The toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques

Journal of Virology

Volumn 79, Issue 22, 2005, Pages 14355-14370

  Wang, Yichuan ^a,b   Abel, Kristina ^a,b,c   Lantz, Katherine ^a,b   Krieg, Arthur M ^e   McChesney, Michael B ^a   Miller, Christopher J ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA CHEMOKINE; BETA INTERFERON; CD4 ANTIGEN; CHEMOKINE; CYTOKINE; DOUBLE STRANDED RNA; IMIQUIMOD; NUCLEIC ACID; OLIGODEOXYNUCLEOTIDE; RNA; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; INOCULATION; INTERFERON PRODUCTION; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SEXUAL TRANSMISSION; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE ACTIVATION; UTERINE CERVIX MUCOSA; VAGINA MUCOSA; VIRUS TITRATION; VIRUS TRANSMISSION;

ADMINISTRATION, INTRAVAGINAL; AMINOQUINOLINES; ANIMALS; CHEMOKINES; CYTOKINES; DINUCLEOSIDE PHOSPHATES; FEMALE; MACACA MULATTA; OLIGODEOXYRIBONUCLEOTIDES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VAGINA;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; MACACA MULATTA; RNA VIRUSES; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 27644446403     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.22.14355-14370.2005     Document Type: Article

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