Assay for high glucose-mediated islet cell sensitization to apoptosis induced by streptozotocin and cytokines

Biological Procedures Online

Volumn 7, Issue 1, 2005, Pages 162-171

  Mellado Gil, Jose M ^a   Aguilar Diosdado, Manuel ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

Author keywords

Apoptosis; Cytokines; Diabetes mellitus; Streptozotocin

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLUCOSE; INTERLEUKIN 1BETA; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; METHODOLOGY; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SENSITIZATION; STATISTICAL ANALYSIS; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALIA;

EID: 27944449284     PISSN: 14809222     EISSN: 14809222     Source Type: Journal    
DOI: 10.1251/bpo113     Document Type: Article

References (36)

1. Castaño L, Eisenbarth GS. Type 1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 1990;8:647-679.
2. O'Brien BA, Harmon BV, Cameron DP, Allan DJ. Apoptosis is the mode of [beta]-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 1997; 46:750-757.
3. Kurrer MO, Pakala SV, Hanson HL, Katz JD. Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc Natl Acad Sci USA 1997;94:213-218.
4. Augstein P, Elefanty AG, Allison J, Harrison LC. Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 1998;41:1381-1388.
5. Kaneto H, Fujii J, Seo HG. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes 1995;44:733-738.
6. Dunger A, Augstein P, Schmidt S, Fisher U. Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA. J Autoimmun 1996;9:309-313.
7. Dunger A, Schroder D, Augstein P, Witstruck T, Wachlin G, Vogt L, Ziegler B, Schmidt S. Impact of metabolic activity of beta cells on cytokine-induced damage and recovery of rat pancreatic islets. Acta Diabetol 1995; 32: 217-224.
8. Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL. Activation of extracellular signal-regulated kinase (ERK) 1-2 contributes to cytokine-induced apoptosis in purified rat pancreatic b-cells. Eur Cyt Network 2000; 11:267-274.
9. Turk J, Corbett JA, Romanadham S, Bohrer A, McDaniel ML. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem Biophys Res Commun 1993; 197:1458-1464.
10. Masutani M, Suzuki H, Kamada N, Watanabe M, Ueda O, Nozaki T, Jishage K, Watanabe T, Sugimoto T, Nakagama H, Ochiya T, Sugimura T. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci USA 1999; 96:2301-2304.
11. Rhodes CJ. Type 2 diabetes - a matter of β-cell life and death? Science 2005; 307:380-384.
12. Sandler S, Bendtzen K, Eizirik DL, Strandell E, Welsh M, Welsh N. Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1beta in the presence of high glucose concentration. Immunology Letters 1990; 26:245-252.
13. Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir G. Beta-cell adaptation to hyperglycemia. Diabetes 2001; 50:S180-S181.
14. Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 2001; 50:1683-1690.
15. Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santiago JV, McDaniel ML. Potential autoantigens in insulin dependent diabetes mellitus: Expression of carboxypepetidase H and insulin but not glutamate decarboxylase on the β cell surface. Diabetes 1994; 43:418-425.
16. Krammer PH. CD95's deadly mission in the immune system (Review). Nature 2000; 407:789-795.
17. Yamada K, Takane-Gyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 1996; 39:1306-1312.
18. Stassi G, Todaro M, Richiusa P, Giordano M, Mattina A, Sbriglia MS, Lo MA, Buscemi G, Galluzzo A, Giordano C. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro. Transplant Proc 1995; 27:3271-3275.
19. Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 1998; 47:727-732.
20. Allison J, Strasser A. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc Natl Acad Sci USA 1998; 95:13818-13822.
21. Thomas HE, Darwiche R, Corbett JA, Kay TW. Evidence that beta cell death in the non-obese diabetic mouse is Fas independent. J Immunol 1999; 163:1562-1569.
22. Hanke J. Apoptosis and occurrence of Bcl-2, Bak, Bax. Fas and FasL in the developing and adult rat endocrine pancreas. Anat Embryol (Berl) 2000; 202:303-312.
23. Garchon HJ, Luan JJ, Eloy L, Bédossa P, Bach JF. Genetic analysis of immune dysfunction in nonobese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur J Immunol 1994; 24:380-384.
24. Lamhamedi-Cherradi SE, Luan JJ, Eloy L, Fluteau G, Bach JF, Garchon HJ. Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulation of Bcl-x. Diabetologia 1998; 41:178-184.
25. McDaniel ML, Colca JR, Kotagal N, Lacy PE. A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol 1983; 98:182-200.
26. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 1997; 138:2610-2614.
27. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrlje M, Nieman A, Geller DA, Pipeleers DG, Bendtzen K, Hellerström C. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 1994; 93:1968-1974.
28. Hoorens A, Pipeleers D. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 1999; 42:55-59.
29. Efanova IB, Zaitsev SV, Zhivotovsky B, Kohler M, Efendic S, Orrenius S, Berggren PO. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells: a process dependent on intracellular Ca2+ concentration. J Biol Chem 1998; 273:33501-33507.
30. Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 2002; 51:1340-1347.
31. Schnedl WJ, Ferber S, Johnson JH, Newgard CB. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994; 43:1326-1333.
32. Szkudelski T. The mechanism of alloxan and streptozotocin action in β cells of the rat pancreas. Physiol Res 2001; 50:536-546.
33. Saldeen J. Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology 2000; 141:2003-2010.
34. Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 2001; 50:1290-1301.
35. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. Glucose-induced beta cell production of IL-1 beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110:851-886.
36. Mellado-Gil JM, Aguilar-Diosdado M. High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes. J Endocrinology 2004; 183:155-162.