메뉴 건너뛰기




Volumn 22, Issue 10, 2005, Pages 1150-1161

Neuroimmunophilin ligands improve functional recovery and increase axonal growth after spinal cord hemisection in rats

Author keywords

FK1706; FK506; Hemisection; Immunophilin; Neuroimmunophilin ligands; Nonimmunosuppressant derivative; Spinal Cord

Indexed keywords

AMOXICILLIN; BACITRACIN ZINC; BUPRENORPHINE; CYCLOSPORIN A; DIMETHYL SULFOXIDE; FK 1706; GOLD; IMMUNOLOGIC AGENT; NEUROIMMUNOPHILIN; POLYMYXIN B; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 27444436746     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2005.22.1150     Document Type: Article
Times cited : (35)

References (60)
  • 1
    • 0032816454 scopus 로고    scopus 로고
    • The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: Neuroprotection and local regeneration
    • BAVETTA, S., HAMLYN, P.J., BURNSTOCK, G., LIEBERMAN, A.R., and ANDERSON, P.N. (1999). The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. Exp. Neurol. 158, 382-393.
    • (1999) Exp. Neurol. , vol.158 , pp. 382-393
    • Bavetta, S.1    Hamlyn, P.J.2    Burnstock, G.3    Lieberman, A.R.4    Anderson, P.N.5
  • 2
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • BONNI, A., BRUNET, A., WEST, A.E., DATTA, S.R., TAKASU, M.A., and GREENBERG, M.E. (1999). Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 3
    • 0015240311 scopus 로고
    • Projections and termination of the corticospinal tract in rodents
    • BROWN, L.T., JR. (1971). Projections and termination of the corticospinal tract in rodents. Exp. Brain Res. 13, 432-450.
    • (1971) Exp. Brain Res. , vol.13 , pp. 432-450
    • Brown Jr., L.T.1
  • 5
    • 0345711646 scopus 로고    scopus 로고
    • Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats
    • DIAZ-RUIZ, A., RIOS, C., DUARTE, I., et al. (1999). Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats. Neurosci. Lett. 266, 61-64.
    • (1999) Neurosci. Lett. , vol.266 , pp. 61-64
    • Diaz-Ruiz, A.1    Rios, C.2    Duarte, I.3
  • 6
    • 13944266687 scopus 로고    scopus 로고
    • Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord
    • FOUAD, K., SCHNELL, L., BUNGE, M.B., SCHWAB, M.E., LIEBSCHER, T., and PEARSE, D.D. (2005). Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J. Neurosci. 25, 1169-1178.
    • (2005) J. Neurosci. , vol.25 , pp. 1169-1178
    • Fouad, K.1    Schnell, L.2    Bunge, M.B.3    Schwab, M.E.4    Liebscher, T.5    Pearse, D.D.6
  • 7
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • FREMAN, D.A., KLEE, C.B., BIERER, B.E., and BURAKOFF, S.J. (1992). Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc. Natl. Acad. Sci. USA. 89, 3686-3690.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3686-3690
    • Freman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 9
    • 0032776433 scopus 로고    scopus 로고
    • FK506 and the role of the immunophilin FKBP-52 in nerve regeneration
    • GOLD, B.G. (1999). FK506 and the role of the immunophilin FKBP-52 in nerve regeneration. Drug Metab. Rev. 31, 649-663.
    • (1999) Drug Metab. Rev. , vol.31 , pp. 649-663
    • Gold, B.G.1
  • 10
    • 0002668514 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands and the role of steroid hormone chaperone proteins in nerve regeneration
    • B.G. Gold, G. Fischer, and T. Herdegen (eds), Prous Science: Barcelona
    • GOLD, B.G. (2000). Neuroimmunophilin ligands and the role of steroid hormone chaperone proteins in nerve regeneration, in: Immunophilins in the Brain. FKBP-Ligands: Novel Strategies for the Treatment of Neurodegenerative Disorders. B.G. Gold, G. Fischer, and T. Herdegen (eds), Prous Science: Barcelona, pps. 3-22.
    • (2000) Immunophilins in the Brain. FKBP-Ligands: Novel Strategies for the Treatment of Neurodegenerative Disorders , pp. 3-22
    • Gold, B.G.1
  • 11
    • 0141595912 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands: The development of novel neuroregenerative/ neuroprotective compounds
    • GOLD, B.G., and VILLAFRANCA, J.E. (2003). Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr. Top. Med. Chem. 3, 1368-1375.
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 1368-1375
    • Gold, B.G.1    Villafranca, J.E.2
  • 12
    • 1842507643 scopus 로고    scopus 로고
    • FK506 requires stimulation of the extracellular signal regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation
    • GOLD, B.G., and ZHONG, Y.P. (2004). FK506 requires stimulation of the extracellular signal regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation. Neurosignals 13, 122-129.
    • (2004) Neurosignals , vol.13 , pp. 122-129
    • Gold, B.G.1    Zhong, Y.P.2
  • 13
    • 0028352763 scopus 로고
    • The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury
    • GOLD, B.G., STORM-DICKERSON, T., and AUSTIN, D.R. (1994). The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor. Neurol. Neurosci. 6, 287-296.
    • (1994) Restor. Neurol. Neurosci. , vol.6 , pp. 287-296
    • Gold, B.G.1    Storm-Dickerson, T.2    Austin, D.R.3
  • 14
    • 0028783373 scopus 로고
    • The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve
    • GOLD, B.G., KATOH, K., and STORM-DICKERSON, T. (1995). The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15, 7509-7516.
    • (1995) J. Neurosci. , vol.15 , pp. 7509-7516
    • Gold, B.G.1    Katoh, K.2    Storm-Dickerson, T.3
  • 16
    • 0001590107 scopus 로고    scopus 로고
    • FK506 produces regeneration, but not neuroprotection, of nigrostriatal dopaminergic neurons in MPTP-treated mice
    • GOLD, B.G., GORDON, H.S., ZELENY-POOLEY, M., and WANG, M.S. (1998). FK506 produces regeneration, but not neuroprotection, of nigrostriatal dopaminergic neurons in MPTP-treated mice. Brain Pathol. 8, 583.
    • (1998) Brain Pathol. , vol.8 , pp. 583
    • Gold, B.G.1    Gordon, H.S.2    Zeleny-Pooley, M.3    Wang, M.S.4
  • 17
    • 0033034203 scopus 로고    scopus 로고
    • Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
    • GOLD, B.G., DENSMORE, V., SHOU, W., MATZUK, M.M., and GORDON, H.S. (1999). Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J. Pharmacol. Exp. Ther. 289, 1202-1210.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1202-1210
    • Gold, B.G.1    Densmore, V.2    Shou, W.3    Matzuk, M.M.4    Gordon, H.S.5
  • 18
    • 1842814246 scopus 로고    scopus 로고
    • The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy
    • GOLD, B.G., VODA, J., YU, X., and GORDON, G. (2004a). The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy. Exp. Neurol. 187, 160-170.
    • (2004) Exp. Neurol. , vol.187 , pp. 160-170
    • Gold, B.G.1    Voda, J.2    Yu, X.3    Gordon, G.4
  • 19
    • 3242814526 scopus 로고    scopus 로고
    • FK506 and a nonimmunosuppressant derivative reduce axonal and myelin damage in experimental autoimmune encephalomyelitis: Neuroimmunophilin ligand-mediated neuroprotection in a model of multiple sclerosis
    • GOLD, B.G., VODA, J., YU, X., MCKEON, G., and BOURDETTE, D.N. (2004b). FK506 and a nonimmunosuppressant derivative reduce axonal and myelin damage in experimental autoimmune encephalomyelitis: neuroimmunophilin ligand-mediated neuroprotection in a model of multiple sclerosis. J. Neurosci. Res. 77, 367-377.
    • (2004) J. Neurosci. Res. , vol.77 , pp. 367-377
    • Gold, B.G.1    Voda, J.2    Yu, X.3    Mckeon, G.4    Bourdette, D.N.5
  • 20
    • 2942565668 scopus 로고    scopus 로고
    • Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neurophathies
    • GOLD, B.G., UDINA, E., BOURDETTE, D., and NAVARRO, X. (2004c). Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neurophathies. Neurol. Res. 26, 371-380.
    • (2004) Neurol. Res. , vol.26 , pp. 371-380
    • Gold, B.G.1    Udina, E.2    Bourdette, D.3    Navarro, X.4
  • 22
    • 0020585011 scopus 로고
    • Collaterals of rubrospinal neurons to the cerebellum in rat. A retrograde fluorescent double labeling study
    • HUISMAN, A.M., KUYPERS, H.G., CONDE, F., and KEIZER, K. (1983). Collaterals of rubrospinal neurons to the cerebellum in rat. A retrograde fluorescent double labeling study. Brain Res. 264, 181-196.
    • (1983) Brain Res. , vol.264 , pp. 181-196
    • Huisman, A.M.1    Kuypers, H.G.2    Conde, F.3    Keizer, K.4
  • 23
    • 0019507823 scopus 로고
    • Quantitative differences in collateralization of the descending spinal pathways from red nucleus and other brain stem cell groups in rat as demonstrated with the multiple fluorescent retrograde tracer technique
    • HUISMAN, A.M., KUYPERS, H.G., and VERBURGH, C.A. (1981). Quantitative differences in collateralization of the descending spinal pathways from red nucleus and other brain stem cell groups in rat as demonstrated with the multiple fluorescent retrograde tracer technique. Brain Res. 209, 271-286.
    • (1981) Brain Res. , vol.209 , pp. 271-286
    • Huisman, A.M.1    Kuypers, H.G.2    Verburgh, C.A.3
  • 24
    • 0036270263 scopus 로고    scopus 로고
    • MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad
    • JIN, K., MAO, X.O., ZHU, Y., and GREENBERG, D.A. (2002). MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J. Neurochem. 80, 119-125.
    • (2002) J. Neurochem. , vol.80 , pp. 119-125
    • Jin, K.1    Mao, X.O.2    Zhu, Y.3    Greenberg, D.A.4
  • 25
    • 13244277654 scopus 로고    scopus 로고
    • Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord
    • KAMADA, T., KODA, M., DEZAWA, M., et al. (2005). Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J. Neuropathol. Exp. Neurol. 64, 37-45.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 37-45
    • Kamada, T.1    Koda, M.2    Dezawa, M.3
  • 26
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • KAPLAN, D.R., and MILLER, F.D. (2000). Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381-391.
    • (2000) Curr. Opin. Neurobiol. , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 27
    • 0023245677 scopus 로고
    • FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physio-chemical and biological characteristics
    • KINO, T., HATANAKA, H., HASHIMOTO, M., and NISHIYAMA, H. (1987). FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physio-chemical and biological characteristics. J. Antibiot. 40, 1249-1255.
    • (1987) J. Antibiot. , vol.40 , pp. 1249-1255
    • Kino, T.1    Hatanaka, H.2    Hashimoto, M.3    Nishiyama, H.4
  • 28
    • 0037352890 scopus 로고    scopus 로고
    • The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
    • KLETTNER, A., and HERDEGEN, T. (2003). The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br. J. Pharmacol. 138, 1004-1012.
    • (2003) Br. J. Pharmacol. , vol.138 , pp. 1004-1012
    • Klettner, A.1    Herdegen, T.2
  • 29
    • 0035041217 scopus 로고    scopus 로고
    • The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats
    • LANG-LAZDUNSKI, L., HEURTEAUX, C., DUPONT, H., ROUELLE, D., WIDMANN, C., and MANTZ, J. (2001). The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. Anesth. Analg. 92, 1237-1244.
    • (2001) Anesth. Analg. , vol.92 , pp. 1237-1244
    • Lang-Lazdunski, L.1    Heurteaux, C.2    Dupont, H.3    Rouelle, D.4    Widmann, C.5    Mantz, J.6
  • 30
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin a and FKBP-FK506 complexes
    • LIU, J., FARMER, J.D., LANE, W.S., FRIEDMAN, J., WEISSMAN, L, and SCHREIBER, S.L. (1991). Calcineurin is a common target of cyclophilin- cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, L.5    Schreiber, S.L.6
  • 31
    • 0036935096 scopus 로고    scopus 로고
    • Grafts of BDNF-producing fibroblasts rescue axotomized rubrospinal neurons and prevent their atrophy
    • LIU, Y., HIMES, B.T., MURRAY, M., TESSLER, A., and FISCHER, I. (2002). Grafts of BDNF-producing fibroblasts rescue axotomized rubrospinal neurons and prevent their atrophy. Exp. Neurol. 178, 150-164.
    • (2002) Exp. Neurol. , vol.178 , pp. 150-164
    • Liu, Y.1    Himes, B.T.2    Murray, M.3    Tessler, A.4    Fischer, I.5
  • 32
    • 0037109228 scopus 로고    scopus 로고
    • Detection of reactive oxygen species by flow cytometry after spinal cord injury
    • LUO, J., LI, N., PAUL ROBINSON, J., and SHI, R. (2002). Detection of reactive oxygen species by flow cytometry after spinal cord injury. J. Neurosci. Methods 120, 105-112.
    • (2002) J. Neurosci. Methods , vol.120 , pp. 105-112
    • Luo, J.1    Li, N.2    Paul Robinson, J.3    Shi, R.4
  • 33
    • 0028202076 scopus 로고
    • Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia
    • LYONS, W.E., GEORGE, E.B., DAWSON, T.M., STEINER, J.P., and SNYDER, S.H. (1994). Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. Natl. Acad. Sci. USA 91, 3191-3195.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3191-3195
    • Lyons, W.E.1    George, E.B.2    Dawson, T.M.3    Steiner, J.P.4    Snyder, S.H.5
  • 34
    • 0028956418 scopus 로고
    • Neuronal regeneration enhances the expression of the immunophilin FKBP-12
    • LYONS, W.E., STEINER, J.P., SNYDER, S.H., and DAWSON, T.M. (1995). Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J. Neurosci. 15, 2985-2994.
    • (1995) J. Neurosci. , vol.15 , pp. 2985-2994
    • Lyons, W.E.1    Steiner, J.P.2    Snyder, S.H.3    Dawson, T.M.4
  • 35
    • 0032411557 scopus 로고    scopus 로고
    • Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats
    • MADSEN, J.R., MACDONALD, P., IRWIN, N., et al. (1998). Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. Exp. Neurol. 154, 673-683.
    • (1998) Exp. Neurol. , vol.154 , pp. 673-683
    • Madsen, J.R.1    Macdonald, P.2    Irwin, N.3
  • 36
    • 0029142480 scopus 로고
    • Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo
    • MURAKI, T., SASAKI, Y., GIDDING, J.C., ISHII, H., KANEKO, T., and YAMAMOTO, J. (1995). Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo. Transplantation. 60, 308-310.
    • (1995) Transplantation , vol.60 , pp. 308-310
    • Muraki, T.1    Sasaki, Y.2    Gidding, J.C.3    Ishii, H.4    Kaneko, T.5    Yamamoto, J.6
  • 37
    • 0032571841 scopus 로고    scopus 로고
    • Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood
    • MURAKI, T., TAKA, T., NOGUCHI, T., ISHII, H., SEKI, J., and YAMAMOTO, J. (1998). Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood. Transplantation 65, 1132-1134.
    • (1998) Transplantation , vol.65 , pp. 1132-1134
    • Muraki, T.1    Taka, T.2    Noguchi, T.3    Ishii, H.4    Seki, J.5    Yamamoto, J.6
  • 38
    • 0018718485 scopus 로고
    • Origin of the rubrospinal tract of the rat
    • MURRAY, H.M., and GURULE, M.E. (1979). Origin of the rubrospinal tract of the rat. Neurosci. Lett. 14, 19-23.
    • (1979) Neurosci. Lett. , vol.14 , pp. 19-23
    • Murray, H.M.1    Gurule, M.E.2
  • 39
    • 1842452818 scopus 로고    scopus 로고
    • Treatment with cyclosporine a promotes axonal regeneration in rats submitted to transverse section of the spinal cord. II. Recovery of function
    • PALLADINI, G., CARONTI, B., POZZESSERE, G., et al. (1996). Treatment with cyclosporine A promotes axonal regeneration in rats submitted to transverse section of the spinal cord. II. Recovery of function. J. Brain Res. 37, 145-153.
    • (1996) J. Brain Res. , vol.37 , pp. 145-153
    • Palladini, G.1    Caronti, B.2    Pozzessere, G.3
  • 40
    • 0034589376 scopus 로고    scopus 로고
    • Plasticity of neuronal networks in the spinal cord: Modifications in response to altered sensory input
    • PEARSON, K.G. (2000). Plasticity of neuronal networks in the spinal cord: modifications in response to altered sensory input. Prog. Brain Res. 128, 61-70.
    • (2000) Prog. Brain Res. , vol.128 , pp. 61-70
    • Pearson, K.G.1
  • 42
    • 13844280494 scopus 로고    scopus 로고
    • FK1706, a novel non-immunosuppressive immunophilin ligand: Neurotrophic activity and mechanism of action
    • in press
    • PRICE, R.D., YAMAJI, T., YAMAMOTO, H., et al. (2005). FK1706, a novel non-immunosuppressive immunophilin ligand: neurotrophic activity and mechanism of action. Eur. J. Pharmacol. (in press).
    • (2005) Eur. J. Pharmacol.
    • Price, R.D.1    Yamaji, T.2    Yamamoto, H.3
  • 43
    • 0035008642 scopus 로고    scopus 로고
    • Cyclosporin a treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing
    • RABCHEVSKY, A.G., FUGACCIA, I., SULLIVAN, P.G., and SCHEFF, S.W. (2001). Cyclosporin A treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing. J. Neurotrauma 18, 513-522.
    • (2001) J. Neurotrauma , vol.18 , pp. 513-522
    • Rabchevsky, A.G.1    Fugaccia, I.2    Sullivan, P.G.3    Scheff, S.W.4
  • 45
    • 0025605444 scopus 로고
    • Hsp56: A novel heat shock protein associated with untransformed steroid receptor complexes
    • SANCHEZ, E.R. (1990). Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes. J. Biol. Chem. 265, 22067-22070.
    • (1990) J. Biol. Chem. , vol.265 , pp. 22067-22070
    • Sanchez, E.R.1
  • 46
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin a and FK506
    • SCHREIBER, S.L., and CRABTREE, G.R. (1992). The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136-142.
    • (1992) Immunol. Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 47
    • 0027937489 scopus 로고
    • Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
    • SHARKEY, J., and BUTCHER, S.P. (1994). Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature 371, 336-339.
    • (1994) Nature , vol.371 , pp. 336-339
    • Sharkey, J.1    Butcher, S.P.2
  • 48
    • 0020663787 scopus 로고
    • Origin of the rubrospinal tract in neonatal, developing, and mature rats
    • SHIEH, J.Y., LEONG, S.K., and WONG, W.C. (1983). Origin of the rubrospinal tract in neonatal, developing, and mature rats. J. Comp. Neurol. 214, 79-86.
    • (1983) J. Comp. Neurol. , vol.214 , pp. 79-86
    • Shieh, J.Y.1    Leong, S.K.2    Wong, W.C.3
  • 49
    • 0026748870 scopus 로고
    • Cyclosporin A, FK-506, and Rapamycin: Pharmacologic probes of lymphocyte signal transduction
    • SIGAL, N.H., and DUMONT, F.J. (1992). Cyclosporin A, FK-506, and Rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10, 519-560.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 519-560
    • Sigal, N.H.1    Dumont, F.J.2
  • 50
    • 0030975605 scopus 로고    scopus 로고
    • Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
    • STEINER, J.P., CONNOLLY, M.A., VALENTINE, H.L., et al. (1997a). Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat. Med. 3, 421-428.
    • (1997) Nat. Med. , vol.3 , pp. 421-428
    • Steiner, J.P.1    Connolly, M.A.2    Valentine, H.L.3
  • 51
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • STEINER, J.P., HAMILTON, G.S., ROSS, D.T., et al. (1997b). Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl. Acad. Sci. USA 94, 2019-2024.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2019-2024
    • Steiner, J.P.1    Hamilton, G.S.2    Ross, D.T.3
  • 52
    • 0036255020 scopus 로고    scopus 로고
    • FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation
    • SULAIMAN, O.A., VODA, J., GOLD, B.G., and GORDON, T. (2002). FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation. Exp. Neurol. 175, 127-137.
    • (2002) Exp. Neurol. , vol.175 , pp. 127-137
    • Sulaiman, O.A.1    Voda, J.2    Gold, B.G.3    Gordon, T.4
  • 53
    • 0026710278 scopus 로고
    • Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex
    • TAI, P.-K.K., ALBERS, M.W., CHANG, H., FABER, L.E., and SCHREIBER, S.L. (1992). Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256, 1315-1318.
    • (1992) Science , vol.256 , pp. 1315-1318
    • Tai, P.-K.K.1    Albers, M.W.2    Chang, H.3    Faber, L.E.4    Schreiber, S.L.5
  • 54
    • 0026744641 scopus 로고
    • Transcription of IL-4 genes is not inhibited by cyclosporin a in competent T cells
    • TERADA, N., OR, R., WEINBERG, K., DOMENICO, J., LUCAS, J.J., and GELFAND, E.W. (1992). Transcription of IL-4 genes is not inhibited by cyclosporin A in competent T cells. J. Biol. Chem. 267, 21207-21210.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21207-21210
    • Terada, N.1    Or, R.2    Weinberg, K.3    Domenico, J.4    Lucas, J.J.5    Gelfand, E.W.6
  • 55
    • 0024412228 scopus 로고
    • The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes
    • TOCCI, M.J., MATKOVICH, D.A., MATKOVICH, K., et al. (1989). The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143, 718-726.
    • (1989) J. Immunol. , vol.143 , pp. 718-726
    • Tocci, M.J.1    Matkovich, D.A.2    Matkovich, K.3
  • 56
    • 0042191634 scopus 로고    scopus 로고
    • Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft
    • UDINA, E., VODA, J., GOLD, B.G., and NAVARRO, X. (2003). Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft. J. Peripher. Nerv. Syst. 8, 145-154.
    • (2003) J. Peripher. Nerv. Syst. , vol.8 , pp. 145-154
    • Udina, E.1    Voda, J.2    Gold, B.G.3    Navarro, X.4
  • 57
    • 0014594221 scopus 로고
    • Descending nerve tracts in the spinal cord of the rat. I. Fibers from the midbrain
    • WALDRON, H.A., and GWYN, D.G. (1969). Descending nerve tracts in the spinal cord of the rat. I. Fibers from the midbrain. J. Comp. Neurol. 137, 143-153.
    • (1969) J. Comp. Neurol. , vol.137 , pp. 143-153
    • Waldron, H.A.1    Gwyn, D.G.2
  • 58
    • 0030839896 scopus 로고    scopus 로고
    • Comparative dose-dependence study of FK506 and cyclosporin a on the rate of axonal regeneration in rat sciatic nerve
    • WANG, M.S., ZELENY-POOLEY, M., and GOLD, B.G. (1997). Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in rat sciatic nerve. J. Pharmacol. Exp. Ther. 282, 1084-1093.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 1084-1093
    • Wang, M.S.1    Zeleny-Pooley, M.2    Gold, B.G.3
  • 59
    • 0033534642 scopus 로고    scopus 로고
    • Zinc and copper inhibit nerve growth factor-mediated protection from oxidative stress-induced apoptosis
    • WANG, W., POST, J.I., DOW, K.E., SHIN, S.H., RIOPELLE, R.J., and ROSS, G.M. (1999). Zinc and copper inhibit nerve growth factor-mediated protection from oxidative stress-induced apoptosis. Neurosci. Lett. 259, 115-118.
    • (1999) Neurosci. Lett. , vol.259 , pp. 115-118
    • Wang, W.1    Post, J.I.2    Dow, K.E.3    Shin, S.H.4    Riopelle, R.J.5    Ross, G.M.6
  • 60
    • 0037302354 scopus 로고    scopus 로고
    • Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes
    • ZAWADZKA, M., and KAMINSKA, B. (2003). Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes. Mol. Cell Neurosci. 22, 202-209.
    • (2003) Mol. Cell Neurosci. , vol.22 , pp. 202-209
    • Zawadzka, M.1    Kaminska, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.