Point: Population stratification: A problem for case-control studies of candidate-gene associations?

Cancer Epidemiology Biomarkers and Prevention

Volumn 11, Issue 6, 2002, Pages 505-512

  Thomas, Duncan C ^a   Witte, John S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; CANCER GENETICS; ETHNOLOGY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW;

BIAS (EPIDEMIOLOGY); CASE-CONTROL STUDIES; DEMOGRAPHY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEOPLASMS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; RISK ASSESSMENT;

EID: 0036277684     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)

1. Genetic dissection of complex traits
2. The transmission/disequilibrium test: History, subdivision, and admixture
3. Genetic polymorphism and disease
4. Population stratification in association studies
5. Applications of the case-control method in genetic epidemiology
6. The future of genetic studies of complex human diseases: An epidemiologic perspective
7. Counterpoint: Bias from population stratification is not a major threat to the validity of conclusions from epidemiologic studies of common polymorphisms and cancer
8. Multipoint linkage disequilibrium mapping with particular reference to the African-American population
9. 3,5,13,14 and type 2 diabetes mellitus: An association in American Indians with genetic admixture
10. The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal
11. Allelic association of human dopamine D2 receptor gene in alcoholism
12. A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism
13. Family-based study of DRD2 alleles in alcohol and drug dependence
14. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
15. Genetic analysis of IDDM: Summary of GAW5-IDDM results
16. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
17. Allele frequencies for 20 microsatellites in a worldwide population survey
18. Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations
19. Tumor antigens recognized by T lymphocytes
20. Spatial patterns of human gene frequencies in Europe
21. Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias
22. Statistical methods in cancer research. I. The analysis of case-control studies
23. Genomic control for association studies
24. Unbiased methods for population-based association studies
25. Genomic control, a new approach to genetic-based association studies
26. Case-control studies of association in structured or admixed populations
27. The common PPARγ Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes
28. Association study designs for complex diseases
29. Parameters for reliable results in genetic association studies in common disease
30. Methodological issues in the interpretation of studies of the CYP 2D6 genotype in relation to lung cancer risk
31. Large upward bias in estimation of locus-specific effects from genomewide scans
32. Freely associating
33. Linkage disequilibrium mapping of complex disease: Fantasy or reality?
34. Publication bias: A problem in interpreting medical data
35. Plots of P-values to evaluate many tests simultaneously
36. Replication validity of genetic association studies
37. A comprehensive review of genetic association studies
38. Methods for epidemiologic analyses of multiple exposures: A review and comparative study of maximum-likelihood, preliminary-testing, and empirical-Bayes regression
39. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
40. The problem of multiple inference in studies designed to generate hypotheses
41. Genetic dissection of complex traits
42. Sequential tests for the detection of linkage
43. Guilt by association
44. Variability of human linkage data
45. The effect of misclassification in the presence of covariates
46. Exposure measurement error: Influence on exposure-disease relationships and methods of correction
47. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada
48. Use of parents, sibs and unrelated controls for detection of associations between genetic markers and disease
49. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II, Individual genotyping
50. Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: Basic family designs
51. Biased selection of controls for case control analysis of cohort studies
52. Family-based association studies
53. Ascertainment bias in family-based case-control studies
54. On estimating HLA/disease association with application to a study of aplastic anemia
55. The power of genomic control
56. Detecting association in a case-control study while correcting for population stratification
57. Use of unlinked genetic markers to detect population stratification in association studies
58. Inference of population structure using multilocus genotype data
59. The future of genetic case-control studies
60. Hierarchical modeling of the relation between sequence variants and a quantitative trait: Addressing multiple comparison and population stratification issues
61. Association mapping in structured populations
62. Association studies for quantitative traits in structured populations
63. Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model
64. Quantitative method in the review of epidemiologic literature