DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulated RNR2

Current Genetics

Volumn 41, Issue 4, 2002, Pages 232-240

  Walsh, Lindsey ^a   Schmuckli Maurer, Jacqueline ^b   Billinton, Nicholas ^a   Barker, M Gordon ^a   Heyer, Wolf Dietrich ^c   Walmsley, Richard M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA damage; RAD54; RNR2; Saccharomyces cerevisiae

Indexed keywords

GENE PRODUCT; GREEN FLUORESCENT PROTEIN; MESYLIC ACID METHYL ESTER; PROTEIN KINASE; RAD54 PROTEIN; REGULATOR PROTEIN; RIBONUCLEOTIDE REDUCTASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CONTROLLED STUDY; DNA DAMAGE; DOWNSTREAM PROCESSING; FUNGAL STRAIN; GENE ACTIVITY; GENE CONTROL; GENE INDUCTION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENOTOXICITY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REPORTER GENE; REVIEW; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; WILD TYPE;

CELL CYCLE PROTEINS; DNA DAMAGE; GENE DELETION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; METHYL METHANESULFONATE; MUTAGENS; MUTATION; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RIBONUCLEOTIDE REDUCTASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 12244274355     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-002-0302-2     Document Type: Review

References (42)

1. Aboussekhra A, Vialard JE, Morrison DE, De la Torre-Ruiz M, Cernakova L, Fabre F, Lowndes NF (1996) A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription. EMBO J 15:3912-3922
2. Afanassiev V, Sefton M, Anantachaiyong T, Barker G, Walmsley R, Wölfl S (2000) Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substances. Mutat Res 464:297-308
3. Averbeck D, Averbeck S (1994) Induction of the genes RAD54 and RNR2 by various DNA damaging agents in Saccharomyces cerevisiae. Mutat Res 315:123-138
4. Bang DD, Timmermans V, Verhage R, Zeeman AM, Van de Putte P, Brouwer J (1995) Regulation of the Saccharomyces cerevisiae DNA repair gene RAD16. Nucleic Acids Res 23:1679-1685
5. Billinton N, Barker MG, Michel CE, Knight AW, Heyer W-D, Goddard NJ, Fielden PR, Walmsley RM (1998) Development of a green fluorescent protein reporter for a yeast genotoxicity biosensor. Biosens Bioelectron 13:831-838
6. Cole GM, Mortimer RK (1989) Failure to induce a DNA repair gene, RAD54, in Saccharomyces cerevisiae does not affect DNA repair or recombination pathways. Mol Cell Biol 9:3314-3322
7. Cole GM, Schild D, Lovett ST, Mortimer RK (1987) Regulation of RAD54 and RAD54-lacZ gene fusions in Saccharomyees cerevisiae in response to DNA damage. Mol Cell Biol 7:1078-1084
8. Cormack BP, Bertram G, Egerton M, Gow NAR, Falkow S, Brown AJP (1997) Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology 143:303-311
9. Cubitt AB, Heim R, Adams SR, Boyd AE, Gross LA, Tsien RY (1995) Understanding, improving and using green fluorescent proteins. Trends Biochem Sci 20:448-455
10. De la Torre-Ruiz M, Lowndes NF (2000) Dun1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae. FEBS Lett 485:205-206
11. De la Torre-Ruiz M, Green CM, Lowndes NF (1998) RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J 17:2687-2698
12. Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274:1664-1672
13. Elledge SJ, Davis RW (1987) Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol 7:2783-2793
14. Elledge SJ, Davis RW (1989a) DNA damage induction of ribonucleotide reductase Mol Cell Biol 9:4932-4940
15. Elledge SJ, Davis RW (1989b) Identification of the DNA damage responsive element of RNR2, evidence that four distinct cellular factors bind to it. Mol Cell Biol 9:5373-5386
16. Elledge SJ, Zhou Z, Allen JB, Navas TA (1993) DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 15:333-339
17. Gardner R, Putnam CW, Weinert T (1999) RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast. EMBO J 18:3173-3185
18. Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown P (2001) Genomic expression responses to DNA damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell 12:2987-3003
19. Gietz RD, Woods RA (1994) High efficiency transformation with lithium acetate. In: Johnson JR (ed) Molecular genetics of yeast, a practical approach. IRL Press, Oxford, pp 121-134
20. Huang M, Zhou Z, Elledge SJ (1998) The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94:595-605
21. Iyer VR, Horak CE, Scafe CS, Botstein D, Snyder M, Brown PO (2001) Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature 409:533-538
22. Johnson LH, Johnston AL (1995) The DNA repair genes RAD54 and UNG1 are cell cycle regulated in budding yeast but MCB promoter elements have no essential role in the DNA damage response. Nucleic Acids Res 23:2147-2152
23. Knight AW, Goddard NJ, Fielden PR, Barker MG, Billinton N, Walmsley RM (1999) Development of a flow through detector for monitoring genotoxic compounds by quantifying the expression of green fluorescent protein in genetically modified yeast cells. Meas Sci Tech 10:211-217
24. Koch C, Moll T, Neuberg M, Ahorn H, Nasmyth K (1993) A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science 261:1551-1557
25. Longhese M, Paciotti V, Fraschini R, Zaccarini R, Plevani P, Lucchini G (1997) The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast EMBO J 16:5216-5226
26. Lowndes NF, Murguia JR (2000) Sensing and responding to DNA damage. Curr Opin Genet Dev 10:17-25
27. Lydall D, Weinert T (1995) Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270:1488-1491
28. Paciotti V, Lucchini G, Plevani P, Longhese M (1998) Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J 17:4199-4209
29. Petukhova G, Stratton S, Sung P (1998) Catalysis of homologous pairing by yeast Rad51 and Rad54 proteins. Nature 393:91-94
30. Reichard P (1988) Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem 57:349-374
31. Sanchez Y, Bachant J, Wong H, Hu F, Liu D, Tetzlaff M, Elledge SJ (1999) Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 286:1166-1171
32. Siede W, Friedberg AS, Friedberg EC (1993) RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 90:7985-7989
33. Singh KK, Samson L (1995) Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes. Proc Natl Acad Sci USA 92:4907-4911
34. Sung P (1994) Catalysis of ATP-dependent homologous DNA-pairing and strand exchange by yeast RAD51 protein. Science 265:1241-1243
35. Wach A, Brachat A, Poehlmann R, Philippsen P (1994) New heterologous modules for classical or PCR-based gene disruptions in S. cerevisiae. Yeast 10:1793-1808
36. Walmsley RM, Gardner DCJ, Oliver SG (1983) Stability of a cloned gene in yeast grown in chemostat culture. Mol Gen Genet 192:361-365
37. Walmsley RM, Billinton N, Heyer W-D (1997) Green fluorescent protein as a reporter for the DNA damage-induced gene RAD54 in Saccharomyces cerevisiae. Yeast 13:1535-1545
38. Weinert T (1998) DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94:555-558
39. Weinert TA, Hartwell LH (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241:317-322
40. Wold MS (1997) Replication protein A: a heterotrimeric, single stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem 66:61-92
41. Xiao W, Singh KK, Chen B, Samson L (1993) A common element involved in transcriptional regulation of two DNA alkylating genes (mag and MTG1) of Saccharomyces cerevisiae. Mol Cell Biol 13:7113-7121
42. Zhou Z, Elledge SJ (1993) DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75:1119-1127