Postischemic apoptosis and functional recovery after angiotensin II type 1 receptor blockade in isolated working rat hearts

Journal of Hypertension

Volumn 19, Issue 6, 2001, Pages 1121-1129

  Moudgil, Rohit ^a   Menon, Vijayan ^a   Xu, Yi ^a   Musat Marcu, Sorin ^a   Kumar, Dinender ^a   Jugdutt, Bodh I ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Apoptosis; AT1 receptor blockade; Ischemia reperfusion; Ventricular function; Working heart

Indexed keywords

5 METHYL 7 PROPYL 8 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDIN 2(3H) ONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CASPASE 3; LOSARTAN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FUNCTION; HEART WORK; ISOLATED HEART; LONG TERM CARE; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; REPERFUSION INJURY;

EID: 0034999256     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200106000-00018     Document Type: Article

References (49)

1. Apoptosis: Basic mechanisms and implications for cardiovascular disease
2. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
3. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis
4. Apoptosis in acute myocardial infarction
5. Apoptotic and necrotic myocyte cell deaths are independent variables of infarct size in rats
6. Apoptosis in ischemic and reperfused rat myocardium
7. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
8. Ischemia-reperfusion induces apoptosis in rat myocardium through a cycloheximide-inhibitable pathway
9. Changes in cardiac Angll postmyocardial infarction in rats: Effects of nephrectomy and ACE inhibitors
10. Increased vulnerability of hypertrophied myocardium to ischemia and reperfusion injury. Relation to cardiac reninangiotensin system
11. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro
12. Angiotensin-II activates programmed myocyte cell death in vitro
13. p53 induces myocyte apoptosis via the activation of the renin-angiotensin system
14. Stretch-mediated release of angiotensin-II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-Bax ratio in the cell
15. Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin-II
16. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats
17. Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure
18. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat
19. Cardioprotective effect of the angiotensin II type 1 receptor antagonist TCV-116 on ischemia-reperfusion injury
20. Opposite effects of angiotensin receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat heads
21. Nonpeptide angiotensin II receptor antagonists. VIII. Characterisation of functional antagonism displayed by DuP753, an orally active antihypertensive agent
22. In vivo pharmacologic characterization of UP269-6, a novel nonpeptide angiotensin II receptor antagonist
23. 1 receptors
24. Apoptosis participates in cellularity regulation during rat aortic intimal thickening
25. A new method to detect apoptosis in paraffin sections: In situ end-labeling of fragmented DNA
26. 'Apoptotic' myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation. Analysis by immunogold electron microscopy combined with in situ nick end-labeling
27. RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis
28. Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy. Not apoptosis but DNA repair
29. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction
30. Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes
31. Regulation of Bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes. Association with changes in mitochondrial membrane potential
32. The isolated perfused heart: A model for studying myocardial hypoxia or ischemia
33. Assessment of ischemic injury and protective interventions: The Langendorff versus the working rat heart preparation
34. Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia
35. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion
36. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis
37. Ischemic preconditioning decreases apoptosis in rat hearts in vivo
38. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo
39. Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart
40. Inhibition of endogenous nitric oxide synthase potentiates ischemia-reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway
41. Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction
42. Intrinsic Ang II type 1 receptor stimulation contributes to recovery of postischemic mechanical function
43. Increase in angiotensin II type 1 receptor expression immediately after ischemia-reperfusion in isolated rat hearts
44. 31Pnuclear magnetic resonance
45. Use of losartan to examine the role of the cardiac renin-angiotensin system in myocardial dysfunction during ischemia and reperfusion
46. Preconditioning in rabbit cardiomyocytes: Role of pH, vacuolar proton ATPase, and apoptosis
47. Apoptosis in myocardial ischemia-reperfusion
48. 2+ exchange
49. Intracellular ATP levels determine cell death fate by apoptosis or necrosis