Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism

Mammalian Genome

Volumn 13, Issue 2, 2002, Pages 108-113

  Glazier, Anne M ^a   Scott, James ^a   Aitman, Timothy J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; DNA TOPOISOMERASE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME DELETION; CONTROLLED STUDY; FATTY ACID METABOLISM; GENE LOCUS; GENE SEQUENCE; HORMONE ACTION; INSULIN RESISTANCE; INTRON; NONHUMAN; PHENOTYPE; QUANTITATIVE TRAIT; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ANTIGENS, CD36; BASE SEQUENCE; FATTY ACIDS; GENE DELETION; HYPERTENSION; INSULIN; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; ORGANIC ANION TRANSPORTERS; RATS; RATS, INBRED SHR;

ANIMALIA; MAMMALIA;

EID: 0036146622     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-001-2132-9     Document Type: Article

References (29)

1. Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia
2. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats
3. Identification of Cd36 (Fat) as an insulin resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
4. Structural organization of the gene for human CD36 glycoprotein
5. Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat
6. Cd36 and molecular mechanisms of insulin resistance in the stroke prone spontaneously hypertensive rat
7. A LINE element is present at the site of a 300-kb deletion starting in intron 10 of the PAX6 gene in a case of familial aniridia
8. Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance
9. Lipid metabolism in spontaneously hypertensive rats (SHR)
10. The deadly quartet: Upper body obesity, glucose intolerance, hypertriglyceridemia, and hypertension
11. A molecular timescale for vertebrate evolution
12. The sequence organization of the long arm pseudoautosomal region of the human sex chromosomes
13. A chimeric 11b-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
14. Detection of tandem duplications and implications for linkage analysis
15. Pathological consequences of sequence duplications in the human genome
16. Deletion in the beige gene of the beige rat owing to recombination between LINE1s
17. Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome
18. The molecular clock ticks regularly in muroid rodents and hamsters
19. Identification of genes from a 500 kb region at 7q11.23 that is commonly deleted in Williams syndrome
20. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains
21. Genetics of Cd36 and the clustering of cardiovascular risk factors in spontaneous hypertension
22. Transgenic rescue of defective Cd36 ameliorates insulin resistance and circulating fatty acid levels in spontaneously hypertensive rats
23. Insulin resistance in spontaneously hypertensive rats: Difference in interpretation based on insulin infusion rate or on plasma insulin in glucose clamp studies
24. Banting Lecture 1988. Role of insulin resistance in human disease
25. Role of insulin resistance in human disease (Syndrome X): An expanded definition
26. The fourth musketeer - From Alexandre Dumas to Claude Bernard
27. Resistance to insulin-stimulated glucose uptake in adipocytes from spontaneously hypertensive rats
28. Non-radioactive detection of 17p11.2 duplication in CMT1A: A study of 78 patients
29. Topoisomerase I and II consensus sequences in a 17 kb deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome