Autorepression of Rfx1 gene expression: Functional conservation from yeast to humans in response to DNA replication arrest

Molecular and Cellular Biology

Volumn 25, Issue 23, 2005, Pages 10665-10673

  Lubelsky, Yoav ^a   Reuven, Nina ^a   Shaul, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; DNA; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; CONTROLLED STUDY; CRT1 GENE; DNA DAMAGE; DNA REPLICATION; ENZYME INHIBITION; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RFX1 GENE; RNR R2 GENE; SEQUENCE HOMOLOGY; ULTRAVIOLET RADIATION; YEAST;

CELL CYCLE; DNA; DNA REPLICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYUREA; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 27944488330     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.23.10665-10673.2005     Document Type: Article

References (49)

1. Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
2. Agami, R., and Y. Shaul. 1998. The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes. Oncogene 16:1779-1788.
3. Ainbinder, E., M. Revach, O. Wolstein, S. Moshonov, N. Diamant, and R. Dikstein. 2002. Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-κB. Mol. Cell. Biol. 22:6354-6362.
4. Araki, R., H. Takahashi, R. Fukumura, F. Sun, N. Umeda, M. Sujino, S. T. Inouye, T. Saito, and M. Abe. 2004. Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus. J. Biol. Chem. 279:10237-10242.
5. Blackshear, P. J., J. P. Graves, D. J. Stumpo, I. Cobos, J. L. R. Rubenstein, and D. C. Zeldin. 2003. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development 130:4539-4552.
6. Bonnafe, E., M. Touka, A. AitLounis, D. Baas, E. Barras, C. Ucla, A. Moreau, F. Flamant, R. Dubruille, P. Couble, J. Collignon, B. Durand, and W. Reith. 2004. The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol. Cell. Biol. 24:4417-4427.
7. Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2:243-247.
8. Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science 296:550-553.
9. Chen, L., L. Smith, M. R. Johnson, K. Wang, R. B. Diasio, and J. B. Smith. 2000. Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells. J. Biol. Chem. 275:32227-32233.
10. David, E., A. D. Garcia, and P. Hearing. 1995. Interaction of EF-C/RFX-1 with the inverted repeat of viral enhancer regions is required for transactivation. J. Biol. Chem. 270:8353-8360.
11. Dikstein, R., O. Faktor, R. Ben-Levy, and Y. Shaul. 1990. Functional organization of the hepatitis B virus enhancer. Mol. Cell. Biol. 10:3682-3689.
12. Durand, B., C. Vandaele, D. Spencer, S. Pantalacci, and P. Couble. 2000. Cloning and characterization of dRFX, the Drosophila member of the RFX family of transcription factors. Gene 246:285-293.
13. Eklund, H., U. Uhlin, M. Farnegardh, D. T. Logan, and P. Nordlund. 2001. Structure and function of the radical enzyme ribonucleotide reductase. Prog. Biophys. Mol. Biol. 77:177-268.
14. Emery, P., B. Durand, B. Mach, and W. Reith. 1996. RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. Nucleic Acids Res. 24:803-807.
15. Emery, P., M. Strubin, K. Hofmann, P. Bucher, B. Mach, and W. Reith. 1996. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494.
16. Filatov, D., S. Bjorklund, E. Johansson, and L. Thelander. 1996. Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light. J. Biol. Chem. 271:23698-23704.
17. Gajiwala, K. S., H. Chen, F. Cornille, B. P. Roques, W. Reith, B. Mach, and S. K. Burley. 2000. Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature 403:916-921.
18. Gasch, A. P., M. Huang, S. Metzner, D. Botstein, S. J. Elledge, and P. O. Brown. 2001. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol. Biol. Cell 12:2987-3003.
19. Goodarzi, G., H. Ohno, R. Adams, A. Darabi, A. Tewari, M. Watabe, and K. Watabe. 1990. Mutational analysis of enhancer domains responsive to trans-activation by the X gene of human hepatitis B virus. Arch. Virol. 114:237-242.
20. Guo, Z., A. Kumagai, S. X. Wang, and W. G. Dunphy. 2000. Requirement for atr in phosphorylation of chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in xenopus egg extracts. Genes Dev. 14:2745-2756.
21. Huang, M., Z. Zhou, and S. J. Elledge. 1998. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94:595-605.
22. Katan, Y., R. Agami, and Y. Shaul. 1997. The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities. Nucleic Acids Res. 25:3621-3628.
23. Katan-Khaykovich, Y., and Y. Shaul. 2001. Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism. Eur. J. Biochem. 268:3108-3116.
24. Katan-Khaykovich, Y., and Y. Shaul. 1998. RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. J. Biol. Chem. 273:24504-24512.
25. Katan-Khaykovich, Y., I. Spiegel, and Y. Shaul. 1999. The dimerization/repression domain of RFX1 is related to a conserved region of its yeast homologues Crt1 and Sak1: a new function for an ancient motif. J. Mol. Biol. 294:121-137.
26. Lee, B. H., M. Liu, and M. B. Mathews. 1998. Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A-associated protein p107. J. Virol. 72:1138-1145.
27. Liu, M., B. H. Lee, and M. B. Mathews. 1999. Involvement of RFX1 protein in the regulation of the human proliferating cell nuclear antigen promoter. J. Biol. Chem. 274:15433-15439.
28. Liu, Q., S. Guntuku, X. S. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. DeMayo, A. Bradley, L. A. Donehower, and S. J. Elledge. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
29. Maijgren, S., I. Sur, M. Nilsson, and R. Toftgard. 2004. Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Arch. Dermatol. Res. 295:482-489.
30. Morotomi-Yano, K., K. Yano, H. Saito, Z. Sun, A. Iwama, and Y. Miki. 2002. Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. J. Biol. Chem. 277:836-842.
31. O'Neill, T., L. Giarratani, P. Chen, L. Iyer, C.-H. Lee, M. Bobiak, F. Kanai, B.-B. Zhou, J. H. Chung, and G. A. Rathbun. 2002. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J. Biol. Chem. 277:16102-16115.
32. Otsuki, K., Y. Hayashi, M. Kato, H. Yoshida, and M. Yamaguchi. 2004. Characterization of dRFX2, a novel RFX family protein in Drosophila. Nucleic Acids Res. 32:5636-5648.
33. Park, J. B., and M. Levine. 2000. Characterization of the promoter of the human ribonucleotide reductase R2 gene. Biochem. Biophys. Res. Commun. 267:651-657.
34. Reith, W., C. Herrero-Sanchez, M. Kobr, P. Silacci, C. Berte, E. Barras, S. Fey, and B. Mach. 1990. MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Genes Dev. 4:1528-1540.
35. Reith, W., S. Satola, C. H. Sanchez, I. Amaldi, B. Lisowska-Grospierre, C. Griscelli, M. R. Hadam, and B. Mach. 1988. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 53:897-906.
36. Rhind, N., and P. Russell. 2000. Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J. Cell Sci. 113:3889-3896.
37. Sarkaria, J. N., E. C. Busby, R. S. Tibbetts, P. Roos, Y. Taya, L. M. Karnitz, and R. T. Abraham. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
38. Schmitt, E. K., and U. Kuck. 2000. The fungal CPCR1 protein, which binds specifically to beta-lactam biosynthesis genes, is related to human regulatory factor X transcription factors. J. Biol. Chem. 275:9348-9357.
39. Swoboda, P., H. T. Adler, and J. H. Thomas. 2000. The RFX-type transcription factor DAF-19 regulates sensory neuron cillium formation in C. elegans. Mol. Cell 5:411-421.
40. Walker, G. C. 1985. Inducible DNA repair systems. Annu. Rev. Biochem. 54:425-457.
41. Walsh, L., J. Schmuckli-Maurer, N. Billinton, M. G. Barker, W. D. Heyer, and R. M. Walmsley. 2002. DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2. Curr. Genet. 41:232-240.
42. Wolfe, S. A., D. C. Wilkerson, S. Prado, and S. R. Grimes. 2004. Regulatory factor X2 (RFX2) binds to the H1t/TE1 promoter element and activates transcription of the testis-specific histone H1t gene. J. Cell Biochem. 91:375-383.
43. + gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle. Mol. Cell. Biol. 15:1479-1488.
44. Yeo, H. J., G. Ziegelin, S. Korolev, R. Calendar, E. Lanka, and G. Waksman. 2002. Phage P4 origin-binding domain structure reveals a mechanism for regulation of DNA-binding activity by homo- and heterodimerization of winged helix proteins. Mol. Microbiol. 43:855-867.
45. Zaim, J., E. Speina, and A. M. Kierzek. 2005. Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. J. Biol. Chem. 280:28-37.
46. Zajac-Kaye, M., N. Ben-Baruch, E. Kastanos, F. J. Kaye, and C. Allegra. 2000. Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells. Biochem. J. 345(Pt. 3):535-41.
47. Zhao, B., M. J. Bower, P. J. McDevitt, H. Zhao, S. T. Davis, K. O. Johanson, S. M. Green, N. O. Concha, and B.-B. S. Zhou. 2002. Structural basis for Chk1 inhibition by UCN-01. J. Biol. Chem. 277:46609-46615.
48. Zhou, M., L. Deng, F. Kashanchi, J. N. Brady, A. J. Shatkin, and A. Kumar. 2003. The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA. Proc. Natl. Acad. Sci. USA 100:12666-12671.
49. Zhou, Z., and S. J. Elledge. 1992. Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics 131:851-866.