'Chemical condoms' for the prevention of HIV infection: Evaluation of novel agents against SHIV89.6PD in vitro and in vivo

AIDS

Volumn 15, Issue 12, 2001, Pages 1563-1568

  Weber, Jonathan ^a   Nunn, Andrew ^b   O'Connor, Tim ^b   Jeffries, Don ^b   Kitchen, Valerie ^a   McCormack, Sheena ^b   Stott, Jim ^c   Almond, Neil ^c   Stone, Alan ^b   Darbyshire, Janet ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Dextrin 2 sulfate; Gramicidin D; HIV; Intravaginal challenge; Microbicide; Nonoxynol 9; PRO 2000; SHIV

Indexed keywords

ANTIVIRUS AGENT; DEXTRIN 2 SULFATE; GRAMICIDIN D; NONOXINOL 9; POLYMER; PRO 2000; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONDOM; CONTROLLED STUDY; DISEASE TRANSMISSION; DRUG ACTIVITY; DRUG SCREENING; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RHESUS MONKEY; SEROCONVERSION; TOXICITY; VIRUS CULTURE;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-HIV AGENTS; CELL LINE; DEXTRINS; FEMALE; GRAMICIDIN; HIV INFECTIONS; HIV-1; HUMANS; MACACA; MICROBIAL SENSITIVITY TESTS; NAPHTHALENESULFONATES; NONOXYNOL; POLYMERS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0035902942     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200108170-00014     Document Type: Article

References (20)

1. Inactivation of HTLV-III/LAV infected cultures of normal lymphocytes by nonoxynol-9 in vitro
2. I. Studies on the development of a vaginal preparation providing both prophylaxis against venereal disease and other genital infections and contraception. II. Effect in vitro of vaginal contraceptive and non-contraceptive preparations on Treponema pallidum and Neisseria gonnorrhoeae
3. Inactivation of clinical isolates of Herpesvirus hominis, types 1 and 2, by chemical contraceptives
4. Efficacy of nonoxynol-9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
5. A controlled trial of nonoxynol-9 film to reduce male-to-female transmission of sexually transmitted diseases
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7. A dosing study of nonoxynol-9 and genital irritation
8. A safety study of nonoxynol-9 as a vaginal microbicide: Evidence of adverse effects
9. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques
10. Dextrin sulphate and fucoidan are potent inhibitors of HIV infection in vitro
11. Naphthalene sulphonate polymers with CD4 blocking and anti-human immunodeficiency virus type 1 activity
12. Sulphated polysaccharides as potent inhibitors of HIV-induced syncytium formation
13. HIV replication in CD4-negative cell lines: Effect of cloning, CD4 expression and inhibition by dextrin sulphate
14. Infection of HIV-1 is blocked by binding of dextrin-2-sulphates to the cell surface of activated human peripheral blood mononuclear cells and cultured T-cells
15. Investigations into the mechanism by which sulphated polysaccharides inhibit HIV infection in vitro
16. Activity of gramicidin D against HIV-1 infection
17. A placebo-controlled, double-blind prospective study in healthy female volunteers of dextrin-2-sulphate gel
18. Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys
19. The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro
20. Comparison of antigen capture assays against HIV-1 in evaluating antiviral compounds