S.T. Nadler, J.P. Stoehr, and K.L. Schueler The expression of adipogenic genes is decreased in obesity and diabetes mellitus Proc Natl Acad Sci U S A 97 2000 11371 11376
32. I. Shimomura, Y. Bashmakov, and J.D. Horton Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 1999 30028 30032
33. R.P. Robertson, J. Harmon, and P.O. Tran Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection Diabetes 52 2003 581 587
34. J.L. Evans, I.D. Goldfine, and B.A. Maddux Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes Endocr Rev 23 2002 599 622
35. T. Hai, and M.G. Hartman The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis Gene 273 2001 1 11
36. P. Schrauwen Skeletal muscle uncoupling protein 3 (UCP3): mitochondrial uncoupling protein in search of a function Curr Opin Clin Nutr Metab Care 5 2002 265 270
37. J. Himms-Hagen, and M.E. Harper Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis Exp Biol Med (Maywood) 226 2001 78 84
38. H. Pilegaard, G.A. Ordway, and B. Saltin Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise Am J Physiol Endocrinol Metab 279 2000 E806 E814
39. M.Y. Cortez, C.E. Torgan, and J.T. Brozinick Jr Insulin resistance of obese Zucker rats exercise trained at two different intensities Am J Physiol 261 1991 E613 E619
40. G. Goldspink Gene expression in skeletal muscle Biochem Soc Trans 30 2002 285 290
41. P. Zammit, and J. Beauchamp The skeletal muscle satellite cell: stem cell or son of stem cell? Differentiation 68 2001 193 204
42. M.D. Grounds Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling Biogerontology 3 2002 19 24
43. C. Reynet, and C.R. Kahn Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans Science 262 1993 1441 1444
44. M.A. Paulik, L.L. Hamacher, and D.P. Yarnall Identification of Rad's effector-binding domain, intracellular localization, and analysis of expression in Pima Indians J Cell Biochem 65 1997 527 541
45. T.A. Gautsch, J.C. Anthony, and S.R. Kimball Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise Am J Physiol 274 1998 C406 C414
46. J.C. Lawrence Jr, P. Fadden, and T.A. Haystead PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation Adv Enzyme Regul 37 1997 239 267
47. S. Ehara, M. Ueda, and T. Naruko Pathophysiological role of oxidized low-density lipoprotein in plaque instability in coronary artery diseases J Diabetes Complications 16 2002 60 64
48. T.J. Aitman, A.M. Glazier, and C.A. Wallace Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats Nat Genet 21 1999 76 83
49. A.M. Glazier, J. Scott, and T.J. Aitman Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism Mamm Genome 13 2002 108 113
50. B. Stallknecht, M. Roesdahl, and J. Vinten The effect of lesions of the sympathoadrenal system on training induced adaptations in adipocytes and pancreatic islets in rats Acta Physiol Scand 156 1996 465 473
51. H. Galbo Influence of aging and exercise on endocrine function Int J Sport Nutr Exerc Metab 11 Suppl 2001 S49 S57
52. P.A. Farrell, A.L. Caston, and D. Rodd Changes in insulin response to glucose after exercise training in partially pancreatectomized rats J Appl Physiol 70 1991 1563 1568
53. F. Dela, K.J. Mikines, and H. Galbo Physical activity and insulin resistance in men G. Reaven A. Laws Contemporary endocrinology: insulin resistance 1999 Humana Press Totowa (NJ) 97 119
54. K. Hermansen Stimulatory effect of beta-hydroxybutyrate on the release of somatostatin from the isolated pancreas of normal and streptozotocin-diabetic dogs Diabetes 31 1982 270 274
55. G.L. Forrest, and B. Gonzalez Carbonyl reductase Chem Biol Interact 129 2000 21 40
56. A. Soukas, P. Cohen, and N.D. Socci Leptin-specific patterns of gene expression in white adipose tissue Genes Dev 14 2000 963 980