Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354)

Clinical and Experimental Allergy

Volumn 35, Issue 8, 2005, Pages 1096-1103

  Blanchard, C ^a   Mishra, A ^a   Saito Akei, H ^a   Monk, P ^b   Anderson, I ^b   Rothenberg, Marc E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b MEDIMMUNE LTD   (United Kingdom)

Author keywords

Allergy; Asthma; Cytokines; Eosinophils; IL 13; Oesophagitis

Indexed keywords

CYTOKINE ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 13 ANTIBODY; METHACHOLINE; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; EOSINOPHILIA; ESOPHAGEAL EOSINOPHILIA; GOBLET CELL; LUNG LAVAGE; METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ASTHMA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EOSINOPHILIA; EOSINOPHILS; ESOPHAGITIS; GOBLET CELLS; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-13; LUNG; METAPLASIA; MICE; MICE, INBRED BALB C;

EID: 27744558641     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02299.x     Document Type: Article

References (48)

1. Sly RM. Increases in deaths from asthma. Ann Allergy 1984; 53:20-5.
2. Halfen N, Newacheck PW. Trends in the hospitalization for acute childhood asthma, 1970-84. Am J Public Health 1986; 76:1308-11.
3. Jackson R, Sears MR, Beaglehole R, Rea HH. International trends in asthma mortality: 1970 to 1985. Chest 1988; 94:914-8.
4. Gergen PJ, Weiss KB. Changing patterns of asthma hospitalization among children: 1979 to 1987. JAMA 1990; 264:1688-92.
5. Gleich GJ. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 1990; 85:422-36.
6. Arora AS, Yamazaki K. Eosinophilic esophagitis: asthma of the esophagus? Clin Gastroenterol Hepatol 2004; 2:523-30.
7. Hamelmann E, Wahn U, Gelfand EW. Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness. Int Arch Allergy Immunol 1999; 118:90-4.
8. Brightling CE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2002; 110:899-905.
9. Wong CK, Ho CY, Ko FW et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001; 125:177-83.
10. Lee YC, Lee KH, Lee HB, Rhee YK. Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthma. J Asthma 2001; 38:665-71.
11. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993; 92:313-24.
12. Corrigan CJ, Hamid Q, North J et al. Peripheral blood CD4 but not CDS T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am J Respir Cell Mol Biol 1995; 12:567-78.
13. Erb KJ, Le Gros G. The role of Th2 type CD4+T cells and Th2 type CD8+T cells in asthma. Immunol Cell Biol 1996; 74: 206-8.
14. Kibe A, Inoue H, Fukuyama S et al. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med 2003; 167:50-6.
15. Caramori G, Ito K, Adcock IM. Targeting Th2 cells in asthmatic airways. Curr Drug Targets Inflamm Allergy 2004; 3:243-55.
16. Wills-Karp M, Luyimbazi J, Xu X et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:2258-61.
17. Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, sub-epithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103:779-88.
18. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology 2003; 125:1419-25.
19. Grunig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261-3.
20. Kuperman DA, Huang X, Koth LL et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002; 8: 885-9.
21. Yang M, Hogan SP, Henry PJ et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 2001; 25:522-30.
22. Hahn C, Teufel M, Herz U et al. Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. J Allergy Clin Immunol 2003; 111:1361-9.
23. Yang G, Volk A, Petley T et al. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine 2004; 28:224-32.
24. Edwards BM, Barash SC, Main SH et al. The remarkable flexibility of the human antibody repertoire; isolation of over one thousand different antibodies to a single protein, BLyS. J Mol Biol 2003; 334:103-18.
25. Smart V, Foster PS, Rothenberg ME, Higgins TJ, Hogan SP. A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4+CD45RBlow T cell-dependent mechanism. J Immunol 2003; 171:2116-26.
26. Lee JJ, Dimina D, Macias MP et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004; 305: 1773-6.
27. D'Agostino B, Advenier C, de Palma R et al. The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica. Clin Exp Allergy 2002; 32:472-9.
28. Martin JG, Duguet A, Eidelman DH. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur Respir J 2000; 16:349-54.
29. Schuiling M, Zuidhof AB, Zaagsma J, Meurs H. Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs. Am J Respir Crit Care Med 1999; 159: 423-30.
30. Taube C, Wei X, Swasey CH et al. Mast cells, FcepsilonRI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol 2004; 172:6398-406.
31. Yang G, Haczku A, Chen H et al. Transgenic smooth muscle expression of the human CysLT 1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. Am J Physiol Lung Cell Mol Physiol 2004; 286:L992-1001.
32. Webb DC, Mahalingam S, Cai Y, Matthaei KI, Donaldson DD, Foster PS. Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity. Eur J Immunol 2003; 33:3377-85.
33. Whittaker L, Niu N, Temann UA et al. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol 2002; 27: 593-602.
34. Nicolaides NC, Holroyd KJ, Ewart SL et al. Interleukin 9: a candidate gene for asthma. Proc Natl Acad Sci USA 1997; 94: 13175-80.
35. Temann UA, Geba GP, Rankin JA, Flavell RA. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 1998; 188:1307-20.
36. Eum SY, Maghni K, Tolloczko B, Eidelman DH, Martin JG. IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2005; 288:L576-84.
37. Walter DM, McIntire JJ, Berry G et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001; 167:4668-75.
38. Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
39. Bryan SA, O'Connor BJ, Matti S et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2149-53.
40. Proust B, Nahori MA, Ruffie C, Lefort J, Vargaftig BB. Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/ c and IL-4Ralpha knockout mice. Clin Exp Allergy 2003; 33: 119-31.
41. Lordan JL, Bucchieri F, Richter A et al. Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J Immunol 2002; 169:407-14.
42. Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 1999; 162:6233-7.
43. Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003; 285:L730-9.
44. Shim JJ, Dabbagh K, Ueki IF et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 2001; 280:L134-40.
45. Loza Cortina C. Severe steroid-dependent asthma with IgG-2 deficiency and recurrent sinusitis: response to treatment with high-dose intravenous immunoglobulin. Allergol Immunopathol (Madrid) 1999; 27:165-7.
46. Sehra S, Pynaert G, Tournoy K et al. Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma. J Immunol 2003; 171:2080-9.
47. Tang C, Rolland JM, Ward C et al. Differential regulation of allergen-specific T(H2)- but not T(H1)-type responses by alveolar macrophages in atopic asthma. J Allergy Clin Immunol 1998; 102:368-75.
48. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol 2001; 108:954-61.