Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: A dual mechanism approach

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1737, Issue 1, 2005, Pages 1-10

  Eitsuka, Takahiro ^a   Nakagawa, Kiyotaka ^a   Suzuki, Toshihide ^b   Miyazawa, Teruo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

c myc; hTERT; PKC; PUFA; Telomerase inhibition

Indexed keywords

11 EICOSENIC ACID; ARACHIDIC ACID; CIS FATTY ACID; DOCOSAHEXAENOIC ACID; DOCOSATRIENOIC ACID; ELAIDIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLELAIDIC ACID; MYC PROTEIN; OLEIC ACID; POLYUNSATURATED FATTY ACID; PROTEIN KINASE C; SATURATED FATTY ACID; STEARIC ACID; TELOMERASE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; TRANS FATTY ACID; UNCLASSIFIED DRUG; VACCENIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL CULTURE; CELL LYSATE; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL-FREE SYSTEM; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXY ACIDS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-MYC; TELOMERASE;

EID: 27644431835     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2005.08.017     Document Type: Article

References (55)

1. M.J. McEachern, A. Krauskopf, and E.H. Blackburn Telomeres and their control Annu. Rev. Genet. 34 2000 331 358
2. G.B. Morin The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats Cell 59 1989 521 529
3. J. Feng, W.D. Funk, S.S. Wang, S.L. Weinrich, A.A. Avilion, C.P. Chiu, R.R. Adams, E. Chang, R.C. Allsopp, J. Yu, S. Le, M.D. West, C.B. Harley, W.H. Andrews, C.W. Greider, and B. Villeponteau The RNA component of human telomerase Science 269 1995 1236 1241
4. L. Harrington, T. McPhail, V. Mar, W. Zhou, R. Oulton, M.B. Bass, I. Arruda, and M.O. Robinson A mammalian telomerase-associated protein Science 275 1997 973 977
5. T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, and T.R. Cech Telomerase catalytic subunit homologs from fission yeast and human Science 277 1997 955 959
6. M. Meyerson, C.M. Counter, E.N. Eaton, L.W. Ellisen, P. Steiner, S.D. Caddle, L. Ziaugra, R.L. Beijersbergen, M.J. Davidoff, Q. Liu, S. Bacchetti, D.A. Haber, and R.A. Weinberg hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization Cell 90 1997 785 795
7. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L.C. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich, and J.W. Shay Specific association of human telomerase activity with immortal cells and cancers Science 266 1994 2011 2015
8. W.T. Cave Jr. Dietary n-3 (ω-3) polyunsaturated fatty acid effects on animal tumorigenesis FASEB J. 5 1991 2160 2166
9. U.N. Das Gamma-linolenic acid, arachidonic acid, and eicosapentaenoic acid as potential anticancer drugs Nutrition 6 1990 429 434
10. C.P. Diggle In vitro studies on the relationship between polyunsaturated fatty acids and cancer: tumour or tissue specific effects? Prog. Lipid Res. 41 2002 240 253
11. K. Tatematsu, J. Nakayama, M. Danbara, S. Shionoya, H. Sato, M. Omine, and F. Ishikawa A novel quantitative 'stretch PCR assay', that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias Oncogene 13 1996 2265 2274
12. W.R. Morrison, and L.M. Smith Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol J. Lipid Res. 5 1964 600 608
13. T. Eitsuka, N. Kiyotaka, M. Igarashi, and T. Miyazawa Telomerase inhibition by sulfoquinovosyldiacylglycerol from edible purple laver (Porphyra yezoensis) Cancer Lett. 212 2004 15 20
14. I. Bieche, C. Nogues, V. Paradis, M. Olivi, P. Bedossa, R. Lidereau, and M. Vidaud Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay Clin. Cancer Res. 6 2000 452 459
15. H.L. Wang, J. Wang, S.Y. Xiao, R. Haydon, D. Stoiber, T.C. He, M. Bissonnette, and J. Hart Elevated protein expression of cyclin D1 and fra-1 but decreased expression of c-myc in human colorectal adenocarcinomas overexpressing β-catenin Int. J. Cancer 101 2002 301 310
16. G.A. Ulaner, J.F. Hu, T.H. Vu, L.C. Giudice, and A.R. Hoffman Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts Cancer Res. 58 1998 4168 4172
17. M. Igarashi, and T. Miyazawa Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? Biochem. Biophys. Res. Commun. 270 2000 649 656
18. K.J. Wu, C. Grandori, M. Amacker, N. Simon-Vermot, A. Polack, J. Lingner, and R. Dalla-Favera Direct activation of TERT transcription by c-MYC Nat. Genet. 21 1999 220 224
19. C. Grandori, S.M. Cowley, L.P. James, and R.N. Eisenman The Myc/Max/Mad network and the transcriptional control of cell behavior Annu. Rev. Cell Dev. Biol. 16 2000 653 699
20. H. Li, L. Zhao, Z. Yang, J.W. Funder, and J.P. Liu Telomerase is controlled by protein kinase Cα in human breast cancer cells J. Biol. Chem. 273 1998 33436 33442
21. W.Y. Sheng, Y.L. Chien, and T.C.V. Wang The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes FEBS Lett. 540 2003 91 95
22. S.R. Coughlin, W.M.F. Lee, P.W. Williams, G.M. Giels, and L.T. Williams c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF Cell 43 1985 243 251
23. R.A. Greenberg, L. Chin, A. Femino, K.H. Lee, G.J. Gottlieb, R.H. Singer, C.W. Greider, and R.A. DePinho Short dysfunctional telomeres impair tumorigenesis in the INK4aΔ2/3 cancer-prone mouse Cell 97 1999 515 525
24. W.C. Hahn, S.A. Stewart, M.W. Brooks, S.G. York, E. Eaton, A. Kurachi, R.L. Beijersbergen, J.H.M. Knoll, M. Meyerson, and R.A. Weinberg Inhibition of telomerase limits the growth of human cancer cells Nat. Med. 5 1999 1164 1170
25. B.S. Herbert, A.E. Pitts, S.I. Baker, S.E. Hamilton, W.E. Wright, J.W. Shay, and D.R. Corey Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death Proc. Natl. Acad. Sci. U. S. A. 96 1999 14276 14281
26. A.E. Pitts, and D.R. Corey Inhibition of human telomerase by 2′-O-methyl-RNA Proc. Natl. Acad. Sci. U. S. A. 95 1998 11549 11554
27. J.C. Norton, M.A. Piatyszek, W.E. Wright, J.W. Shay, and D.R. Corey Inhibition of human telomerase activity by peptide nucleic acids Nat. Biotechnol. 14 1996 615 619
28. C. Strahl, and E.H. Blackburn Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines Mol. Cell. Biol. 16 1996 53 65
29. R.B. Pai, S.B. Pai, M. Kukhanova, G.E. Dutschman, X. Guo, and Y.C. Cheng Telomerase from human leukemia cells: properties and its interaction with deoxynucleoside analogues Cancer Res. 58 1998 1909 1913
30. R.T. Wheelhouse, D. Sun, H. Han, F.X. Han, and L.H. Hurley Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4- pyridyl)porphine with quadruplex DNA J. Am. Chem. Soc. 120 1998 3261 3262
31. O.Y. Fedoroff, M. Salazar, H. Han, V.V. Chemeris, S.M. Kerwin, and L.H. Hurley NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA Biochemistry 37 1998 12367 12374
32. N. Hayakawa, K. Nozawa, K. Ogawa, N. Kato, K. Yoshida, K. Akamatsu, M. Tsuchiya, A. Nagasawa, and S. Yoshida Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro Biochemistry 38 1999 11501 11507
33. K. Damm, U. Hemmann, P. Garin-Chesa, N. Hauel, I. Kauffmann, H. Priepke, C. Niestroj, C. Daiber, B. Enenkel, B. Guilliard, I. Lauritsch, E. Muller, E. Pascolo, G. Sauter, M. Pantic, U.M. Martens, C. Wenz, J. Lingner, N. Kraut, W.J. Rettig, and A. Schnapp A highly selective telomerase inhibitor limiting human cancer cell proliferation EMBO J. 20 2001 6958 6968
34. K. Shin-ya, K. Wierzba, K. Matsuo, T. Ohtani, Y. Yamada, K. Furihata, Y. Hayakawa, and H. Seto Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus J. Am. Chem. Soc. 123 2001 1262 1263
35. 3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid Leukemic cells Cancer Res. 59 1999 4023 4029
36. B. Ogretmen, J.M. Kraveka, D. Schady, J. Usta, Y.A. Hannun, and L.M. Obeid Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line J. Biol. Chem. 276 2001 32506 32514
37. C. Ramachandran, H.B. Fonseca, P. Jhabvala, E.A. Escalon, and S.J. Melnick Curcumin inhibits telomerase activity through human telomerase reverse transcriptase in MCF-7 breast cancer cell line Cancer Lett. 184 2002 1 6
38. M. Oda, T. Ueno, N. Kasai, H. Takahashi, H. Yoshida, F. Sugawara, K. Sakaguchi, H. Hayashi, and Y. Mizushina Inhibition of telomerase by linear-chain fatty acids: structural analysis Biochem. J. 367 2002 329 334
39. L.K. White, W.E. Wright, and J.W. Shay Telomerase inhibitors Trends Biotechnol. 19 2001 114 120
40. F. Lavelle, J. Riou, A. Laoui, and P. Mailliet Telomerase: a therapeutic target for the third millennium? Crit. Rev. Oncol./Hematol. 34 2000 111 126
41. L.A. Kohlstaedt, J. Wang, J.M. Friedman, P.A. Rice, and T.A. Steitz Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor Science 256 1992 1783 1790
42. A. Jacobo-Molina, J. Ding, R.G. Nanni, A.D. Clark, X. Lu, C. Tantillo, R.L. Williams, G. Kamer, A.L. Ferris, P. Clark, A. Hizi, S.H. Hughes, and E. Arnold Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA Proc. Natl. Acad. Sci. U. S. A. 90 1993 6320 6324
43. H. Huang, R. Chopra, G.L. Verdine, and S.C. Harrison Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications of drug resistance Science 282 1998 1669 1675
44. R. Esnouf, J. Ren, C. Ross, Y. Jones, D. Stammers, and D. Stuart Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleotide inhibitors Nat. Struct. Biol. 2 1995 303 308
45. D. Bosoy, and N.F. Lue Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase J. Biol. Chem. 276 2001 46305 46312
46. Y. Peng, I.S. Mian, and N.F. Lue Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomerase maintenance Mol. Cell 7 2001 1201 1211
47. M. Takakura, S. Kyo, T. Kanaya, M. Tanaka, and M. Inoue Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer Cancer Res. 58 1998 1558 1561
48. P.C. Calder, J.A. Bond, D.J. Harvey, S. Gordon, and E.A. Newsholme Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis Biochem. J. 269 1990 807 814
49. Y.S. Cong, J. Wen, and S. Bacchetti The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter Hum. Mol. Genet. 8 1999 137 142
50. M. Takakura, S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo, and M. Inoue Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal promoter sequences essential for transcriptional activation in immortalized and cancer cells Cancer Res. 59 1999 551 557
51. I. Horikawa, P.L. Cable, C. Afshari, and J.C. Barrett Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene Cancer Res. 59 1999 826 830
52. K. Fujimoto, and M. Takahashi Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA Biochem. Biophys. Res. Commun. 241 1997 775 781
53. D.P. Rose, and J.M. Connolly Omega-3 fatty acids as cancer chemopreventive agents Pharmacol. Ther. 83 1999 217 244
54. W. Yu, N.R. Murray, C. Weems, L. Chen, H. Guo, R. Ethridge, J.D. Ceci, B.M. Evers, E.A. Thompson, and A.P. Fields Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis J. Biol. Chem. 278 2003 11167 11174
55. N.R. Murray, C. Weems, L. Chen, J. Leon, W. Yu, L.A. Davidson, L. Jamieson, R.S. Chapkin, E.A. Thompson, and A.P. Fields Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis J. Cell Biol. 157 2002 915 920