Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes

Human Gene Therapy

Volumn 9, Issue 3, 1998, Pages 315-323

  Barron, G Lee ^a   Meyer, Kathleen B ^a   Szoka Jr , Francis C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BENZAMIDINE DERIVATIVE; CHOLESTEROL; COBROTOXIN; COMPLEMENT; COMPLEMENT COMPONENT C3; DNA; IODINE 125; IODINE 131; LIPID; LUCIFERASE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; HEART; INTRAVENOUS ADMINISTRATION; ISOTOPE LABELING; LIVER; MOUSE; NONHUMAN; REPORTER GENE; SPLEEN; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 17344368550     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.3-315     Document Type: Article

References (8)

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2. BRIGHAM, K., MEYRICK, B., CHRISTMAN, B., CONARY, J., KING, G., BERRY, L.C., and MAGNUSON, M. (1993). Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice. Am. J. Respir. Cell Mol. Biol. 8, 209-213.
3. BRIGHAM, K.L., MEYRICK, B., CHRISTMAN, B., MAGNUSON, M., KING, G., and BERRY, L. (1989). In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am. J. Med. Sci. 298, 278-281.
4. CANONICO, A., CONARY, J., MEYRICK, B., and BRIGHAM, K. (1994). Aerosol and intravenous transfection of human alpha-1 antitrypsin gene to s of rabbits. Am. J. Respir. Cell Mol. Biol. 10,24-29.
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6. CHONN, A., SEMPLE, S.C., and CULLIS, P. (1992). Association of blood proteins with large unilamellar liposomes in vivo. J. Biol. Chem. 267, 18759-18765.
7. COCHRANE, C.G., MULLER-EBERHARD, H.J., and AIKIN, B.S. (1970). Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J. Immunol. 105, 55-69.
8. ZHANG, S.C., SCHULTZ, D.R., and RYAN, U.S. (1986). Receptor-mediated binding of C1q on pulmonary endothelial cells. Tissue and Cell 18, 13-18.