Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1

Journal of Cancer Research and Clinical Oncology

Volumn 131, Issue 12, 2005, Pages 789-796

  Kwak, Hee Jin ^a   Kim, Sung Hak ^a   Yoo, Hyeon Gyeong ^a   Park, Seok Hee ^a,b   Lee, Chang Hun ^a  

^a National Cancer Center   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

53BP1; Hyperphosphorylation; Jab1; Mitotic checkpoint; Protein interaction

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; HISTONE H3; NOCODAZOLE; PROTEIN; PROTEIN 53BP1; PROTEIN C JUN; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SCREENING TEST; YEAST;

ANTINEOPLASTIC AGENTS; CELL CYCLE; DNA DAMAGE; DNA REPAIR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOSIS; MITOTIC INDEX; NOCODAZOLE; PEPTIDE HYDROLASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 27744541319     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-005-0035-y     Document Type: Article

References (25)

1. Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ (2004) Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol 24:10448-10455
2. Amato SF, Swart JM, Berg M, Wanebo HJ, Mehta SR, Chiles TC (1998) Transient stimulation of the c-Jun-NH2-terminal kinase/ activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts. Cancer Res 58:241-247
3. Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW (2002) Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem 277:9-12
4. Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W (2001) COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Embo J 20:1630-1639
5. Claret FX, Hibi M, Dhut S, Toda T, Karin M (1996) A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature 383:453-457
6. Cohen-Fix O, Peters JM, Kirschner MW, Koshland D (1996) Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev 10:3081-3093
7. Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cull. Science 298:608-611
8. DiTullio RA Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD (2002) 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol 4:998-1002
9. Doronkin S, Djagaeva I, Beckendorf SK (2002) CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint. Development 129:5053-5064
10. Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S (1994) Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci USA 91:6098-6102
11. Iwabuchi K, Li B, Massa HF, Trask BJ, Date T, Fields S (1998) Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem 273:26061-26068
12. Jullien D, Vagnarelli P, Earnshaw WC, Adachi Y (2002) Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J Cell Sci 115:71-79
13. Kim BC, Lee HJ, Park SH, Lee SR, Karpova TS, McNally JG, Felici A, Lee DK, Kim SJ (2004) Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation. Mol Cell Biol 24:2251-2262
14. Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature 408:211-216
15. Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Deshaies RJ (2001) Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292:1382-1385
16. Mundt KE, Porte J, Murray JM, Brikos C, Christensen PU, Caspari T, Hagan IM, Millar JB, Simanis V, Hofmann K, Carr AM (1999) The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Curr Biol 9:1427-1430
17. Peters JM (2002) The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell 9:931-943
18. Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ (2002) hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. Mol Cell Biol 22:8635-8647
19. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (1998) A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. Faseb J 12:469-478
20. Sun Y, Wilson MP, Majerus PW (2002) Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. J Biol Chem 277:45759-45764
21. Tomoda K, Kubota Y, Kato J (1999) Degradation of the cyclin-dependent- kinase inhibitor p27Kip1 is instigated by Jab1. Nature 398:160-165
22. Uhlmann F, Lottspeich F, Nasmyth K (1999) Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature 400:37-42
23. Wang B, Matsuoka S, Carpenter PB, Elledge SJ (2002) 53BP1, a mediator of the DNA damage checkpoint. Science 298:1435-1438
24. Wei N, Deng XW (2003) The COP9 signalosome. Annu Rev Cell Dev Biol 19:261-286
25. Wilson MP, Sun Y, Cao L, Majerus PW (2001) Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2. J Biol Chem 276:40998-41004