Genetically engineered protein-based polymers: Potential in gene delivery

Polymeric Gene Delivery: Principles and Applications

Volumn , Issue , 2004, Pages 489-507

  Megeed, Zaki ^a   Ghandehari, Hamidreza ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 28444441368     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780203500477     Document Type: Chapter

References (73)

1. Krammer, A., Lu, H., Isralewitz, B., Schulten, K., and Vogel, V., The fibronectin type III10 module:A tensile molecular recognition switch, Biophys. J. 76, A9, 1999.
2. Tinoco, I. and Bustamante, C., The effect of force on thermodynamics and kinetics of single molecule reactions, Biophys. Chem. 101, 513-533, 2002.
3. Li, H.B., Linke, W.A., Oberhauser, A.F., Carrion-Vazquez, M., Kerkviliet, J.G., Lu, H., Marszalek, P.E., and Fernandez, J.M., Reverse engineering of the giant muscle protein titin, Nature 418, 998-1002, 2002.
4. Cappello, J., Synthetically designed protein-polymer biomaterials, in Controlled Drug Delivery:Challenges and Strategies, Park, K. (Ed.), American Chemical Society, Washington, D.C., 1997, 439-453.
5. Cappello, J., Crissman, J., Dorman, M., Mikolajczak, M., Textor, G., Marquet, M., and Ferrari, F., Genetic engineering of structural protein polymers, Biotechnol. Prog. 6, 198-202, 1990.
6. Herzog, R.W., Singh, N.K., Urry, D.W., and Daniell, H., Expression of a synthetic protein-based polymer (elastomer) gene in Aspergillus nidulans, Appl. Microbiol. Biotechnol. 47, 368-372, 1997.
7. Zhang, X.R., Urry, D.W., and Daniell, H., Expression of an environmentally friendly synthetic proteinbased polymer gene in transgenic tobacco plants, Plant Cell Rep. 16, 174-179, 1996.
8. Teule, F., Aube, C., Abbott, A.G., and Ellison, M.S. Production of customized novel fiber proteins in yeast (Pichia pastoris) for specialized applications, Proceedings of the 3rd International Silk Conference, Montreal, Quebec, Canada, 2003.
9. Ferrari, F., Richardson, C., Chambers, J., Causey, S.C., Pollock, T.J., Cappello, J., and Crissman, J.W., Protein Polymer Technologies, Inc., U.S. Patent 5,243,038, 1993.
10. Ferrari, F. and Cappello, J., Biosynthesis of protein polymers, in Protein-Based Materials, Kaplan, D.L., (Ed.), Birkhauser, Boston, 1997, 37-60.
11. Lohe, A.R. and Brutlag, D.L., Multiplicity of satellite DNA sequences in Drosophila melanogaster, Proc. Nat. Acad. Sci. U.S.A. 83, 696-700, 1986.
12. Sadler, J.R., Tecklenburg, M., and Betz, J.L., Plasmids containing many tandem copies of a synthetic lactose operator, Gene 8, 279-300, 1980.
13. Carlson, M. and Brutlag, D., Cloning and characterization of a complex satellite DNA from Drosophila melanogaster, Cell 11, 371-381, 1977.
14. Sambrook, J. and Russell, S.J., Molecular Cloning: A Laboratory Manual, 3rd edition, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 2001.
15. Meyer, D.E. and Chilkoti, A., Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastinlike polypeptide system, Biomacromolecules 3, 357-367, 2002.
16. Won, J.I. and Barron, A.E., A new cloning method for the preparation of long repetitive polypeptides without a sequence requirement, Macromolecules 35, 8281-8287, 2002.
17. McMillan, R.A., Lee, T.A.T., and Conticello, V.P., Rapid assembly of synthetic genes encoding protein polymers, Macromolecules 32, 3643-3648, 1999.
18. Goeden-Wood, N.L., Conticello, V.P., Muller, S.J., and Keasling, J.D., Improved assembly of multimeric genes for the biosynthetic production of protein polymers, Biomacromolecules 3, 874-879, 2002.
19. Cappello, J., Ferrari, F.A., Buerkle, T.L., and Textor, G., Protein Polymer Technologies, Inc., U.S. Patent 5,235,041, 1993.
20. McPherson, D.T., Xu, J., and Urry, D.W., Product purification by reversible phase transition following Escherichia coli expression of genes encoding up to 251 repeats of the elastomeric pentapeptide GVGVP, Protein Expr. Purif. 7, 51-57, 1996.
21. Meyer, D.E. and Chilkoti, A., Purification of recombinant proteins by fusion with thermally-responsive polypeptides, Nat. Biotechnol. 17, 1112-1115, 1999.
22. Kiick, K.L., Saxon, E., Tirrell, D.A., and Bertozzi, C.R., Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation, Proc. Nat. Acad. Sci. U.S.A. 99, 19-24, 2002.
23. Cappello, J., Genetically engineered protein polymers, in Handbook of Biodegradable Polymers, Wiseman, D.M., (Ed.), Harwood Academic Publishers, Amsterdam, 1997, 387-416.
24. Halstenberg, S., Panitch, A., Rizzi, S., Hall, H., and Hubbell, J.A., Biologically engineered proteingraft- poly(ethylene glycol) hydrogels: A cell adhesive and plasmin-degradable biosynthetic material for tissue repair, Biomacromolecules 3, 710-723, 2002.
25. Urry, D.W., Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers, J. Phys. Chem. B 101, 11007-11028, 1997.
26. Cappello, J., Genetic production of synthetic protein polymers, MRS Bull. 17, 48-53, 1992.
27. Cappello, J. and Ferrari, F., Microbial production of structural protein polymers, in Plastics from Microbes, Mobley, D.P., (Ed.) Hanser Publishers, Munich, 1994, 35-92.
28. Panitch, A., Yamaoka, T., Fournier, M.J., Mason, T.L., and Tirrell, D.A., Design and biosynthesis of elastin-like artificial extracellular matrix proteins containing periodically spaced fibronectin CS5 domains, Macromolecules 32, 1701-1703, 1999.
29. Meyer, D.E., Shin, B.C., Kong, G.A., Dewhirst, M.W., and Chilkoti, A., Drug targeting using thermally responsive polymers and local hyperthermia, J. Control. Release 74, 213-224, 2001.
30. Betre, H., Setton, L.A., Meyer, D.E., and Chilkoti, A., Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair, Biomacromolecules 3, 910-916, 2002.
31. Frey, W.G., Meyer, D.E., and Chilkoti, A., Thermodynamically reversible addressing of a stimuli responsive fusion protein onto a patterned surface template, Langmuir 19, 1641-1653, 2003.
32. Hoffman, A.S., Hydrogels for biomedical applications, Adv. Drug Del. Rev. 54, 3-12, 2002.
33. Megeed, Z., Cappello, J., and Ghandehari, H., Controlled release of plasmid DNA from a genetically engineered silk-elastinlike hydrogel, Pharm. Res. 19, 954-959, 2002.
34. Petka, W.A., Harden, J.L., McGrath, K.P., Wirtz, D., and Tirrell, D.A., Reversible hydrogels from self-assembling artificial proteins, Science 281, 389-392, 1998.
35. Cappello, J., Crissman, J.W., Crissman, M., Ferrari, F.A., Textor, G., Wallis, O., Whitledge, J.R., Zhou, X., Burman, D., Aukerman, L., and Stedronsky, E.R., In situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs, J. Control. Release 53, 105-117, 1998.
36. Dinerman, A.A., Cappello, J., Ghandehari, H., and Hoag, S.W., Swelling behavior of a genetically engineered silk-elastinlike protein polymer hydrogel, Biomaterials 23, 4203-4210, 2002.
37. Dinerman, A.A., Cappello, J., Ghandehari, H., and Hoag, S.W., Solute diffusion in genetically engineered silk-elastinlike protein polymer hydrogels, J. Control. Release 82, 277-287, 2002.
38. Urry, D.W., Harris, C.M., Luan, C.X., Luan, C.-H., Channe Gowda, D., Parker, T.M., Peng, S.Q., and Xu, J., Transductional protein-based polymers as new controlled release vehicles, in Controlled Drug Delivery: Challenges and Strategies, Park, K., (Ed.) American Chemical Society, Washington, D.C., 1997, 405-438.
39. Wright, E.R. and Conticello, V.P., Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences, Adv. Drug Del. Rev. 54, 1057-1073, 2002.
40. Wright, E.R., McMillan, R.A., Cooper, A., Apkarian, R.P., and Conticello, V.P., Thermoplastic elastomer hydrogels via self-assembly of an elastin-mimetic triblock polypeptide, Adv. Funct. Mater. 12, 149-154, 2002.
41. McMillan, R.A., Caran, K.L., Apkarian, R.P., and Conticello, V.P., High-resolution topographic imaging of environmentally responsive, elastin-mimetic hydrogels, Macromolecules 32, 9067-9070, 1999.
42. Lee, T.A.T., Cooper, A., Apkarian, R.P., and Conticello, V.P., Thermo-reversible self-assembly of nanoparticles derived from elastin-mimetic polypeptides, Adv. Mater. 12, 1105-1110, 2000.
43. Harada-Shiba, M., Yamauchi, K., Harada, A., Takamisawa, I., Shimokado, K., and Kataoka, K., Polyion complex micelles as vectors in gene therapy - pharmacokinetics and in vivo gene transfer, Gene Ther. 9, 407-414, 2002.
44. Wang, C., Stewart, R.J., and Kopecek, J., Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains, Nature 397, 417-420, 1999.
45. Chen, L., Kopecek, J., and Stewart, R.J., Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module, Bioconj. Chem. 11, 734-740, 2000.
46. Lee, C.H., Hsiao, M., Tseng, Y.L., and Chang, F.H., Enhanced gene delivery to HER-2-overexpressing breast cancer cells by modified immunolipoplexes conjugated with the anti-HER-2 antibody, J. Biomed. Sci. 10, 337-344, 2003.
47. Xu, L.N., Pirollo, K.F., and Chang, E.H., Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro, Hum. Gene Ther. 8, 467-475, 1997.
48. Hofland, H.E.J., Masson, C., Iginla, S., Osetinsky, I., Reddy, J.A., Leamon, C.P., Scherman, D., Bessodes, M., and Wils, P., Folate-targeted gene transfer in vivo, Mol. Ther. 5, 739-744, 2002.
49. Shadidi, M. and Sioud, M., Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells, FASEB J. 16, U478-U494, 2002.
50. Maeda, H., Fang, J., Inutsuka, T., and Kitamoto, Y., Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications, Int. Immunopharmacol. 3, 319-328, 2003.
51. Bonadio, J., Smiley, E., Patil, P., and Goldstein, S., Localized, direct plasmid gene delivery in vivo:prolonged therapy results in reproducible tissue regeneration, Nat. Med. 5, 753-759, 1999.
52. Luo, D., Woodrow-Mumford, K., Belcheva, N., and Saltzman, W.M., Controlled DNA delivery systems, Pharm. Res. 16, 1300-1308, 1999.
53. Shea, L.D., Smiley, E., Bonadio, J., and Mooney, D.J., DNA delivery from polymer matrices for tissue engineering, Nat. Biotechnol. 17, 551-554, 1999.
54. Jong, Y.S., Jacob, J.S., Yip, K.-P., Gardner, G., Seitelman, E., Whitney, M., Montgomery, S., and Mathiowitz, E., Controlled release of plasmid DNA, J. Control. Release 47, 123-134, 1997.
55. Gebrekidan, S., Woo, B.H., and Deluca, P.P., Formulation and in vitro transfection efficiency of poly (D, L-lactide-co-glycolide) microspheres containing plasmid DNA for gene delivery, AAPS Pharm-SciTech. 1, Article 28, 2000.
56. Megeed, Z., Haider, M., Li, D., O’Malley, Jr. B. W., Cappello, J., and Ghandehari, H., In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy, J. Control. Release, 94, 433-445, 2004.
57. Nagarsekar, A., Crissman, J., Crissman, M., Ferrari, F., Cappello, J., and Ghandehari, H., Genetic synthesis and characterization of pH- and temperature-sensitive silk-elastinlike protein block copolymers, J. Biomed. Mater. Res. 62, 195-203, 2002.
58. Nagarsekar, A., Crissman, J., Crissman, M., Ferrari, F., Cappello, J., and Ghandehari, H., Genetic engineering of stimuli-sensitive silk-elastinlike protein block copolymers, Biomacromolecules 4, 602-607, 2003.
59. Chen, Z.Y., Yant, S.R., He, C.Y., Meuse, L., Shen, S., and Kay, M.A., Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver, Mol. Ther. 3, 403-410, 2001.
60. Bergan, D., Galbraith, T., and Sloane, D.L., Gene transfer in vitro and in vivo by cationic lipids is not significantly affected by levels of supercoiling of a reporter plasmid, Pharm. Res. 17, 967-973, 2000.
61. Fu, J.C., Hagemeir, C., and Moyer, D.L., A unified mathematical model for diffusion from drugpolymer composite tablets, J. Biomed. Mater. Res. 10, 743-758, 1976.
62. Siepmann, J., Ainaoui, A., Vergnaud, J.M., and Bodmeier, R., Calculation of the dimensions of drugpolymer devices based on diffusion parameters, J. Pharm. Sci. 87, 827-832, 1998.
63. Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I., Villeval, J.L., Fraser, C.C., Cavazzana-Calvo, M., and Fischer, A., A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency, New Engl. J. Med. 348, 255-256, 2003.
64. Kalyanasundaram, S., Feinstein, S., Nicholson, J.P., Leong, K.W., and Garver, R.I., Jr., Coacervate microspheres as carriers of recombinant adenoviruses, Cancer Gene Ther. 6, 107-112, 1999.
65. Chandler, L.A., Doukas, J., Gonzalez, A.M., Hoganson, D.K., Gu, D.L., Ma, C., Nesbit, M., Crombleholme, T.M., Herlyn, M., Sosnowski, B.A., and Pierce, G.F., FGF2-targeted adenovirus encoding platelet-derived growth factor-β enhances de novo tissue formation, Mol. Ther. 2, 153-160, 2000.
66. Doukas, J., Chandler, L.A., Gonzalez, A.M., Gu, D., Hoganson, D.K., Ma, C., Nguyen, T., Printz, M.A., Nesbit, M., Herlyn, M., Crombleholme, T.M., Aukerman, S.L., Sosnowski, B.A., and Pierce, G.F., Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors, Hum. Gene Ther. 12, 783-798, 2001.
67. Hosseinkhani, H. and Tabata, Y., In vitro gene expression by cationized derivatives of an artificial protein with repeated RGD sequences, Pronectin, J. Control. Release 86, 169-182, 2003.
68. Tang, M.X. and Szoka, F.C., The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes, Gene Ther. 4, 823-832, 1997.
69. Haider, M. and Ghandehari, H., Influence of poly (amino acid) composition on the complexation of plasmid DNA and transfection efficiency, J. Bioact. Compat. Polym. 18, 93-111, 2003.
70. Hancock, R.E.W., Host defense (cationic) peptides: what is their future clinical potential? Drugs 57, 469-473, 1999.
71. Rosenberg, H.F., Recombinant human eosinophil cationic protein - ribonuclease-activity is not essential for cytotoxicity, J. Biol. Chem. 270, 7876-7881, 1995.
72. Piers, K.L., Brown, M.H., and Hancock, R.E.W., Recombinant-DNA procedures for producing small antimicrobial cationic peptides in bacteria, Gene 134, 7-13, 1993.
73. Megeed, Z., Genetically engineered polymers for cancer gene therapy, PhD thesis, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 2003.