-
1
-
-
0035313697
-
HIF-1 and mechanisms of hypoxia sensing
-
G.L. Semenza HIF-1 and mechanisms of hypoxia sensing Curr. Opin. Cell Biol. 13 2001 167 171
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 167-171
-
-
Semenza, G.L.1
-
2
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
G.L. Wang, B.H. Jiang, E.A. Rue, and G.L. Semenza Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc. Natl. Acad. Sci. USA 92 1995 5510 5514
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
3
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
-
P.J. Kallio, W.J. Wilson, S. O'Brien, Y. Makino, and L. Poellinger Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway J. Biol. Chem. 274 1999 6519 6525
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
4
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
G.L. Wang, and G.L. Semenza Purification and characterization of hypoxia-inducible factor 1 J. Biol. Chem. 270 1995 1230 1237
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
6
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
P.H. Maxwell, M.S. Wiesener, G.W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, and P.J. Ratcliffe The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 399 1999 271 275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
7
-
-
0035917313
-
2 sensing
-
2 sensing Science 292 2001 464 468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
8
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
P. Jaakkola, D.R. Mole, Y.M. Tian, M.I. Wilson, J. Gielbert, S.J. Gaskell, A. Kriegsheim, H.F. Hebestreit, M. Mukherji, C.J. Schofield, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 292 2001 468 472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
9
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
N. Masson, C. Willam, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation EMBO J. 20 2001 5197 5206
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
10
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
J.W. Jeong, M.K. Bae, M.Y. Ahn, S.H. Kim, T.K. Sohn, M.H. Bae, M.A. Yoo, E.J. Song, K.J. Lee, and K.W. Kim Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation Cell 111 2002 709 720
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
Yoo, M.A.7
Song, E.J.8
Lee, K.J.9
Kim, K.W.10
-
11
-
-
0030792094
-
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
-
A. Rolfs, I. Kvietikova, M. Gassmann, and R.H. Wenger Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1 J. Biol. Chem. 272 1997 20055 20062
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 20055-20062
-
-
Rolfs, A.1
Kvietikova, I.2
Gassmann, M.3
Wenger, R.H.4
-
12
-
-
0033588021
-
Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation
-
L. Tacchini, L. Bianchi, A. Bernelli-Zazzera, and G. Cairo Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation J. Biol. Chem. 274 1999 24142 24146
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24142-24146
-
-
Tacchini, L.1
Bianchi, L.2
Bernelli-Zazzera, A.3
Cairo, G.4
-
13
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
G.L. Wang, and G.L. Semenza Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction Blood 82 1993 3610 3615
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
14
-
-
0030962028
-
Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase
-
J. Myllyharju, and K.I. Kivirikko Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase EMBO. J. 16 1997 1173 1180
-
(1997)
EMBO. J.
, vol.16
, pp. 1173-1180
-
-
Myllyharju, J.1
Kivirikko, K.I.2
-
15
-
-
0037083845
-
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene
-
Y.S. Chun, E. Choi, T.Y. Kim, M.S. Kim, and J.W. Park A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene Biochem. J. 362 2002 71 79
-
(2002)
Biochem. J.
, vol.362
, pp. 71-79
-
-
Chun, Y.S.1
Choi, E.2
Kim, T.Y.3
Kim, M.S.4
Park, J.W.5
-
16
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
E. Berra, E. Benizri, A. Ginouves, V. Volmat, D. Roux, and J. Pouyssegur HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia EMBO. J. 22 2003 4082 4090
-
(2003)
EMBO. J.
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
17
-
-
4243607831
-
Toxicity of iron and hydrogen peroxide: The Fenton reaction
-
C.C. Winterbourn Toxicity of iron and hydrogen peroxide: the Fenton reaction Toxicol. Lett. 82 1995 969 974
-
(1995)
Toxicol. Lett.
, vol.82
, pp. 969-974
-
-
Winterbourn, C.C.1
-
18
-
-
0027080934
-
Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury
-
R.J. Rothman, A. Serroni, and J.L. Farber Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury Mol. Pharmacol. 42 1992 703 710
-
(1992)
Mol. Pharmacol.
, vol.42
, pp. 703-710
-
-
Rothman, R.J.1
Serroni, A.2
Farber, J.L.3
-
19
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
L.E. Huang, Z. Arany, D.M. Livingston, and H.F. Bunn Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit J. Biol. Chem. 271 1996 32253 32259
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
20
-
-
0034647933
-
Antioxidant/pro-oxidant equilibrium regulates HIF-1alpha and NF-kappa B redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells
-
J.J. Haddad, R.E. Olver, and S.C. Land Antioxidant/pro-oxidant equilibrium regulates HIF-1alpha and NF-kappa B redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells J. Biol. Chem. 275 2000 21130 21139
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21130-21139
-
-
Haddad, J.J.1
Olver, R.E.2
Land, S.C.3
-
21
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
R.K. Bruick, and S.L. McKnight A conserved family of prolyl-4- hydroxylases that modify HIF Science 294 2001 1337 1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
22
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
A.C. Epstein, J.M. Gleadle, L.A. McNeill, K.S. Hewitson, J. O'Rourke, D.R. Mole, M. Mukherji, E. Metzen, M.I. Wilson, A. Dhanda, Y.M. Tian, N. Masson, D.L. Hamilton, P. Jaakkola, R. Barstead, J. Hodgkin, P.H. Maxwell, C.W. Pugh, C.J. Schofield, and P.J. Ratcliffe C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 107 2001 43 54
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
23
-
-
0037124173
-
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
-
L.A. McNeill, K.S. Hewitson, J.M. Gleadle, L.E. Horsfall, N.J. Oldham, P.H. Maxwell, C.W. Pugh, P.J. Ratcliffe, and C.J. Schofield The use of dioxygen by HIF prolyl hydroxylase (PHD1) Bioorg. Med. Chem. Lett. 12 2002 1547 1550
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1547-1550
-
-
McNeill, L.A.1
Hewitson, K.S.2
Gleadle, J.M.3
Horsfall, L.E.4
Oldham, N.J.5
Maxwell, P.H.6
Pugh, C.W.7
Ratcliffe, P.J.8
Schofield, C.J.9
-
24
-
-
0346059588
-
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: Implications for tumor promotion
-
Y.S. Chun, K.H. Lee, E. Choi, S.Y. Bae, E.J. Yeo, L.E. Huang, M.S. Kim, and J.W. Park Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion Cancer Res. 63 2003 8700 8707
-
(2003)
Cancer Res.
, vol.63
, pp. 8700-8707
-
-
Chun, Y.S.1
Lee, K.H.2
Choi, E.3
Bae, S.Y.4
Yeo, E.J.5
Huang, L.E.6
Kim, M.S.7
Park, J.W.8
-
25
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
K. Tanimoto, Y. Makino, T. Pereira, and L. Poellinger Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein EMBO J. 19 2000 4298 4309
-
(2000)
EMBO J.
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
|