Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes

Vascular Pharmacology

Volumn 43, Issue 5, 2005, Pages 327-335

  Mascareno, Eduardo ^a   Beckles, Daniel L ^a   Siddiqui, M A Q ^a  

^a SUNY Downstate Medical Center   (United States)

Author keywords

Angiotensin; Apoptosis; Gene expression; Hypoxia

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CASPASE 3; HEAT SHOCK PROTEIN 27; INTERLEUKIN 1BETA CONVERTING ENZYME; JANUS KINASE 2; LOSARTAN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BAX; PROTEIN S6; RIBOSOME PROTEIN; STAT1 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; HEART MUSCLE CELL; HEART PROTECTION; HYPOXIA; NEGATIVE FEEDBACK; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANGIOTENSIN II; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL LINE; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; JANUS KINASE 2; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; TYROSINE;

EID: 27744497308     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2005.08.023     Document Type: Article

References (44)

1. B. Antus, I. Mucsi, and L. Roisvall Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives Acta Physiol. Hung. 87 2000 5 24
2. P. Anversa, A. Leri, B. Li, Y. Liu, S. Di Somma, and J. Kajstura Ischemic cardiomyopathy and the cellular renin-angiotensin system J. Heart Lung Transplant. 19 8 Suppl 2000 S1 S11 Aug
3. C.J. Auernhammer, F. Dorn, G. Vlotides, S. Hengge, F.B. Kopp, G. Spoettl, N. Cengic, D. Engelhardt, and M.M. Weber The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells J. Endocrinol. 180 2004 479 486
4. B.K. Brar, A. Stephanou, M.J. Wagstaff, R.S. Coffin, M.S. Marber, G. Engelmann, and D.S. Latchman Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress J. Mol. Cell Cardiol. 31 1999 135 146
5. R. Caballero, R. Gomez, I. Moreno, L. Nunez, T. Gonzalez, C. Arias, M. Guizy, C. Valenzuela, J. Tamargo, and E. Delpon Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current Cardiovasc. Res. 62 2004 86 95
6. J. Cairns, S. Qin, R. Philp, Y.H. Tan, and G.R. Guy Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A J. Biol. Chem. 269 1994 9176 9183
7. Y. Chen, A.P. Arrigo, and R.W. Currie Heat shock treatment suppresses angiotensin II-induced activation of NF-kappaB pathway and heart inflammation: a role for IKK depletion by heat shock? Am. J. Physiol. Heart Circ. Physiol. 287 2004 H1104 H1114
8. Y.E. Chin, B. Kitagawa, and K. Kuida Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis Mol. Cell Biol. 17 1997 5328 5337
9. W.S. Colucci Apoptosis in the heart N. Engl. J. Med. 335 1996 1224 1226
10. A. Elsasser, K. Suzuki, and J. Schaper The role of apoptosis in myocardial ischemia: a critical appraisal J. Mol. Cell. Cardiol. 32 2000 711 724
11. C. Ferrandi, R. Ballerio, P. Gaillard, C. Giachetti, S. Carboni, P.A. Vitte, J.P. Gotteland, and R. Cirillo Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats Br. J. Pharmacol. 142 2004 953 960
12. G.Z. Feuerstein, and P.R. Young Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways Cardiol. Res. 45 2000 560 569
13. G. Filippatos, and B.D. Uhal Blockade of apoptosis by ACE inhibitors and angiotensin receptor antagonists Curr. Pharm. Des. 9 2003 707 714
14. V. Guaiquil, D.W. Golde, D.L. Beckles, E. Mascareno, and M.A.Q. Siddiqui Vitamin C inhibits hypoxia induced damage and apoptosis signaling pathways in cardiomyocytes and ischemic a hearts Free Radical. Biol. Med. 37 2004 1419 1429
15. Y. Guo, E. Mascareno, and M.A.Q. Siddiqui Distinct components of Janus kinase/signal transducer and activator of transcription signaling pathway mediate the regulation of systemic and tissue localized renin-angiotensin system Mol. Endocrinol. 18 2004 1033 1041
16. R. Hattori, N. Maulik, H. Otani, L. Zhu, G. Cordis, R.M. Engelman, M.A.Q. Siddiqui, and D.K. Das Role of STAT3 in ischemic preconditioning J. Mol. Cell Cardiol. 33 2001 1929 1936
17. A. Haunstetter, and S. Izumo Apoptosis: basic mechanisms and implications for cardiovascular disease Circ. Res. 82 1998 1111 1129
18. J. Hescheler, R. Meyer, S. Plant, D. Krautwurst, W. Rosenthal, and G. Schultz Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9C2) line from rat heart Circ. Res. 69 1991 1476 1486
19. J.M. Ho, B.K. Beattie, and J.A. Squire Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling Blood 93 1999 4354 4364
20. F. Hong, S.J. Kwon, B.S. Jhun, S.S. Kim, J. Ha, S.J. Kim, N.W. Sohn, C. Kang, and I. Kang Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways Life Sci. 68 2001 1095 1105
21. J.N. Ihle The Janus kinase family and signaling through members of the cytokine receptor superfamily Proc. Soc. Exp. Biol. Med. 206 1994 268 272
22. P. Kang, A. Haunstetter, and H. Aoki Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation Circ. Res. 87 2000 118 125
23. H. Kodama, K. Fukuda, and J. Pan Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes Circ. Res. 81 1997 656 663
24. A. Leri, P.P. Claudio, and Q. Li Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell J. Clin. Invest. 101 1998 1326 1342
25. D.J. Lips, O.F. Bueno, B.J. Wilkins, N.H. Purcell, R.A. Kaiser, J.N. Lorenz, L. Voisin, M.K. Saba-El-Leil, S. Meloche, J. Pouyssegur, G. Pages, L.J. De Windt, P.A. Doevendans, and J.D. Molkentin MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo Circulation 109 2004 1938 1941
26. H. Lou, I. Danelisen, and P.K. Singal Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy Am. J. Physiol. Heart Circ. Physiol. 288 2005 H1925 H1930
27. E. Mascareno, and M.A.Q. Siddiqui The role of Jak/STAT signaling in heart tissue renin-angiotensin system Mol. Cell. Biochem. 212 2000 171 175
28. E. Mascareno, M. Dhar, and M.A.Q. Siddiqui Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle Proc. Natl. Acad. Sci. U. S. A. 95 1998 5590 5594
29. E. Mascareno, M. El-Shafie, and N. Maulik JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion Circulation 104 2001 325 329
30. N. Meydan, T. Grunberger, and H. Dadi Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor Nature 379 1996 645 646
31. R. Moudgil, V. Menon, Y. Xu, S. Musat-Marcu, D. Kumar, and B.I. Jugdutt Postischemic apoptosis and functional recovery after angiotensin II type 1 receptor blockade in isolated working rat hearts J. Hypertens. 19 2001 1121 1129
32. J. Narula, N. Haider, and R. Virmani Apoptosis in myocytes in end-stage heart failure N. Engl. J. Med. 335 1996 1182 1189
33. S. Negoro, K. Kunisada, E. Tone, M. Funamoto, H. Oh, T. Kishimoto, and K. Yamauchi-Takihara Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction Cardiovasc. Res. 47 2000 797 805
34. T. Okamura, T. Miura, and G. Takemura Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart Cardiovasc. Res. 45 2000 642 650
35. T. Omura, M. Yoshiyama, F. Ishikura, H. Kobayashi, K. Takeuchi, S. Beppu, and J. Yoshikawa Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats J. Mol. Cell. Cardiol. 33 2001 307 316
36. D. Pennica, W.I. Wood, and K.R. Chien Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways Cytokine Growth-Factor Rev. 7 1996 81 91
37. P. Pierzchalski, K. Reiss, and W. Cheng p53 induces myocyte apoptosis via the activation of the renin-angiotensin system Exp. Cell. Res. 234 1997 57 65
38. S. Ravassa, M.A. Fortune, and A. Gonzalez Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats Hypertension 36 2000 1065 1074
39. T. Ruckle, M. Biamonte, T. Grippi-Vallotton, S. Arkinstall, Y. Cambet, M. Camps, C. Chabert, D.J. Church, S. Halazy, X. Jiang, I. Martinou, A. Nichols, W. Sauer, and J.P. Gotteland Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase J. Med. Chem. 47 2004 6921 6934
40. E.M. Sandberg, and P.P. Sayeski Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells J. Biol. Chem. 279 2004 34547 34552
41. E.M. Sandberg, X. Ma, D. VonDerLinden, M.D. Godeny, and P.P. Sayeski Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1 J. Biol. Chem. 279 2004 1956 1967
42. A. Stephanou, B.K. Brar, and T.M. Searabel Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis J. Biol. Chem. 275 2000 10001 10008
43. E. Teiger, V.D. Than, L. Richard, and C. Wisnewsky Apoptosis in pressure overload-induced heart hypertrophy in the rat J. Clin. Invest. 97 1996 2891 2897
44. C.R. Yellaturu, M. Bhanoori, I. Neeli, and G.N. Rao N-ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A J. Biol. Chem. 277 2002 40148 40155