The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: A meta-analysis

Journal of Human Genetics

Volumn 50, Issue 11, 2005, Pages 560-566

  Zintzaras, Elias ^a   Hadjigeorgiou, Georgios M ^b  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY HOSPITAL OF LARISSA   (Greece)

Author keywords

BDNF; Brain derived neurotrophic factor; G196A; Meta analysis; Parkinson's disease; Polymorphism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ALLELE; ARTICLE; ASIAN; CASE CONTROL STUDY; CLINICAL TRIAL; CONFIDENCE INTERVAL; DNA POLYMORPHISM; EUROPEAN AMERICAN; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC SUSCEPTIBILITY; HOMOZYGOSITY; HUMAN; META ANALYSIS; PARKINSON DISEASE; PATHOGENESIS; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW;

ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN-DERIVED NEUROTROPHIC FACTOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHERITANCE PATTERNS; ODDS RATIO; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; SENSITIVITY AND SPECIFICITY;

EID: 27944457221     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0295-z     Document Type: Article

References (44)

1. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-1101
2. Cardon LR, Bell JI (2001) Association study designs for complex diseases. Nat Genet Rev 2:91-99
3. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101-129
4. Dawson TM, Dawson VL (2003) Rare genetic mutations shed light on the pathogenesis of Parkinson disease. J Clin Invest 111:145-151
5. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269
6. Egger M, Davey SG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634
7. Hakansson A, Melke J, Westberg L, Shahabi HN, Buervenich S, Carmine A, Klingborg K, Grundell MB, Schulhof B, Holmberg B, Ahlberg J, Eriksson E, Sydow O, Olson L, Johnels B, Nissbrandt H (2003) Lack of association between the BDNF Val66Met polymorphism and Parkinson's disease in a Swedish population. Ann Neurol 53:823
8. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557-560
9. Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M (2000) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 76:347-354
10. Hong CJ, Liu HC, Liu TY, Lin CH, Cheng CY, Tsai SJ (2003) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset. Neurosci Lett 353:75-77
11. Huang X, Chen PC, Poole C (2004) APOE-[varepsilon]2 allele associated with higher prevalence of sporadic Parkinson disease. Neurology 62:2198-2202
12. Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230-232
13. Ioannidis JP, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG (2003) Genetic associations in large versus small studies: an empirical assessment. Lancet 361:567-571
14. Ioannidis JP, Ntzani EE, Trikalinos TA (2004) "Racial" differences in genetic effects for complex diseases. Nat Genet 36:1312-1318
15. Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC (1992) Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med 327:248-254
16. Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820-826
17. Lewis PO, Zaykin D (2001) Genetic Data Analysis: computer program for the analysis of allelic data. Version 1.0 (d16c). Available from http://lewis.eeb.uconn.edu/lewishome/software.html
18. Liu QR, Walter D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR (2005) Human brain neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 134:93-103
19. Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S (2003) Association between a polymorphism of brain-derived neurotrophic factor gene and sporadic Parkinson's disease. Ann Neurol 54:276-277
20. Mellick GD, Maraganore DM, Silburn PA (2005) Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease. Neurosci Lett 375:112-116
21. Mizuta I, Mizuta E, Yamasaki S, Kuno S, Yasuda M, Tanaka C (2000) Meta-analysis of polymorphism of the catechol- O-methyltransferase gene in relation to the etiology of Parkinson's disease in Japan. Mov Disord 15:1013-1014
22. Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, Nagatsu T (1999) Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci Lett 270:45-48
23. Momose Y, Murata M, Kobayashi K, Tachikawa M, Nakabayashi Y, Kanazawa I, Toda T (2002) Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms. Ann Neurol 51:133-136
24. Muncer S (2002) Response to: "Power dressing and meta-analysis: incorporating power analysis into meta-analysis". J Adv Nurs 38:274-280
25. Murer MG, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63:71-124
26. Nishimura M, Kuno S, Kaji R, Kawakami H (2005) Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Mov Disord 20:1031-1033
27. Parsian A, Sinha R, Racette B, Zhao JH, Perlmutter JS (2004) Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease. Parkinsonism Relat Disord 10:213-219
28. Persad AS, Stedeford T, Tanaka S, Chen L, Banasik M (2003) Parkinson's disease and CYP2D6 polymorphism in Asian populations: a meta-analysis. Neuroepidemiology 22:357-361
29. Piccini P, Burn DJ, Ceravolo R, Maraganore D, Brooks DJ (1999) The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol 45:577-582
30. Racette BA, Rundle M, Parsian A, Perlmutter JS (1999) Evaluation of a screening questionnaire for genetic studies of Parkinson's disease. Am J Med Genet 88:539-543
31. Schapira AH (1997) Pathogenesis of Parkinson's disease. Baillieres Clin Neurol 6:15-36
32. Sveinbjornsdottir S, Hicks AA, Jonsson T, Petursson H, Gugmundsson G, Frigge ML, Kong A, Gulcher JR, Stefansson K (2000) Familial aggregation of Parkinson's disease in Iceland. N Engl J Med 343:1765-1770
33. Thomas DC, White JS (2002) Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev 11:505-512
34. Toda T, Momose Y, Murata M, Tamiya G, Yamamoto M, Hattori N, Inoko H (2003) Toward identification of susceptibility genes for sporadic Parkinson's disease. J Neurol 250[Suppl]:III/40-III/43
35. Weir BS (1996) Genetic data analysis II: methods for discrete population genetic data. Sinauer, Sunderland, MA
36. Whitehead A (1997) A prospectively planned cumulative meta-analysis applied to a series of concurrent clinical trials. Stat Med 16:2901-2913
37. Whitehead A (2002) Meta-analysis of controlled clinical trials. Wiley, Chichester
38. Wirdefeldt K, Burgess CE, Westerberg L, Payami H, Schalling (2003) A linkage study of candidate loci in familial Parkinson's disease. Biomed Cent Neurol 3:6
39. Xu J, Turner A, Little J, Bleecker ER, Meyers DA (2002) Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? Hum Genet 111:573-574
40. Zhang J, Song Y, Chen H, Fan D (2005) The tau gene haplotype h1 confers a susceptibility to Parkinson's disease. Eur Neurol 53:15-21
41. Zintzaras E, Hadjigeorgiou GM (2004) Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis. J Hum Genet 49:474-481
42. Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28:123-137
43. Zintzaras E, Stefanidis I (2005) Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis. J Hum Genet 50:84-91
44. Zintzaras E, Chatzoulis DZ, Karabatsas CH, Stefanidis I (2005) The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis. J Hum Genet 50:267-275