Conformational studies of irreversible HIV-1 protease inhibitors containing cis-epoxide as an amide isostere

Journal of Peptide Research

Volumn 54, Issue 3, 1999, Pages 242-248

  Ro, Seonggu ^a   Baek, S G ^a   Lee, B ^a   Ok, J H ^a  

^a LG Chemical Ltd   (South Korea)

Author keywords

Cis epoxide amide isostere; HIV 1 protease inhibitor, irreversible inhibitor, molecular modeling; NMR spectroscopy; Peptidomimetic inhibitor

Indexed keywords

AMIDE; EPOXIDE; LB 71116; LB 71148; PENICILLAMINE DERIVATIVE; PROTEINASE INHIBITOR; QUINALDIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SELECTIVITY; DRUG STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

AMIDES; CRYSTALLOGRAPHY, X-RAY; EPOXY COMPOUNDS; HIV PROTEASE INHIBITORS; HIV-1; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MODELS, STRUCTURAL; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032847037     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00112.x     Document Type: Article

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