IAP family proteins delay motoneuron cell death in vivo

European Journal of Neuroscience

Volumn 12, Issue 6, 2000, Pages 2059-2067

  Perrelet, Daniel ^a   Ferri, A ^a   MacKenzie, A E ^d   Smith, G M ^b   Korneluk, R G ^d   Liston, P ^d   Sagot, Y ^a,c   Terrado, J ^a   Monnier, D ^a   Kato, A C ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Serono International SA   (Switzerland)

^d NONE

Author keywords

Adenovirus; Apoptosis; Axotomy; HIAP1; HIAP2; NAIP; Rodents

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE TRANSFER; HIPPOCAMPUS; LUMBAR SPINAL CORD; MOTONEURON; MOTOR NEURON DISEASE; NERVE FIBER TRANSECTION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; SCIATIC NERVE; TIME;

ADENOVIRIDAE; ANIMALS; AXOTOMY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CILIARY NEUROTROPHIC FACTOR; GENE EXPRESSION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INSECT PROTEINS; MOTOR NEURONS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD; TRANSFECTION; TRANSGENES;

EID: 0034087982     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00098.x     Document Type: Article

References (32)

1. Baumgartner, B.J. & Shine, H.D. (1997) Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population. J. Neurosci., 17, 6504-6511.
2. Baumgartner, B.J. & Shine, H.D. (1998) Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor. Exp. Neurol., 153, 102-112.
3. Bergelson, J.M., Cunningham, J.A., Droguett, G., Kurt-Jones, E.A., Krithivas, A., Hong, J.S., Horwitz, M.S., Crowell, R.L. & Finherg, R.W. (1997) Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science, 275, 1320-1323.
4. Bergelson, J.M., Krithivas, A., Celi, L., Droguett, G., Horwitz, M.S., Wickham, T., Crowell, R.L. & Finherg, R.W. (1998) The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J. Virol., 72, 415-419.
5. Casanovas, A., Ribera, J., Hukkanen, M., Riveros-Moreno, V. & Esquerda, J.E. (1996) Prevention by lamotrigine, MK-801 and N omega-nitro-L-arginine methyl ester of motoneuron cell death after neonatal axotomy. Neuroscience, 71, 313-325.
6. DeMatteo, R.P., Markmann, J.F., Kozarsky, K.F., Barker, C.F. & Raper, S.E. (1996) Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Ther., 3, 4-12.
7. Deveraux, Q.L. & Reed, J.C. (1999) IAP family proteins - suppressors of apoptosis. Genes Dev., 13, 239-252.
8. Dubois-Dauphin, M., Frankowski, H., Tsujimoto, Y., Huarte, J. & Martinou, J.C. (1994) Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl Acad. Sci. USA, 91, 3309-3313.
9. Finiels, F., Gimenez, y. R.M., Barkats, M., Samolyk, M.L., Robert, J.J., Privat, A., Revah, F. & Mallet, J. (1995) Specific and efficient gene transfer strategy offers new potentialities for the treatment of motor neurone diseases. Neuroreport, 7, 373-378.
10. Gimenez y Ribotta, M., Revah, F., Pradier, L., Loquet, I., Mallet, J. & Privat, A. (1997) Prevention of motoneuron death by adenovirus-mediated neurotrophic factors. J. Neurosci. Res., 48, 281-285.
11. Gravel, C., Gotz, R., Lorrain, A. & Sendtner, M. (1997) Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nature Med., 3, 765-770.
12. Guarin, E., Seuret, P., Nef, S., de Bilbao, F., Nef, P. & Dubois-Dauphin, M. (1999) cpp. 32 messenger RNA neosynthesis is induced by fatal axotomy and is not regulated by athanatal Bcl-2 over-expression. Neuroscience, 90, 653-664.
13. Guérette, B., Vilquin, J.T., Gingras, M., Gravel, C., Wood, K.J. & Tremblay, J.P. (1996) Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig. Hum. Gene Ther., 7, 1455-1463.
14. Kaplan, D.R. & Miller, F.D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol., 9, 213-221.
15. Kermer, P., Klocker, N., Labes, M., Thomsen, S., Srinivasan, A. & Bahr, M. (1999) Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett., 453, 361-364.
16. LaCasse, E.C., Baird, S., Korneluk, R.G. & MacKenzie, A.E. (1998) The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene, 17, 3247-3259.
17. Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G., Farahani, R., McLean, M., Ikeda, J.E., MacKenzie, A. & Korneluk, R.G. (1996) Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature, 379, 349-353.
18. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F.H., Verma, I.M. & Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science, 272, 263-267.
19. Pettmann, B. & Henderson, C.E. (1998) Neuronal cell death. Neuron, 20, 633-647.
20. Rabizadeh, S., Gralla, E.B., Borchelt, D.R., Gwinn, R., Valentine, J.S., Sisodia, S., Wong, P., Lee, M., Hahn, H. & Bredesen, D.E. (1995) Mutations associated with amyotrophic lateral sclerosis convert Superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl Acad. Sci. USA, 92, 3024-3028.
21. Rossiter, J.P., Riopelle, R.J. & Bisby, M.A. (1996) Axotomy-induced apoptotic cell death of neonatal rat facial motoneurons: time course analysis and relation to NADPH-diaphorase activity. Exp. Neural, 138, 33-44.
22. Roy, N., Mahadevan, M.S., McLean, M., Shutler, G., Yaraghi, Z., Farahani, R., Baird, S., Besner-Johnston, A., Lefebvre, C. & Kang, X. (1995) The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell, 80, 167-178.
23. Sendtner, M., Kreutzberg, G.W. & Thoenen, H. (1990) Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature, 345, 440-441.
24. Simons, M., Beinroth, S., Gleichmann, M., Liston, P., Komeluk, R.G., MacKenzie, A.E., Bahr, M., Klockgether, T., Robertson, G.S., Weller, M. & Schulz, J.B. (1999) Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons. J. Neurochem., 72, 292-301.
25. Smith, G.M., Hale, J., Pasnikowski, E.M., Lindsay, R.M., Wong, V. & Rudge, J.S. (1996) Astrocytes infected with replication-defective adenovirus containing a secreted form of CNTF or NT3 show enhanced support of neuronal populations in vitro. Exp. Neurol., 139, 156-166.
26. Thompson, C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
27. Vanderluit, J.L., McPhail, L.T., Fernandes, K.J.L., Huguenot, C. & Tetzlaff, W. (1999) Caspase-3 accelerates, but is not required for, the apoptosis of axotomized neonatal motoneurons. Soc. Neurosci. Abstr., 25, 1773.
28. Vejsada, R., Sagot, Y. & Kato, A.C. (1995) Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo. Eur. J. Neurosci., 7, 108-115.
29. Vejsada, R., Tseng, J.L., Lindsay, R.M., Acheson, A., Aebischer, P. & Kato, A.C. (1998) Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons. Neuroscience, 84, 129-139.
30. Wiese, S., Digby, M.R., Gunnersen, J.M., Gotz, R., Pei, G., Holtmann, B., Lowenthal, J. & Sendtner, M. (1999) The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons. Nature Neurosci., 2, 978-983.
31. Xu, D.G., Crocker, S.J., Doucet, J.P., St-Jean, M., Tamai, K., Hakim, A.M., Ikeda, J.E., Liston, P., Thompson, C.S., Komeluk, R.G., MacKenzie, A. & Robertson, G.S. (1997) Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nature Med., 3, 997-1004.
32. Yan, Q., Elliott, J. & Snider, W.D. (1992) Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature, 360, 753-755.